Suresh Kumar
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View article: Oxidative stress, serum metabolites, inflammatory cytokine changes associated with lumpy skin disease in cattle
Oxidative stress, serum metabolites, inflammatory cytokine changes associated with lumpy skin disease in cattle Open
Understanding the underlying mechanisms of LSD infection can help in devising suitable anti-oxidant and immunomodulatory interventions and strategies to mitigate tissue damage, bolster the host immune response, and effectively manage LSD o…
View article: Cryo-EM Structure of a Type I Anti-Prothrombin Antibody Reveals a Novel Kringle-1 Epitope and Its Functional Impact
Cryo-EM Structure of a Type I Anti-Prothrombin Antibody Reveals a Novel Kringle-1 Epitope and Its Functional Impact Open
Introduction. Antiphospholipid syndrome (APS) is an autoimmune disorder characterized by the presence of antiphospholipid antibodies (aPLs) that disrupt coagulation and increase thrombosis risk. Prothrombin is a key antigen for aPL, and we…
View article: POmAb, an antibody targeting open prothrombin, results in anticoagulation without excessive bleeding in mice
POmAb, an antibody targeting open prothrombin, results in anticoagulation without excessive bleeding in mice Open
Anti-prothrombin antibodies are commonly found in patients with Antiphospholipid Syndrome (APS), yet their role in clinical manifestations remains unclear. We recently identified two classes of anti-prothrombin antibodies based on their ab…
View article: Aurones as versatile enzyme Inhibitors: Recent advancements, structural insights, mechanisms, and therapeutic potential
Aurones as versatile enzyme Inhibitors: Recent advancements, structural insights, mechanisms, and therapeutic potential Open
View article: Antiphospholipid IgG Certified Reference Material ERM<sup>®</sup>-DA477/IFCC: a tool for aPL harmonization?
Antiphospholipid IgG Certified Reference Material ERM<sup>®</sup>-DA477/IFCC: a tool for aPL harmonization? Open
Objectives The Certified Reference Material (CRM) ERM ® -DA477/IFCC is a new polyclonal IgG anti-beta2-glycoprotein I (anti-β2GPI) material for the harmonization of the laboratory diagnosis of antiphospholipid syndrome (APS). We evaluated …
View article: Cryo-EM reveals the structural and functional role of prothrombin recognition by type-I anti-prothrombin antibody in Antiphospholipid Syndrome
Cryo-EM reveals the structural and functional role of prothrombin recognition by type-I anti-prothrombin antibody in Antiphospholipid Syndrome Open
Anti-prothrombin (anti-PT) antibodies are a type of antiphospholipid antibodies frequently found in antiphospholipid syndrome (APS) patients. Our previous studies have shown that prothrombin adopts closed and open forms and that Type-I ant…
View article: Crystal structure, thermal behavior, electric and dielectric properties of a novel organic–inorganic hybrid compound based on iron (III) chloride
Crystal structure, thermal behavior, electric and dielectric properties of a novel organic–inorganic hybrid compound based on iron (III) chloride Open
The current research work describes the preparation and characterizations of a new metal halide hybrid: (C12H14N2O2S)2(FeCl4)1.5(FeCl6)0.5Cl·3H2O Single crystals of the studied sample were grown by the solvent evaporation method. X ray dif…
View article: Understanding the structure of β2-glycoprotein I: new insights and future paths for antiphospholipid syndrome
Understanding the structure of β2-glycoprotein I: new insights and future paths for antiphospholipid syndrome Open
View article: Exploring the synergy of enzymes, nutrients, and gene networks in rice starch granule biogenesis
Exploring the synergy of enzymes, nutrients, and gene networks in rice starch granule biogenesis Open
Introduction Rice is a primary food source almost for more than 50% of the total world's population. Glycemic index (GI) is high in most of the rice varieties, limiting their consumption by diabetic and obese people. As a result, developin…
View article: Stemming the Flow: Causes and Solutions for Blood and Blood Component Wastage in a Tertiary Care Hospital
Stemming the Flow: Causes and Solutions for Blood and Blood Component Wastage in a Tertiary Care Hospital Open
Aim This study aims to analyze the discard rates and causes of blood and blood component wastage in a hospital transfusion service and identify strategies for improvement. Methodology We conducted a retrospective study reviewing data from …
View article: Evaluating the Behaviour of Sahiwal Calves under Azolla pinnata Feeding During the Cold Season
Evaluating the Behaviour of Sahiwal Calves under Azolla pinnata Feeding During the Cold Season Open
The purpose of the present research was to evaluate the feeding behaviour of Sahiwal calves raised under Azolla pinnata feeding throughout the cold season in the morning hours. Eighteen female Sahiwal calves weighing 56 kg at four months o…
View article: Forecasting the Future of Antiphospholipid Syndrome: Prospects and Challenges.
Forecasting the Future of Antiphospholipid Syndrome: Prospects and Challenges. Open
Antiphospholipid syndrome (APS) is an autoimmune condition affecting young patients, primarily women, negatively impacting their quality of life. APS is under-recognized and underdiagnosed and can have devastating results if untreated, mai…
View article: Structural analyses of β2-glycoprotein I: is there a circular conformation?
