Susanna Guerrini
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View article: Lymph Node Involvement and Radiologic Predictors of Invasiveness in Pure Ground-Glass Adenocarcinomas: The GORDON Study
Lymph Node Involvement and Radiologic Predictors of Invasiveness in Pure Ground-Glass Adenocarcinomas: The GORDON Study Open
Adenocarcinomas presenting as pGGOs are low-risk lesions with rare lymph node involvement or recurrence, suggesting that lymphadenectomy may be unnecessary. Preoperative chest CT enables risk stratification of lesion invasiveness, supporti…
View article: Improved detection and quantification of peritoneal metastases using delayed contrast-enhanced dual-energy CT scans
Improved detection and quantification of peritoneal metastases using delayed contrast-enhanced dual-energy CT scans Open
Background Computed tomography (CT) is widely used to diagnose peritoneal metastases (PM), with debated accuracy. Dual-energy CT (DECT) may improve accuracy, yet its diagnostic performance is still unknown. We explored the potential of DEC…
View article: Neighboring Countries, Diverging Protocols: A Comparison of Stroke Pathways from MDRinAIS Study
Neighboring Countries, Diverging Protocols: A Comparison of Stroke Pathways from MDRinAIS Study Open
Background The MDRinAIS study, funded by the EU under Horizon Europe, aims to develop a telemedicine-based pathway for acute ischemic stroke patients with large vessel occlusion requiring mechanical thrombectomy, to reduce treatment delays…
View article: A Precision Surgery Framework for Lung Resection: Robotic, Video-Assisted, and Open Segmentectomy
A Precision Surgery Framework for Lung Resection: Robotic, Video-Assisted, and Open Segmentectomy Open
Objectives: To evaluate outcomes of patients undergoing lung segmentectomy using open thoracotomy, Video-Assisted Thoracoscopic Surgery (VATS), or Robotic-Assisted Thoracoscopic Surgery (RATS) approaches. Methods: A total of 157 patients (…
View article: Roles of artificial intelligence and high frame-rate contrast-enhanced ultrasound in the differential diagnosis of Breast Imaging Reporting and Data System 4 breast nodules
Roles of artificial intelligence and high frame-rate contrast-enhanced ultrasound in the differential diagnosis of Breast Imaging Reporting and Data System 4 breast nodules Open
Compared with AI alone or HiFR-CEUS alone, the combined use of these two methods had higher diagnostic performance in distinguishing between benign and malignant BI-RADS 4 breast nodules. Thus, our combination method could further improve …
View article: Diagnostic test of conventional ultrasonography combined with contrast-enhanced ultrasound in the subcategorization of suspicious Breast Imaging-Reporting and Data System (BI-RADS) 4 breast lesions
Diagnostic test of conventional ultrasonography combined with contrast-enhanced ultrasound in the subcategorization of suspicious Breast Imaging-Reporting and Data System (BI-RADS) 4 breast lesions Open
The CEUS-BI-RADS significantly enhances diagnostic efficacy for BI-RADS category 4 breast lesions, outperforming the US-BI-RADS and could reduce unnecessary biopsies.
View article: Sarcoid Nodule or Lung Cancer? A High-Resolution Computed Tomography-Based Retrospective Study of Pulmonary Nodules in Patients with Sarcoidosis
Sarcoid Nodule or Lung Cancer? A High-Resolution Computed Tomography-Based Retrospective Study of Pulmonary Nodules in Patients with Sarcoidosis Open
Background: The objective of this retrospective study was to compare the characteristics of sarcoid nodules and neoplastic nodules using high-resolution computed tomography (HRCT) in sarcoidosis patients. Methods: This is a single-center r…
View article: Dual-Energy CT as a Well-Established CT Modality to Reduce Contrast Media Amount: A Systematic Review from the Computed Tomography Subspecialty Section of the Italian Society of Radiology
Dual-Energy CT as a Well-Established CT Modality to Reduce Contrast Media Amount: A Systematic Review from the Computed Tomography Subspecialty Section of the Italian Society of Radiology Open
Background: Our study aims to provide an overview of existing evidence regarding the image quality of dual-energy CT (DECT) employing reduced contrast media (CM) volumes, in comparison to single-energy CT (SECT) with standard CM loads. The…
View article: The application of computer-aided diagnosis in Breast Imaging Reporting and Data System ultrasound training for residents—a randomized controlled study
The application of computer-aided diagnosis in Breast Imaging Reporting and Data System ultrasound training for residents—a randomized controlled study Open
Chinese Clinical Trial Registry (ChiCTR2400081672).
