Stefania Cerri
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View article: Predicting and Treating Pulmonary Fibrosis with Proteomic Biomarker Investigations
Predicting and Treating Pulmonary Fibrosis with Proteomic Biomarker Investigations Open
Idiopathic pulmonary fibrosis (IPF) is a chronic, rare, and fatal disease that is the consequence of aberrant remodeling and defective repair mechanisms within the lung, culminating in the loss of alveolar integrity. Although significant p…
View article: Predicting and Treating Pulmonary Fibrosis with Proteomic Biomarker Investigations
Predicting and Treating Pulmonary Fibrosis with Proteomic Biomarker Investigations Open
Idiopathic pulmonary fibrosis (IPF) is a chronic, rare and fatal disease that is the conse-quence of aberrant remodeling and defective repair mechanisms within the lung cul-minating in the loss of alveolar integrity. Although significant p…
View article: Drug-Induced Sarcoid-like Reactions Associated to Targeted Therapies and Biologic Agents
Drug-Induced Sarcoid-like Reactions Associated to Targeted Therapies and Biologic Agents Open
Background: Sarcoidosis is a multisystem inflammatory disease characterized by the immune-mediated formation of non-necrotizing epithelioid granulomas. Several commonly used medications can induce similar granulomatous reactions, known as …
View article: Role of <scp>COVID</scp>‐19 in the Progression of Scleroderma Interstitial Lung Disease and New Onset Pulmonary Hypertension: A Challenging Case Report
Role of <span>COVID</span>‐19 in the Progression of Scleroderma Interstitial Lung Disease and New Onset Pulmonary Hypertension: A Challenging Case Report Open
This case report describes an 80‐year‐old woman with systemic sclerosis (SSc), complicated by interstitial lung disease (ILD) and new‐onset pulmonary hypertension (PH), likely triggered by an atypical SARS‐CoV‐2 infection. Diagnosed with S…
View article: The Link Between Sleep-Related Breathing Disorders and Idiopathic Pulmonary Fibrosis: Pathophysiological Mechanisms and Treatment Options—A Review
The Link Between Sleep-Related Breathing Disorders and Idiopathic Pulmonary Fibrosis: Pathophysiological Mechanisms and Treatment Options—A Review Open
In recent years, several studies have examined the impact of sleep-disordered breathing (SBD) on the quality of life and prognosis of patients with idiopathic pulmonary fibrosis (IPF). Among these disorders, obstructive sleep apnea (OSA) a…
View article: Efficacy and safety of mepolizumab in eosinophilic granulomatosis with polyangiitis: Insights from real-life cases and literature analysis.
Efficacy and safety of mepolizumab in eosinophilic granulomatosis with polyangiitis: Insights from real-life cases and literature analysis. Open
After a median follow-up of 16 months (3-60), all EGPA patients were in remission for both vasculitis and asthma manifestations. Mepolizumab was associated with a reduction in corticosteroids daily dose, with a significant number of patien…
View article: Genetic Risk Factors in Idiopathic and Non-Idiopathic Interstitial Lung Disease: Similarities and Differences
Genetic Risk Factors in Idiopathic and Non-Idiopathic Interstitial Lung Disease: Similarities and Differences Open
Recent advances in genetics and epigenetics have provided critical insights into the pathogenesis of both idiopathic and non-idiopathic interstitial lung diseases (ILDs). Mutations in telomere-related genes and surfactant proteins have bee…
View article: Pulmonary Progressive Fibrosis in Rheumatoid Arthritis and Primary Sjogren Syndrome: Similarities and Differences
Pulmonary Progressive Fibrosis in Rheumatoid Arthritis and Primary Sjogren Syndrome: Similarities and Differences Open
Background: Progressive pulmonary fibrosis (PPF) has been associated with a worse prognosis, even when interstitial lung disease (ILD) is related to rheumatic diseases. Since many differences are detectable among rheumatic diseases in prev…
View article: Acute exacerbations in patients with progressive pulmonary fibrosis
Acute exacerbations in patients with progressive pulmonary fibrosis Open
Background Acute exacerbations of fibrosing interstitial lung diseases (ILDs) are associated with high mortality. We used prospective data from the INBUILD trial to investigate risk factors for acute exacerbations and the impact of these e…
View article: Automatic diagnostic support for diagnosis of pulmonary fibrosis
Automatic diagnostic support for diagnosis of pulmonary fibrosis Open
Patients with pulmonary fibrosis (PF) often experience long waits before getting a correct diagnosis, and this delay in reaching specialized care is associated with increased mortality, regardless of the severity of the disease. Early diag…
View article: Longitudinal changes of systemic vascular resistances in pregnancies complicated by hypertensive disorders and/or foetal growth rest riction
Longitudinal changes of systemic vascular resistances in pregnancies complicated by hypertensive disorders and/or foetal growth rest riction Open
Objective.To study the longitudinal trend of maternal systemic vascular resistances (SVR) in pregnancies complicated by hypertension (HDP) and/or foetal growth restriction (FGR).
