Emerich S. Fiala
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View article: The role of nitric oxide on DNA damage induced by benzene metabolites
The role of nitric oxide on DNA damage induced by benzene metabolites Open
Benzene, a tobacco constituent, is a leukemogen in humans and a carcinogen in rodents. Several benzene metabolites generate superoxide anion (O(2)(.-)) and induce nitric oxide synthase in the bone marrow of mice. We hypothesized that the r…
View article: Inhibition of Nuclear Factor-κB DNA Binding by Organoselenocyanates through Covalent Modification of the p50 Subunit
Inhibition of Nuclear Factor-κB DNA Binding by Organoselenocyanates through Covalent Modification of the p50 Subunit Open
Most known chemopreventive agents including certain selenium compounds suppress the activation of the nuclear factor κB (NF-κB), but the mechanisms remain largely elusive. Toward this end, we initially showed that the inhibition of NF-κB D…
View article: Investigations into the metabolism and mode of action of the colon carcinogen 1, 2-dimethylhydrazine
Investigations into the metabolism and mode of action of the colon carcinogen 1, 2-dimethylhydrazine Open
Chromatographic methods have been developed which allow the separation and identification of azomethane (AM), azoxymethane (AOM), and methylazoxymethanol (MAM). These methods have been applied to the analysis of bile, urine, and the exhale…
View article: Quantitative analysis of associations between DNA hypermethylation, hypomethylation, and DNMT RNA levels in ovarian tumors
Quantitative analysis of associations between DNA hypermethylation, hypomethylation, and DNMT RNA levels in ovarian tumors Open
View article: Induction of preneoplastic lung lesions in guinea pigs by cigarette smoke inhalation and their exacerbation by high dietary levels of vitamins C and E
Induction of preneoplastic lung lesions in guinea pigs by cigarette smoke inhalation and their exacerbation by high dietary levels of vitamins C and E Open
The development of effective chemopreventive agents against cigarette smoke-induced lung cancer could be greatly facilitated by the availability of suitable laboratory animal models. Here we report that male Hartley guinea pigs treated wit…
View article: DNA hypomethylation is prevalent even in low-grade breast cancers
DNA hypomethylation is prevalent even in low-grade breast cancers Open
Hypomethylation of some portions of the genome and hypermethylation of others are very frequent attributes of human cancer. We previously showed that cancer-associated DNA hypomethylation often involves satellite 2 (Sat2), the main DNA com…
View article: Synthesis and excretion profile of 1,4- [14C]phenylenebis(methylene)selenocyanate in the rat
Synthesis and excretion profile of 1,4- [14C]phenylenebis(methylene)selenocyanate in the rat Open
1,4-Phenylenebis(methylene)selenocyanate (p-XSC) inhibits chemically induced tumors in several laboratory animal models. To understand its mode of action, we synthesized p-[14C]XSC, examined its excretion pattern in female CD rats and also…
View article: Inhibition of 2-nitropropane-induced rat liver DNA and RNA damage by benzyl selenocyanate
Inhibition of 2-nitropropane-induced rat liver DNA and RNA damage by benzyl selenocyanate Open
We observed that pretreatment of male F344 rats with benzyl selenocyanate, a versatile organoselenium chemopreventive agent in several animal model systems, decreases the levels of DNA and RNA modifications produced in the liver by the hep…
View article: Differential effects of 4-iodopyrazole and 3-methylpyrazole on the metabolic activation of methylazoxymethanol to a DNA methylating species by rat liver and rat colon mucosa in vivo
Differential effects of 4-iodopyrazole and 3-methylpyrazole on the metabolic activation of methylazoxymethanol to a DNA methylating species by rat liver and rat colon mucosa in vivo Open
View article: Metabolism of methylazoxymethanol acetate in the F344 rat and strain-2 guinea pig and its inhibition by pyrazole and disulfiram
Metabolism of methylazoxymethanol acetate in the F344 rat and strain-2 guinea pig and its inhibition by pyrazole and disulfiram Open
View article: In vivo Metabolism of 3,2 prime -Dimethyl-4-Aminobiphenyl (DMAB) Bearing on Its Organotropism in the Syrian Golden Hamster and the F344 Rat
In vivo Metabolism of 3,2 prime -Dimethyl-4-Aminobiphenyl (DMAB) Bearing on Its Organotropism in the Syrian Golden Hamster and the F344 Rat Open
The in vivo metabolism of tritiated DMAB was examined in male Syrian golden hamsters, which are susceptible to both urinary bladder and intestinal carcinogenesis by this agent and in male F344 rats in which intestinal tumors represent the …
View article: In vivo metabolism of 3,2'-dimethyl-4-aminobiphenyl (DMAB) bearing on its organotropism in the Syrian golden hamster and the F344 rat.
In vivo metabolism of 3,2'-dimethyl-4-aminobiphenyl (DMAB) bearing on its organotropism in the Syrian golden hamster and the F344 rat. Open
The in vivo metabolism of tritiated DMAB was examined in male Syrian golden hamsters, which are susceptible to both urinary bladder and intestinal carcinogenesis by this agent and in male F344 rats in which intestinal tumors represent the …
View article: Investigations into the metabolism and mode of action of the colon carcinogens 1,2-dimethylhydrazine and azoxymethane
Investigations into the metabolism and mode of action of the colon carcinogens 1,2-dimethylhydrazine and azoxymethane Open
Colon cancer can be induced reliably in rodents with 1,2-dimethylhydrazine and azoxymethane (AOM). Our studies deal with the mode of action of these compounds and their organotropism. A partial summary of our previous work on the metabolis…
View article: The inhibition of turbidities caused by iron and other metals in wine.
The inhibition of turbidities caused by iron and other metals in wine. Open
View article: The separation of colloidal turbidities in wine.
The separation of colloidal turbidities in wine. Open