Steven R. Hays
YOU?
Author Swipe
View article: Improvements in Patient-reported Functioning After Lung Transplant Is Associated With Improved Quality of Life and Survival
Improvements in Patient-reported Functioning After Lung Transplant Is Associated With Improved Quality of Life and Survival Open
Background. Lung transplantation aims to improve health-related quality of life (HRQL) and survival. Although improvements in lung function are associated with these outcomes, the role of physical functioning is less clear. We investigated…
View article: Persistent and progressive acute lung allograft dysfunction is linked to cell compositional and transcriptional changes in small airways
Persistent and progressive acute lung allograft dysfunction is linked to cell compositional and transcriptional changes in small airways Open
In this pilot study, persistent and progressive ALAD was associated with changes in bronchiolar cell composition and transcriptional programs. Molecular phenotyping may help identify and characterize individuals with ALAD at increased risk…
View article: Cytomegalovirus-associated CD57 + KLRG1 + CD8 + TEMRA T cells are associated with reduced risk of CMV viremia in kidney transplantation and chronic allograft dysfunction in lung transplantation
Cytomegalovirus-associated CD57 + KLRG1 + CD8 + TEMRA T cells are associated with reduced risk of CMV viremia in kidney transplantation and chronic allograft dysfunction in lung transplantation Open
Cytomegalovirus (CMV) infection threatens outcomes across solid organ transplantation, but organ-specific differences in CMV immunity are incompletely understood. We investigated whether lung and kidney CMV infection drove similar immune p…
View article: Evaluation of Crushed Posaconazole Delayed Release Tablets in Lung Transplant Recipients
Evaluation of Crushed Posaconazole Delayed Release Tablets in Lung Transplant Recipients Open
Background Invasive fungal infections can cause serious complications after lung transplant; therefore, prophylaxis with posaconazole is common. The posaconazole delayed‐release (DR) tablet is preferred. Although the package insert states …
View article: Disturbed sleep after lung transplantation is associated with worse patient-reported outcomes and chronic lung allograft dysfunction
Disturbed sleep after lung transplantation is associated with worse patient-reported outcomes and chronic lung allograft dysfunction Open
Poor sleep after lung transplant appears associated with PROs, frailty, CLAD, and death. Clarifying the nature of this association may have important screening implications.
View article: Improvements in Patient-Reported Functioning after Lung Transplant is Associated with Improved Quality of Life and Survival
Improvements in Patient-Reported Functioning after Lung Transplant is Associated with Improved Quality of Life and Survival Open
Lung transplantation aims to improve health-related quality of life (HRQL) and survival. While lung function improvements are associated with these outcomes, the association between physical functioning and these outcomes is less clear. We…
View article: CD94<sup>+</sup>natural killer cells potentiate pulmonary ischaemia–reperfusion injury
CD94<sup>+</sup>natural killer cells potentiate pulmonary ischaemia–reperfusion injury Open
Background Pulmonary ischaemia–reperfusion injury (IRI) is a major contributor to poor lung transplant outcomes. We recently demonstrated a central role of airway-centred natural killer (NK) cells in mediating IRI; however, there are no ex…
View article: Macrophage and CD8 T cell discordance are associated with acute lung allograft dysfunction progression
Macrophage and CD8 T cell discordance are associated with acute lung allograft dysfunction progression Open
BAL anti-inflammatory macrophages may protect against CLAD by suppressing CD8 T cells. These populations merit functional and longitudinal assessment in additional cohorts.
View article: Patient Engagement With and Perspectives on a Mobile Health Home Spirometry Intervention: Mixed Methods Study
Patient Engagement With and Perspectives on a Mobile Health Home Spirometry Intervention: Mixed Methods Study Open
Background Patient engagement attrition in mobile health (mHealth) remote patient monitoring (RPM) programs decreases program benefits. Systemic disparities lead to inequities in RPM adoption and use. There is an urgent need to understand …
View article: <i>MICB</i> Genomic Variant Is Associated with NKG2D-mediated Acute Lung Injury and Death
<i>MICB</i> Genomic Variant Is Associated with NKG2D-mediated Acute Lung Injury and Death Open
Rationale: Acute lung injury (ALI) carries a high risk of mortality but has no established pharmacologic therapy. We previously found that experimental ALI occurs through natural killer (NK) cell NKG2D receptor activation and that the cogn…
View article: Disturbed sleep after lung transplantation is associated with worse patient-reported outcomes and chronic lung allograft dysfunction
Disturbed sleep after lung transplantation is associated with worse patient-reported outcomes and chronic lung allograft dysfunction Open
Many lung transplant recipients fail to derive the expected improvements in functioning, HRQL, or long-term survival. Sleep may represent an important, albeit rarely examined, factor influencing lung transplant outcomes. Within a larger co…
View article: CCR5 drives NK cell–associated airway damage in pulmonary ischemia-reperfusion injury
CCR5 drives NK cell–associated airway damage in pulmonary ischemia-reperfusion injury Open
Primary graft dysfunction (PGD) limits clinical benefit after lung transplantation, a life-prolonging therapy for patients with end-stage disease. PGD is the clinical syndrome resulting from pulmonary ischemia-reperfusion injury (IRI), dri…
View article: Decreased Lymphocytic Bronchitis Severity in the Era of Azithromycin Prophylaxis
Decreased Lymphocytic Bronchitis Severity in the Era of Azithromycin Prophylaxis Open
Background. Large-airway lymphocytic inflammation (LB), assessed on endobronchial biopsies, has been associated with acute cellular rejection and chronic lung allograft dysfunction (CLAD). Azithromycin (AZI) prophylaxis has been used to pr…
View article: Patient Engagement With and Perspectives on a Mobile Health Home Spirometry Intervention: Mixed Methods Study (Preprint)
Patient Engagement With and Perspectives on a Mobile Health Home Spirometry Intervention: Mixed Methods Study (Preprint) Open
BACKGROUND Patient engagement attrition in mobile health (mHealth) remote patient monitoring (RPM) programs decreases program benefits. Systemic disparities lead to inequities in RPM adoption and use. There is an urgent need to understand…
View article: The Association Between Frailty and Chronic Lung Allograft Dysfunction After Lung Transplantation
The Association Between Frailty and Chronic Lung Allograft Dysfunction After Lung Transplantation Open
Background. After lung transplantation, both frailty and chronic lung allograft dysfunction (CLAD) commonly develop, and when they do, are associated with poorer outcomes. Given their potential shared mechanisms, we sought to explore the t…
View article: Echocardiographic estimation of pulmonary vascular resistance in advanced lung disease
Echocardiographic estimation of pulmonary vascular resistance in advanced lung disease Open
Noninvasive assessment of pulmonary hemodynamics is often performed by echocardiographic estimation of the pulmonary artery systolic pressure (ePASP), despite limitations in the advanced lung disease population. Other noninvasive hemodynam…
View article: NKG2D receptor activation drives primary graft dysfunction severity and poor lung transplantation outcomes
NKG2D receptor activation drives primary graft dysfunction severity and poor lung transplantation outcomes Open
Clinical outcomes after lung transplantation, a life-saving therapy for patients with end-stage lung diseases, are limited by primary graft dysfunction (PGD). PGD is an early form of acute lung injury with no specific pharmacologic therapi…