Stephan Brons
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View article: Achieving high-resolution spatial mapping of dose and linear energy transfer in ion-beam therapy
Achieving high-resolution spatial mapping of dose and linear energy transfer in ion-beam therapy Open
Objective. We present a novel detector system capable of simultaneously obtaining two-dimensional (2D) dose and linear energy transfer (LET) maps from Al 2 O 3 films of sizes up to mm 2 using optically stimulated luminescence (OSL).…
View article: Hybrid compton-PET imaging for ion-range verification: a preclinical study for proton, helium, and carbon therapy at HIT
Hybrid compton-PET imaging for ion-range verification: a preclinical study for proton, helium, and carbon therapy at HIT Open
Enhanced-accuracy ion-range verification in real time shall enable a significant step forward in the use of therapeutic ion beams. Positron-emission tomography (PET) and prompt-gamma imaging (PGI) are two of the most promising and research…
View article: Photon and particle radiotherapy induce redundant modular chemotaxis of human lymphocytes
Photon and particle radiotherapy induce redundant modular chemotaxis of human lymphocytes Open
Radiotherapy triggers chemokine release and leukocyte infiltration in preclinical models through activation of the senescence-associated secretory phenotype (SASP). However, effects of irradiation on senescence and SASP in human tissue and…
View article: First in vitro and in vivo experiments with ultra high-dose rate oxygen ion radiotherapy
First in vitro and in vivo experiments with ultra high-dose rate oxygen ion radiotherapy Open
Within this study, we demonstrated the feasibility of ultra-high dose rate (UHDR) oxygen ion irradiation at three different levels of biological complexity. The difference in oxygen consumption between UHDR and standard dose rates (SDR) wa…
View article: Characterizing diamond detectors for various dose and dose rate measurements in scanned carbon and oxygen beams
Characterizing diamond detectors for various dose and dose rate measurements in scanned carbon and oxygen beams Open
Background The emerging FLASH radiotherapy technique employs “Ultra‐High Dose Rate” (UHDR) irradiations and offers the potential to spare normal tissue while maintaining iso‐effective tumor treatment. Given the physical and biological adva…
View article: Hybrid Compton-PET Imaging for ion-range verification:A Preclinical Study for Proton-, Helium-, and Carbon-Therapy at HIT
Hybrid Compton-PET Imaging for ion-range verification:A Preclinical Study for Proton-, Helium-, and Carbon-Therapy at HIT Open
Enhanced-accuracy ion-range verification in real time shall enable a significant step forward in the use of therapeutic ion beams. Positron-emission tomography (PET) and prompt-gamma imaging (PGI) are two of the most promising and research…
View article: Out‐of‐field neutron radiation from clinical proton, helium, carbon, and oxygen ion beams
Out‐of‐field neutron radiation from clinical proton, helium, carbon, and oxygen ion beams Open
Background In hadron therapy, out‐of‐field doses, which may in the long‐term cause secondary cancers, are mostly due to neutrons. Very recently, 4 He and 16 O beams have been added to protons and 12 C ions for clinical therapy. Purpose The…
View article: First experimental test of a coded-mask gamma camera for proton therapy monitoring
First experimental test of a coded-mask gamma camera for proton therapy monitoring Open
Objective. The objective of the presented study was to evaluate the feasibility of a coded-mask (CM) gamma camera for real-time range verification in proton therapy, addressing the need for a precise and efficient method of treatment monit…
View article: Dose assessment in moving targets and organs at risk during carbon ion therapy for pancreatic cancer with respiratory gating
Dose assessment in moving targets and organs at risk during carbon ion therapy for pancreatic cancer with respiratory gating Open
Accurate CIRT dosimetry with variable breathing-induced motions can be conducted with PPIeT for a pancreatic tumour and the OARs. Gating mitigated the effects of breathing-induced motion in the tumour.
