Stefan Flasche
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View article: Estimating the Uptake of and Factors Associated With a New Vaccine Outside of the National Immunisation Programme: A Case Study of the EV‐A71 Vaccine Against Hand, Foot, and Mouth Disease
Estimating the Uptake of and Factors Associated With a New Vaccine Outside of the National Immunisation Programme: A Case Study of the EV‐A71 Vaccine Against Hand, Foot, and Mouth Disease Open
The burden of hand, foot, and mouth disease (HFMD) in children under five is substantial, with the greatest burden in China. Most cases are mild, although some are severe and even fatal. A vaccine against EV‐A71, the pathogen most commonly…
View article: Safety and coverage of Pneumosil pneumococcal polysaccharide conjugate vaccine (10-valent PCV) in a camp for internally displaced persons in Somaliland
Safety and coverage of Pneumosil pneumococcal polysaccharide conjugate vaccine (10-valent PCV) in a camp for internally displaced persons in Somaliland Open
NCT04945681.
View article: Seroprevalence of antibodies against Diphtheria, Tetanus and Pertussis over a 12-year period in children in Kilifi, Kenya (2009-2021)
Seroprevalence of antibodies against Diphtheria, Tetanus and Pertussis over a 12-year period in children in Kilifi, Kenya (2009-2021) Open
Background In Kilifi, no diphtheria or tetanus cases and only sporadic pertussis cases have been reported but the absence of disease does not guarantee sustained immunity. Case surveillance cannot reveal age-specific gaps or waning protect…
View article: Identification of age-group reservoirs for persistent vaccine-type pneumococcal carriage in rural Gambia
Identification of age-group reservoirs for persistent vaccine-type pneumococcal carriage in rural Gambia Open
Background Although pneumococcal conjugate vaccines (PCVs) have been used widely in many low and middle-income countries, residual vaccine-type (VT) carriage persists in these settings. We examined the role of specific age groups in transm…
View article: Modelling the relative contribution of infection, routine vaccination and supplementary immunisation activities to measles seroconversion in Kenyan Children
Modelling the relative contribution of infection, routine vaccination and supplementary immunisation activities to measles seroconversion in Kenyan Children Open
Background Measles outbreaks continue to cause a large burden of disease in Africa including Kenya. We used information from regular serological surveys in Kilifi Health and Demographic Surveillance System (KHDSS) in combination with mathe…
View article: Effectiveness of pneumococcal vaccination campaigns in humanitarian settings: a modelling study
Effectiveness of pneumococcal vaccination campaigns in humanitarian settings: a modelling study Open
Summary Background A large and increasing number of people are forcibly displaced worldwide because of war, food insecurity, and other crises. Streptococcus pneumoniae (the pneumococcus) likely causes a substantial health burden in crisis-…
View article: Multiple mechanisms of strain competition are needed to explain pneumococcal serotype-specific antibiotic resistance patterns
Multiple mechanisms of strain competition are needed to explain pneumococcal serotype-specific antibiotic resistance patterns Open
2 Abstract Background Disease caused by antibiotic resistant pneumococcal strains is an important public health concern. The impact of public health interventions depend on the complex ecology governing serotype and antibiotic resistant st…
View article: Effect of the 13-valent pneumococcal conjugate vaccine on pneumococcal carriage in rural Gambia 10 years after its introduction: A population-based cross-sectional study
Effect of the 13-valent pneumococcal conjugate vaccine on pneumococcal carriage in rural Gambia 10 years after its introduction: A population-based cross-sectional study Open
Ten years after the introduction of PCV13 in the Gambia, residual VT carriage persists, particularly in age groups in whom direct protection from immunization in infancy has waned. A booster dose or catch-up vaccinations could aid control …
View article: Modelling the impact of climate and the environment on the spatiotemporal dynamics of Lyme borreliosis in Germany
Modelling the impact of climate and the environment on the spatiotemporal dynamics of Lyme borreliosis in Germany Open
Helmholtz Association, Helmholtz Climate Initiative, Wellcome Trust, Royal Society, and Horizon Europe.
