Sébastien Bailly
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View article: Redefining telemedicine in obstructive sleep apnea management through artificial intelligence
Redefining telemedicine in obstructive sleep apnea management through artificial intelligence Open
Obstructive sleep apnea (OSA) represents a significant and increasingly prevalent health burden, impacting individual patients through diminished quality of life, increased morbidity and mortality, as well as society at large, via reduced …
View article: Excessive Daytime Sleepiness, but Not Insomnia Is Associated With Dyslipidaemia in Patients With Obstructive Sleep Apnoea Participating in <scp>ESADA</scp>
Excessive Daytime Sleepiness, but Not Insomnia Is Associated With Dyslipidaemia in Patients With Obstructive Sleep Apnoea Participating in <span>ESADA</span> Open
Excessive daytime sleepiness (EDS) as well as insomnia have been associated with a higher risk for cardiovascular disease in patients with obstructive sleep apnoea (OSA). The link is not fully understood but may involve dyslipidaemia. The …
View article: An overview of longitudinal data analyses in sleep research
An overview of longitudinal data analyses in sleep research Open
This structured overview proposes a coherent analytical pathway for longitudinal data, supported by implementation examples, to help researchers and clinicians navigate complex longitudinal-measure analyses in sleep research and related fi…
View article: How do we sleep while our beds are burning? High ambient temperatures are associated with substantial sleep loss
How do we sleep while our beds are burning? High ambient temperatures are associated with substantial sleep loss Open
Study Objectives High ambient temperatures are associated with negative health outcomes, including heat stress, injuries and accidents, and poor mental health. Sleep loss may contribute to these adverse impacts. However, robust supporting …
View article: FIB-4: A screening tool for advanced liver fibrosis in a cohort of subjects participating in a primary care weight-loss program
FIB-4: A screening tool for advanced liver fibrosis in a cohort of subjects participating in a primary care weight-loss program Open
Systematic screening for liver fibrosis using FIB-4 score is recommended in primary care for patients with chronic liver disease risk factors. This study assesses the prevalence and characteristics of patients at risk for advanced fibrosis…
View article: Dose-response relationship between Obstructive Sleep Apnoea severity and C-reactive protein levels: Data from the European Sleep Apnoea Database
Dose-response relationship between Obstructive Sleep Apnoea severity and C-reactive protein levels: Data from the European Sleep Apnoea Database Open
Introduction Obstructive Sleep Apnoea (OSA) characterised by intermittent hypoxia promotes systemic inflammation. This study evaluated the association between OSA severity and circulating C-reactive protein (CRP) levels as marker of system…
View article: Brentuximab vedotin addition to gemcitabine in relapsed or refractory peripheral T-cell lymphoma: a LYSA phase 2 study
Brentuximab vedotin addition to gemcitabine in relapsed or refractory peripheral T-cell lymphoma: a LYSA phase 2 study Open
We aim to evaluate the efficacy of brentuximab vedotin (BV) combined with gemcitabine (GBV) followed by BV maintenance in relapsed or refractory (R/R) peripheral T-cell lymphoma (PTCL). Patients with at least 5% CD30+ cells by immunohistoc…
View article: Treatment choice in mild to moderate sleep apnoea in the European Sleep Apnea Database
Treatment choice in mild to moderate sleep apnoea in the European Sleep Apnea Database Open
Introduction In mild to moderate obstructive sleep apnoea (OSA), positive airway pressure (PAP) and mandibular advancement devices (MADs) are recommended treatments according to guidelines. This cross-sectional study aimed to determine the…
View article: Global warming may increase the burden of obstructive sleep apnea
Global warming may increase the burden of obstructive sleep apnea Open
High ambient temperatures are associated with reduced sleep duration and quality, but effects on obstructive sleep apnea (OSA) severity are unknown. Here we quantify the effect of 24 h ambient temperature on nightly OSA severity in 116,620…
View article: PCSK9 as a new player in intermittent hypoxia-induced vascular alterations
PCSK9 as a new player in intermittent hypoxia-induced vascular alterations Open
International audience
View article: Impact of long-term non-invasive ventilation on severe exacerbations and survival in COPD: a French nationwide cohort study using multistate models