View article: Accuracy of a helium‐beam radiography system based on thin pixel detectors for an anthropomorphic head phantom
Accuracy of a helium‐beam radiography system based on thin pixel detectors for an anthropomorphic head phantom Open
Background Ion‐beam radiography is a promising technique to verify the range of ion‐beam radiotherapy treatments regularly. To detect and quantify the water‐equivalent thickness (WET) of potential anatomical changes, ion‐beam radiographs m…
View article: First experimental test of a coded-mask gamma camera for proton therapy monitoring
First experimental test of a coded-mask gamma camera for proton therapy monitoring Open
Objective. The objective of the presented study was to evaluate the feasibility of a coded-mask (CM) gamma camera for real-time range verification in proton therapy, addressing the need for a precise and efficient method of treatment monit…
View article: Exploring High LET Oxygen-Ion FLASH Radiation for Targeting Pancreatic Cancer in Vitro and In Vivo
Exploring High LET Oxygen-Ion FLASH Radiation for Targeting Pancreatic Cancer in Vitro and In Vivo Open
Summary This study showcases the feasibility of oxygen ion ultra-high dose rate irradiation for in vitro and in vivo experiments at the Heidelberg Ion-Beam Therapy Center. The results indicate comparable effectiveness to standard dose rate…
View article: Oxygen consumption measurements at ultra‐high dose rate over a wide LET range
Oxygen consumption measurements at ultra‐high dose rate over a wide LET range Open
Background The role of radiolytic oxygen consumption for the in‐vitro “Ultra‐High Dose Rate” (UHDR) sparing and in‐vivo FLASH effect is subject to active debate, but data on key dependencies such as the radiation quality are lacking. Purpo…
View article: Carbon ion mono-energetic and spread-out Bragg peak measurements using nanocomposite Fricke gel dosimeters with LET-independent response
Carbon ion mono-energetic and spread-out Bragg peak measurements using nanocomposite Fricke gel dosimeters with LET-independent response Open
This study investigates the LET-dependence of dose measurements performed with a nanocomposite Fricke gel (NC-FG) upon irradiation with carbon ion beams to address the problem of quenching of gel dosimeters in high-LET particle therapy. Th…
View article: Irradiation with Carbon Ions Effectively Counteracts Hypoxia-related Radioresistance in a Rat Prostate Carcinoma
Irradiation with Carbon Ions Effectively Counteracts Hypoxia-related Radioresistance in a Rat Prostate Carcinoma Open
The reduced oxygen enhancement ratio of carbon ions indicated that the required dose increase in hypoxic tumors was 17% lower for carbon ions than for photons. Additionally, carbon ions reduced the effect of intertumor heterogeneity on the…
View article: An essentially radiation‐transparent body coil integrated with a patient rotation system for MR‐guided particle therapy
An essentially radiation‐transparent body coil integrated with a patient rotation system for MR‐guided particle therapy Open
Background The pursuit of adaptive radiotherapy using MR imaging for better precision in patient positioning puts stringent demands on the hardware components of the MR scanner. Particularly in particle therapy, the dose distribution and t…
View article: Evaluation of Helium Ion Radiotherapy in Combination with Gemcitabine in Pancreatic Cancer In Vitro
Evaluation of Helium Ion Radiotherapy in Combination with Gemcitabine in Pancreatic Cancer In Vitro Open
Background: Pancreatic cancer is one of the most aggressive and lethal cancers. New treatment strategies are highly warranted. Particle radiotherapy could offer a way to overcome the radioresistant nature of pancreatic cancer because of it…
View article: Relative biological effectiveness of oxygen ion beams in the rat spinal cord: Dependence on linear energy transfer and dose and comparison with model predictions
Relative biological effectiveness of oxygen ion beams in the rat spinal cord: Dependence on linear energy transfer and dose and comparison with model predictions Open
This study established first RBE data for the late reacting central nervous system after single and split doses of oxygen ions. The data was used to validate the RBE-dependence on LET and dose of three RBE-models. This study extends the ex…
View article: A time-resolved clonogenic assay for improved cell survival and RBE measurements
A time-resolved clonogenic assay for improved cell survival and RBE measurements Open
The IVCA suffers from substantial uncertainty caused by the overlap of size distributions of delayed abortive and clonogenic colonies. This impairs precise quantification of cell survival and RBE. By considering colony growth over time, ou…
View article: Proton beam dosimetry in the presence of magnetic fields using Farmer‐type ionization chambers of different radii
Proton beam dosimetry in the presence of magnetic fields using Farmer‐type ionization chambers of different radii Open
Background Magnetic resonance‐guided proton therapy is promising, as it combines high‐contrast imaging of soft tissue with highly conformal dose delivery. However, proton dosimetry in magnetic fields using ionization chambers is challengin…