Sébastien Causse
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View article: Blockade of cannabinoid CB<sub>1</sub> receptors potentiates the anti‐fibrotic effects mediated by SGLT2 inhibition in a mouse model of diabetic nephropathy
Blockade of cannabinoid CB<sub>1</sub> receptors potentiates the anti‐fibrotic effects mediated by SGLT2 inhibition in a mouse model of diabetic nephropathy Open
Background and purpose Diabetic nephropathy (DN) is a common complication of diabetes. Current treatments include renin‐angiotensin‐aldosterone system (RAAS) blockers and sodium‐glucose co‐transporter 2 (SGLT2) inhibitors. The cannabinoid …
View article: HSP110 Regulates the Assembly of the SWI/SNF Complex
HSP110 Regulates the Assembly of the SWI/SNF Complex Open
HSP110 is a ubiquitous chaperone contributing to proteostasis. It has a disaggregation activity and can refold denatured proteins. It can regulate fundamental signaling pathways involved in oncogenesis, such as Wnt/β-catenin, NF-κB and STA…
View article: A Simplified and Robust Model for the Study of Diabetic Nephropathy: Streptozotocin-Induced Diabetic Mice Fed a High-Protein Diet
A Simplified and Robust Model for the Study of Diabetic Nephropathy: Streptozotocin-Induced Diabetic Mice Fed a High-Protein Diet Open
To better understand diabetic nephropathy (DN), developing accurate animal models is crucial. Current models often fail to fully mimic human DN, showing only mild albuminuria, glomerular hypertrophy, and limited mesangial matrix expansion.…
View article: Tumor-Derived Exosomes: Hidden Players in PD-1/PD-L1 Resistance
Tumor-Derived Exosomes: Hidden Players in PD-1/PD-L1 Resistance Open
Recently, immunotherapy has garnered increasing importance in cancer therapy, leading to substantial improvements in patient care and survival. By blocking the immune checkpoints—protein regulators of the immune system—immunotherapy preven…
View article: XPO1 regulates erythroid differentiation and is a new target for the treatment of β-thalassemia
XPO1 regulates erythroid differentiation and is a new target for the treatment of β-thalassemia Open
β-thalassemia major (β-TM) is an inherited hemoglobinopathy caused by a quantitative defect in the synthesis of β-globin chains of hemoglobin, leading to the accumulation of free a-globin chains that aggregate and cause ineffective erythro…
View article: 0624 Anticataplectic Efficacy of Pitolisant, the First Potent and Highly Selective Histamine H3-Receptor Antagonist/Inverse Agonist
0624 Anticataplectic Efficacy of Pitolisant, the First Potent and Highly Selective Histamine H3-Receptor Antagonist/Inverse Agonist Open
Pitolisant, the first potent and highly selective histamine H3-receptor antagonist/inverse agonist, has demonstrated efficacy in reducing excessive daytime sleepiness (EDS) in narcolepsy and cataplexy in narcolepsy. In this report, the ant…
View article: P087 <break /> Inhibition of pleural inflammation hampers with bleomycin-induced lung profibrotic toxicity.
P087 Inhibition of pleural inflammation hampers with bleomycin-induced lung profibrotic toxicity. Open
IF 2.824
View article: Extracellular HSP110 skews macrophage polarization in colorectal cancer
Extracellular HSP110 skews macrophage polarization in colorectal cancer Open
HSP110 is induced by different stresses and, through its anti-apoptotic and chaperoning properties, helps the cells to survive these adverse situations. In colon cancers, HSP110 is abnormally abundant. We have recently showed that colorect…