Structural analyses of β2-glycoprotein I: is there a circular conformation? Open
View article: Diagnostic Performance of Direct Microscopic Techniques and Culture Media for Fungal Isolates from Hair Specimens
Diagnostic Performance of Direct Microscopic Techniques and Culture Media for Fungal Isolates from Hair Specimens Open
Objective: To compare the diagnostic performance of direct microscopic techniques and culture media for detecting fungal isolates in hair specimens.Study Design: Cross-sectional study.Place and Duration of Study: The study was conducted at…
View article: Assessment of Vitamin A Status in Patients with Iron Deficiency Anemia
Assessment of Vitamin A Status in Patients with Iron Deficiency Anemia Open
Introduction: Iron and vitamin A deficiency are two very prevalent and easily preventable nutrient deficiencies. This study was conducted to assess vitamin A status in patients with iron deficiency anemia and to further study the correlati…
View article: Dynamics of lipid mobilization and other serum metabolites during transitional period in Frieswal dairy cattle
Dynamics of lipid mobilization and other serum metabolites during transitional period in Frieswal dairy cattle Open
The transition period in a dairy cow is defined as a change from a gestational non-lactating to a non-gestational lactating state and usually spans between 3 weeks prior to calving and 3 weeks post-calving. The period is characterized by s…
View article: Cytological, Bacteriological and Antibiogram Studies for the Management of Uterine Infection in Repeat Breeder Bovines
Cytological, Bacteriological and Antibiogram Studies for the Management of Uterine Infection in Repeat Breeder Bovines Open
Background: Repeat breeding syndrome (RBS) associated with sub-clinical uterine infection (UI) remains to be a major reproductive problem faced by Indian farmers. Present study documents its diagnosis, prevalent etiological agents, antibio…
View article: Prevalence of Candida species in onychomycosis at a Tertiary Care Hospital Karachi
Prevalence of Candida species in onychomycosis at a Tertiary Care Hospital Karachi Open
Objective: This study was designed to determine the frequency of Candida in clinically diagnosed cases of onychomycosis. Study Design: It was a cross-sectional study.Setting: It was conducted in the Department of Microbiology, BMSI, JPMC, …
View article: An allosteric redox switch in domain V of β2-glycoprotein I controls membrane binding and anti-domain I autoantibody recognition
An allosteric redox switch in domain V of β2-glycoprotein I controls membrane binding and anti-domain I autoantibody recognition Open
View article: Postpartum acyclicity and its management in bovines
Postpartum acyclicity and its management in bovines Open
Prolonged ovarian acyclicity after parturition is one of the major problems faced by Bovine (Cattle and Buffalo) owners under field conditions. The present study was conducted on pre-selected 18 healthy and high milk producing crossbred ca…
View article: Unique C-terminal extension and interactome of <i>Mycobacterium tuberculosis</i> GlmU impacts its <i>in vivo</i> function and the survival of the pathogen
Unique C-terminal extension and interactome of <i>Mycobacterium tuberculosis</i> GlmU impacts its <i>in vivo</i> function and the survival of the pathogen Open
N-acetyl glucosamine-1-phosphate uridyltransferase (GlmU) is a bifunctional enzyme involved in the biosynthesis of Uridine diphosphate N-acetylglucosamine (UDP-GlcNAc). UDP-GlcNAc is a critical precursor for the synthesis of peptidoglycan …
View article: Clinical Profile of Non-neutropenic Patients with Invasive Candidiasis: A Retrospective Study in a Tertiary Care Center
Clinical Profile of Non-neutropenic Patients with Invasive Candidiasis: A Retrospective Study in a Tertiary Care Center Open
Introduction: Invasive candidiasis (IC) is a major cause of morbidity and mortality in critically ill patients in the intensive care unit (ICU). In this study, we aim to analyze the clinical profile, species distribution, and suscep…
View article: Effect of Heat Stress on Reproductive Performance, Blood Biochemical and Physiological Parameters of Sows Following Mating
Effect of Heat Stress on Reproductive Performance, Blood Biochemical and Physiological Parameters of Sows Following Mating Open
The experiment was conducted with a total of 12 sows of different breeds (Pure Hampshire, Khasi local and Ghungroo) for evaluating the effect of heat stress on reproductive performance, blood biochemical and physiological parameters of sow…
View article: Astrocytes influence medulloblastoma phenotypes and CD133 surface expression
Astrocytes influence medulloblastoma phenotypes and CD133 surface expression Open
The medulloblastoma (MB) microenvironment is diverse, and cell-cell interactions within this milieu is of prime importance. Astrocytes, a major component of the microenvironment, have been shown to impact primary tumor cell phenotypes and …
View article: Body Condition Scoring in Dairy Cows - A Conceptual and Systematic Review
Body Condition Scoring in Dairy Cows - A Conceptual and Systematic Review Open
As herd sizes have increased in the last decades due to commercialization of dairy sector, computer monitoring solutions, which provide fast and accurate evaluation of body condition score, gain more and more importance. The main reasons t…
View article: Crosstalk between food components and microRNAs: Role in metabolism, nutrition, health and diseases
Crosstalk between food components and microRNAs: Role in metabolism, nutrition, health and diseases Open
View article: Analysis of factors affecting multiple births, abnormal kidding, litter size and sex ratio in Alpine Beetal goats
Analysis of factors affecting multiple births, abnormal kidding, litter size and sex ratio in Alpine Beetal goats Open
The present investigation was conducted using 220 kidding records of Alpine Beetal goats to evaluate the influence of various factors on abnormal kidding, multiple birth, litter size and sex ratio. In this study, the abnormal kidding was 3…
View article: PARP inhibition enhances cisplatin sensitivity in cervical cancer by modulating β-catenin signaling
PARP inhibition enhances cisplatin sensitivity in cervical cancer by modulating β-catenin signaling Open
View article: Author Index
Author Index Open