Shekhar Patil
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View article: Transdermal delivery of Telmisartan through rat skin from formulation containing synthetic and natural penetration enhancer
Transdermal delivery of Telmisartan through rat skin from formulation containing synthetic and natural penetration enhancer Open
Telmisartan, an angiotensin-II receptor antagonist, has shown promising effects when delivered through transdermal patches for effective hypertension management. This study aimed to develop a matrix-type transdermal therapeutic system for …
View article: Relationship Between Sunlight Exposure, Erythemal Dose, and Vitamin D Concentrations in Adolescents: A Cross-Sectional, Multi-center Study
Relationship Between Sunlight Exposure, Erythemal Dose, and Vitamin D Concentrations in Adolescents: A Cross-Sectional, Multi-center Study Open
View article: <span>An Overview of Gaming Peripheral and Gadgets and its Effect on Gaming Performance</span>
<span>An Overview of Gaming Peripheral and Gadgets and its Effect on Gaming Performance</span> Open
View article: Transdermal patch: A potential application for pain management
Transdermal patch: A potential application for pain management Open
View article: Clinical Utility of Agad (Antidote): An Ayurvedic Perspective on Toxicology
Clinical Utility of Agad (Antidote): An Ayurvedic Perspective on Toxicology Open
The diagnosis, prevention, and treatment of poisoning from a variety of sources, such as plants, animals, minerals, and synthetic chemicals, are the main goals of Agad Tantra, a speciality area of Ayurveda. The clinical uses of agad tantra…
View article: 117P Genomic landscape of biliary tract cancers from India show distinct geographic variation
117P Genomic landscape of biliary tract cancers from India show distinct geographic variation Open
View article: Survival of Trial-Like and Non–Trial-Like Patients With Immunotherapy in Advanced Hepatocellular Carcinoma in Real World: A Collaborative Multicenter Indian Study (IMHEP)
Survival of Trial-Like and Non–Trial-Like Patients With Immunotherapy in Advanced Hepatocellular Carcinoma in Real World: A Collaborative Multicenter Indian Study (IMHEP) Open
PURPOSE Immune checkpoint inhibitors (ICIs) is the initial line of management in advanced hepatocellular carcinoma (HCC), but survivals in the real world are not known. MATERIALS AND METHODS A retrospective study of patients with advanced …
View article: An experience of Methylguanine-DNA Methylation Assay (MGMT) characterization in glial tumors
An experience of Methylguanine-DNA Methylation Assay (MGMT) characterization in glial tumors Open
Background: MGMT (O6-methylguanine DNA methyltransferase) is a DNA repair enzyme, that rescues tumor cells from damage by alkylating agents like temozolomide (TMZ). Promotor methylation of MGMT leads to epigenetic silencing and potentially…
View article: Practical Consensus Recommendations for Optimizing Risk versus Benefit of Chemotherapy in Patients with HR Positive Her2 Negative Early Breast Cancer in India
Practical Consensus Recommendations for Optimizing Risk versus Benefit of Chemotherapy in Patients with HR Positive Her2 Negative Early Breast Cancer in India Open
Breast cancer is a public health challenge globally as well as in India. Improving outcome and cure requires appropriate biomarker testing to assign risk and plan treatment. Because it is documented that significant ethnic and geographical…
View article: The clinical utility and safety of short‐course immune checkpoint inhibitors in multiple tumours—A real‐world multicentric study from India
The clinical utility and safety of short‐course immune checkpoint inhibitors in multiple tumours—A real‐world multicentric study from India Open
The real‐world data on short course of immune checkpoint inhibitor (ICI) use are sparse and merit exploration. A multicentric observational study on the safety and efficacy of ICI in oncology patients between August 2014 and October 2020 i…
View article: Impact of Acute Confusional State in Patients With COVID-19 and a Predictive Score