View article: The age-specific concentrations and seroprevalence of antibodies against<i>Salmonella</i>Enteritidis (O:9) and<i>Salmonella</i>Typhimurium (O:4,5) across three sites in Kenya
The age-specific concentrations and seroprevalence of antibodies against<i>Salmonella</i>Enteritidis (O:9) and<i>Salmonella</i>Typhimurium (O:4,5) across three sites in Kenya Open
Background Seroprevalence studies can indicate the age-distribution of first infection with non-typhoidal Salmonella (NTS) and estimate the rate of infection by age. This can help target interventions, particularly vaccination. Method We c…
View article: The benefits and risks of maternal RSV vaccination on mortality in South Africa: a modelling study
The benefits and risks of maternal RSV vaccination on mortality in South Africa: a modelling study Open
Background Maternal respiratory syncytial virus (RSV) vaccine, RSV prefusion F protein vaccine (RSVpreF (Abrysvo ® )), was found to be safe and efficacious in its phase III trial. However, post-hoc stratified analyses identified an excess …
View article: Social contacts and mixing patterns in rural Gambia
Social contacts and mixing patterns in rural Gambia Open
In rural Gambia, social contact patterns were primarily driven by household mixing. Most contacts were physical and mostly age-assortative, particularly among school-aged children. Our data can improve infectious disease transmission model…
View article: Seroprevalence of Immunoglobulin G against measles and rubella over a 12-year period (2009 – 2021) in Kilifi, Kenya and the impact of the Measles-Rubella (MR) Vaccine campaign of 2016
Seroprevalence of Immunoglobulin G against measles and rubella over a 12-year period (2009 – 2021) in Kilifi, Kenya and the impact of the Measles-Rubella (MR) Vaccine campaign of 2016 Open
Background Measles and rubella have been targeted for elimination by the World Health Organization. Age-specific population immunity to measles and rubella is important to assess progress towards elimination but data are scarce. We conduct…
View article: Pre-vaccination carriage prevalence of Streptococcus pneumoniae serotypes among internally displaced people in Somaliland: a cross-sectional study
Pre-vaccination carriage prevalence of Streptococcus pneumoniae serotypes among internally displaced people in Somaliland: a cross-sectional study Open
Background Populations affected by humanitarian crises likely experience high burdens of pneumococcal disease. Streptococcus pneumoniae carriage estimates are essential to understand pneumococcal transmission dynamics and the potential imp…
View article: Effect of a Reduced PCV10 Dose Schedule on Pneumococcal Carriage in Vietnam
Effect of a Reduced PCV10 Dose Schedule on Pneumococcal Carriage in Vietnam Open
A reduced vaccination schedule involving a single primary dose and booster dose of PCV10 was noninferior to alternative schedules in protecting against vaccine-serotype carriage in infants and toddlers. (Funded by the Bill and Melinda Gate…
View article: Natural immunity and protection against variants in South African children through five COVID-19 waves: A prospective study
Natural immunity and protection against variants in South African children through five COVID-19 waves: A prospective study Open
Children responded robustly to successive waves of SARS-CoV-2, mounting IgG responses to S antigen that were protective against subsequent waves. In the absence of vaccination, almost all children were seropositive after wave V but none we…
View article: Evaluating methods for identifying and quantifying <i>Streptococcus pneumoniae</i> co-colonization using next-generation sequencing data
Evaluating methods for identifying and quantifying <i>Streptococcus pneumoniae</i> co-colonization using next-generation sequencing data Open
Detection of multiple pneumococcal serotype carriage can enhance monitoring of pneumococcal vaccine impact, particularly among high-burden childhood populations. We assessed methods for identifying co-carriage of pneumococcal serotypes fro…
View article: Report from the World Health Organization's immunization and vaccines-related implementation research advisory committee (IVIR-AC) ad hoc meeting, 28 June – 1 July 2024
Report from the World Health Organization's immunization and vaccines-related implementation research advisory committee (IVIR-AC) ad hoc meeting, 28 June – 1 July 2024 Open
The World Health Organization's Immunization and Vaccines-related Implementation Research Advisory Committee (IVIR-AC) serves to independently review and evaluate vaccine-related research to maximize the potential impact of vaccination pro…
View article: Directly observed social contact patterns among school children in rural Gambia
Directly observed social contact patterns among school children in rural Gambia Open
Social contact rates observed among pupils at schools in rural Gambia were high, strongly age-assortative, and physical. Reporting of school contacts by proxies may underestimate the effect of school-age children in modelling studies of tr…