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View article: Hybrid Scaffolds Decouple Biochemical & Biophysical Regulation of Cell Phenotype
Hybrid Scaffolds Decouple Biochemical & Biophysical Regulation of Cell Phenotype Open
The extracellular matrix changes dramatically during the progression of diseases like cancer. These complex, tissue‐specific changes are not adequately replicated by most current biomaterial disease models. This work demonstrates, for the …
View article: Porous scaffolds for in vitro modelling and monitoring of the extracellular matrix
Porous scaffolds for in vitro modelling and monitoring of the extracellular matrix Open
View article: Anisotropic ice-templated collagen scaffolds for soft tissue engineering: a mechanical characterisation toolkit
Anisotropic ice-templated collagen scaffolds for soft tissue engineering: a mechanical characterisation toolkit Open
Collagen-based soft tissues are often anisotropic in structure, and in regenerative medicine, it is important that scaffolds are designed to closely mimic their architecture and mechanical behaviour. Existing testing standards are not dire…
View article: Production of platelets <i>in vitro</i> in functionalised 3-dimensional scaffolds mimicking the bone marrow niche
Production of platelets <i>in vitro</i> in functionalised 3-dimensional scaffolds mimicking the bone marrow niche Open
The safety, quality and supply of donor-derived platelet units intended for transfusion have improved over the past decades but significant problems still remain. In vitroderived platelets offer a possible alternative but up-scaling produc…
View article: Design and evaluation of an auxetic biaxial substrate straining device for tissue engineering applications
Design and evaluation of an auxetic biaxial substrate straining device for tissue engineering applications Open
Mechanical forces play a critical role in cellular behaviour, yet devising systems capable of applying multiaxial strain to three-dimensional (3D) tissue engineering substrates remains challenging. This study introduces an innovative appro…
View article: Influence of joint deformation on the auxetic behaviour of 3D printed polypropylene structures
Influence of joint deformation on the auxetic behaviour of 3D printed polypropylene structures Open
Auxetic structures studied in the literature are often based on relatively stiff, metallic materials and theories regarding their response to mechanical loading cannot be translated directly to polymeric materials. As "soft" auxetics incre…
View article: Predictive control of pore architecture in ice-templated scaffolds via heat flux density modulation
Predictive control of pore architecture in ice-templated scaffolds via heat flux density modulation Open
Replicating the intricate architecture of native tissues remains a significant challenge in tissue engineering. Ice-templated biomimetic scaffolds possess controlled porosity that conveniently resembles the native parenchyma of many tissue…
View article: Accelerated degradation testing impacts the degradation processes in 3D printed amorphous PLLA
Accelerated degradation testing impacts the degradation processes in 3D printed amorphous PLLA Open
Additive manufacturing and electrospinning are widely used to create degradable biomedical components. This work presents important new data showing that the temperature used in accelerated tests has a significant impact on the degradation…
View article: Characterizing collagen scaffold compliance with native myocardial strains using an ex-vivo cardiac model: The physio-mechanical influence of scaffold architecture and attachment method
Characterizing collagen scaffold compliance with native myocardial strains using an ex-vivo cardiac model: The physio-mechanical influence of scaffold architecture and attachment method Open
Applied to the epicardium in-vivo, regenerative cardiac patches support the ventricular wall, reduce wall stresses, encourage ventricular wall thickening, and improve ventricular function. Scaffold engraftment, however, remains a challenge…
View article: Positive-strand RNA viruses—a Keystone Symposia report
Positive-strand RNA viruses—a Keystone Symposia report Open
Positive-strand RNA viruses have been the cause of several recent outbreaks and epidemics, including the Zika virus epidemic in 2015, the SARS outbreak in 2003, and the ongoing SARS-CoV-2 pandemic. On June 18–22, 2022, researchers focusing…
View article: The diazirine-mediated photo-crosslinking of collagen improves biomaterial mechanical properties and cellular interactions
The diazirine-mediated photo-crosslinking of collagen improves biomaterial mechanical properties and cellular interactions Open
View article: Controlling the Architecture of Freeze-Dried Collagen Scaffolds with Ultrasound-Induced Nucleation
Controlling the Architecture of Freeze-Dried Collagen Scaffolds with Ultrasound-Induced Nucleation Open
Collagen is a naturally occurring polymer that can be freeze-dried to create 3D porous scaffold architectures for potential application in tissue engineering. The process comprises the freezing of water in an aqueous slurry followed by sub…
View article: Characterizing Collagen Scaffold Compliance with Native Myocardial Strains Using an Ex-Vivo Cardiac Model: The Physio-Mechanical Influence of Scaffold Architecture and Attachment Method
Characterizing Collagen Scaffold Compliance with Native Myocardial Strains Using an Ex-Vivo Cardiac Model: The Physio-Mechanical Influence of Scaffold Architecture and Attachment Method Open
View article: Endothelial Vessel-Like Assembly in Co-Culture with Primary Osteoblasts on 2D and 3D Collagen Substrates
Endothelial Vessel-Like Assembly in Co-Culture with Primary Osteoblasts on 2D and 3D Collagen Substrates Open
View article: Influence of Joint Deformation on the Auxetic Behaviour of 3d Printed Polypropylene Structures
Influence of Joint Deformation on the Auxetic Behaviour of 3d Printed Polypropylene Structures Open
View article: Mimicking Transmural Helical Cardiomyofibre Orientation Using Bouligand-like Pore Structures in Ice-Templated Collagen Scaffolds
Mimicking Transmural Helical Cardiomyofibre Orientation Using Bouligand-like Pore Structures in Ice-Templated Collagen Scaffolds Open
