Laurent David
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View article: Towards tunable mechanical properties of in situ gelling chitosan hydrogels: impact of macromolecular structure including pattern of acetylation
Towards tunable mechanical properties of in situ gelling chitosan hydrogels: impact of macromolecular structure including pattern of acetylation Open
Injectable in situ gelling physically crosslinked chitosan (CH) hydrogels allowing cell encapsulation are appealing for biomedical applications. However, the variability of the CH source is one of the major difficulties in ensuring their r…
View article: Smart zwitterionic biodegradable hydrogel for sustained peptide delivery: Application to the neurotherapeutic peptide NX210c
Smart zwitterionic biodegradable hydrogel for sustained peptide delivery: Application to the neurotherapeutic peptide NX210c Open
Therapeutic peptides offer a promising balance between specificity, safety, and bioavailability. However, their clinical use is limited by poor in vivo stability and short half-life, requiring frequent administrations that can compromise p…
View article: Engineered biodegradables fibres for brain metal ion regulation
Engineered biodegradables fibres for brain metal ion regulation Open
Exposure to environmental heavy metals and disruptions in physiological metal homeostasis are significant contributors to neurological and neurodegenerative disorders. To counteract heavy metal toxicity, a biopolymer consisting of chitosan…
View article: Prognostic factors of disability progression in multiple sclerosis in real life: the OFSEP-high definition (OFSEP-HD) prospective cohort in France
Prognostic factors of disability progression in multiple sclerosis in real life: the OFSEP-high definition (OFSEP-HD) prospective cohort in France Open
Purpose To determine prognostic factors of disability in multiple sclerosis (MS), that is, (1) identify determinants of the dynamics of disability progression; (2) study the effectiveness of disease-modifying treatments (DMTs); (3) merge d…
View article: Focus on therapeutic peptides and their delivery
Focus on therapeutic peptides and their delivery Open
Peptides are bioactive intermediates between small organic molecules and large biological compounds like antibodies or proteins. These compounds play a unique and valuable role as therapeutic agents, owing to their unique biochemical prope…
View article: Chitin-binding protein behavior at chitosan interface studied by quartz crystal microbalance with dissipation monitoring (QCM-D): Binding quantification, orientation and affinity constants
Chitin-binding protein behavior at chitosan interface studied by quartz crystal microbalance with dissipation monitoring (QCM-D): Binding quantification, orientation and affinity constants Open
A full comprehension of chitosan interaction with proteins is yet to be achieved, in view of the complexity of the physico-chemical behaviors found in the chitosan family, and the diversity of possible protein interaction mechanisms. In th…
View article: Chitosan surface interaction platform for protein binding quantification by fluorescence microscopy, application to the specificity of CBD proteins
Chitosan surface interaction platform for protein binding quantification by fluorescence microscopy, application to the specificity of CBD proteins Open
Surface-proteins interactions play key roles in many domains such as biomedicine, nanotechnology and the biology of plant-insect interactions. This article proposes a platform that allows to quantify surface interaction of proteins with ch…
View article: Nanotubes of pristine poly(3-hexylthiophene) with modulable conductive properties: the interplay between confinement-induced orientation and interfacial effects
Nanotubes of pristine poly(3-hexylthiophene) with modulable conductive properties: the interplay between confinement-induced orientation and interfacial effects Open
Nanotubes of P3HT exhibit broadly modulable conductive properties in dependence on their thickness. Conductivity values higher for P3HT nanotubes than for the bulk or P3HT nanowires are reported, due to orientation effects.
View article: Biomechanical properties of ovarian tissue and their impact on the activation of follicular growth: a narrative review
Biomechanical properties of ovarian tissue and their impact on the activation of follicular growth: a narrative review Open
Follicular recruitment is tightly regulated to ensure long-term balance between the pools of dormant and growing follicles. While the growth of secondary to antral follicles is well understood, the initiation of folliculogenesis remains el…
View article: Chitosan based hydrogel for iron (III) chelation in biological conditions
Chitosan based hydrogel for iron (III) chelation in biological conditions Open
In this study, a chitosan derivative with strong iron (III) chelating capabilities was developed by grafting the Deferoxamine (DFO) chelator to achieve a substitution degree of 3.8 ± 0.2 %. Through blending with ungrafted chitosan of low d…
View article: In situ effect of printing parameters on microstructural anisotropy of bioink based hydrogel during micro-extrusion bioprinting process for
In situ effect of printing parameters on microstructural anisotropy of bioink based hydrogel during micro-extrusion bioprinting process for Open
Bioprinting is a promising process to provide hospitals with tissue substitutes mimicking any organ without having to resort to donors. During bioprinting, a cell-encapsulating hydrogel, also known as bioink, is deposited layer by layer to…
View article: Correction to “Encapsulation of Human Spinal Cord Progenitor Cells in Hyaluronan-Gelatin Hydrogel for Spinal Cord Injury Treatment”
Correction to “Encapsulation of Human Spinal Cord Progenitor Cells in Hyaluronan-Gelatin Hydrogel for Spinal Cord Injury Treatment” Open
ADVERTISEMENT RETURN TO ARTICLES ASAPPREVAddition/CorrectionNEXTORIGINAL ARTICLEThis notice is a correctionCorrection to "Encapsulation of Human Spinal Cord Progenitor Cells in Hyaluronan-Gelatin Hydrogel for Spinal Cord Injury Treatment"C…
