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View article: Multidecadal forcing of European windstorm losses in CMIP6-DAMIP models
Multidecadal forcing of European windstorm losses in CMIP6-DAMIP models Open
Large variations of European storm activity at decadal and longer timescales have been found to be driven by major tropical volcanic eruptions, internal climate variability and anthropogenic aerosols (AA). The insurance industry have the a…
View article: Structural basis for the synergistic assembly of the snRNA export complex
Structural basis for the synergistic assembly of the snRNA export complex Open
The nuclear cap-binding complex (CBC) and its partner Arsenite-Resistance Protein 2 (ARS2) regulate the fate of RNA polymerase II transcripts via mutually exclusive interactions with RNA effectors. One such effector is PHAX, which mediates…
View article: Structure of the tilapia lake virus nucleoprotein bound to RNA
Structure of the tilapia lake virus nucleoprotein bound to RNA Open
Tilapia Lake virus (TiLV) belongs to the Amnoonviridae family within the Articulavirales order of segmented negative-strand RNA viruses and is highly diverged from more familiar orthomyxoviruses, such as influenza. The viral nucleoprotein …
View article: Structural basis for the synergistic assembly of the snRNA export complex
Structural basis for the synergistic assembly of the snRNA export complex Open
The nuclear cap-binding complex (CBC) and its partner ARS2 play crucial roles in regulating Pol II transcript fate through mutually exclusive interactions with RNA effectors. One such effector, PHAX, mediates the nuclear export of U-rich s…
View article: Structure of the Tilapia lake virus nucleoprotein bound to RNA
Structure of the Tilapia lake virus nucleoprotein bound to RNA Open
Tilapia Lake virus (TiLV) belongs to the Amnoonviridae family within the Articulavirales order of segmented negative-strand RNA viruses and is highly diverged from more familiar orthomyxoviruses, such as influenza. The viral nucleoprotein …
View article: Brief Communication: Investigating trends in European hailstorm damage using CMIP6-DAMIP climate models
Brief Communication: Investigating trends in European hailstorm damage using CMIP6-DAMIP climate models Open
Warming seas around Europe have been driving recent upward trends in hailstorm severity. Therefore, learning more about changes to sea temperatures can give insights into hail climate too. Here, we use the DAMIP (Detection and Attribution …
View article: The molecular dissection of TRIM25’s RNA-binding mechanism provides key insights into its antiviral activity
The molecular dissection of TRIM25’s RNA-binding mechanism provides key insights into its antiviral activity Open
TRIM25 is an RNA-binding ubiquitin E3 ligase with central but poorly understood roles in the innate immune response to RNA viruses. The link between TRIM25’s RNA binding and its role in innate immunity has not been established. Thus, we ut…
View article: The RNA receptor RIG-I binding synthetic oligodeoxynucleotide promotes pneumonia survival
The RNA receptor RIG-I binding synthetic oligodeoxynucleotide promotes pneumonia survival Open
Pneumonia is a worldwide threat to public health, demanding novel preventative and therapeutic strategies. The lung epithelium is a critical environmental interface that functions as a physical barrier to pathogen invasion while also activ…
View article: The RBPome of influenza A virus NP-mRNA reveals a role for TDP-43 in viral replication
The RBPome of influenza A virus NP-mRNA reveals a role for TDP-43 in viral replication Open
Genome-wide approaches have significantly advanced our knowledge of the repertoire of RNA-binding proteins (RBPs) that associate with cellular polyadenylated mRNAs within eukaryotic cells. Recent studies focusing on the RBP interactomes of…
View article: Structures of influenza A and B replication complexes explain avian to human host adaption and reveal a role of ANP32 as an electrostatic chaperone for the apo-polymerase
Structures of influenza A and B replication complexes explain avian to human host adaption and reveal a role of ANP32 as an electrostatic chaperone for the apo-polymerase Open
Replication of influenza viral RNA depends on at least two viral polymerases, a parental replicase and an encapsidase, and cellular factor ANP32. ANP32 comprises an LRR domain and a long C-terminal low complexity acidic region (LCAR). Here…
View article: Structural snapshots of phenuivirus cap-snatching and transcription
Structural snapshots of phenuivirus cap-snatching and transcription Open
Severe fever with thrombocytopenia syndrome virus (SFTSV) is a human pathogen that is now endemic to several East Asian countries. The viral large (L) protein catalyzes viral transcription by stealing host mRNA caps via a process known as …
View article: Structural basis for competitive binding of productive and degradative co-transcriptional effectors to the nuclear cap-binding complex
Structural basis for competitive binding of productive and degradative co-transcriptional effectors to the nuclear cap-binding complex Open
The nuclear cap-binding complex (CBC) coordinates co-transcriptional maturation, transport, or degradation of nascent RNA polymerase II (Pol II) transcripts. CBC with its partner ARS2 forms mutually exclusive complexes with diverse "effect…
View article: The molecular dissection of TRIM25‘s RNA-binding mechanism provides key insights into its antiviral activity
The molecular dissection of TRIM25‘s RNA-binding mechanism provides key insights into its antiviral activity Open
TRIM25 is an RNA-binding ubiquitin E3 ligase with central but poorly understood roles in the innate immune response to RNA viruses. The link between TRIM25’s RNA binding and its role in innate immunity has not been established. Thus, we ut…
