Silvio Borrelli
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View article: Human Albumin-enriched Peritoneal Dialysis: A Novel Approach to Manage Refractory Ascites and Kidney Dysfunction in Decompensated Advanced Chronic Liver Disease
Human Albumin-enriched Peritoneal Dialysis: A Novel Approach to Manage Refractory Ascites and Kidney Dysfunction in Decompensated Advanced Chronic Liver Disease Open
For individuals with decompensated advanced chronic liver disease (dACLD), the onset of refractory ascites (RA) represents a dramatic event. In this setting, a relevant proportion of RA patients develop kidney dysfunction, as well as hepat…
View article: Laparoscopic Placement of the Tenckhoff Catheter with a New Regional Anesthesia: A Two-Year Experience
Laparoscopic Placement of the Tenckhoff Catheter with a New Regional Anesthesia: A Two-Year Experience Open
Background: The peritoneal dialysis (PD) catheter is commonly placed using an open surgery approach. However, mechanical peritoneal catheter-related complications are common causes of peritoneal dialysis technical failure. In recent years,…
View article: SGLT2 inhibitors in hemodialysis or peritoneal dialysis patients: rationale and state-of-the art
SGLT2 inhibitors in hemodialysis or peritoneal dialysis patients: rationale and state-of-the art Open
Sodium-glucose cotransporter-2 inhibitors (SGLT2i) reduce the risk of end-stage kidney disease (ESKD), cardiovascular events, and all-cause mortality in chronic kidney disease (CKD), regardless of diabetes or baseline renal function. Howev…
View article: #3713 Integrated conservative therapy-low dose peritoneal dialysis in patients with severe CKD (I-COPE CKD): multicentre prospective controlled study in Italian Nephrology Units
#3713 Integrated conservative therapy-low dose peritoneal dialysis in patients with severe CKD (I-COPE CKD): multicentre prospective controlled study in Italian Nephrology Units Open
Background and Aims The effectiveness of nutritional and pharmacological treatment in patients with advanced chronic kidney disease (CKD) decreases with worsening of renal function due to the onset of resistance to the conservative managem…
View article: #3574 Predicting absolute time to kidney failure in chronic kidney disease patients using machine learning
#3574 Predicting absolute time to kidney failure in chronic kidney disease patients using machine learning Open
Background and Aims In patients with chronic kidney disease (CKD), timely preparation for kidney replacement therapy requires adequate prediction of the absolute time until kidney failure. To date, no algorithm exists to perform such predi…
View article: #3628 Rationale and study design of EXCITE, a pilot study to evaluate safety and efficacy of PolyCore, a ternary combination of xylitol, L-carnitine and polydextrIn, to treat end-stage kidney disease patients starting peritoneal dialysis
#3628 Rationale and study design of EXCITE, a pilot study to evaluate safety and efficacy of PolyCore, a ternary combination of xylitol, L-carnitine and polydextrIn, to treat end-stage kidney disease patients starting peritoneal dialysis Open
Background Incremental Peritoneal Dialysis (PD) is a strategy for initiating PD that aims to reduce dialysis burden and, consequently, improve patients’ therapy acceptance and quality of life. Incremental PD may help to preserve diuresis, …
View article: Managing Ascites and Kidney Dysfunction in Decompensated Advanced Chronic Liver Disease: From “One Size Fits All” to a Multidisciplinary-Tailored Approach
Managing Ascites and Kidney Dysfunction in Decompensated Advanced Chronic Liver Disease: From “One Size Fits All” to a Multidisciplinary-Tailored Approach Open
Ascites and renal dysfunction are among the most frequent and severe complications of decompensated advanced chronic liver disease (dACLD), often representing two interrelated manifestations of a shared pathophysiological continuum. Recurr…
View article: Asymptomatic Bacteriuria in Kidney Transplant Recipients: Always Not to Treat?
