Girish S. Kulkarni
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View article: Development of a reoperative risk prediction model of muscle-invasive upper tract urothelial carcinoma using clinical and radiomic computed tomography features
Development of a reoperative risk prediction model of muscle-invasive upper tract urothelial carcinoma using clinical and radiomic computed tomography features Open
Introduction: Accurate pre-intervention staging of upper tract urothelial carcinoma (UTUC) remains a significant clinical challenge, particularly in identifying muscle-invasive disease (≥pT2), where kidney-sparing surgery may not be approp…
View article: Risk of metachronous upper tract urothelial carcinoma following non‐muscle‐invasive bladder cancer
Risk of metachronous upper tract urothelial carcinoma following non‐muscle‐invasive bladder cancer Open
Objective To determine the risk and timing of metachronous upper tract urothelial carcinoma (UTUC) after non‐muscle‐invasive bladder cancer (NMIBC). Patients and Methods In this multi‐institutional retrospective cohort study involving acad…
View article: Comparison of 90-day morbidity and mortality between ileal conduit and orthotopic neobladder following radical cystectomy in a large multi-institutional database
Comparison of 90-day morbidity and mortality between ileal conduit and orthotopic neobladder following radical cystectomy in a large multi-institutional database Open
Introduction: In patients undergoing radical cystectomy, ileal conduit (IC) urinary diversions are more frequently carried out than orthotopic neo-bladder reconstructions (ONB). Patients selected for IC likely have more comorbidities, adva…
View article: Association of patient and physician characteristics with androgen‐deprivation‐therapy intensification in patients with de novo hormone‐sensitive metastatic prostate cancer: A population‐based study
Association of patient and physician characteristics with androgen‐deprivation‐therapy intensification in patients with de novo hormone‐sensitive metastatic prostate cancer: A population‐based study Open
Introduction Treatment intensification with androgen receptor signaling inhibitors and/or chemotherapy is guideline recommended for patients with de novo metastatic hormone‐sensitive prostate cancer (mHSPC). However, most patients only rec…
View article: A population-based analysis of patterns of care in patients with de novo muscle-invasive bladder cancer from Alberta, Canada
A population-based analysis of patterns of care in patients with de novo muscle-invasive bladder cancer from Alberta, Canada Open
Introduction: Approximately 25% of patients diagnosed with bladder cancer have muscle-invasive disease (MIBC). While real-world data have highlighted opportunities to improve curative-intent treatment rates, comprehensive population-level …
View article: Is it time for Canada to revisit its approach to prostate cancer screening?
Is it time for Canada to revisit its approach to prostate cancer screening? Open
Prostate cancer is the third leading cause of cancer death among Canadian men. Despite advances in the last decade mitigating overdiagnosis and overtreatment, Canadian guidelines have recommended against routine prostate-specific antigen (…
View article: A population-based analysis of patterns of care in patients with high-risk non-muscle-invasive bladder cancer from Alberta, Canada
A population-based analysis of patterns of care in patients with high-risk non-muscle-invasive bladder cancer from Alberta, Canada Open
Introduction: Approximately three-quarters of patients newly diagnosed with bladder cancer have non-muscle-invasive disease (NMIBC). Among these patients, those with high-risk (HR) features should be managed more aggressively in an attempt…
View article: Sasanlimab plus BCG in BCG-naive, high-risk non-muscle invasive bladder cancer: the randomized phase 3 CREST trial
Sasanlimab plus BCG in BCG-naive, high-risk non-muscle invasive bladder cancer: the randomized phase 3 CREST trial Open
Bacillus Calmette-Guérin (BCG) induction and maintenance (I+M) after transurethral resection of bladder tumor is standard of care (SOC) in high-risk non-muscle invasive bladder cancer (NMIBC). However, disease recurrence/progression occurs…
View article: Impact of concomitant carcinoma in situ distribution on non‐muscle‐invasive bladder cancer progression risk
Impact of concomitant carcinoma in situ distribution on non‐muscle‐invasive bladder cancer progression risk Open
Objective To assess whether the distribution of concomitant carcinoma in situ (CIS; unifocal or multifocal) with papillary non‐muscle‐invasive bladder cancer (NMIBC) impacts the risk of progression, as concomitant CIS is an established ris…
View article: Prostate-specific antigen density does not predict metastatic disease on PSMA-PET in high-risk prostate cancer patients with negative conventional imaging
Prostate-specific antigen density does not predict metastatic disease on PSMA-PET in high-risk prostate cancer patients with negative conventional imaging Open
Introduction: The ability of prostate-specific antigen density (PSAD) to predict metastatic disease on prostate-specific membrane antigen-positron emission tomography (PSMA-PET) at initial staging in high-risk prostate cancer (PCa) for men…
View article: Association of marginalization and PSMA-PET in prostate cancer
Association of marginalization and PSMA-PET in prostate cancer Open
Introduction: Prostate-specific membrane antigen positron emission tomography (PSMA PET) is a new standard for the imaging of high-risk or recurrent prostate cancer. While marginalization disparities exist for prostate cancer, less is know…