View article: Structural snapshots of phenuivirus cap-snatching and transcription
Structural snapshots of phenuivirus cap-snatching and transcription Open
Severe fever with thrombocytopenia syndrome virus (SFTSV) is a human pathogen that is now endemic to several East Asian countries. The viral large (L) protein catalyzes viral transcription by stealing host mRNA caps via a process known as …
View article: High-resolution structure of a replication-initiation like configuration of influenza polymerase active site visualises the essential role of a conserved dibasic motif in the PA subunit
High-resolution structure of a replication-initiation like configuration of influenza polymerase active site visualises the essential role of a conserved dibasic motif in the PA subunit Open
Influenza polymerase, comprising subunits PA, PB1 and PB2, transcribes the negative-sense genomic viral RNA (vRNA) into mRNA or replicates it first into complementary RNA (cRNA) and then back to vRNA. Here we investigate the mechanism of d…
View article: Multivalent Dynamic Colocalization of Avian Influenza Polymerase and Nucleoprotein by Intrinsically Disordered ANP32A Reveals the Molecular Basis of Human Adaptation
Multivalent Dynamic Colocalization of Avian Influenza Polymerase and Nucleoprotein by Intrinsically Disordered ANP32A Reveals the Molecular Basis of Human Adaptation Open
Adaptation of avian influenza RNA polymerase (FluPol) to human cells requires mutations on the 627-NLS domains of the PB2 subunit. The E627K adaptive mutation compensates a 33-amino-acid deletion in the acidic intrinsically disordered doma…
View article: Structure shows that the BIR2 domain of E3 ligase XIAP binds across the RIPK2 kinase dimer interface
Structure shows that the BIR2 domain of E3 ligase XIAP binds across the RIPK2 kinase dimer interface Open
RIPK2 is an essential adaptor for NOD signalling and its kinase domain is a drug target for NOD-related diseases, such as inflammatory bowel disease. However, recent work indicates that the phosphorylation activity of RIPK2 is dispensable …
View article: A long record of European windstorm losses and its comparison to standard climate indices
A long record of European windstorm losses and its comparison to standard climate indices Open
Traditional insurance has both a great exposure to decadal variations in European storm activity and the ability to adjust its business strategy over these timescales. Hence, the recent development of skilful predictions of multiannual mea…
View article: Structural and functional analysis of the minimal orthomyxovirus-like polymerase of Tilapia Lake Virus from the highly diverged<i>Amnoonviridae</i>family
Structural and functional analysis of the minimal orthomyxovirus-like polymerase of Tilapia Lake Virus from the highly diverged<i>Amnoonviridae</i>family Open
Tilapia Lake Virus (TiLV), a recently discovered pathogen of tilapia fish, belongs to the Amnoonviridae family from the Articulavirales order. Its ten genome segments have characteristic conserved ends and encode proteins with no known hom…
View article: Structural and functional characterization of the Sin Nombre virus L protein
Structural and functional characterization of the Sin Nombre virus L protein Open
The Bunyavirales order is a large and diverse group of segmented negative-strand RNA viruses. Several virus families within this order contain important human pathogens, including Sin Nombre virus (SNV) of the Hantaviridae . Despite the hi…
View article: The host RNA polymerase II C-terminal domain is the anchor for replication of the influenza virus genome
The host RNA polymerase II C-terminal domain is the anchor for replication of the influenza virus genome Open
Summary The current model is that the influenza virus polymerase (FluPol) binds either to host RNA polymerase II (RNAP II) or to the acidic nuclear phosphoprotein 32 (ANP32), which drives its conformation and activity towards transcription…
View article: Structural basis for competitive binding of productive and degradative co-transcriptional effectors to the nuclear cap-binding complex
Structural basis for competitive binding of productive and degradative co-transcriptional effectors to the nuclear cap-binding complex Open
Summary The nuclear cap-binding complex (CBC) co-ordinates co-transcriptional maturation, transport, or degradation of nascent Pol II transcripts. CBC with its partner ARS2 form mutually exclusive complexes with diverse ‘effectors’ that pr…
View article: Multivalent dynamic colocalization of avian influenza polymerase and nucleoprotein by intrinsically disordered ANP32A reveals the molecular basis of human adaptation
Multivalent dynamic colocalization of avian influenza polymerase and nucleoprotein by intrinsically disordered ANP32A reveals the molecular basis of human adaptation Open
Adaptation of avian influenza RNA polymerase (FluPol) to human cells requires mutations on the 627-NLS domains of the PB2 subunit. The E627K adaptive mutation compensates a 33-amino-acid deletion in the acidic intrinsically disordered doma…
View article: Reply on RC1
Reply on RC1 Open
Abstract. The insurance sector is affected by decadal-scale variations in annual European windstorm losses amounting to a few billion euros, yet has not applied recent advances in understanding and predicting this variability to their pric…
View article: Reply on CC1
Reply on CC1 Open
Abstract. The insurance sector is affected by decadal-scale variations in annual European windstorm losses amounting to a few billion euros, yet has not applied recent advances in understanding and predicting this variability to their pric…