Anand S. Dighe
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View article: Progressive natural killer cell dysfunction in advanced-stage clear-cell renal cell carcinoma and association with clinical outcomes
Progressive natural killer cell dysfunction in advanced-stage clear-cell renal cell carcinoma and association with clinical outcomes Open
A dysfunctional, tumor-resident NK cell phenotype was enriched among patients with metastatic disease and associated with worse survival in patients with advanced ccRCC across multiple patient cohorts. Restoration of NK cell function (via …
View article: Structure-Based Virtual Screening in Oncology: Repurposing FDAApproved Drugs for Breast Cancer
Structure-Based Virtual Screening in Oncology: Repurposing FDAApproved Drugs for Breast Cancer Open
Structure-based virtual screening (SBVS) has been recently established as a significant and fruitful computational method in drug repurposing, where drugs already approved by the FDA are screened for their potential therapeutic effects aga…
View article: CRISPR-enabled point-of-care genotyping for APOL1 genetic risk assessment
CRISPR-enabled point-of-care genotyping for APOL1 genetic risk assessment Open
Detecting genetic variants enables risk factor identification, disease screening, and initiation of preventative therapeutics. However, current methods, relying on hybridization or sequencing, are unsuitable for point-of-care settings. In …
View article: Clinical decision support to improve CBC and differential ordering
Clinical decision support to improve CBC and differential ordering Open
Objectives Complete blood count and differential (CBC diff) is a common laboratory test that may be overused or misordered, particularly in an inpatient setting. We assessed the ability of a clinical decision support (CDS) alert to decreas…
View article: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine response in adults with predominantly antibody deficiency
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine response in adults with predominantly antibody deficiency Open
In all of the patients with PAD, anti-spike antibody levels increased with successive SARS-CoV-2 immunizations and were correlated with neutralization of both the SARS-CoV-2 wild-type strain and the Omicron BA.5 variant. Secondary PAD, sev…
View article: Clinical Decision Support in Laboratory Medicine
Clinical Decision Support in Laboratory Medicine Open
Journal Article Clinical Decision Support in Laboratory Medicine Get access Kay Weng Choy, Kay Weng Choy Director of Chemical Pathology, Department of Pathology, Northern Health, Epping, Australia Address correspondence to this author at: …
View article: Using machine learning to develop smart reflex testing protocols
Using machine learning to develop smart reflex testing protocols Open
Objective Reflex testing protocols allow clinical laboratories to perform second line diagnostic tests on existing specimens based on the results of initially ordered tests. Reflex testing can support optimal clinical laboratory test order…
View article: Delayed and Attenuated Antibody Responses to Coronavirus Disease 2019 Vaccination With Poor Cross-Variant Neutralization in Solid-Organ Transplant Recipients—A Prospective Longitudinal Study
Delayed and Attenuated Antibody Responses to Coronavirus Disease 2019 Vaccination With Poor Cross-Variant Neutralization in Solid-Organ Transplant Recipients—A Prospective Longitudinal Study Open
Background Therapeutically immunosuppressed transplant recipients exhibit attenuated responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines. To elucidate the kinetics and variant cross-protection of vaccine-indu…
View article: Using Machine Learning to Develop Smart Reflex Testing Protocols
Using Machine Learning to Develop Smart Reflex Testing Protocols Open
Objective: Reflex testing protocols allow clinical laboratories to perform second line diagnostic tests on existing specimens based on the results of initially ordered tests. Reflex testing can support optimal clinical laboratory test orde…
View article: Use of Clinical Decision Support to Improve the Laboratory Evaluation of Monoclonal Gammopathies
Use of Clinical Decision Support to Improve the Laboratory Evaluation of Monoclonal Gammopathies Open
Objectives There is considerable variation in ordering practices for the initial laboratory evaluation of monoclonal gammopathies (MGs) despite clear society guidelines to include serum free light chain (sFLC) testing. We assessed the abil…
View article: Clinical decision support improves blood culture collection before intravenous antibiotic administration in the emergency department
Clinical decision support improves blood culture collection before intravenous antibiotic administration in the emergency department Open
Objective Surviving Sepsis guidelines recommend blood cultures before administration of intravenous (IV) antibiotics for patients with sepsis or moderate to high risk of bacteremia. Clinical decision support (CDS) that reminds emergency de…
View article: The Effect of Vaccine Type and SARS-CoV-2 Lineage on Commercial SARS-CoV-2 Serologic and Pseudotype Neutralization Assays in mRNA Vaccine Recipients
The Effect of Vaccine Type and SARS-CoV-2 Lineage on Commercial SARS-CoV-2 Serologic and Pseudotype Neutralization Assays in mRNA Vaccine Recipients Open
We evaluated anti-spike antibody concentrations in healthy mRNA vaccinated individuals and compared these concentrations to values obtained from pseudotype neutralization assays targeting SARS-CoV-2 variants of concern to determine how wel…