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View article: White sharks under threats in South Africa: a call for precautionary management action
White sharks under threats in South Africa: a call for precautionary management action Open
South Africa was the first country to protect white sharks Carcharodon carcharia s —an important decision taken despite limited data on population status, but guided by a precautionary approach in recognition of the species’ ecological and…
View article: HES1 oscillations are required for cell cycle re-entry in oestrogen receptor positive breast cancer cells
HES1 oscillations are required for cell cycle re-entry in oestrogen receptor positive breast cancer cells Open
Long-term recurrence in breast cancer is driven by reactivation of dormant disseminated tumour cells (DTCs) and remains a major clinical challenge, particularly in oestrogen receptor positive (ER⁺) tumours. This process is underpinned by r…
View article: NGN3 oscillatory expression controls the timing of human pancreatic endocrine differentiation
NGN3 oscillatory expression controls the timing of human pancreatic endocrine differentiation Open
Understanding protein expression dynamics is crucial for the mechanistic understanding of cell differentiation. We investigate the dynamics and decoding of NEUROGENIN3 (NGN3), a transcription factor critical for pancreatic endocrine develo…
View article: Dual production of polyhydroxyalkanoates and antibacterial/antiviral gold nanoparticles
Dual production of polyhydroxyalkanoates and antibacterial/antiviral gold nanoparticles Open
Gold nanoparticles (AuNPs) have been explored for their use in medicine. Here, we report a sustainable, and cost-effective method to produce AuNPs using a bacterial strain such as Pseudomonas mendocina CH50 which is also known to be a poly…
View article: Curcumin and N-Acetylcysteine Nanocarriers Alone or Combined with Deferoxamine Target the Mitochondria and Protect against Neurotoxicity and Oxidative Stress in a Co-Culture Model of Parkinson’s Disease
Curcumin and N-Acetylcysteine Nanocarriers Alone or Combined with Deferoxamine Target the Mitochondria and Protect against Neurotoxicity and Oxidative Stress in a Co-Culture Model of Parkinson’s Disease Open
As the blood-brain barrier (BBB) prevents most compounds from entering the brain, nanocarrier delivery systems are frequently being explored to potentially enhance the passage of drugs due to their nanometer sizes and functional characteri…
View article: Enhanced production of biobased, biodegradable, Poly(3-hydroxybutyrate) using an unexplored marine bacterium Pseudohalocynthiibacter aestuariivivens, isolated from highly polluted coastal environment
Enhanced production of biobased, biodegradable, Poly(3-hydroxybutyrate) using an unexplored marine bacterium Pseudohalocynthiibacter aestuariivivens, isolated from highly polluted coastal environment Open
The production and disposal of plastics from limited fossil reserves, has prompted research for greener and sustainable alternatives. Polyhydroxyalkanoates (PHAs) are biocompatible, biodegradable, and thermoprocessable polyester produced b…