Stephen P. Ethier
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View article: A Bayesian framework for pathway‐guided identification of cancer subgroups by integrating multiple types of genomic data
A Bayesian framework for pathway‐guided identification of cancer subgroups by integrating multiple types of genomic data Open
In recent years, comprehensive cancer genomics platforms, such as The Cancer Genome Atlas (TCGA), provide access to an enormous amount of high throughput genomic datasets for each patient, including gene expression, DNA copy number alterat…
View article: Supplementary Tables 1-7 from Comprehensive Profiling of 8p11-12 Amplification in Breast Cancer
Supplementary Tables 1-7 from Comprehensive Profiling of 8p11-12 Amplification in Breast Cancer Open
Supplementary Tables 1-7 from Comprehensive Profiling of 8p11-12 Amplification in Breast Cancer
View article: Supplementary Figure 1 from SNAI2 Modulates Colorectal Cancer 5-Fluorouracil Sensitivity through miR145 Repression
Supplementary Figure 1 from SNAI2 Modulates Colorectal Cancer 5-Fluorouracil Sensitivity through miR145 Repression Open
Supplemental Figure 1. Western blot analysis of cancer stem cell transcription factor expression in colorectal cancer cell lines. Actin was used as a loading control.
View article: Data from Comprehensive Profiling of 8p11-12 Amplification in Breast Cancer
Data from Comprehensive Profiling of 8p11-12 Amplification in Breast Cancer Open
In human carcinomas, especially breast cancer, chromosome arm 8p is frequently involved in complex chromosomal rearrangements that combine amplification at 8p11-12, break in the 8p12-21 region, and loss of 8p21-ter. Several studies have id…
View article: Supplementary Figures 1-4 from Comprehensive Profiling of 8p11-12 Amplification in Breast Cancer
Supplementary Figures 1-4 from Comprehensive Profiling of 8p11-12 Amplification in Breast Cancer Open
Supplementary Figures 1-4 from Comprehensive Profiling of 8p11-12 Amplification in Breast Cancer
View article: Data from Comprehensive Profiling of 8p11-12 Amplification in Breast Cancer
Data from Comprehensive Profiling of 8p11-12 Amplification in Breast Cancer Open
In human carcinomas, especially breast cancer, chromosome arm 8p is frequently involved in complex chromosomal rearrangements that combine amplification at 8p11-12, break in the 8p12-21 region, and loss of 8p21-ter. Several studies have id…
View article: Supplementary Figure 1 from SNAI2 Modulates Colorectal Cancer 5-Fluorouracil Sensitivity through miR145 Repression
Supplementary Figure 1 from SNAI2 Modulates Colorectal Cancer 5-Fluorouracil Sensitivity through miR145 Repression Open
Supplemental Figure 1. Western blot analysis of cancer stem cell transcription factor expression in colorectal cancer cell lines. Actin was used as a loading control.
View article: Supplementary Figure 2 from SNAI2 Modulates Colorectal Cancer 5-Fluorouracil Sensitivity through miR145 Repression
Supplementary Figure 2 from SNAI2 Modulates Colorectal Cancer 5-Fluorouracil Sensitivity through miR145 Repression Open
Supplemental Figure 2. A ) qPCR analysis of miR-145 in SW620 cells transiently transfected with miR-145 or scrambled control normalized to RNU6B. B) qPCR analysis of nanog, myc, SNAI2 and Vimentin mRNA expression in SW620 cells transiently…
View article: Supplementary Tables 1-7 from Comprehensive Profiling of 8p11-12 Amplification in Breast Cancer
Supplementary Tables 1-7 from Comprehensive Profiling of 8p11-12 Amplification in Breast Cancer Open
Supplementary Tables 1-7 from Comprehensive Profiling of 8p11-12 Amplification in Breast Cancer
View article: Data from SNAI2 Modulates Colorectal Cancer 5-Fluorouracil Sensitivity through miR145 Repression