View article: A genome-wide association study for survival from a multi-centre European study identified variants associated with COVID-19 risk of death
A genome-wide association study for survival from a multi-centre European study identified variants associated with COVID-19 risk of death Open
The clinical manifestations of SARS-CoV-2 infection vary widely among patients, from asymptomatic to life-threatening. Host genetics is one of the factors that contributes to this variability as previously reported by the COVID-19 Host Gen…
View article: Silencing of AJAP1 expression by promoter methylation activates the Wnt/β-catenin signaling pathway to promote tumor proliferation and metastasis in salivary adenoid cystic carcinoma
Silencing of AJAP1 expression by promoter methylation activates the Wnt/β-catenin signaling pathway to promote tumor proliferation and metastasis in salivary adenoid cystic carcinoma Open
In conclusion, these results suggest that the downregulation of AJAP1 protein expression may play a certain role in progression and metastasis of SACC. Our study indicates that AJAP1 may be a potential prognostic molecular marker and thera…
View article: Pleuroparenchymal Fibroelastosis-like Lesions in Clinical Practice: A Rare Entity? Review of a Radiological Database
Pleuroparenchymal Fibroelastosis-like Lesions in Clinical Practice: A Rare Entity? Review of a Radiological Database Open
Background: Pleuroparenchymal Fibroelastosis (PPFE) is a rare disease that consists of elastofibrosis that involves the pleura and subpleural lung parenchyma; it is an unusual pulmonary disease with unique clinical, radiological and pathol…
View article: Isolated pulmonary langerhans cell histiocytosis: A diagnostic challenge in oncologic patients
Isolated pulmonary langerhans cell histiocytosis: A diagnostic challenge in oncologic patients Open
Sir, Langerhans cell histiocytosis is a rare disorder with unknown aetiology that can involve different organs, rarely just the lungs. Isolated pulmonary involvement (pulmonary langerhans cell histiocytosis [PLCH]) primarily affects young …
View article: Effect of Pre-Existent Sarcopenia on Oncological Outcome of Advanced Thyroid Cancer Patients Treated with Tyrosine Kinase Inhibitors
Effect of Pre-Existent Sarcopenia on Oncological Outcome of Advanced Thyroid Cancer Patients Treated with Tyrosine Kinase Inhibitors Open
(1) Background: Sarcopenia is associated with poor survival and treatment outcomes in several human cancers. The aim of the study was to investigate the prevalence of sarcopenia in a cohort of 58 Caucasian patients with advanced thyroid ca…
View article: Lung Cancer Imaging: Screening Result and Nodule Management
Lung Cancer Imaging: Screening Result and Nodule Management Open
Background: Lung cancer (LC) represents the main cause of cancer-related deaths worldwide, especially because the majority of patients present with an advanced stage of the disease at the time of diagnosis. This systematic review describes…
View article: Rare variants in Toll-like receptor 7 results in functional impairment and downregulation of cytokine-mediated signaling in COVID-19 patients
Rare variants in Toll-like receptor 7 results in functional impairment and downregulation of cytokine-mediated signaling in COVID-19 patients Open
Toll-like receptors (TLR) are crucial components in the initiation of innate immune responses to a variety of pathogens, triggering the production of pro-inflammatory cytokines and type I and II interferons, which are responsible for innat…
View article: Management of Giant Pulmonary Artery Aneurysm with Quadricuspid Valve Stenosis
Management of Giant Pulmonary Artery Aneurysm with Quadricuspid Valve Stenosis Open
