Ronald S. Duman
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View article: Neuron‐specific deletion of <scp>VEGF</scp> or its receptor Flk‐1 occludes the antidepressant‐like effects of desipramine and fluoxetine in mice
Neuron‐specific deletion of <span>VEGF</span> or its receptor Flk‐1 occludes the antidepressant‐like effects of desipramine and fluoxetine in mice Open
Vascular endothelial growth factor (VEGF) signaling is known to be involved in the antidepressant‐like effects of conventional antidepressants, such as desipramine (DMI), a tricyclic antidepressant, and fluoxetine (FLX), a selective seroto…
View article: The endogenous opioid system in the medial prefrontal cortex mediates ketamine’s antidepressant-like actions
The endogenous opioid system in the medial prefrontal cortex mediates ketamine’s antidepressant-like actions Open
Recent studies have implicated the endogenous opioid system in the antidepressant actions of ketamine, but the underlying mechanisms remain unclear. We used a combination of pharmacological, behavioral, and molecular approaches in rats to …
View article: Prefrontal cortex astroglia modulate anhedonia-like behavior
Prefrontal cortex astroglia modulate anhedonia-like behavior Open
Reductions of astroglia expressing glial fibrillary acidic protein (GFAP) are consistently found in the prefrontal cortex (PFC) of patients with depression and in rodent chronic stress models. Here, we examine the consequences of PFC GFAP+…
View article: Prefrontal Cortex Astroglia Modulate Anhedonia-like Behavior
Prefrontal Cortex Astroglia Modulate Anhedonia-like Behavior Open
Reductions of astroglia expressing glial fibrillary acidic protein (GFAP) are consistently found in the prefrontal cortex (PFC) of patients with depression and in rodent chronic stress models. Here, we examine the consequences of PFC GFAP+…
View article: Prefrontal Cortex Astroglia Modulate Anhedonia-like Behavior
Prefrontal Cortex Astroglia Modulate Anhedonia-like Behavior Open
Reductions of astroglia expressing glial fibrillary acidic protein (GFAP) are consistently found in the prefrontal cortex (PFC) of patients with depression and in rodent chronic stress models. Here, we examine the consequences of PFC GFAP+…
View article: A Proteome-wide, Multi-Omics Analysis Implicates Novel Protein Dysregulation in Post-Traumatic Stress Disorder
A Proteome-wide, Multi-Omics Analysis Implicates Novel Protein Dysregulation in Post-Traumatic Stress Disorder Open
Post-traumatic stress disorder (PTSD) is a common and disabling psychiatric disorder. Here we present findings from the first proteome-wide study of the postmortem PTSD brain. We performed tandem mass spectrometry on large cohort of donors…
View article: Functional annotation of the human PTSD methylome identifies tissue-specific epigenetic variation across subcortical brain regions
Functional annotation of the human PTSD methylome identifies tissue-specific epigenetic variation across subcortical brain regions Open
Post-traumatic stress disorder is a mental disorder that may occur in the aftermath of severe psychological trauma. We examined 1,065,750 DNA methylation (DNAm) sites from 171 donors including neurotypicals, PTSD, and major depressive diso…
View article: Influence of Chronic Electroconvulsive Seizures on Plasticity-Associated Gene Expression and Perineuronal Nets Within the Hippocampi of Young Adult and Middle-Aged Sprague-Dawley Rats
Influence of Chronic Electroconvulsive Seizures on Plasticity-Associated Gene Expression and Perineuronal Nets Within the Hippocampi of Young Adult and Middle-Aged Sprague-Dawley Rats Open
Background Electroconvulsive seizure therapy is often used in both treatment-resistant and geriatric depression. However, preclinical studies identifying targets of chronic electroconvulsive seizure (ECS) are predominantly focused on anima…
View article: Positive modulation of N-methyl-D-aspartate receptors in the mPFC reduces the spontaneous recovery of fear
Positive modulation of N-methyl-D-aspartate receptors in the mPFC reduces the spontaneous recovery of fear Open
N-methyl-D-aspartate receptor (NMDAR) modulators have recently received increased attention as potential therapeutics for posttraumatic stress disorder (PTSD). Here, we tested a novel NMDAR-positive modulator, NYX-783, in the following two…
