Shiral S. Gangadin
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View article: Association between the exposome score for schizophrenia and functioning in remitted first-episode psychosis: results from the HAMLETT study
Association between the exposome score for schizophrenia and functioning in remitted first-episode psychosis: results from the HAMLETT study Open
This study independently replicated the finding that ES-SCZ predicts general functioning in FEP, showing its potential for forecasting functioning in remitted FEP patients.
View article: Trajectories of Clozapine Concentrations in Women Across Menopausal Age
Trajectories of Clozapine Concentrations in Women Across Menopausal Age Open
Background and Hypothesis During menopause, estrogen levels change dramatically, which may decrease clozapine blood concentrations in women via estrogen’s inhibitory effect on CYP1A2 activity. This reduction could contribute to increased r…
View article: The Association of Antipsychotic Treatment and Side Effects With Societal Recovery and Happiness: A Naturalistic Cohort Study of People in Long-term Care for a Psychotic Disorder
The Association of Antipsychotic Treatment and Side Effects With Societal Recovery and Happiness: A Naturalistic Cohort Study of People in Long-term Care for a Psychotic Disorder Open
Background Antipsychotics are used to manage symptoms and reduce the risk of relapse. However, the antipsychotic side effects are associated with a lower quality of life and are seen as major barriers to achieving societal recovery by anti…
View article: The Effects of Antipsychotic Dose Reduction on Movement Disorders and Cardiometabolic Indices in Patients Remitted from a First Episode of Psychosis
The Effects of Antipsychotic Dose Reduction on Movement Disorders and Cardiometabolic Indices in Patients Remitted from a First Episode of Psychosis Open
Background and Hypothesis The extent to which tapering antipsychotic (AP) attenuates AP-related movement disorders and cardiometabolic dysfunction remains unclear. We aim to investigate the long-term effects of AP-dose reduction on these a…
View article: Risk of relapse during tapering of antipsychotic medication after a first psychotic episode: association with D2 receptor affinity but not with tapering speed
Risk of relapse during tapering of antipsychotic medication after a first psychotic episode: association with D2 receptor affinity but not with tapering speed Open
While antipsychotic maintenance treatment effectively prevents relapse after a first psychotic episode, many remitted antipsychotic users wish to reduce or discontinue their medication, due to side effects, long‐term health concerns, stigm…
View article: Trends in Antipsychotic Polypharmacy and Potential Overtreatment with Antipsychotics: A Naturalistic Cohort Study of People in Long-term Care
Trends in Antipsychotic Polypharmacy and Potential Overtreatment with Antipsychotics: A Naturalistic Cohort Study of People in Long-term Care Open
Background Due to the side effects of antipsychotics, overtreatment is an important concern. Previous research focused on antipsychotic polypharmacy and excessively high doses. In this study, the aim is to map changes over the years in pot…
View article: Cognitive Adaptation Training for healthcare professionals & relatives: The development of a web-application through User Centered Design
Cognitive Adaptation Training for healthcare professionals & relatives: The development of a web-application through User Centered Design Open
Introduction Cognitive impairments often hinder daily functioning in people with severe mental illness (SMI). Cognitive Adaptation Training (CAT) is an effective psychosocial intervention that reduces this impact. However, barriers such as…
View article: Dopamine D<sub>2/3</sub>R availability after discontinuation of antipsychotic treatment: a [<sup>11</sup>C]raclopride PET study in remitted first-episode psychosis patients
Dopamine D<sub>2/3</sub>R availability after discontinuation of antipsychotic treatment: a [<sup>11</sup>C]raclopride PET study in remitted first-episode psychosis patients Open
Background After remission of a first-episode psychosis (FEP), antipsychotic discontinuation is associated with an increased risk of relapse compared to maintenance treatment. We studied short and longer-term effects of discontinuation of …
View article: Psychological side effects of antipsychotic medication after remission from first-episode psychosis: a HAMLETT ecological momentary assessment study
Psychological side effects of antipsychotic medication after remission from first-episode psychosis: a HAMLETT ecological momentary assessment study Open
Background Evidence on psychological side effects (PSEs) of antipsychotic medication after remission from first-episode psychosis (FEP), and their momentary impact on daily life, is limited. This study examined how Dopamine-2 (D 2 ) affini…
View article: Dutch Validation of the Self-Evaluation of Negative Symptoms Scale (SNS)
Dutch Validation of the Self-Evaluation of Negative Symptoms Scale (SNS) Open
Background/objectives: Negative symptoms in schizophrenia spectrum disorders are related to impaired social functioning and lower quality of life, making accurate assessment important. To date, most tools for assessing negative symptoms ar…
View article: Real-World Effectiveness of Menopausal Hormone Therapy in Preventing Relapse in Women With Schizophrenia or Schizoaffective Disorder
Real-World Effectiveness of Menopausal Hormone Therapy in Preventing Relapse in Women With Schizophrenia or Schizoaffective Disorder Open
The findings underscore the potential value of MHT in preventing psychosis relapse among women with SSD of menopausal age. These findings translate clinical evidence on the neuroprotective effects of estrogens to real-world settings, encom…
View article: Immune Dysfunction in Schizophrenia Spectrum Disorders
Immune Dysfunction in Schizophrenia Spectrum Disorders Open
Evidence from epidemiological, clinical, and biological research resulted in the immune hypothesis: the hypothesis that immune system dysfunction is involved in the pathophysiology of schizophrenia spectrum disorders (SSD). The promising i…
View article: In the afterglow: Immune dysfunction in schizophrenia spectrum disorders
In the afterglow: Immune dysfunction in schizophrenia spectrum disorders Open
Recovering from schizophrenia spectrum disorders (SSD) is challenging, because current treatments are sub-optimal. Motivated to find a cure, researchers study the immune system as a biological underpinning of schizophrenia. This thesis exp…