Impact of long-term non-invasive ventilation on severe exacerbations and survival in COPD: a French nationwide cohort study using multistate models Open
Rationale Chronic obstructive pulmonary disease (COPD) is the most common indication for domiciliary non-invasive ventilation (NIV), but long-term outcomes data are limited. Objective This multistate model analysis estimated the impact of …
View article: Variations in sleep duration and timing: weekday and seasonal variations in sleep are common in an analysis of 73 million nights from an objective sleep tracker
Variations in sleep duration and timing: weekday and seasonal variations in sleep are common in an analysis of 73 million nights from an objective sleep tracker Open
Study Objectives Irregular sleep is a major risk factor for adverse health. In a global sample with technology-enabled long-term objective sleep data spanning 3.5 years, we investigated variability in sleep duration and timing over weekday…
View article: Primary mediastinal B-cell lymphoma (PMBCL): The LYSA pragmatic guidelines
Primary mediastinal B-cell lymphoma (PMBCL): The LYSA pragmatic guidelines Open
Primary mediastinal B-cell lymphoma (PMBCL) is a distinct subtype of large B-cell lymphoma with unique clinical, histopathological, and molecular characteristics. Despite its aggressive nature, PMBCL has a high cure rate when managed appro…
View article: Association of positive airway pressure adherence with use of antihypertensive drugs in patients with sleep apnoea
Association of positive airway pressure adherence with use of antihypertensive drugs in patients with sleep apnoea Open
Background The impact of positive airway pressure (PAP) therapy on the use of oral antihypertensive drugs (OAHDs) in patients with obstructive sleep apnoea (OSA) remains unclear. This study aimed to evaluate the association between PAP use…
View article: Incident Cheyne-Stokes respiration occurring in CPAP-treated patients and cardiovascular risk: a 2-years prospective follow-up (The Alertapnee study)
Incident Cheyne-Stokes respiration occurring in CPAP-treated patients and cardiovascular risk: a 2-years prospective follow-up (The Alertapnee study) Open
The Alertapnée study followed 555 adults with obstructive sleep apnea treated with CPAP and found that the occurrence of Cheyne-Stokes respiration (CSR) was linked to a 14-fold increase in the risk of significant cardiac events (SCE) after…
View article: Exploring phenotypes to improve long-term mortality risk stratification in obstructive sleep apnea through a machine learning approach: an observational cohort study
Exploring phenotypes to improve long-term mortality risk stratification in obstructive sleep apnea through a machine learning approach: an observational cohort study Open
This study demonstrated the interest of attributing OSA patients to distinct phenotypes including precise determination of nocturnal hypoxemia to improve mortality risk stratification.
View article: FIB-4: a screening tool for advanced liver fibrosis in a cohort of subjects participating in a primary care weight-loss program
FIB-4: a screening tool for advanced liver fibrosis in a cohort of subjects participating in a primary care weight-loss program Open
Systematic screening for liver fibrosis using FIB-4 score is recommended in primary care for patients with chronic liver disease risk factors. This study assesses the prevalence and characteristics of patients at risk for advanced fibrosis…
View article: Circulating Tumor DNA for Primary Mediastinal B-Cell Lymphoma Genotyping: A Prospective Multicenter Study
Circulating Tumor DNA for Primary Mediastinal B-Cell Lymphoma Genotyping: A Prospective Multicenter Study Open
Introduction: Primary mediastinal B-cell lymphoma (PMBL) is a rare and aggressive B-cell lymphoma. Its diagnosis primarily relies on small core biopsies. Therefore, alternative sources of tumor DNA are needed for genotyping when the tissue…
View article: Classic Hodgkin Lymphoma: The LYSA pragmatic guidelines
Classic Hodgkin Lymphoma: The LYSA pragmatic guidelines Open
Classic Hodgkin lymphoma (HL) is a distinct entity among hematological malignancies of B-cell origin. It is characterized by its unique histopathological features and generally favorable prognosis. Over the years, advancements in understan…
View article: Outcome of patients with large B-cell lymphoma treated with tafasitamab plus lenalidomide either before or after CAR T-cell therapy
Outcome of patients with large B-cell lymphoma treated with tafasitamab plus lenalidomide either before or after CAR T-cell therapy Open
Tafasitamab plus lenalidomide (TAFA-LEN) treatment relevance pre- or post-anti-CD19 chimeric antigen receptor (CAR) T-cell therapy is debated. We analyzed patients with large B-cell lymphoma in the DESCAR-T registry treated with axi[1]cel …