Asymptomatic Bacteriuria in Kidney Transplant Recipients: Always Not to Treat? Open
Asymptomatic bacteriuria (ASB) is a very frequent condition in kidney transplant recipients (KTRs). Guidelines advise against screening and treatment of ASB beyond the first month after renal transplantation. Here, we report the case of a …
View article: Efficacy and safety of dapagliflozin in patients with CKD: real-world experience in 93 Italian renal clinics
Efficacy and safety of dapagliflozin in patients with CKD: real-world experience in 93 Italian renal clinics Open
Background Sodium-glucose co-transporter-2 inhibitors (SGLT2i) are recommended for reducing the renal and cardiovascular risk in patients with chronic kidney disease (CKD) based on the positive results reported by clinical trials. However,…
View article: Changes in 24-hour blood pressure profile after 12 weeks of dapagliflozin treatment in patients with diabetic kidney disease: an Italian multicenter prospective study
Changes in 24-hour blood pressure profile after 12 weeks of dapagliflozin treatment in patients with diabetic kidney disease: an Italian multicenter prospective study Open
Background Sodium-glucose cotransporter 2 inhibitors (SGLT2i) lower ambulatory blood pressure (ABP) in patients with type 2 diabetes mellitus; whether the same holds true in diabetic kidney disease (DKD) is unknown. This information is cri…
View article: #2264 Efficacy and safety of oral iron supplementation with liposomal iron in non-dialysis chronic kidney disease patients with iron deficiency
#2264 Efficacy and safety of oral iron supplementation with liposomal iron in non-dialysis chronic kidney disease patients with iron deficiency Open
Background and Aims Iron deficiency (ID) is very common in patients with non-dialysis dependent chronic kidney disease (NDD-CKD). In these patients, oral iron supplementation is recommended as first-line treatment for ID. However, the effi…
View article: #2969 One-year longitudinal changes in nutritional parameters associated with low-protein diets in patients starting with incremental PD
#2969 One-year longitudinal changes in nutritional parameters associated with low-protein diets in patients starting with incremental PD Open
Background and Aims Starting peritoneal dialysis (PD) with an incremental approach, that is, a low dose of PD (1-2 dwells a day in continuous ambulatory PD and until 5 sessions a week in automated PD) based on residual kidney function, is …
View article: Efficacy and Safety of Oral Supplementation with Liposomal Iron in Non-Dialysis Chronic Kidney Disease Patients with Iron Deficiency
Efficacy and Safety of Oral Supplementation with Liposomal Iron in Non-Dialysis Chronic Kidney Disease Patients with Iron Deficiency Open
Introduction. Iron deficiency is common in patients with non-dialysis-dependent chronic kidney disease (NDD-CKD). Oral iron supplementation is recommended in these patients, but it is associated with a higher incidence of gastrointestinal …
View article: Secular Trend in GFR Decline in Non-Dialysis CKD Based on Observational Data From Standard of Care Arms of Trials
Secular Trend in GFR Decline in Non-Dialysis CKD Based on Observational Data From Standard of Care Arms of Trials Open
This study evaluated the secular trend in the change in glomerular filtration rate (GFR) decline in the placebo arms of randomized controlled trials (RCTs) that were studying approaches to protect the kidneys in the setting of chronic kidn…
View article: Efficacy and safety of hypoxia-inducible factor prolyl hydroxylase inhibitors in patients with chronic kidney disease: meta-analysis of phase 3 randomized controlled trials
Efficacy and safety of hypoxia-inducible factor prolyl hydroxylase inhibitors in patients with chronic kidney disease: meta-analysis of phase 3 randomized controlled trials Open
Background Hypoxia-inducible factor prolyl hydroxylase inhibitors (HIF-PHIs) are new therapeutic agents for anaemia in chronic kidney disease (CKD). We evaluated by meta-analysis and meta-regression the efficacy and safety of HIF-PHIs in p…
View article: #3957 SUSTAINED RECOVERY OF KIDNEY FUNCTION IN PATIENTS WITH ESKD UNDER CHRONIC DIALYSIS TREATMENT: A SYSTEMATIC REVIEW AND META-ANALYSIS
#3957 SUSTAINED RECOVERY OF KIDNEY FUNCTION IN PATIENTS WITH ESKD UNDER CHRONIC DIALYSIS TREATMENT: A SYSTEMATIC REVIEW AND META-ANALYSIS Open
Background and Aims The prevalence of recovery of kidney function (RKF) in patients under maintenance dialysis is poorly defined mainly because of different definitions of RKF. The accurate assessment of sustained RKF is critical because t…
