Daniël Bos
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View article: Electronic nose for detecting abnormal glucose metabolism in heart transplant recipients
Electronic nose for detecting abnormal glucose metabolism in heart transplant recipients Open
Prediabetes or PTDM is common in HTR. eNose technology, especially when combined with clinical data, shows promise as a non-invasive screening tool with high specificity and PPV. This approach may reduce OGTT burden, pending further confir…
View article: Can machine learning improve on the early prediction of upper limb recovery after stroke?
Can machine learning improve on the early prediction of upper limb recovery after stroke? Open
View article: MyDigiTwin: A privacy-preserving framework for personalized cardiovascular risk prediction and scenario exploration
MyDigiTwin: A privacy-preserving framework for personalized cardiovascular risk prediction and scenario exploration Open
Cardiovascular disease (CVD) remains a leading cause of death, and primary prevention through personalized interventions is crucial. This paper introduces MyDigiTwin, a framework that integrates health digital twins with personal health en…
View article: Improving reproducibility of data analysis and code in medical research: 5 recommendations to get started
Improving reproducibility of data analysis and code in medical research: 5 recommendations to get started Open
Due to the growing use of high-dimensional data and methodological advances in medical research, reproducibility of research is increasingly dependent on the availability of reproducible code. However, code is rarely made available and too…
View article: Arteriosclerosis in the heart-brain axis and Alzheimer's disease plasma markers in the Rotterdam Study
Arteriosclerosis in the heart-brain axis and Alzheimer's disease plasma markers in the Rotterdam Study Open
Background Arteriosclerosis in the heart-brain axis has emerged as an important area of study in Alzheimer's disease (AD) dementia research. While previous research primarily focused on structural brain changes, the relationship between ar…
View article: Physical activity relates to carotid plaque vulnerability in older persons with subclinical carotid atherosclerosis
Physical activity relates to carotid plaque vulnerability in older persons with subclinical carotid atherosclerosis Open
View article: The Carotid Siphon as a Pulsatility Modulator for Brain Protection: Role of Arterial Calcification Formation
The Carotid Siphon as a Pulsatility Modulator for Brain Protection: Role of Arterial Calcification Formation Open
A healthy vasculature with well-regulated perfusion and pulsatility is essential for the brain. One vascular structure that has received little attention is the carotid siphon. The proximal portion of the siphon is stiff due to the narrow …
View article: Multiphase aortic valve calcium scoring on true-non-contrast and calcium-preserving spectral reconstructions using dual-source photon-counting detector CT
Multiphase aortic valve calcium scoring on true-non-contrast and calcium-preserving spectral reconstructions using dual-source photon-counting detector CT Open
Objectives: This study investigated differences between aortic valve calcium (AVC) scores derived from true non-contrast (TNC) and virtual-non-contrast reconstructions acquired with photon-counting detector CT (PCD-CT) and the impact of EC…
View article: Association of CRP levels and clinical and radiological outcomes in patients with large-vessel occlusion stroke: A MR CLEAN Registry study
Association of CRP levels and clinical and radiological outcomes in patients with large-vessel occlusion stroke: A MR CLEAN Registry study Open
Introduction: Inflammation is important in the pathogenesis of acute ischemic stroke (AIS). The association between CRP and outcomes in patients with large vessel occlusion (LVO) stroke receiving endovascular therapy (EVT) has not been ful…
View article: The role of mechanical wall stress and wall shear stress on coronary artery disease
The role of mechanical wall stress and wall shear stress on coronary artery disease Open
Our results from in-silico coronary-specific models suggest that WSS and MWS may play a dominant role at different stages of coronary artery disease. WSS may be more critical in the early stages of plaque formation while MWS might have gre…
View article: Incidence and Determinants of Nonfocal Transient Neurologic Attacks
Incidence and Determinants of Nonfocal Transient Neurologic Attacks Open
Nonfocal TNAs predominantly affect older adults and those with lower educational attainment, suggesting that these attacks originate from socioeconomic determinants rather than from established cardiovascular risk factors.