Impact of Acute Confusional State in Patients With COVID-19 and a Predictive Score Open
View article: Prevalence of <i>BRCA1</i> and <i>BRCA2</i> Mutations Among Patients With Ovarian, Primary Peritoneal, and Fallopian Tube Cancer in India: A Multicenter Cross-Sectional Study
Prevalence of <i>BRCA1</i> and <i>BRCA2</i> Mutations Among Patients With Ovarian, Primary Peritoneal, and Fallopian Tube Cancer in India: A Multicenter Cross-Sectional Study Open
PURPOSE There are deficient data on prevalence of germline mutations in breast cancer susceptibility genes 1 and 2 ( BRCA1/ BRCA2) in Indian patients with ovarian cancer who are not selected by clinical features. METHODS This prospective, …
View article: A Multi- institutional Prospective Analysis of Impact of CanAssist Breast (Morphometric Immunohistochemistry Based Test) on Adjuvant Chemotherapy Decisions in Early Breast Cancer
A Multi- institutional Prospective Analysis of Impact of CanAssist Breast (Morphometric Immunohistochemistry Based Test) on Adjuvant Chemotherapy Decisions in Early Breast Cancer Open
Purpose: CanAssist Breast (CAB) has been validated retrospectively for assessing risk of recurrence and thereby usefulness of chemotherapy in HR+/HER2- breast cancer. The objective of this study is to assess the agreement between physician…
View article: Treatment of advanced non-small-cell lung cancer
Treatment of advanced non-small-cell lung cancer Open
The management of patients with advanced non-small-cell lung cancer (NSCLC) is becoming increasingly complex, with the identification of driver mutations/rearrangements and the development and availability of appropriate targeted therapies…
View article: Transarterial Radioembolization (TARE) with 131Iodine-Lipiodol for Unresectable Primary Hepatocellular Carcinoma: Experience from a Tertiary Care Center in India
Transarterial Radioembolization (TARE) with 131Iodine-Lipiodol for Unresectable Primary Hepatocellular Carcinoma: Experience from a Tertiary Care Center in India Open
Purpose This article presents our experience regarding survival benefits in inoperable intermediate stage hepatocellular carcinoma (HCC) and advanced stage HCC treated with 131I-lipiodol. Materials and Methods This is a retrospective study…
View article: Identification of circulating tumor cells using 4‐color fluorescence in situ hybridization: Validation of a noninvasive aid for ruling out lung cancer in patients with low‐dose computed tomography–detected lung nodules
Identification of circulating tumor cells using 4‐color fluorescence in situ hybridization: Validation of a noninvasive aid for ruling out lung cancer in patients with low‐dose computed tomography–detected lung nodules Open
Background Approximately one third of needle biopsies that are performed to rule out malignancy of indeterminate pulmonary nodules detected radiologically during lung cancer screening are negative, thus exposing cancer‐free patients to ris…
View article: B35 Circulating Tumor-Associated Cells in Lung Cancers Are Resistance-Educated per Previous Chemotherapy Treatments
B35 Circulating Tumor-Associated Cells in Lung Cancers Are Resistance-Educated per Previous Chemotherapy Treatments Open
View article: Safety and Efficacy of Neoadjuvant DOF [Docetaxel, Oxaliplatin, 5-Fluorouracil] Chemotherapy Regimen in Patients with Locally Advanced Gastric and Gastro-Esophageal Junction Cancers: A Single Center Experience from India
Safety and Efficacy of Neoadjuvant DOF [Docetaxel, Oxaliplatin, 5-Fluorouracil] Chemotherapy Regimen in Patients with Locally Advanced Gastric and Gastro-Esophageal Junction Cancers: A Single Center Experience from India Open
Background: The role of chemotherapy in Gastric Cancer is constantly evolving with various neoadjuvant and adjuvant strategies. Several chemotherapeutic agents are used in the treatment of locally advanced gastric cancer (LAGC) namely Plat…
View article: CanAssist Breast Impacting Clinical Treatment Decisions in Early-Stage HR+ Breast Cancer Patients: Indian Scenario
CanAssist Breast Impacting Clinical Treatment Decisions in Early-Stage HR+ Breast Cancer Patients: Indian Scenario Open