The pulmonary artery aneurysm (PAA) is a rare disease with no well-defined guidelines about the diagnostic criteria and its management. In fact, the indications for surgical treatment and the type of surgical approach are not clear. Howeve…
View article: Advancement in Diagnostic Imaging of Thymic Tumors
Advancement in Diagnostic Imaging of Thymic Tumors Open
Thymic tumors are rare neoplasms even if they are the most common primary neoplasm of the anterior mediastinum. In the era of advanced imaging modalities, such as functional MRI, dual-energy CT, perfusion CT and radiomics, it is possible t…
View article: Large Bowel Ischemia/Infarction: How to Recognize It and Make Differential Diagnosis? A Review
Large Bowel Ischemia/Infarction: How to Recognize It and Make Differential Diagnosis? A Review Open
Ischemic colitis represents the most frequent form of intestinal ischemia occurring when there is an acute impairment or chronic reduction in the colonic blood supply, resulting in mucosal ulceration, inflammation, hemorrhage and ischemic …
View article: Pleuroparenchymal fibroelastosis in interstitial lung disease with antineutrophil cytoplasmic antibody-associated vasculitis
Pleuroparenchymal fibroelastosis in interstitial lung disease with antineutrophil cytoplasmic antibody-associated vasculitis Open
Letters to the Editor; Authors: E. Bargagli, E. Conticini, M.A. Mazzei, P. Cameli, S. Guerrini, M. D'alessandro, B. FredianiCollaborator/s: L. Cantarini, F. Bellisai, L. Alderighi, E. Selvi, L. Bergantinion behalf of Pleuroparenchymal Fibr…
View article: Association of Toll-like receptor 7 variants with life-threatening COVID-19 disease in males: findings from a nested case-control study
Association of Toll-like receptor 7 variants with life-threatening COVID-19 disease in males: findings from a nested case-control study Open
Background: Recently, loss-of-function variants in TLR7 were identified in two families in which COVID-19 segregates like an X-linked recessive disorder environmentally conditioned by SARS-CoV-2. We investigated whether the two families re…
View article: Author response: Association of Toll-like receptor 7 variants with life-threatening COVID-19 disease in males: findings from a nested case-control study
Author response: Association of Toll-like receptor 7 variants with life-threatening COVID-19 disease in males: findings from a nested case-control study Open
Background: Recently, loss-of-function variants in TLR7 were identified in two families in which COVID-19 segregates like an X-linked recessive disorder environmentally conditioned by SARS-CoV-2.We investigated whether the two families rep…
View article: Inflammatory Bowel Diseases and Coexisting Spondyloarthritis: A Neglected and too Often Under-Reported Association by Radiologists. A Multicenter Study by Italian Research Group of Imaging in Rheumatology
Inflammatory Bowel Diseases and Coexisting Spondyloarthritis: A Neglected and too Often Under-Reported Association by Radiologists. A Multicenter Study by Italian Research Group of Imaging in Rheumatology Open
Purpose: The purpose of this study was to evaluate the prevalence and the underreporting rate of sacroiliitis (SI) in a large cohort of patients with biopsy-proved Crohn’s disease (CD) who underwent magnetic resonance enterography (MRE) or…
View article: Dual energy CT in gland tumors: a comprehensive narrative review and differential diagnosis
Dual energy CT in gland tumors: a comprehensive narrative review and differential diagnosis Open
Dual energy CT (DECT)with image acquisition at two different photon X-ray levels allows the characterization of a specific tissue or material/elements, the extrapolation of virtual unenhanced and monoenergetic images, and the quantificatio…