Christopher S. Colwell
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View article: Dissociating the Effects of Light at Night from Circadian Misalignment in a Neurodevelopmental Disorder Mouse Model Using Ultradian Light–Dark Cycles
Dissociating the Effects of Light at Night from Circadian Misalignment in a Neurodevelopmental Disorder Mouse Model Using Ultradian Light–Dark Cycles Open
Individuals with neurodevelopmental disorders (NDDs) often experience sleep disturbances and are frequently exposed to light during nighttime hours. Our previous studies using the Contactin-associated protein-like 2 (Cntnap2) knockout (KO)…
View article: Scheduled feeding improves behavioral outcomes and reduces inflammation in a mouse model of fragile X syndrome
Scheduled feeding improves behavioral outcomes and reduces inflammation in a mouse model of fragile X syndrome Open
Fragile X syndrome (FXS), a leading inherited cause of intellectual disability and autism, is frequently accompanied by sleep and circadian rhythm disturbances. In this study, we comprehensively characterized these disruptions and evaluate…
View article: Scheduled feeding improves behavioral outcomes and reduces inflammation in a mouse model of Fragile X syndrome
Scheduled feeding improves behavioral outcomes and reduces inflammation in a mouse model of Fragile X syndrome Open
Fragile X syndrome (FXS), a leading inherited cause of intellectual disability and autism, is frequently accompanied by sleep and circadian rhythm disturbances. In this study, we comprehensively characterized these disruptions and evaluate…
View article: Scheduled feeding improves behavioral outcomes and reduces inflammation in a mouse model of Fragile X syndrome
Scheduled feeding improves behavioral outcomes and reduces inflammation in a mouse model of Fragile X syndrome Open
Fragile X syndrome (FXS), a leading inherited cause of intellectual disability and autism, is frequently accompanied by sleep and circadian rhythm disturbances. In this study, we comprehensively characterized these disruptions and evaluate…
View article: Dissociating the Effects of Light at Night from Circadian Misalignment in a Neurodevelopmental Disorder Mouse Model Using Ultradian Light-Dark Cycles.
Dissociating the Effects of Light at Night from Circadian Misalignment in a Neurodevelopmental Disorder Mouse Model Using Ultradian Light-Dark Cycles. Open
Individuals with neurodevelopmental disorders (NDDs) often experience sleep disturbances and are frequently exposed to light during nighttime hours. Our previous studies using the Cntnap2 knockout (KO) mouse model of NDDs demonstrated that…
View article: A Randomized, Placebo-Controlled, Double-Blind Trial to Assess the Effects of Apocynum venetum L. (A. venetum) Venetron® on Sleep and Stress in Those Expressing Feelings of Anxiety
A Randomized, Placebo-Controlled, Double-Blind Trial to Assess the Effects of Apocynum venetum L. (A. venetum) Venetron® on Sleep and Stress in Those Expressing Feelings of Anxiety Open
Background/Objectives: Anxiety and stress are interrelated and connected to reduced health-related quality of life. Botanicals such as Apocynum venetum L. (A. venetum) have been shown to improve health outcomes. No human studies have been …
View article: Dim Light at Night Disrupts the Sleep-Wake Cycle and Exacerbates Seizure Activity in <i>Cntnap2</i> Knockout Mice: Implications for Autism Spectrum Disorders
Dim Light at Night Disrupts the Sleep-Wake Cycle and Exacerbates Seizure Activity in <i>Cntnap2</i> Knockout Mice: Implications for Autism Spectrum Disorders Open
Epilepsy is one of the most common comorbidities in individuals with autism spectrum disorders (ASDs). Many patients with epilepsy as well as ASD experience disruptions in their sleep-wake cycle and exhibit daily rhythms in expression of s…
View article: A Randomized, Placebo-Controlled, Double-Blind Trial to Assess the Effects of Apocynum venetum L. (A. venetum) Venetron® on Sleep and Stress in Those Expressing Feelings of Anxiety
A Randomized, Placebo-Controlled, Double-Blind Trial to Assess the Effects of Apocynum venetum L. (A. venetum) Venetron® on Sleep and Stress in Those Expressing Feelings of Anxiety Open
Background/Objectives: Anxiety and stress are interrelated and connected to reduced health-related quality of life. Botanicals such as Apocynum venetum L. (A. venetum) have been shown to improve health outcomes. No human studies have been …
View article: Scheduled feeding improves behavioral outcomes and reduces inflammation in a mouse model of Fragile X syndrome
Scheduled feeding improves behavioral outcomes and reduces inflammation in a mouse model of Fragile X syndrome Open
Fragile X syndrome (FXS) is a neurodevelopmental disorder caused by the abnormal expansion of CGG repeats in the fragile X mental retardation 1 (FMR1) gene. Many FXS patients experience sleep disruptions, and we sought to explore these sym…
View article: Scheduled feeding improves behavioral outcomes and reduces inflammation in a mouse model of fragile X syndrome
Scheduled feeding improves behavioral outcomes and reduces inflammation in a mouse model of fragile X syndrome Open
Fragile X syndrome (FXS), a leading inherited cause of intellectual disability and autism, is frequently accompanied by sleep and circadian rhythm disturbances. In this study, we comprehensively characterized these disruptions and evaluate…
View article: Scheduled feeding improves behavioral outcomes and reduces inflammation in a mouse model of Fragile X syndrome
Scheduled feeding improves behavioral outcomes and reduces inflammation in a mouse model of Fragile X syndrome Open