CanAssist Breast (CAB) has thus far been validated on a retrospective cohort of 1123 patients who are mostly Indians. Distant metastasis–free survival (DMFS) of more than 95% was observed with significant separation ( P < 0.0001) between l…
View article: PD01.10 Diagnostic Non-Invasive Biopsy Can Substitute Conventional Tissue Dependent Procedures in Suspected Cases of Lung Cancer
PD01.10 Diagnostic Non-Invasive Biopsy Can Substitute Conventional Tissue Dependent Procedures in Suspected Cases of Lung Cancer Open
View article: Ribociclib (RIB) + letrozole (LET) in patients (pts) with hormone receptor-positive (HR+), human epidermal growth factor receptor-2–negative (HER2–) advanced breast cancer (ABC) and central nervous system (CNS) metastases: Subgroup analysis from the phase IIIb CompLEEment-1 trial
Ribociclib (RIB) + letrozole (LET) in patients (pts) with hormone receptor-positive (HR+), human epidermal growth factor receptor-2–negative (HER2–) advanced breast cancer (ABC) and central nervous system (CNS) metastases: Subgroup analysis from the phase IIIb CompLEEment-1 trial Open
View article: Utility of EBUS-TBNA in PET-positive mediastinal lymph nodes in subjects with extra-thoracic malignancy
Utility of EBUS-TBNA in PET-positive mediastinal lymph nodes in subjects with extra-thoracic malignancy Open
This study shows a significant incidence of EBUS-TBNA proven benign diagnoses 45/65 (69.2%) in 'SUV-deemed-malignant MLN' and a poor relationship between high SUV and malignant MLN, in patients with known ETM. The ETM related HM-MLN have a…
View article: RARE-20. BRAF MUTATIONS IN PEDIATRIC GANGLIOGLIOMAS AND THE CLINICAL SIGNIFICANCE AN MD ANDERSON CANCER CENTER EXPERIENCE
RARE-20. BRAF MUTATIONS IN PEDIATRIC GANGLIOGLIOMAS AND THE CLINICAL SIGNIFICANCE AN MD ANDERSON CANCER CENTER EXPERIENCE Open
INTRODUCTION: Ganglioglioma (GG) is a rare mixed glioneuronal neoplasm accounting for 0.5–5% of all pediatric central nervous system tumors. BRAF V600E mutation has been previously reported in GG but its incidence and impact remain unknown…
View article: LGG-18. GANGLIOGLIOMAS IN CHILDREN - MD ANDERSON CANCER CENTER EXPERIENCE
LGG-18. GANGLIOGLIOMAS IN CHILDREN - MD ANDERSON CANCER CENTER EXPERIENCE Open
INTRODUCTION: Ganglioglioma (GG) is a rare mixed glial-neuronal neoplasm accounting for 0.5-5% of all pediatric brain tumors. Optimal therapeutic strategy remains unknown. This retrospective study evaluates the prognostic factors and outco…
View article: Retrospective multicentric analysis of Indian patients with metastatic renal cell carcinoma on first-line sunitinib 2/1 schedule
Retrospective multicentric analysis of Indian patients with metastatic renal cell carcinoma on first-line sunitinib 2/1 schedule Open
View article: Effects of yoga in managing fatigue in breast cancer patients: A randomized controlled trial
Effects of yoga in managing fatigue in breast cancer patients: A randomized controlled trial Open
The results suggest that yoga reduces fatigue in advanced breast cancer patients.
View article: Effects of a yoga program on mood states, quality of life, and toxicity in breast cancer patients receiving conventional treatment: A randomized controlled trial
Effects of a yoga program on mood states, quality of life, and toxicity in breast cancer patients receiving conventional treatment: A randomized controlled trial Open
The results suggest a possible use for yoga as a psychotherapeutic intervention in breast cancer patients undergoing conventional treatment.
View article: Effect of yoga on sleep quality and neuroendocrine immune response in metastatic breast cancer patients
Effect of yoga on sleep quality and neuroendocrine immune response in metastatic breast cancer patients Open
The results suggest modulation of neuroendocrine responses and improvement in sleep in patients with advanced breast cancer following yoga intervention.
View article: Problems and prospects of rural tourism: The case of ‘B’ & ‘C’ category pilgrimage places in Pune area
Problems and prospects of rural tourism: The case of ‘B’ & ‘C’ category pilgrimage places in Pune area Open