View article: Imaging cross-degree-of-freedom structures in biphoton spatial-polarization hyperentanglement
Imaging cross-degree-of-freedom structures in biphoton spatial-polarization hyperentanglement Open
Hyperentanglement, which refers to entanglement across more than one degree of freedom (DoF), is a valuable resource in photonic quantum technology. Although hyperentangled states inherently facilitate access to high-dimensional Hilbert sp…
View article: Prospects of a statistical detection of the 21-cm forest and its potential to constrain the thermal state of the neutral IGM during reionization
Prospects of a statistical detection of the 21-cm forest and its potential to constrain the thermal state of the neutral IGM during reionization Open
The 21-cm forest signal is a promising probe of the Epoch of Reionization complementary to other 21-cm line observables and Ly$α$ forest signal. Prospects of detecting it have significantly improved in the last decade thanks to the discove…
View article: Effectiveness of level two anomaly ultrasound scan for detection of congenital anomalies - an observational retrospective study
Effectiveness of level two anomaly ultrasound scan for detection of congenital anomalies - an observational retrospective study Open
Objectives: This study was done to find the effectiveness of level two anomaly scan in detection of congenital anomalies and also to find the maternal and neonatal factors associated with congenital anomalies. Methods: Pregnant women with …
View article: Proportion of Gleason Score ≥8 Prostate Cancer on Biopsy and Tumor Aggressiveness in Matched Cohorts of East Asian and Non-East Asian Men
Proportion of Gleason Score ≥8 Prostate Cancer on Biopsy and Tumor Aggressiveness in Matched Cohorts of East Asian and Non-East Asian Men Open
Background: Historically, Asia had a lower prostate cancer (PCa) incidence and mortality compared with Western countries, but the gap is narrowing. Paradoxically, Asians have been reported to present with more advanced disease though more …
View article: Long-Term Recurrence Risk, Metastatic Potential, and Length of Cystoscopic Surveillance of Low-Grade Nonmuscle-Invasive Bladder Cancer
Long-Term Recurrence Risk, Metastatic Potential, and Length of Cystoscopic Surveillance of Low-Grade Nonmuscle-Invasive Bladder Cancer Open
This study with long-term data challenges the assumption that primary TaLG NMIBC nearly never progresses to lethal disease if followed long enough. However, the risk of BC-related mortality is extremely low in patients who are recurrence f…
View article: Metabolic, cardiac, and bone health testing in patients with prostate cancer on androgen‐deprivation therapy: A population‐based assessment of adherence to therapeutic monitoring guidelines
Metabolic, cardiac, and bone health testing in patients with prostate cancer on androgen‐deprivation therapy: A population‐based assessment of adherence to therapeutic monitoring guidelines Open
Background Androgen‐deprivation therapy (ADT) remains a cornerstone in treatment for patients with advanced prostate cancer. ADT is associated with several adverse effects, including osteoporosis, metabolic syndrome, and cardiovascular eve…
View article: Efficient characterization of spatial Schmidt modes of multiphoton entangled states produced from high-gain parametric down-conversion
Efficient characterization of spatial Schmidt modes of multiphoton entangled states produced from high-gain parametric down-conversion Open
The ability to efficiently characterize the spatial correlations of entangled states of light is critical for applications of many quantum technologies such as quantum imaging. Here, we demonstrate highly efficient theoretical and experime…
View article: Tranexamic Acid During Radical Cystectomy
Tranexamic Acid During Radical Cystectomy Open
Importance Among cancer surgeries, patients requiring open radical cystectomy have the highest risk of red blood cell (RBC) transfusion. Prophylactic tranexamic acid (TXA) reduces blood loss during cardiac and orthopedic surgery, and it is…
View article: Supplementary Tables 1-2 from Neoadjuvant Cabazitaxel Plus Abiraterone/Leuprolide Acetate in High-Risk Prostate Cancer Patients: ACDC-RP Phase II Trial
Supplementary Tables 1-2 from Neoadjuvant Cabazitaxel Plus Abiraterone/Leuprolide Acetate in High-Risk Prostate Cancer Patients: ACDC-RP Phase II Trial Open
Supplementary Tables 1-2
View article: Supplementary Material 1 from Neoadjuvant Cabazitaxel Plus Abiraterone/Leuprolide Acetate in High-Risk Prostate Cancer Patients: ACDC-RP Phase II Trial
Supplementary Material 1 from Neoadjuvant Cabazitaxel Plus Abiraterone/Leuprolide Acetate in High-Risk Prostate Cancer Patients: ACDC-RP Phase II Trial Open
Supplementary Material. Study protocol
View article: Data from Neoadjuvant Cabazitaxel Plus Abiraterone/Leuprolide Acetate in High-Risk Prostate Cancer Patients: ACDC-RP Phase II Trial
Data from Neoadjuvant Cabazitaxel Plus Abiraterone/Leuprolide Acetate in High-Risk Prostate Cancer Patients: ACDC-RP Phase II Trial Open
Purpose: Early treatment intensification with neoadjuvant therapy may improve outcomes in high-risk, localized prostate cancer (PCa) patients treated with radical prostatectomy (RP). Our objective was to compare pathologic, oncologic, and …
View article: Supplementary Tables 1-2 from Neoadjuvant Cabazitaxel Plus Abiraterone/Leuprolide Acetate in High-Risk Prostate Cancer Patients: ACDC-RP Phase II Trial
Supplementary Tables 1-2 from Neoadjuvant Cabazitaxel Plus Abiraterone/Leuprolide Acetate in High-Risk Prostate Cancer Patients: ACDC-RP Phase II Trial Open
Supplementary Tables 1-2