Fragile X syndrome (FXS), a leading inherited cause of intellectual disability and autism, is frequently accompanied by sleep and circadian rhythm disturbances. In this study, we comprehensively characterized these disruptions and evaluate…
View article: Circadian Interventions in Preclinical Models of Huntington’s Disease: A Narrative Review
Circadian Interventions in Preclinical Models of Huntington’s Disease: A Narrative Review Open
Huntington’s Disease (HD) is a neurodegenerative disorder caused by an autosomal-dominant mutation in the huntingtin gene, which manifests with a triad of motor, cognitive and psychiatric declines. Individuals with HD often present with di…
View article: Scheduled feeding improves sleep in a mouse model of Huntington’s disease
Scheduled feeding improves sleep in a mouse model of Huntington’s disease Open
Sleep disturbances are common features of neurodegenerative disorders including Huntington’s disease (HD). Sleep and circadian disruptions are recapitulated in animal models, providing the opportunity to evaluate the effectiveness of circa…
View article: A Randomized, Double-Blind, Placebo-Controlled Trial to Assess the Effectiveness and Safety of Melatonin and Three Formulations of Floraworks Proprietary TruCBN™ for Improving Sleep
A Randomized, Double-Blind, Placebo-Controlled Trial to Assess the Effectiveness and Safety of Melatonin and Three Formulations of Floraworks Proprietary TruCBN™ for Improving Sleep Open
The phytocannabinoid cannabinol (CBN) has a potential mechanism of action as an alternative sleep aid but there is minimal evidence to support its effectiveness. The aim of this randomized, double-blind, placebo-controlled study was to ass…
View article: Sleep EEG signatures in mouse models of 15q11.2-13.1 duplication (Dup15q) syndrome
Sleep EEG signatures in mouse models of 15q11.2-13.1 duplication (Dup15q) syndrome Open
Background Sleep disturbances are a prevalent and complex comorbidity in neurodevelopmental disorders (NDDs). Dup15q syndrome (duplications of 15q11.2-13.1) is a genetic disorder highly penetrant for NDDs such as autism and intellectual di…
View article: Relative importance of intensity and spectrum of artificial light at night in disrupting behavior of a nocturnal rodent
Relative importance of intensity and spectrum of artificial light at night in disrupting behavior of a nocturnal rodent Open
The influence of light spectral properties on circadian rhythms is of substantial interest to laboratory-based investigation of the circadian system and to field-based understanding of the effects of artificial light at night. The trade-of…
View article: Scheduled feeding improves sleep in a mouse model of Huntington’s disease
Scheduled feeding improves sleep in a mouse model of Huntington’s disease Open
Sleep disturbances are common features of neurodegenerative disorders including Huntington’s disease (HD). The sleep and circadian disruptions are recapitulated in animal models, and these models provide the opportunity to evaluate whether…
View article: Editorial: Recent advances in sleep and circadian rhythms: the hypothalamus and its relationship with appetite
Editorial: Recent advances in sleep and circadian rhythms: the hypothalamus and its relationship with appetite Open
Editorial: Recent advances in sleep and circadian rhythms: the hypothalamus and its relationship with appetite
View article: Sex differences in sleep architecture in a mouse model of Huntington's disease
Sex differences in sleep architecture in a mouse model of Huntington's disease Open
Sleep and circadian rhythm disturbances are common features of Huntington's disease (HD). HD is an autosomal dominant neurodegenerative disorder that affects men and women in equal numbers, but some epidemiological studies as well as precl…
View article: Hydrogen-rich water improves sleep consolidation and enhances forebrain neuronal activation in mice
Hydrogen-rich water improves sleep consolidation and enhances forebrain neuronal activation in mice Open
Study Objectives Sleep loss contributes to various health issues and impairs neurological function. Molecular hydrogen has recently gained popularity as a nontoxic ergogenic and health promoter. The effect of molecular hydrogen on sleep an…
View article: The Negative Effects of Travel on Student Athletes Through Sleep and Circadian Disruption
The Negative Effects of Travel on Student Athletes Through Sleep and Circadian Disruption Open
Collegiate athletes must satisfy the academic obligations common to all undergraduates, but they have the additional structural and social stressors of extensive practice time, competition schedules, and frequent travel away from their hom…
View article: A Randomized, Double-Blind, Placebo Controlled Trial to Assess the Effectiveness and Safety of Melatonin and Three Formulations of Floraworks Proprietary TruCBN™ for Improving Sleep
A Randomized, Double-Blind, Placebo Controlled Trial to Assess the Effectiveness and Safety of Melatonin and Three Formulations of Floraworks Proprietary TruCBN™ for Improving Sleep Open
Introduction: Prescription sleep aids often have side effects, making alternative solutions necessary. Melatonin is an efficacious sleep aid and is often the comparator for alternatives. The phytocannabinoid cannabinol (CBN), has a potenti…
View article: Motor Activity-Induced White Matter Repair in White Matter Stroke
Motor Activity-Induced White Matter Repair in White Matter Stroke Open
Subcortical white matter stroke (WMS) is a progressive disorder which is demarcated by the formation of small ischemic lesions along white matter tracts in the CNS. As lesions accumulate, patients begin to experience severe motor and cogni…