Sirkka Goebeler
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View article: Viridans Streptococcal Biofilm Evades Immune Detection and Contributes to Inflammation and Rupture of Atherosclerotic Plaques
Viridans Streptococcal Biofilm Evades Immune Detection and Contributes to Inflammation and Rupture of Atherosclerotic Plaques Open
Background Bacterial DNA from the oral cavity, respiratory tract, gut, and skin has been detected in atherosclerotic plaques, suggesting a role in chronic inflammation linked to atherosclerosis. Chronic bacterial infections often form biof…
View article: COVID-19 vaccination as a rare potential etiology for cause of death after medicolegal autopsy. A Finnish nationwide study.
COVID-19 vaccination as a rare potential etiology for cause of death after medicolegal autopsy. A Finnish nationwide study. Open
COVID-19 vaccinations began globally at the end of 2020. By the end of 2021, 9.8 million doses were given in Finland. Regarding safety, most vaccine-related adverse reactions have been mild, but severe and lethal ones have also occurred. A…
View article: Common occurrence of atrophic gastritis in an ageing non-hospitalised population: an autopsy study
Common occurrence of atrophic gastritis in an ageing non-hospitalised population: an autopsy study Open
Background Atrophic gastritis—the end stage of chronic gastritis—is an asymptomatic disease due to Helicobacter pylori infection causing decreased vitamin B12 and folate absorption, which may lead to severe haematological and neuropsycholo…
View article: Next-generation sequencing reveals the presence of a rich bacterial microbiome in atherosclerotic coronary artery plaques. The Tampere Sudden Death Study
Next-generation sequencing reveals the presence of a rich bacterial microbiome in atherosclerotic coronary artery plaques. The Tampere Sudden Death Study Open
Background Molecular microbial techniques have identified several DNA sequences from oral and gut bacteria in atherosclerotic plaques. The composition of the plaque microbiome has shown great heterogeneity due to varying DNA extraction and…
View article: Genetic risk score for coronary artery calcification and its predictive ability for coronary artery disease
Genetic risk score for coronary artery calcification and its predictive ability for coronary artery disease Open
This study showed that CAC GRS is a new risk marker for CAD in three European cohorts, with added predictive value over the traditional CVD risk factors.
View article: Relative effectiveness of bivalent boosters against severe COVID-19 outcomes among people aged ≥ 65 years in Finland, September 2022 to August 2023
Relative effectiveness of bivalent boosters against severe COVID-19 outcomes among people aged ≥ 65 years in Finland, September 2022 to August 2023 Open
Background Long-term effectiveness data on bivalent COVID-19 boosters are limited. Aim We evaluated the long-term protection of bivalent boosters against severe COVID-19 among ≥ 65-year-olds in Finland. Methods In this register-based cohor…
View article: Genetic risk score for coronary artery calcification predicts coronary artery disease beyond traditional risk factors
Genetic risk score for coronary artery calcification predicts coronary artery disease beyond traditional risk factors Open
Aim The modest added predictive value of the existing genetic risk scores (GRSs) for coronary artery disease (CAD) could be partly due to missing genetic components, hidden in the genetic architecture of intermediate phenotypes such as cor…
View article: COVID-19 vaccination was a rare potential etiology for cause of death after medicolegal autopsy. A Finnish nationwide study
COVID-19 vaccination was a rare potential etiology for cause of death after medicolegal autopsy. A Finnish nationwide study Open
COVID-19 vaccinations began globally at the end of 2020. By the end of 2021, 9.8 million doses were given in Finland. Regarding safety, most vaccine-related adverse reactions have been mild, but serious and lethal ones have also occurred. …
View article: Sex differences in coronary atherosclerosis during the pre- and postmenopausal period: The Tampere Sudden Death Study
Sex differences in coronary atherosclerosis during the pre- and postmenopausal period: The Tampere Sudden Death Study Open
We did not detect any major sex-difference in coronary atherosclerosis in the premenopausal period when women are considered to be protected from CHD. However, in line with CHD mortality statistics, postmenopausal women showed a slower spe…
View article: COVID-19 endemic phase in Finland: An analysis of health policies and vaccination strategy
COVID-19 endemic phase in Finland: An analysis of health policies and vaccination strategy Open
Objectives To analyze how the vaccines and various measures to control the pandemic affected epidemiological, health and socioeconomic outcomes of COVID-19 in Finland. The focus of the analysis is on the endemic phase of the COVID-19 pande…
View article: Bivalent booster effectiveness against severe COVID-19 outcomes in Finland, September 2022 – March 2023
Bivalent booster effectiveness against severe COVID-19 outcomes in Finland, September 2022 – March 2023 Open
Bivalent COVID-19 vaccines were introduced in 2022 but knowledge of their effectiveness against severe COVID-19 outcomes is currently limited. In Finnish register-based cohort analyses, we compared the risk of severe COVID-19 outcomes amon…
View article: Vainajien kylmäsäilytystilat ja vainajakuljetukset
Vainajien kylmäsäilytystilat ja vainajakuljetukset Open
Sosiaali- ja terveysministeriö (STM) esitti marraskuussa 2018 Terveyden ja hyvinvoinnin laitokselle (THL) pyynnön (STM/4659/2018) tarvittaessa yhteistyössä Etelä-Suomen aluehallintoviraston kanssa selvittää vainajien kylmäsäilytystilojen r…
View article: Age-dependent association of gut bacteria with coronary atherosclerosis: Tampere Sudden Death Study
Age-dependent association of gut bacteria with coronary atherosclerosis: Tampere Sudden Death Study Open
DNA of the Clostridium leptum group and pathogenic Enterobactericeae increase in the gut microbiome with age and can be detected in the same individual's coronary plaques along with pathogenic Streptococcus spp., associating with more seve…
View article: Vibration transmittance measures sternotomy stability – a preliminary study in human cadavers
Vibration transmittance measures sternotomy stability – a preliminary study in human cadavers Open
View article: A device for measuring sternal bone connectivity using vibration analysis techniques
A device for measuring sternal bone connectivity using vibration analysis techniques Open
Objectives:Stability of bone splitting sternotomy is essential for normal healing after open cardiac surgery. Mechanical vibration transmittance may offer a means for early detection of separation of bone (diastasis) in the sternotomy and …
View article: Age-dependent association of gut bacteria with coronary atherosclerosis: Tampere Sudden Death Study
Age-dependent association of gut bacteria with coronary atherosclerosis: Tampere Sudden Death Study Open
Background The gut microbiome is thought to remain stable into old age. Gut bacteria and their translocation may play a role in the development of coronary heart disease (CHD) by modulating cholesterol levels and immune responses, as well…
View article: HRO:sta gerasteniaan
HRO:sta gerasteniaan Open
Ehdotamme, että gerastenia otettaisiin termiksi kuvaamaan määriteltyä geriatrista tilaa (oireyhtymää), johon kuuluvat uupumus, heikkous, hitaus, tahaton painonlasku ja fyysinen inaktiivisuus ja joka voidaan tunnistaa noin 10-14 %:lla koton…