View article: #2710 SEX DIFFERENCE IN CARDIOVASCULAR RISK IN PATIENTS WITH CHRONIC KIDNEY DISEASE: A POOLED ANALYSIS OF FOUR COHORT STUDIES
#2710 SEX DIFFERENCE IN CARDIOVASCULAR RISK IN PATIENTS WITH CHRONIC KIDNEY DISEASE: A POOLED ANALYSIS OF FOUR COHORT STUDIES Open
Background and Aims Progression of chronic kidney disease (CKD) has proven to be faster in men than in Women [1-3]. Whether the same holds true for cardiovascular risk remains ill-defined. Method We conducted a pooled analysis of 4 cohort …
View article: Sustained Recovery of Kidney Function in Patients with ESKD under Chronic Dialysis Treatment: Systematic Review and Meta-Analysis
Sustained Recovery of Kidney Function in Patients with ESKD under Chronic Dialysis Treatment: Systematic Review and Meta-Analysis Open
The prevalence of recovery of kidney function (RKF) in patients under maintenance dialysis is poorly defined mainly because of different definitions of RKF. Therefore, to gain more insights into the epidemiology of RKF, we performed a syst…
View article: Sex difference in cardiovascular risk in patients with chronic kidney disease: pooled analysis of four cohort studies
Sex difference in cardiovascular risk in patients with chronic kidney disease: pooled analysis of four cohort studies Open
Background Progression of chronic kidney disease (CKD) has proven to be faster in men than in women. Whether the same holds true for cardiovascular risk remains ill-defined. Methods We conducted a pooled analysis of 4 cohort studies from 4…
View article: Chronic Hyperkaliemia in Chronic Kidney Disease: An Old Concern with New Answers
Chronic Hyperkaliemia in Chronic Kidney Disease: An Old Concern with New Answers Open
Increasing potassium intake ameliorates blood pressure (BP) and cardiovascular (CV) prognoses in the general population; therefore the World Health Organization recommends a high-potassium diet (90–120 mEq/day). Hyperkalaemia is a rare con…
View article: Fibrosis of Peritoneal Membrane as Target of New Therapies in Peritoneal Dialysis
Fibrosis of Peritoneal Membrane as Target of New Therapies in Peritoneal Dialysis Open
Peritoneal dialysis (PD) is an efficient renal replacement therapy for patients with end-stage renal disease. Even if it ensures an outcome equivalent to hemodialysis and a better quality of life, in the long-term, PD is associated with th…
View article: Risk of end-stage kidney disease in kidney transplant recipients versus patients with native chronic kidney disease: multicentre unmatched and propensity-score matched analyses
Risk of end-stage kidney disease in kidney transplant recipients versus patients with native chronic kidney disease: multicentre unmatched and propensity-score matched analyses Open
Background In kidney transplant recipients (KTR), the end-stage kidney disease (ESKD) risk dependent on the risk factors acting in native chronic kidney disease (CKD) remains undefined. Methods We compared risk and determinants of ESKD bet…
View article: New-onset anemia and associated risk of ESKD and death in non-dialysis CKD patients: a multicohort observational study
New-onset anemia and associated risk of ESKD and death in non-dialysis CKD patients: a multicohort observational study Open
Background Anemia is a common complication of chronic kidney disease (CKD), but its incidence in nephrology settings is poorly investigated. Similarly, the risks of adverse outcomes associated with new-onset anemia are not known. Methods W…
View article: Successful Treatment of Peritoneal Dialysis Related Peritonitis from Multi-Drug Resistant <i>Sphingomonas paucimobilis</i> with Combination Therapy: A Case Report
Successful Treatment of Peritoneal Dialysis Related Peritonitis from Multi-Drug Resistant <i>Sphingomonas paucimobilis</i> with Combination Therapy: A Case Report Open
Sphingomonas paucimobilis is an emerging gram-negative aerobic bacterium, generally causing infections in immunocompromised patients. Few data are available about peritonitis in peritoneal dialysis due to this pathogen. The clinical course…
View article: Volume-Independent Sodium Toxicity in Peritoneal Dialysis: New Insights from Bench to Bed
Volume-Independent Sodium Toxicity in Peritoneal Dialysis: New Insights from Bench to Bed Open
Sodium overload is common in end-stage kidney disease (ESKD) and is associated with increased cardiovascular mortality that is traditionally considered a result of extracellular volume expansion. Recently, sodium storage was detected by Na…