Stuart B. Levy
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View article: Reconceptualising cleft habitus: belonging and inclusion at Australian regional universities
Reconceptualising cleft habitus: belonging and inclusion at Australian regional universities Open
An autoethnographic exploration of the life and career experiences of ten academics across the Australian Regional University Network (RUN) unearthed a prevailing disjuncture between formative cultural experiences and academia that expands…
View article: 336 Significant myeloid and dendritic cellular enrichment of omidubicel graft suggests fast homeostatic proliferation of lymphoid populations
336 Significant myeloid and dendritic cellular enrichment of omidubicel graft suggests fast homeostatic proliferation of lymphoid populations Open
Background Allogeneic hematopoietic cell transplantation is a potentially curative treatment for hematologic malignancies and nonmalignant disorders. Rapid immune reconstitution (IR) following transplantation has been associated with impro…
View article: Abstract 2 Results of an Open Label Expanded Access Study of Omidubicel-onlv for Allogeneic Transplantation (allo-HCT) in Patients with Hematologic Malignancies
Abstract 2 Results of an Open Label Expanded Access Study of Omidubicel-onlv for Allogeneic Transplantation (allo-HCT) in Patients with Hematologic Malignancies Open
Introduction Omidubicel, a nicotinamide expanded allogeneic hematopoietic progenitor cell therapy derived from umbilical cord blood (UCB) was recently FDA approved for use as a sole donor source in allo-HCT based on phase III study results…
View article: Benchmarking Australian Enabling Programs for a National Framework of Standards
Benchmarking Australian Enabling Programs for a National Framework of Standards Open
Enabling education programs in Australia assist students, who would otherwise have been excluded from higher education, to transition into undergraduate study. These programs emerged independently in response to the needs of individual uni…
View article: Immune Reconstitution Profiling Suggests Antiviral Protection after Transplantation with Omidubicel: A Phase 3 Substudy
Immune Reconstitution Profiling Suggests Antiviral Protection after Transplantation with Omidubicel: A Phase 3 Substudy Open
Allogeneic hematopoietic cell transplantation (HCT) is a potentially curative treatment for hematologic malignancies and nonmalignant disorders. Rapid immune reconstitution (IR) following allogeneic HCT has been shown to be associated with…
View article: Evidence-Based Methods of Communicating Science to the Public Through Data Visualization
Evidence-Based Methods of Communicating Science to the Public Through Data Visualization Open
This essay presents a real-world demonstration of the evidence-based science communication process, showing how it can be used to create scientific data visualizations for public audiences. Visualizing research data can be an important sci…
View article: Abstract 9 Hematopoietic Stem Cell Transplantation (HSCT) with Omidubicel Leads to Robust Recovery and Diversity of T Cells
Abstract 9 Hematopoietic Stem Cell Transplantation (HSCT) with Omidubicel Leads to Robust Recovery and Diversity of T Cells Open
Introduction Omidubicel is a cell therapy used for allogeneic hematopoietic stem cell transplant. A phase III randomized study (NCT02730299) comparing omidubicel to umbilical cord blood (UCB) demonstrated faster hematopoietic recovery, low…
View article: Cyclic AMP Regulates Bacterial Persistence through Repression of the Oxidative Stress Response and SOS-Dependent DNA Repair in Uropathogenic <i>Escherichia coli</i>
Cyclic AMP Regulates Bacterial Persistence through Repression of the Oxidative Stress Response and SOS-Dependent DNA Repair in Uropathogenic <i>Escherichia coli</i> Open
Bacterial persistence is a transient, nonheritable physiological state that provides tolerance to bactericidal antibiotics. The stringent response, toxin-antitoxin modules, and stochastic processes, among other mechanisms, play roles in th…
View article: A Novel Regulatory Cascade Involving BluR, YcgZ, and Lon Controls the Expression of Escherichia coli OmpF Porin
A Novel Regulatory Cascade Involving BluR, YcgZ, and Lon Controls the Expression of Escherichia coli OmpF Porin Open
In Escherichia coli, OmpF is an important outer membrane protein, which serves as a passive diffusion pore for small compounds including nutrients, antibiotics, and toxic compounds. OmpF expression responds to environmental changes such as…
View article: Triclosan: an Instructive Tale
Triclosan: an Instructive Tale Open
The Food and Drug Administration (FDA) recently released a final rule to ban triclosan and 18 other antimicrobial chemicals from soaps. We applaud this rule specifically because of the associated risks that triclosan poses to the spread of…
View article: Transposon-Sequencing Analysis Unveils Novel Genes Involved in the Generation of Persister Cells in Uropathogenic Escherichia coli
Transposon-Sequencing Analysis Unveils Novel Genes Involved in the Generation of Persister Cells in Uropathogenic Escherichia coli Open
Persister cells are highly tolerant to different antibiotics and are associated with relapsing infections. In order to understand this phenomenon further, we exposed a transposon library to a lethal concentration of ampicillin, and mutants…
View article: Rapid radiation in bacteria leads to a division of labour
Rapid radiation in bacteria leads to a division of labour Open
The division of labour is a central feature of the most sophisticated biological systems, including genomes, multicellular organisms and societies, which took millions of years to evolve. Here we show that a well-organized and robust divis…
View article: Structure-Activity Relationship of the Aminomethylcyclines and the Discovery of Omadacycline
Structure-Activity Relationship of the Aminomethylcyclines and the Discovery of Omadacycline Open
A series of novel tetracycline derivatives were synthesized with the goal of creating new antibiotics that would be unaffected by the known tetracycline resistance mechanisms. New C-9-position derivatives of minocycline (the aminomethylcyc…
View article: Does use of the polyene natamycin as a food preservative jeopardise the clinical efficacy of amphotericin B? A word of concern
Does use of the polyene natamycin as a food preservative jeopardise the clinical efficacy of amphotericin B? A word of concern Open
Natamycin is a poorly soluble, polyene macrolide antifungal agent used in the food industry for the surface treatment of cheese and sausages. This use is not of safety concern. However, highly soluble natamycin-cyclodextrin inclusion compl…