View article: A Decision-Analytic Model to Evaluate Cost-Effectiveness of Regional Implementation of a Mobile Stroke Unit
A Decision-Analytic Model to Evaluate Cost-Effectiveness of Regional Implementation of a Mobile Stroke Unit Open
Adding an MSU to the dispatch strategy for suspected stroke patients is expected to be cost-effective in our region. Our model facilitates evaluation of the cost-effectiveness of MSU implementation in different regions, settings, and scena…
View article: Regressing calcifications in the carotid artery: What’s going on? A case series
Regressing calcifications in the carotid artery: What’s going on? A case series Open
View article: Cross-validation of an artificial intelligence tool for fracture classification and localization on conventional radiography in Dutch population
Cross-validation of an artificial intelligence tool for fracture classification and localization on conventional radiography in Dutch population Open
Objectives The aim of this study is to validate the effectiveness of an AI tool trained on Indian data in a Dutch medical center and to assess its ability to classify and localize fractures. Methods Conventional radiographs acquired betwee…
View article: The Effect of Carotid Atherosclerosis on the Risk for Open-Angle Glaucoma
The Effect of Carotid Atherosclerosis on the Risk for Open-Angle Glaucoma Open
Among participants with OAG, an increased cIMT was associated with a younger age at diagnosis. In patients with OAG and unexplained continuous progression, a screening ultrasound examination of the carotid arteries might be considered.
View article: Metabolomics Profiling of Epicardial Adipose Tissue: MESA and the Rotterdam Study
Metabolomics Profiling of Epicardial Adipose Tissue: MESA and the Rotterdam Study Open
Background Excess epicardial adipose tissue (EAT) has been associated with cardiovascular diseases such as atrial fibrillation, coronary artery disease, and heart failure. The metabolomic signature of EAT is not well studied. Methods Untar…
View article: Photon-counting CT: An updated review of clinical results
Photon-counting CT: An updated review of clinical results Open
Photon-counting computed tomography (PCD-CT) is an advancing imaging technology that offers improved spatial resolution, energy-resolved imaging, and spectral post-processing compared to conventional CT. These advantages contribute to incr…
View article: Intracranial arteriosclerosis and cerebrovascular function in the general aging population – A 7T MRI Study
Intracranial arteriosclerosis and cerebrovascular function in the general aging population – A 7T MRI Study Open
Structured Abstract Background and Objectives Intracranial arteriosclerosis is a prevalent condition linked to serious health outcomes, such as stroke and dementia. It is hypothesized that intracranial arteriosclerosis compromises brain he…
View article: Individualized MRI-Based Stroke Prediction Score Using Plaque Vulnerability for Symptomatic Carotid Artery Disease Patients (IMPROVE)
Individualized MRI-Based Stroke Prediction Score Using Plaque Vulnerability for Symptomatic Carotid Artery Disease Patients (IMPROVE) Open
BACKGROUND: In symptomatic carotid stenosis, treatment decisions are currently primarily based on stenosis degree. We developed a clinical prediction model (Individualized Magnetic Resonance Imaging–Based Stroke Prediction Score Using Plaq…
View article: In-depth carotid calcification morphometrics and their temporal changes are associated with cardiovascular risk factors in patients with recent ischemic event: The Plaque at Risk (PARISK) Study
In-depth carotid calcification morphometrics and their temporal changes are associated with cardiovascular risk factors in patients with recent ischemic event: The Plaque at Risk (PARISK) Study Open
Introduction: Ischemic stroke incidence varies significantly with respect to sex and cardiovascular risk factors (CVRF), a relationship that it is not well understood. Calcification in carotid atherosclerosis is known to impact plaque stab…
View article: Association of 10-year blood pressure trajectory with calcification volume in different vessel beds
Association of 10-year blood pressure trajectory with calcification volume in different vessel beds Open
Background Elevated blood pressure (BP) is identified as a risk factor for atherosclerosis and its relevant diseases. However, the trajectories of BP in development of atherosclerosis has not been studied extensively, which provides inform…
