Explanipedia

P2X4 Receptor Antagonist Ameliorates Ocular Pain in Rats After Lacrimal Gland Removal Open

Minjie Chen, Stefan Bäurle, Marcus Karlstetter, Xianni Simmons, Stefanie Seo , et al. · 2025

These results suggest that BAY-776 may be a promising option for managing chronic ocular pain.

Endoscopic full-thickness resection using full-thickness resection device for treatment of upper and lower gastrointestinal tract lesions—the first New Zealand study Open

Samuel C. Yiu, Erin Horsfall, Ravinder Ogra, Cameron Schauer, Anurag Sekra · 2025

aim: The full-thickness resection device (FTRD) offers an innovative treatment approach for lesions unsuitable for traditional endoscopic resection. This study evaluates FTRD’s safety and efficacy for resection of upper and lower gastroint…

OcuPair, a Novel Photo‐crosslinkable PAMAM Dendrimer‐Hyaluronic Acid Hydrogel Bandage/Bioadhesive for Corneal Injuries and Temporary Corneal Repair Open

Siva P. Kambhampati, Rishi Sharma, Hui Lin, Santiago Appiani, Jeffrey L. Cleland , et al. · 2025

Traumatic corneal injuries are a leading cause of blindness among military personnel. These injuries need immediate attention in the combat zone, but treatment options are limited as life‐saving measures are often prioritized. To address t…

Viral oncogene EBNALP regulates YY1 DNA binding and alters host 3D genome organization Open

Chong Wang, Merrin Man‐Long Leong, Weiyue Ding, Yohei Narita, Xiang Liu , et al. · 2025

Precise longitudinal monitoring of corneal change through in vivo confocal microscopy in a rat dry eye disease model. Open

Minjie Chen, Stefanie Seo, Xianni Simmons, Youssef Maroud, Trystin Wong , et al. · 2024

We demonstrated that our precise monitoring method revealed detailed changes in the corneal nerves, the epithelium, and the stroma.

Dendrimers in Corneal Drug Delivery: Recent Developments and Translational Opportunities Open

Anubhav Dhull, Carson Yu, Alex Hunter Wilmoth, Minjie Chen, Anjali Sharma , et al. · 2023

Dendrimers are biocompatible organic nanomaterials with unique physicochemical properties, making them the focus of recent research in drug delivery. The cornea of the human eye presents a challenge for drug transit due to its inherently i…

Primary cilia control cellular patterning of Meibomian glands during morphogenesis but not lipid composition Open

Céline Portal, Yvonne G. Lin, Varuni Rastogi, Cornelia Peterson, Samuel C. Yiu , et al. · 2023

Meibomian glands (MGs) are modified sebaceous glands producing the tear film’s lipids. Despite their critical role in maintaining clear vision, the mechanisms underlying MG morphogenesis in development and disease remain obscure. Cilia-med…

Primary cilia control cellular patterning and dimension of Meibomian glands during morphogenesis but not lipid composition of the meibum Open

Céline Portal, Yvonne G. Lin, Varuni Rastogi, Cornelia Peterson, Samuel C. Yiu , et al. · 2022

Meibomian glands (MGs) are modified sebaceous glands which produce the tear film's lipid component. Despite their critical function in maintaining clear vision, the mechanisms underlying MG morphogenesis during development and disease path…

Monitoring corneal change in a murine dry eye disease model using in vivo confocal microcopy Open

Stefanie Seo, Minjie Chen, William Schubert, Samuel C. Yiu · 2021

PEGlyated TRAIL alleviats alkali burn induced rat corneal fibrosis by targeting DR5 Open

Minjie Chen, Hui Lin, Stefanie Seo, Yumin Oh, Seulki Lee , et al. · 2021

Three Dimensional Culture of Potential Epithelial Progenitor Cells in Human Lacrimal Gland Open

Hui Lin, Ying Liu, Samuel C. Yiu · 2019

Future studies of differentiation in human lacrimal gland tissue may aid in developing stem cell-based therapies for dry eye disease.

