Samuel J. Cler
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View article: The Combination of <scp>PARP</scp> and Topoisomerase 1 Inhibitors Improves Radiation Therapy for Ewing Sarcoma
The Combination of <span>PARP</span> and Topoisomerase 1 Inhibitors Improves Radiation Therapy for Ewing Sarcoma Open
Although primary tumor control rates after surgery and/or radiation therapy (RT) are generally high in patients with Ewing sarcoma (EWS), those with unresectable tumors have failure rates approaching 30% and experience poorer outcomes. Add…
View article: A review of technological innovations leading to modern endovascular brain aneurysm treatment
A review of technological innovations leading to modern endovascular brain aneurysm treatment Open
Tools and techniques utilized in endovascular brain aneurysm treatment have undergone rapid evolution in recent decades. These technique and device-level innovations have allowed for treatment of highly complex intracranial aneurysms and i…
View article: E-084 Day-of-week effect on safety of elective brain aneurysm treatment
E-084 Day-of-week effect on safety of elective brain aneurysm treatment Open
Introduction Elective treatment of intracranial aneurysms comprises a large share of neurointerventional practice. With increasing demand for endovascular aneurysm treatment, there is a need to assess factors such as operator fatigue and t…
View article: Retreatment of previously flow diverted intracranial aneurysms with the pipeline embolization device
Retreatment of previously flow diverted intracranial aneurysms with the pipeline embolization device Open
Background and Purpose Flow diversion of intracranial aneurysms with the Pipeline Embolization Device (PED) is frequently performed, but the outcomes of retreatment for aneurysms that failed to occlude after prior treatment with PED have n…
View article: LGG-01. Children with Supratentorial Midline Pilocytic Astrocytomas Exhibit Multiple Progressions and Acquisition of Neurologic Deficits over Time
LGG-01. Children with Supratentorial Midline Pilocytic Astrocytomas Exhibit Multiple Progressions and Acquisition of Neurologic Deficits over Time Open
Pilocytic astrocytomas are the most common solid tumor of childhood and can arise anywhere in the central nervous system, including the posterior fossa (pf-PA), supratentorial midline (sm-PA; including optic pathway, hypothalamus, thalamus…
View article: Comparative study of on-label versus off-label treatment of intracranial aneurysms with the Pipeline embolization device
Comparative study of on-label versus off-label treatment of intracranial aneurysms with the Pipeline embolization device Open
OBJECTIVE The Pipeline embolization device (PED) is widely used for the treatment of intracranial aneurysms, including in off-label applications. In this work, the authors compared the real-world efficacy and safety of PED use in on-label …
View article: A Low Subfrontal Dural Opening for Operative Management of Anterior Skull Base Lesions
A Low Subfrontal Dural Opening for Operative Management of Anterior Skull Base Lesions Open
Introduction A low subfrontal dural opening technique that limits brain manipulation was assessed in patients who underwent frontotemporal approaches for anterior fossa lesions. Methods A retrospective review was performed for cases using …
View article: Children with supratentorial midline pilocytic astrocytomas exhibit multiple progressions and acquisition of neurologic deficits over time
Children with supratentorial midline pilocytic astrocytomas exhibit multiple progressions and acquisition of neurologic deficits over time Open
Summary Tumor location has been proposed as a prognostic factor for pilocytic astrocytoma (PA), but since resection status varies by CNS location, these two variables are difficult to separate on multivariate analysis. To eliminate resecti…
View article: E-146 The value of long-term angiographic follow-up following pipeline embolization of intracranial aneurysms
E-146 The value of long-term angiographic follow-up following pipeline embolization of intracranial aneurysms Open
Introduction/Purpose Flow diversion of intracranial aneurysms with the Pipeline embolization device is commonly performed, but the value of long-term angiographic follow-up has not been rigorously evaluated. Here, we examine the prevalence…
View article: O-005 Comparison of on-label versus off-label treatment of intracranial aneurysms with the pipeline embolization devices
O-005 Comparison of on-label versus off-label treatment of intracranial aneurysms with the pipeline embolization devices Open
Background and Purpose The Pipeline Embolization Device (PED) is widely used for treatment of intracranial aneurysms, including in off-label applications. The performance of PED in off-label applications is not well understood. In this wor…
View article: E-106 Timeline of occlusion for intracranial aneurysms treated with pipeline embolization devices
E-106 Timeline of occlusion for intracranial aneurysms treated with pipeline embolization devices Open
Introduction/Purpose The Pipeline Embolization Device (PED) is commonly used to treat intracranial aneurysms. The rate of aneurysm occlusion at pre-specified timepoints after PED treatment is known from clinical trials, but the actual time…
View article: LGG-07. IS BRAF ALTERATION OR A HISTOLOGIC ‘QUALIFIER’ A PREDICTOR OF OUTCOME IN PEDIATRIC PILOCYTIC ASTROCYTOMA?
LGG-07. IS BRAF ALTERATION OR A HISTOLOGIC ‘QUALIFIER’ A PREDICTOR OF OUTCOME IN PEDIATRIC PILOCYTIC ASTROCYTOMA? Open
Introduction Pediatric pilocytic astrocytomas (PA) are the most common pediatric central nervous system tumor. Surgical resection is the primary treatment for PA with five-year survival rates up to 95%. Despite a favorable prognosis, our u…