S. D. Mankar
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View article: Assessment of Antimicrobial Efficacy of Mulethi and Guava Leaf Extract Gels against Periodontal Pathogens in Localised Aggressive Periodontitis
Assessment of Antimicrobial Efficacy of Mulethi and Guava Leaf Extract Gels against Periodontal Pathogens in Localised Aggressive Periodontitis Open
Introduction: Localised aggressive periodontitis (LAP) is a rapidly progressive form of periodontitis affecting systemically healthy adolescents and young adults. Herbal agents such as Glycyrrhiza glabra (mulethi) and Psidium guajava (guav…
View article: Formulation and evaluation of microspheres-loaded capsule of duloxetine HCL by extrusion-spheronization techniques
Formulation and evaluation of microspheres-loaded capsule of duloxetine HCL by extrusion-spheronization techniques Open
The present Investigation focuses on the formulation; optimization and evaluation of a microsphere-loaded capsule containing Duloxetine HCl; aimed at enhancing its oral bioavailability and therapeutic efficacy. Duloxetine HCl; a selective …
View article: Reversed phase high-performance liquid chromatography for the evaluation of Luliconazole in bulk and pharmaceutical preparations
Reversed phase high-performance liquid chromatography for the evaluation of Luliconazole in bulk and pharmaceutical preparations Open
A new precise economical RP-HPLC analytical approach will serve as the basis for Luliconazole assay determination – both in bulk drug form and topical cream format. The separation took place on a HPLC device. The chromatographic separation…
View article: Formulation and evaluation of herbal tablet of jackfruit root for the treatment of antiasthmatic activity
Formulation and evaluation of herbal tablet of jackfruit root for the treatment of antiasthmatic activity Open
Jackfruit is a highly nutritious plant. The ancient fruit known as jackfruit ( Artocarpus heterophyllus Lam) is commonly eaten raw. Documenting the therapeutic value of the main jackfruit parts ( Artocarpus heterophyllus L.) was the primar…
View article: Exploring the synergistic effect in polyherbal chewable antacid tablets: formulation and evaluation study
Exploring the synergistic effect in polyherbal chewable antacid tablets: formulation and evaluation study Open
Polyherbal chewable tablets of Phyllanthus emblica and Glycyrrhiza glabra were developed with the objective to formulate an effective, safe and convenient dosage form for acid-related disorders. A standard calibration curve was constructed…
View article: Formulation and development of bilayer tablet containing irbesartan and metformin hydrochloride for diabetic hypertensive patients
Formulation and development of bilayer tablet containing irbesartan and metformin hydrochloride for diabetic hypertensive patients Open
Background: Hypertension is a common complication of type II diabetes. The present research work aimed to develop bilayer tablets that would manage type II diabetes patients with hypertension. The prepared bilayer tablet has an immediate-r…
View article: Development and Validation of RP-HPLC Method for Estimation of Ticagrelor in Pharmaceutical Dosage Form and Force degradation study
Development and Validation of RP-HPLC Method for Estimation of Ticagrelor in Pharmaceutical Dosage Form and Force degradation study Open
Ticagrelor is a selective Adenosine diphosphate (ADP)-receptor antagonist which is prescribed in the form of tablets and acts as an oral antiplatelet for the prevention of further thrombotic events in patients with Acute coronary syndrome …
View article: Optimizing irbesartan spherical agglomerates through principal component analysis and experimental design
Optimizing irbesartan spherical agglomerates through principal component analysis and experimental design Open
Background: This study explores the amalgamation of crystallization and agglomeration through spherical crystallization, aiming to develop the spherical crystals of Irbesartan with improved micromeritic properties. The main objective is to…
View article: Optimization and evaluation of transdermal delivery system for nebivolol hydrochloride
Optimization and evaluation of transdermal delivery system for nebivolol hydrochloride Open
Background: Nebivolol hydrochloride, a β1-receptor antagonist known for its antihypertensive properties, boasts a plasma half-life of 10 hours and an oral bioavailability of 12%. In this study, we aimed to enhance the therapeutic effective…
View article: Considerations for Optimal Dental Management in a 10-year-old Child with Congenital Heart Disease and Dextrocardia: A Case Report
Considerations for Optimal Dental Management in a 10-year-old Child with Congenital Heart Disease and Dextrocardia: A Case Report Open