View article: Enhancing radioprotection: A chitosan-based chelating polymer is a versatile radioprotective agent for prophylactic and therapeutic interventions against radionuclide contamination
Enhancing radioprotection: A chitosan-based chelating polymer is a versatile radioprotective agent for prophylactic and therapeutic interventions against radionuclide contamination Open
To mitigate the risk of radioactive isotope dissemination, the development of preventative and curative measures is of particular interest. For mass treatment, the developed solution must be easily administered, preferably orally, with eff…
View article: Chitosan-Coated Superparamagnetic Fe<sub>3</sub>O<sub>4</sub> Nanoparticles for Magnetic Resonance Imaging, Magnetic Hyperthermia, and Drug Delivery
Chitosan-Coated Superparamagnetic Fe<sub>3</sub>O<sub>4</sub> Nanoparticles for Magnetic Resonance Imaging, Magnetic Hyperthermia, and Drug Delivery Open
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View article: Subcutaneous Administration of a Zwitterionic Chitosan‐Based Hydrogel for Controlled Spatiotemporal Release of Monoclonal Antibodies (Adv. Mater. 13/2024)
Subcutaneous Administration of a Zwitterionic Chitosan‐Based Hydrogel for Controlled Spatiotemporal Release of Monoclonal Antibodies (Adv. Mater. 13/2024) Open
Subcutaneous Administration of Monoclonal Antibodies Alexandre Detappe and co-workers developed a novel chitosan-based hydrogel formulation for minute-mixing with clinically approved intravenous-based monoclonal antibodies to reformulate t…
View article: Wet-Spun Chitosan–Sodium Caseinate Fibers for Biomedicine: From Spinning Process to Physical Properties
Wet-Spun Chitosan–Sodium Caseinate Fibers for Biomedicine: From Spinning Process to Physical Properties Open
We designed and characterized chitosan–caseinate fibers processed through wet spinning for biomedical applications such as drug delivery from knitted medical devices. Sodium caseinate was either incorporated directly into the chitosan dope…
View article: Subcutaneous Administration of a Zwitterionic Chitosan‐Based Hydrogel for Controlled Spatiotemporal Release of Monoclonal Antibodies
Subcutaneous Administration of a Zwitterionic Chitosan‐Based Hydrogel for Controlled Spatiotemporal Release of Monoclonal Antibodies Open
Subcutaneous (SC) administration of monoclonal antibodies (mAbs) is a proven strategy for improving therapeutic outcomes and patient compliance. The current FDA‐/EMA‐approved enzymatic approach, utilizing recombinant human hyaluronidase (r…
View article: Iron as an emerging therapeutic target in critically ill patients
Iron as an emerging therapeutic target in critically ill patients Open
The multiple roles of iron in the body have been known for decades, particularly its involvement in iron overload diseases such as hemochromatosis. More recently, compelling evidence has emerged regarding the critical role of non-transferr…
View article: Encapsulation of Human Spinal Cord Progenitor Cells in Hyaluronan-Gelatin Hydrogel for Spinal Cord Injury Treatment
Encapsulation of Human Spinal Cord Progenitor Cells in Hyaluronan-Gelatin Hydrogel for Spinal Cord Injury Treatment Open
Transplanting human induced pluripotent stem cells (iPSCs)-derived spinal cord progenitor cells (SCPCs) is a promising approach to treat spinal cord injuries. However, stem cell therapies face challenges in cell survival, cell localization…
View article: A New Bioreactor to Promote Human Follicular Growth with or without Activin A in Transgender Men
A New Bioreactor to Promote Human Follicular Growth with or without Activin A in Transgender Men Open
The aim of the present study was to evaluate the effect of activin A on the activation of in vitro folliculogenesis of human ovarian tissues from transgender men with or without our new compartmented chitosan hydrogel microbioreactor (“thr…
View article: Development and Survival of Human Ovarian Cells in Chitosan Hydrogel Micro-Bioreactor
Development and Survival of Human Ovarian Cells in Chitosan Hydrogel Micro-Bioreactor Open
Background and Objectives: To test the long-term ability of human ovarian cortex cells to develop in unconventional culture conditions. Materials and Methods. Ovarian cortex cells from fetuses aged 23 to 39 weeks gestation were cultured fo…
View article: Structural anisotropy characterization of fiber-reinforced hydrogels scaffolds during extrusion-based 3D printing for soft tissue repair.
Structural anisotropy characterization of fiber-reinforced hydrogels scaffolds during extrusion-based 3D printing for soft tissue repair. Open
Engineered biomimicking soft tissues have been greatly improved by the use of extrusion-based 3D bioprinting techniques. They are classically made of fiberreinforced hydrogels with designed rheological behavior in order to give mechanical …
View article: 3D Printing of Cellulase-Laden Cellulose Nanofiber/Chitosan Hydrogel Composites: Towards Tissue Engineering Functional Biomaterials with Enzyme-Mediated Biodegradation
3D Printing of Cellulase-Laden Cellulose Nanofiber/Chitosan Hydrogel Composites: Towards Tissue Engineering Functional Biomaterials with Enzyme-Mediated Biodegradation Open
The 3D printing of a multifunctional hydrogel biomaterial with bioactivity for tissue engineering, good mechanical properties and a biodegradability mediated by free and encapsulated cellulase was proposed. Bioinks of cellulase-laden and c…
View article: Pure Chitosan Biomedical Textile Fibers from Mixtures of Low- and High-Molecular Weight Bidisperse Polymer Solutions: Processing and Understanding of Microstructure–Mechanical Properties’ Relationship
Pure Chitosan Biomedical Textile Fibers from Mixtures of Low- and High-Molecular Weight Bidisperse Polymer Solutions: Processing and Understanding of Microstructure–Mechanical Properties’ Relationship Open
Natural polymers, as extracted from biomass, may exhibit large macromolecular polydispersity. We investigated the impact of low molar mass chitosan (LMW, DPw~115) on the properties of chitosan fibers obtained by wet spinning of chitosan so…