View article: Prevalence of Progressive Fibrosing Interstitial Lung Disease in Patients with Primary Sjogren Syndrome
Prevalence of Progressive Fibrosing Interstitial Lung Disease in Patients with Primary Sjogren Syndrome Open
Background: Interstitial lung disease (ILD) represents a frequent cause of morbidity and mortality in primary Sjogren syndrome (pSS). However, the prevalence and behavior of pSS-ILD remains incomplete, largely based on retrospective hetero…
View article: Expression of HOXB7 in the Lung of Patients with Idiopathic Pulmonary Fibrosis: A Proof-of-Concept Study
Expression of HOXB7 in the Lung of Patients with Idiopathic Pulmonary Fibrosis: A Proof-of-Concept Study Open
Background: The molecular pathways involved in the onset and progression of idiopathic pulmonary fibrosis (IPF) still need to be fully clarified as some are shared with lung cancer development. HOXB7, a member of the homeobox (Hox) gene fa…
View article: When sarcoidosis hits down: a case of prostatic sarcoidosis
When sarcoidosis hits down: a case of prostatic sarcoidosis Open
A 69-year-old North African male with established diagnosis of sarcoidosis underwent a stereotactic prostate biopsy with fusion technique. At the histological analysis, non-necrotizing micro-granulomas were highlighted in 2 samples, while …
View article: Quantitative CT-analysis of over aerated lung tissue and correlation with fibrosis extent in patients with idiopathic pulmonary fibrosis
Quantitative CT-analysis of over aerated lung tissue and correlation with fibrosis extent in patients with idiopathic pulmonary fibrosis Open
INTRODUCTION The usual interstitial pneumonia (UIP) pattern, hallmark of idiopathic pulmonary fibrosis (IPF), may induce harmful local overdistension during mechanical ventilation given the juxtaposition of different tissue elasticities. M…
View article: Proteomic profiling of formalin-fixed paraffine-embedded tissue reveals key proteins related to lung dysfunction in idiopathic pulmonary fibrosis
Proteomic profiling of formalin-fixed paraffine-embedded tissue reveals key proteins related to lung dysfunction in idiopathic pulmonary fibrosis Open
Introduction Idiopathic pulmonary fibrosis (IPF) severely affects the lung leading to aberrant deposition of extracellular matrix and parenchymal stiffness with progressive functional derangement. The limited availability of fresh tissues …
View article: COVID-19, A New Possible Mimicker of Interstitial Lung Disease Related to Primary Sjögren’s Syndrome
COVID-19, A New Possible Mimicker of Interstitial Lung Disease Related to Primary Sjögren’s Syndrome Open
Introduction. Acute exacerbation of interstitial lung disease (ILD) and COVID-19 pneumonia show many similarities, but also COVID-19 sequelae, mainly when fibrotic features are present, can be difficult to distinguish from chronic ILD obse…
View article: Stress-strain curve and elastic behavior of the fibrotic lung with usual interstitial pneumonia pattern during protective mechanical ventilation
Stress-strain curve and elastic behavior of the fibrotic lung with usual interstitial pneumonia pattern during protective mechanical ventilation Open
Background Patients with acute exacerbation of lung fibrosis with usual interstitial pneumonia (AE-ILD-UIP) pattern are at increased risk for ventilator-induced lung injury (VILI) and mortality when exposed to mechanical ventilation (MV). …
View article: Physiological effects of lung-protective ventilation in patients with lung fibrosis and usual interstitial pneumonia pattern versus primary ARDS: a matched-control study
Physiological effects of lung-protective ventilation in patients with lung fibrosis and usual interstitial pneumonia pattern versus primary ARDS: a matched-control study Open
Background Although patients with interstitial pneumonia pattern (ILD-UIP) and acute exacerbation (AE) leading to severe acute respiratory failure may require invasive mechanical ventilation (MV), physiological data on lung mechanics durin…
View article: Bronchiectasis as long-term complication of acute fire smoke inhalation?
Bronchiectasis as long-term complication of acute fire smoke inhalation? Open
In this letter to editor, we discuss the occurrence of radiological and clinical evidence of bronchiectasis syndrome three years after acute exposure to fire smoke in a Caucasian non-smoker asthmatic patient.
View article: AB0879 SAFETY AND EFFECTIVENESS OF RITUXIMAB TREATMENT FOR SYSTEMIC SCLEROSIS: AN UPDATE OF OUR CLINICAL EXPERIENCE
AB0879 SAFETY AND EFFECTIVENESS OF RITUXIMAB TREATMENT FOR SYSTEMIC SCLEROSIS: AN UPDATE OF OUR CLINICAL EXPERIENCE Open
Background The treatment of systemic sclerosis-SSc is challenging because of its complex pathogenesis. Data on Rituximab-RTX use in SSc are still conflicting but information from case reports or non-randomized clinical trials are somehow p…
View article: Physiological effects of lung protective ventilation in patients with lung fibrosis and usual interstitial pneumonia pattern versus primary ARDS: a matched-control study
Physiological effects of lung protective ventilation in patients with lung fibrosis and usual interstitial pneumonia pattern versus primary ARDS: a matched-control study Open
Background Although patients with AE-ILD and UIP pattern may experience severe acute respiratory failure requiring invasive MV, physiological data on lung mechanics during these events are lacking. We aimed to describe the physiological ef…