Congenital Heart Disease (CHD) is one of the most common developmental anomalies seen in children and there is an increased risk of developing oral disease and its systemic effects in children with CHD. The present case report highlights t…
View article: Analytical Method Development and Validation of RP-HPLC Method for Estimation of Pazopanib Drug Sample and It’s Dosage Form
Analytical Method Development and Validation of RP-HPLC Method for Estimation of Pazopanib Drug Sample and It’s Dosage Form Open
The study focuses on developing and verifying a cost-effective Reverse Phase High-Performance Liquid Chromatography (RP-HPLC) technique for quantifying Pazopanib HCl in both bulk and tablet forms. The study aims to develop a cost-effective…
View article: Formulation and Drug Release Study of Rivaroxaban Oral Disintegrating Tablets Using Various Super-Disintegrants
Formulation and Drug Release Study of Rivaroxaban Oral Disintegrating Tablets Using Various Super-Disintegrants Open
This study aims to improve Rivaroxaban's solubility, dissolution, and bioavailability. Orally disintegrating tablets (ODTs) made with super-disintegrants like crospovidone, sodium starch glycolate, and cross-carmellose sodium will do this.…
View article: A Review on H3N2 Influenza Virus
A Review on H3N2 Influenza Virus Open
The aim of this review is to discuss the influenza A i.e H3N2 influenza virus with their characteristics. Here we present the outline of the treatment regarding the H3N2 infection, precautions to be taken. The review focused on the symptom…
View article: Solubility enhancement and evaluation of Cilnidipine using solid Dispersion techniques
Solubility enhancement and evaluation of Cilnidipine using solid Dispersion techniques Open
The poor solubility of Cilnidipine leads to low bioavailability and limits its therapeutic efficacy. To develop a dosage form that is stable, effective and has a higher bioavailability. It is necessary to increase the solubility of such me…
View article: Development and validation of RP-HPLC method for simultaneous estimation of Ertugliflozin and Sitagliptin in bulk drug and tablet dosage form
Development and validation of RP-HPLC method for simultaneous estimation of Ertugliflozin and Sitagliptin in bulk drug and tablet dosage form Open
To treat type 2 diabetes, in a combined tablet dosage form the ertugliflozin and sitagliptin were administered. Considering the less complication and readily availability of HPLC, the main objective of present study was to develop a new, p…
View article: DESIGN, DEVELOPMENT AND OPTIMIZATION OF MOUTH DISSOLVING TABLET OF AMBRISENTAN USING DESIGN EXPERT SOFTWARE
DESIGN, DEVELOPMENT AND OPTIMIZATION OF MOUTH DISSOLVING TABLET OF AMBRISENTAN USING DESIGN EXPERT SOFTWARE Open
Objective: The rationale of the current work is to design, develop and optimize of mouth dissolving tablet of ambrisentan to treat hypertension. Methods: Sodium starch glycolate and crospovidone were used as the super disintegrants in the …
View article: Evaluation and Validation of Carvedilol in Bulk and Pharmaceutical Dosage Forms
Evaluation and Validation of Carvedilol in Bulk and Pharmaceutical Dosage Forms Open
Background: Quality may be described as the character that determines the degree of excellence. A good quality medication is anything that meets the product specifications, can be purchased safely, and can be used confidently for the purpo…
View article: Formulation, Development, Evaluation and Solubility Enhancement of Lercanidipine Hydrochloride by Solid Dispersion Techniques
Formulation, Development, Evaluation and Solubility Enhancement of Lercanidipine Hydrochloride by Solid Dispersion Techniques Open
Background: Solid dispersions (SDs) are the dispersion of hydrophobic drugs in an inert hydrophilic carrier. SDs are prepared to improve the dissolution properties and bioavailability of slightly water-soluble drug molecules by dispersing …
View article: Design, Development, Characterization of Solid Lipid Nanoparticles for Oral Administration
Design, Development, Characterization of Solid Lipid Nanoparticles for Oral Administration Open
A high potential for drug delivery has been attributed to particulate drug carriers, especially small particles such as micro particles and colloidal system in nanometer range. Controlled and targeted delivery is one the most enviable requ…
View article: Development and Validation of Stability indicating RP- HPLC method for Simultaneous Estimation of Sofosbuvir and Ledipasvir in Bulk Tablet Dosage Form
Development and Validation of Stability indicating RP- HPLC method for Simultaneous Estimation of Sofosbuvir and Ledipasvir in Bulk Tablet Dosage Form Open
The present research work describes a simple, accurate, precise, effective, Stability indicating RP-HPLC method for simultaneous estimation of Sofosbuvir and Ledipasvir in their tablet dosage form. A reverse phase high performance chromato…