View article: Experimenter sex modulates mouse biobehavioural and pharmacological responses
Experimenter sex modulates mouse biobehavioural and pharmacological responses Open
Differential rodent responses to the sex of human experimenters could have far reaching consequences in preclinical studies. Here, we show that the sex of human experimenters affects mouse behaviours and responses to the rapid-acting antid…
View article: Distinct downstream targets of the medial prefrontal cortex underlie discrete antidepressant responses to ketamine
Distinct downstream targets of the medial prefrontal cortex underlie discrete antidepressant responses to ketamine Open
Ketamine, an N-methyl-D-aspartate (NMDA) receptor antagonist, is the prototype for a potential new generation of glutamate-based antidepressants that rapidly relieve symptoms of depression within hours of treatment. Studies in rodents have…
View article: Stress resilience and hippocampal synaptoprotection
Stress resilience and hippocampal synaptoprotection Open
This dataset is related to our research article published in Neuroscience: Huzian et al., Stress resilience is associated with hippocampal synaptoprotection in the female rat learned helplessness paradigm Neuroscience (2021), https://doi.o…
View article: Stress Resilience is Associated with Hippocampal Synaptoprotection in the Female Rat Learned Helplessness Paradigm
Stress Resilience is Associated with Hippocampal Synaptoprotection in the Female Rat Learned Helplessness Paradigm Open
The synaptogenic hypothesis of major depressive disorder implies that preventing the onset of depressive-like behavior also prevents the loss of hippocampal spine synapses. By applying the psychoactive drugs, diazepam and fluoxetine, we in…
View article: Antipsychotic Drugs: Comparison in Animal Models of Efficacy, Neurotransmitter Regulation, and Neuroprotection
Antipsychotic Drugs: Comparison in Animal Models of Efficacy, Neurotransmitter Regulation, and Neuroprotection Open
Various lines of evidence indicate the presence of progressive pathophysiological processes occurring within the brains of patients with schizophrenia. By modulating chemical neurotransmission, anti-psychotic drugs may influence a variety …
View article: Cortical Transcriptomic Alterations in Association With Appetitive Neuropeptides and Body Mass Index in Posttraumatic Stress Disorder
Cortical Transcriptomic Alterations in Association With Appetitive Neuropeptides and Body Mass Index in Posttraumatic Stress Disorder Open
Background The molecular pathology underlying posttraumatic stress disorder (PTSD) remains unclear mainly due to a lack of human PTSD postmortem brain tissue. The orexigenic neuropeptides ghrelin, neuropeptide Y, and hypocretin were recent…
View article: Antibodies From Children With PANDAS Bind Specifically to Striatal Cholinergic Interneurons and Alter Their Activity
Antibodies From Children With PANDAS Bind Specifically to Striatal Cholinergic Interneurons and Alter Their Activity Open
These findings provide strong evidence for striatal CINs as a critical cellular target that may contribute to pathophysiology in children with rapid-onset OCD symptoms, and perhaps in other conditions.
View article: Rapastinel, an NMDAR positive modulator, produces distinct behavioral, sleep, and EEG profiles compared with ketamine
Rapastinel, an NMDAR positive modulator, produces distinct behavioral, sleep, and EEG profiles compared with ketamine Open
Rapastinel, a positive NMDAR modulator, produces rapid-acting and long-lasting antidepressant-like effects; however, unlike ketamine, the abuse potential for rapastinel is minimal. Ketamine has also been shown to induce psychotomimetic/dis…
View article: PTSD is associated with neuroimmune suppression: evidence from PET imaging and postmortem transcriptomic studies
PTSD is associated with neuroimmune suppression: evidence from PET imaging and postmortem transcriptomic studies Open
Despite well-known peripheral immune activation in posttraumatic stress disorder (PTSD), there are no studies of brain immunologic regulation in individuals with PTSD. [ 11 C]PBR28 Positron Emission Tomography brain imaging of the 18-kDa t…