View article: Carotid Plaque Calcification Attenuation Characteristics are Associated with Intraplaque Hemorrhage Volumes: A 3D Segmentation-Based Analysis
Carotid Plaque Calcification Attenuation Characteristics are Associated with Intraplaque Hemorrhage Volumes: A 3D Segmentation-Based Analysis Open
Background and Purpose Despite the high prevalence of plaque calcifications in carotid atherosclerosis, the association between morphologic and attenuation features of calcifications and intraplaque hemorrhage (IPH) remains unclear. Method…
View article: Carotid Plaque-RADS: Inter- and Intrareader Agreement and Learning Curve Analysis in CTA
Carotid Plaque-RADS: Inter- and Intrareader Agreement and Learning Curve Analysis in CTA Open
In the CTA application of the Carotid Plaque-RADS, interreader agreement is substantial to near perfect among experienced and intermediate readers, with a notable learning curve for beginners. Intrareader agreement is almost perfect in exp…
View article: Onset and progression of atherosclerosis in patients with melanoma treated with immune checkpoint inhibitors
Onset and progression of atherosclerosis in patients with melanoma treated with immune checkpoint inhibitors Open
Background Immune checkpoint inhibitors (ICIs) are effective anticancer agents but significantly increase cardiovascular risk. This could be due to its potential to induce or worsen atherosclerosis. We evaluated the onset and progression o…
View article: The relationship between fibrous cap status or plaque surface morphology and intraplaque hemorrhage volume over time: The PARISK Study
The relationship between fibrous cap status or plaque surface morphology and intraplaque hemorrhage volume over time: The PARISK Study Open
View article: Coffee consumption and mortality in colorectal cancer patients: Does the co-existence of cardiometabolic disease matter?
Coffee consumption and mortality in colorectal cancer patients: Does the co-existence of cardiometabolic disease matter? Open
We observed a U-shaped, nonlinear inverse association between coffee consumption and mortality in CRC patients regardless of their CMD status. More mechanistic studies are needed to understand how consuming coffee may lower mortality risk …
View article: Guideline-Directed Application of Coronary Artery Calcium Scores for Primary Prevention of Atherosclerotic Cardiovascular Disease
Guideline-Directed Application of Coronary Artery Calcium Scores for Primary Prevention of Atherosclerotic Cardiovascular Disease Open
The ACC/AHA and ESC/EAS guidelines differ in the selection and application of the CAC score for primary prevention of ASCVD. Guideline-directed application of CAC score in a middle-aged apparently healthy population improved risk stratific…
View article: Lipoprotein(a) immunoassays and their associations with coronary artery calcification and aortic valve calcification
Lipoprotein(a) immunoassays and their associations with coronary artery calcification and aortic valve calcification Open
The Rotterdam Study has been entered in the Netherlands National Trial Register and the WHO International Clinical Trials Registry Platform under shared catalog number NTR6831.
View article: Variations in intracranial arterial anatomy of the circle of Willis and their association with arteriosclerosis in patients with ischemic cerebrovascular disease
Variations in intracranial arterial anatomy of the circle of Willis and their association with arteriosclerosis in patients with ischemic cerebrovascular disease Open
Introduction: An estimated 20–31% of all people are born with a textbook anatomical configuration of the intracranial arteries comprising the Circle of Willis. Individuals with specific anatomical variants may be at elevated risk of intrac…
View article: IMPROVE Decision Rule for Carotid Revascularization: Clinician Perspectives on Acceptability and Implementation Barriers
IMPROVE Decision Rule for Carotid Revascularization: Clinician Perspectives on Acceptability and Implementation Barriers Open
Background: Current selection of patients for carotid revascularization is mainly based on neurological symptoms and the degree of carotid artery stenosis. The IMPROVE decision rule can improve the identification of high-risk patients that…