The helical arrangement of cardiac muscle fibres underpins the contractile properties of the heart chamber. Across the heart wall, the helical angle of the aligned fibres changes gradually across the range of 90–180°. It is essential to re…
View article: Extracellular macrostructure anisotropy improves cardiac tissue-like construct function and phenotypic cellular maturation
Extracellular macrostructure anisotropy improves cardiac tissue-like construct function and phenotypic cellular maturation Open
Regenerative cardiac tissue is a promising field of study with translational potential as a therapeutic option for myocardial repair after injury, however, poor electrical and contractile function has limited translational utility. Emergin…
View article: <i>In vitro</i>angiogenesis in response to biomaterial properties for bone tissue engineering: a review of the state of the art
<i>In vitro</i>angiogenesis in response to biomaterial properties for bone tissue engineering: a review of the state of the art Open
Bone tissue engineering (BTE) aims to improve the healing of bone fractures using scaffolds that mimic the native extracellular matrix. For successful bone regeneration, scaffolds should promote simultaneous bone tissue formation and blood…
View article: Adjusting the physico-chemical properties of collagen scaffolds to accommodate primary osteoblasts and endothelial cells
Adjusting the physico-chemical properties of collagen scaffolds to accommodate primary osteoblasts and endothelial cells Open
Collagen-based biomaterials are used widely as tissue engineering scaffolds because of their excellent bioactivity and their similarity to the natural ECM. The regeneration of healthy bone tissue requires simultaneous support for both oste…
View article: Complex architectural control of ice-templated collagen scaffolds using a predictive model
Complex architectural control of ice-templated collagen scaffolds using a predictive model Open
The architectural and physiomechanical properties of regenerative scaffolds have been shown to improve engineered tissue function at both a cellular and tissue level. The fabrication of regenerative three-dimensional scaffolds that precise…
View article: Induced Birefringence in 3D Printing: Concealing Information Optically within Printed Objects
Induced Birefringence in 3D Printing: Concealing Information Optically within Printed Objects Open
This paper presents a novel method to spatially vary the intra‐layer birefringence of Fused Filament Fabricated (FFF) parts by controlling chain alignment during extrusion along individual rasters. The role of print speed, extrusion factor…
View article: A Mathematical Model of a Valve-Controlled Bioreactor for Platelet Production
A Mathematical Model of a Valve-Controlled Bioreactor for Platelet Production Open
As blood donor numbers decrease, while demand for platelets increases, hospitals worldwide are becoming increasingly vulnerable to critical platelet shortages. Alternative methods of supplying platelets are therefore required. One approach…
View article: Complex Architectural Control of Ice-Templated Collagen Scaffolds Using a Predictive Model
Complex Architectural Control of Ice-Templated Collagen Scaffolds Using a Predictive Model Open
View article: The evolution of the structure and mechanical properties of fully bioresorbable polymer-glass composites during degradation
The evolution of the structure and mechanical properties of fully bioresorbable polymer-glass composites during degradation Open
View article: Feature importance in multi-dimensional tissue-engineering datasets: Random forest assisted optimization of experimental variables for collagen scaffolds
Feature importance in multi-dimensional tissue-engineering datasets: Random forest assisted optimization of experimental variables for collagen scaffolds Open
Ice-templated collagen-based tissue-engineering scaffolds are ideal for controlled tissue regeneration since they mimic the micro-environment experienced in vivo. The structure and properties of scaffolds are fine-tuned during fabrication …
View article: Research data supporting "Feature importance in multi-dimensional tissue-engineering datasets: Random forest assisted optimisation of experimental variables for collagen scaffolds"
Research data supporting "Feature importance in multi-dimensional tissue-engineering datasets: Random forest assisted optimisation of experimental variables for collagen scaffolds" Open
Excel file containing raw structural and circular dichroism data supporting the paper 'Feature importance in multi-dimensional tissue-engineering datasets: Random forest assisted optimisation of experimental variables for collagen scaffold…
View article: Research data supporting "A technique for improving dispersion within polymer-glass composites using polymer precipitation"
Research data supporting "A technique for improving dispersion within polymer-glass composites using polymer precipitation" Open
Particle size distribution data measured by dynamic light scattering for coarse glass powder and fine (attritor milled) glass powder (Fig02). Contains Microsoft Excel .xlsx files and .txt files with particle size distributions, as well as …
View article: Research data supporting "Tailoring the biofunctionality of collagen biomaterials via tropoelastin incorporation and EDC-crosslinking"
Research data supporting "Tailoring the biofunctionality of collagen biomaterials via tropoelastin incorporation and EDC-crosslinking" Open
Data set used to generate the figures in the Acta Biomaterialia paper titled 'Tailoring the biofunctionality of collagen biomaterials via tropoelastin incorporation and EDC-crosslinking' . Absorbance data were obtained on a Fluostar Optima…
View article: A technique for improving dispersion within polymer–glass composites using polymer precipitation
A technique for improving dispersion within polymer–glass composites using polymer precipitation Open
View article: Unravelling Form and Function: Improved function of engineered cardiac tissue through extra-cellular anisotropy
Unravelling Form and Function: Improved function of engineered cardiac tissue through extra-cellular anisotropy Open
Cardiac tissue engineering is a promising therapeutic option for myocardial repair after injury, however, so far engineered heart patches have shown limited translational utility due to poor electrical integration and tissue contractility.…