Data from SNAI2 Modulates Colorectal Cancer 5-Fluorouracil Sensitivity through miR145 Repression Open
Epithelial-to-mesenchymal transition (EMT) has been associated with poor treatment outcomes in various malignancies and is inversely associated with miRNA145 expression. Therefore, we hypothesized that SNAI2 (Slug) may mediate 5-fluorourac…
View article: Supplementary Figure 2 from SNAI2 Modulates Colorectal Cancer 5-Fluorouracil Sensitivity through miR145 Repression
Supplementary Figure 2 from SNAI2 Modulates Colorectal Cancer 5-Fluorouracil Sensitivity through miR145 Repression Open
Supplemental Figure 2. A ) qPCR analysis of miR-145 in SW620 cells transiently transfected with miR-145 or scrambled control normalized to RNU6B. B) qPCR analysis of nanog, myc, SNAI2 and Vimentin mRNA expression in SW620 cells transiently…
View article: Data from SNAI2 Modulates Colorectal Cancer 5-Fluorouracil Sensitivity through miR145 Repression
Data from SNAI2 Modulates Colorectal Cancer 5-Fluorouracil Sensitivity through miR145 Repression Open
Epithelial-to-mesenchymal transition (EMT) has been associated with poor treatment outcomes in various malignancies and is inversely associated with miRNA145 expression. Therefore, we hypothesized that SNAI2 (Slug) may mediate 5-fluorourac…
View article: Supplementary Figures 1-4 from Comprehensive Profiling of 8p11-12 Amplification in Breast Cancer
Supplementary Figures 1-4 from Comprehensive Profiling of 8p11-12 Amplification in Breast Cancer Open
Supplementary Figures 1-4 from Comprehensive Profiling of 8p11-12 Amplification in Breast Cancer
View article: Supplemental Figure Legends from MYC Is a Crucial Mediator of TGFβ-Induced Invasion in Basal Breast Cancer
Supplemental Figure Legends from MYC Is a Crucial Mediator of TGFβ-Induced Invasion in Basal Breast Cancer Open
Legends for Supplemental Figures S1-S5.
View article: Data from MYC Is a Crucial Mediator of TGFβ-Induced Invasion in Basal Breast Cancer
Data from MYC Is a Crucial Mediator of TGFβ-Induced Invasion in Basal Breast Cancer Open
Basal subtype breast cancers have a particularly poor prognosis, with high invasiveness and resistance to most targeted therapies. TGFβ and MYC drive central features of basal breast cancer: TGFβ is an autocrine and paracrine signaling fac…
View article: Supplemental Figure Legends from MYC Is a Crucial Mediator of TGFβ-Induced Invasion in Basal Breast Cancer
Supplemental Figure Legends from MYC Is a Crucial Mediator of TGFβ-Induced Invasion in Basal Breast Cancer Open
Legends for Supplemental Figures S1-S5.
View article: Supplementary Methods from MYC Inhibition Depletes Cancer Stem-like Cells in Triple-Negative Breast Cancer
Supplementary Methods from MYC Inhibition Depletes Cancer Stem-like Cells in Triple-Negative Breast Cancer Open
Additional methods on drug screen, CSC sorting, real-time PCR, flow cytometric apoptosis assay and immunohistochemical (IHC) analysis are provided.
View article: Data from MYC Inhibition Depletes Cancer Stem-like Cells in Triple-Negative Breast Cancer
Data from MYC Inhibition Depletes Cancer Stem-like Cells in Triple-Negative Breast Cancer Open
There is mounting evidence that cancer stem-like cells (CSC) are selectively enriched in residual tumors after anticancer therapies, which may account for tumor recurrence and metastasis by regenerating new tumors. Thus, there is a critica…
View article: Supplementary Methods from MYC Inhibition Depletes Cancer Stem-like Cells in Triple-Negative Breast Cancer
Supplementary Methods from MYC Inhibition Depletes Cancer Stem-like Cells in Triple-Negative Breast Cancer Open
Additional methods on drug screen, CSC sorting, real-time PCR, flow cytometric apoptosis assay and immunohistochemical (IHC) analysis are provided.