View article: Exploring peripheral biomarkers of response to simvastatin supplementation in schizophrenia
Exploring peripheral biomarkers of response to simvastatin supplementation in schizophrenia Open
Schizophrenia is one of the most debilitating mental disorders, and its diagnosis and treatment present significant challenges. Several clinical trials have previously evaluated the effectiveness of simvastatin, a lipid-lowering medication…
View article: Personal recovery in first-episode psychosis: Beyond clinical and functional recovery
Personal recovery in first-episode psychosis: Beyond clinical and functional recovery Open
View article: Comparing Early Tapering of Antipsychotic Medication to 12 Months Maintenance Treatment after Remission of a First Psychotic Episode
Comparing Early Tapering of Antipsychotic Medication to 12 Months Maintenance Treatment after Remission of a First Psychotic Episode Open
View article: Correction to: Addressing the Evidence to Practice Gap: What to Expect From International Antipsychotic Dose Reduction Studies in the Tapering Anti-Psychotics and Evaluating Recovery Consortium
Correction to: Addressing the Evidence to Practice Gap: What to Expect From International Antipsychotic Dose Reduction Studies in the Tapering Anti-Psychotics and Evaluating Recovery Consortium Open
View article: Complement component 4A protein levels are negatively related to frontal volumes in patients with schizophrenia spectrum disorders
Complement component 4A protein levels are negatively related to frontal volumes in patients with schizophrenia spectrum disorders Open
This study demonstrated that C4A was negatively related to - specifically - frontal brain volumes in SSD, but this relation was inverse for HC. The results support the hypothesis of complement-mediated brain volume reduction in SSD. The re…
View article: The association of childhood trauma with depressive and negative symptoms in recent onset psychosis: a sex-specific analysis
The association of childhood trauma with depressive and negative symptoms in recent onset psychosis: a sex-specific analysis Open
Background Childhood trauma may impact the course of schizophrenia spectrum disorders (SSD), specifically in relation to the increased severity of depressive or negative symptoms. The type and impact of trauma may differ between sexes. In …
View article: The impact of cannabidiol treatment on resting state functional connectivity, prefrontal metabolite levels and reward processing in recent-onset patients with a psychotic disorder
The impact of cannabidiol treatment on resting state functional connectivity, prefrontal metabolite levels and reward processing in recent-onset patients with a psychotic disorder Open
View article: Association between gut permeability, brain volume, and cognition in healthy participants and patients with schizophrenia spectrum disorder
Association between gut permeability, brain volume, and cognition in healthy participants and patients with schizophrenia spectrum disorder Open
Introduction The barrier function of the gut is important for many organs and systems, including the brain. If gut permeability increases, bacterial fragments may enter the circulation, giving rise to increased systemic inflammation. Incre…
View article: Personal Recovery in First-Episode Psychosis Beyond Clinical and Functional Recovery
Personal Recovery in First-Episode Psychosis Beyond Clinical and Functional Recovery Open
View article: Lower fractional anisotropy without evidence for neuro-inflammation in patients with early-phase schizophrenia spectrum disorders
Lower fractional anisotropy without evidence for neuro-inflammation in patients with early-phase schizophrenia spectrum disorders Open
Various lines of research suggest immune dysregulation as a potential therapeutic target for negative and cognitive symptoms in schizophrenia spectrum disorders (SSD). Immune dysregulation would lead to higher extracellular free-water (EFW…
View article: Inflammatory monocyte gene signature predicts beneficial within group effect of simvastatin in patients with schizophrenia spectrum disorders in a secondary analysis of a randomized controlled trial
Inflammatory monocyte gene signature predicts beneficial within group effect of simvastatin in patients with schizophrenia spectrum disorders in a secondary analysis of a randomized controlled trial Open
View article: Diagnostic model development for schizophrenia based on peripheral blood mononuclear cell subtype-specific expression of metabolic markers
Diagnostic model development for schizophrenia based on peripheral blood mononuclear cell subtype-specific expression of metabolic markers Open
View article: Women with Schizophrenia-Spectrum Disorders After Menopause: A Vulnerable Group for Relapse
Women with Schizophrenia-Spectrum Disorders After Menopause: A Vulnerable Group for Relapse Open
Background and Hypothesis Throughout the life stages of women with schizophrenia-spectrum disorders (SSD), lower estrogen levels are associated with more severe disease course. At perimenopause in the mid-forties, estrogen levels decline t…
View article: The neurobiological characterization of distinct cognitive subtypes in early-phase schizophrenia-spectrum disorders
The neurobiological characterization of distinct cognitive subtypes in early-phase schizophrenia-spectrum disorders Open
View article: Longitudinal clinical and functional outcome in distinct cognitive subgroups of first-episode psychosis: a cluster analysis
Longitudinal clinical and functional outcome in distinct cognitive subgroups of first-episode psychosis: a cluster analysis Open
Background Cognitive deficits may be characteristic for only a subgroup of first-episode psychosis (FEP) and the link with clinical and functional outcomes is less profound than previously thought. This study aimed to identify cognitive su…
View article: Tapering antipsychotic medication: practical considerations
Tapering antipsychotic medication: practical considerations Open
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View article: Reduced resting state functional connectivity in the hippocampus-midbrain-striatum network of schizophrenia patients
Reduced resting state functional connectivity in the hippocampus-midbrain-striatum network of schizophrenia patients Open
Contemporary preclinical models suggest that abnormal functioning of a brain network consisting of the hippocampus, midbrain and striatum plays a critical role in the pathophysiology of schizophrenia. Previous neuroimaging studies examined…