Drug eluting dendrimer-hyaluronic acid nanoglue sealants to minimize corneal sutures Open

Siva P. Kambhampati, Uri Soiberman, Tony Wu, Abdul Elah Al Towerki, Walter Stark , et al. · 2018

Comparison of 20% sulfur hexafluoride with air for intraocular tamponade in Descemet membrane endothelial keratoplasty (DMEK) Open

Benjamin Botsford, Gustavo Vedana, Leslie Cope, Samuel C. Yiu, Albert S. Jun · 2018

Purpose: To compare the effect of 20% sulfur hexafluoride (SF6) with that of air on graft detachment rates for intraocular tamponade in Descemet membrane endothelial keratoplasty (DMEK). Methods: Forty-two eyes of patients who underwent DM…

Lacrimal Gland Repair after Short-term Obstruction of Excretory Duct in Rabbits Open

Hui Lin, Ying Liu, Hong He, Benjamin Botsford, Samuel C. Yiu · 2017

Chondroitin Sulfate–Based Biocompatible Crosslinker Restores Corneal Mechanics and Collagen Alignment Open

Xiaokun Wang, Shoumyo Majumdar, Garret Ma, Jeeyeon Sohn, Samuel C. Yiu , et al. · 2017

Our results demonstrated that CS-NHS can reinforce normal and KC model corneal mechanics, and restore collagen density and alignment in KC model corneas without causing extensive keratocyte apoptosis and proinflammatory gene upregulation. …

Dendrimer-dexamethasone therapy improved lacrimal gland function in an induced autoimmune dacryoadenitis rabbit model Open

Ying Liu, Hui Lin, Siva P. Kambhampati, Sujatha Kannan, Samuel C. Yiu · 2017

Human Lacrimal Gland Epithelial Cells Culture Open

Hui Lin, Ying Liu, Samuel C. Yiu · 2017

PAMAM dendrimer based injectable gels for the treatment of corneal inflammation Open

Siva P. Kambhampati, Uri Soiberman, Tony Wu, Samuel C. Yiu, Abdul Elah Al Towerki , et al. · 2017

Role of TRAIL signaling in corneal fibrosis Open

Yumin Oh, Hui Lin, Ying Liu, Adriana Bora, Samuel C. Yiu , et al. · 2017

Biocompatible Chondroitin sulfate-based cross-linker restores corneal mechanics and collagen alignment Open

Xiaokun Wang, Jeeyeon Sohn, Garret Ma, Samuel C. Yiu, Jennifer H. Elisseeff · 2016

Comparison of lacrimal gland progenitor cells isolated from duct ligation-induced tissues and intact tissues Open

Benjamin Botsford, Hui Lin, Helen P. Makarenkova, Samuel C. Yiu · 2016

Dendrimer-based anti-inflammatory therapy for induced autoimmune dacryoadenitis in a rabbit model Open

Hui Lin, Siva P. Kambhampati, Rangaramanujam M. Kannan, Samuel C. Yiu · 2016

Gene Expression Profile of Extracellular Matrix and Adhesion Molecules in the Human Normal Corneal Stroma Open

Ying Liu, Huang Hu, Guoying Sun, Saeed Alwadani, Richard D. Semba , et al. · 2016

This study identified genes not previously described in the corneal stroma, revealed regional differences in gene expression between central and peripheral stroma, and also detected some interesting candidate genes that may play important …

Comparison of 20% sulfur hexafluoride with air for intraocular tamponade in Descemet membrane endothelial keratoplasty (DMEK) Open

Benjamin Botsford, Gustavo Vedana, Leslie Cope, Samuel C. Yiu, Albert S. Jun · 2016

In comparison with air, graft detachment rates for intraocular tamponade in DMEK were significantly reduced by 20% SF6.

Gene Expression Profile of Extracellular Matrix and Adhesion Molecules in the Human Normal Corneal Stroma Open

Ying Liu, Huang Hu, Guoying Sun, Saeed Alwadani, Richard D. Semba , et al. · 2016

Purpose: There is limited information on region-specific gene expression in the human corneal stroma. In this study, we aimed to investigate the expression profile of the extracellular matrix and adhesion molecules in the normal cor…

Protective Effects of Soluble Collagen during Ultraviolet-A Crosslinking on Enzyme-Mediated Corneal Ectatic Models Open

Xiaokun Wang, Yong Huang, Sabah Jastaneiah, Shoumyo Majumdar, Jin U. Kang , et al. · 2015

Collagen crosslinking is a relatively new treatment for structural disorders of corneal ectasia, such as keratoconus. However, there is a lack of animal models of keratoconus, which has been an obstacle for carefully analyzing the mechanis…

Repair of Spontaneous Corneal Perforation in Pellucid Marginal Degeneration Using Amniotic Membrane Open

Martin Heur, Samuel C. Yiu · 2015

A 47-year-old woman with a history of pellucid marginal degeneration was referred for management of hydrops and peripheral perforation of the right cornea. The initial management with cyanoacrylate tissue adhesive and bandage contact lens …

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