View article: Data from MYC Is a Crucial Mediator of TGFβ-Induced Invasion in Basal Breast Cancer
Data from MYC Is a Crucial Mediator of TGFβ-Induced Invasion in Basal Breast Cancer Open
Basal subtype breast cancers have a particularly poor prognosis, with high invasiveness and resistance to most targeted therapies. TGFβ and MYC drive central features of basal breast cancer: TGFβ is an autocrine and paracrine signaling fac…
View article: Data from MYC Inhibition Depletes Cancer Stem-like Cells in Triple-Negative Breast Cancer
Data from MYC Inhibition Depletes Cancer Stem-like Cells in Triple-Negative Breast Cancer Open
There is mounting evidence that cancer stem-like cells (CSC) are selectively enriched in residual tumors after anticancer therapies, which may account for tumor recurrence and metastasis by regenerating new tumors. Thus, there is a critica…
View article: Supplemental Figures S1-S5 from MYC Is a Crucial Mediator of TGFβ-Induced Invasion in Basal Breast Cancer
Supplemental Figures S1-S5 from MYC Is a Crucial Mediator of TGFβ-Induced Invasion in Basal Breast Cancer Open
Responsiveness of different molecular subtypes breast cancer cell lines to TGFβ as measured by PAI-1 expression levels (S1); TGFβï�¢and MYC knockdown inhibit cell proliferation (S2); MYC reduction potentiates TGFβ induced invasive pheno…
View article: Supplementary Figures and Legends from MYC Inhibition Depletes Cancer Stem-like Cells in Triple-Negative Breast Cancer
Supplementary Figures and Legends from MYC Inhibition Depletes Cancer Stem-like Cells in Triple-Negative Breast Cancer Open
The Supplementary Figures and Legends provide additional information on Flow Cytometry gating strategy for TNBC CSC sorting, the effects of C1572 on additional TNBC cells, the evidence that C1572 reversibly inhibits MYC, comparing the effe…
View article: Supplementary Figures and Legends from MYC Inhibition Depletes Cancer Stem-like Cells in Triple-Negative Breast Cancer
Supplementary Figures and Legends from MYC Inhibition Depletes Cancer Stem-like Cells in Triple-Negative Breast Cancer Open
The Supplementary Figures and Legends provide additional information on Flow Cytometry gating strategy for TNBC CSC sorting, the effects of C1572 on additional TNBC cells, the evidence that C1572 reversibly inhibits MYC, comparing the effe…
View article: Supplemental Figures S1-S5 from MYC Is a Crucial Mediator of TGFβ-Induced Invasion in Basal Breast Cancer
Supplemental Figures S1-S5 from MYC Is a Crucial Mediator of TGFβ-Induced Invasion in Basal Breast Cancer Open
Responsiveness of different molecular subtypes breast cancer cell lines to TGFβ as measured by PAI-1 expression levels (S1); TGFβï�¢and MYC knockdown inhibit cell proliferation (S2); MYC reduction potentiates TGFβ induced invasive pheno…
View article: Gene Expression Report from HER-2 Signaling, Acquisition of Growth Factor Independence, and Regulation of Biological Networks Associated with Cell Transformation
Gene Expression Report from HER-2 Signaling, Acquisition of Growth Factor Independence, and Regulation of Biological Networks Associated with Cell Transformation Open
Gene Expression Report from HER-2 Signaling, Acquisition of Growth Factor Independence, and Regulation of Biological Networks Associated with Cell Transformation
View article: Data from Transforming Properties of 8p11-12 Amplified Genes in Human Breast Cancer
Data from Transforming Properties of 8p11-12 Amplified Genes in Human Breast Cancer Open
Amplification of the 8p11-12 region has been found in about 15% of human breast cancers and is associated with poor prognosis. Earlier, we used genomic analysis of copy number and gene expression to perform a detailed analysis of the 8p11-…
View article: Data from Activation of Src by Protein Tyrosine Phosphatase 1B Is Required for ErbB2 Transformation of Human Breast Epithelial Cells
Data from Activation of Src by Protein Tyrosine Phosphatase 1B Is Required for ErbB2 Transformation of Human Breast Epithelial Cells Open
Protein tyrosine phosphatase (PTP) 1B plays a major role in inhibiting signaling from the insulin and leptin receptors. Recently, PTP1B was found to have an unexpected positive role in ErbB2 signaling in a mouse model of breast cancer, but…
View article: Data from Genome-wide Methylation Analysis Identifies Genes Specific to Breast Cancer Hormone Receptor Status and Risk of Recurrence
Data from Genome-wide Methylation Analysis Identifies Genes Specific to Breast Cancer Hormone Receptor Status and Risk of Recurrence Open
To better understand the biology of hormone receptor–positive and–negative breast cancer and to identify methylated gene markers of disease progression, we carried out a genome-wide methylation array analysis on 103 primary invasive breast…
View article: Data from Genome-wide Methylation Analysis Identifies Genes Specific to Breast Cancer Hormone Receptor Status and Risk of Recurrence
Data from Genome-wide Methylation Analysis Identifies Genes Specific to Breast Cancer Hormone Receptor Status and Risk of Recurrence Open
To better understand the biology of hormone receptor–positive and–negative breast cancer and to identify methylated gene markers of disease progression, we carried out a genome-wide methylation array analysis on 103 primary invasive breast…