Christophe Wiart
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View article: Phytochemical fingerprinting, antioxidant and antibacterial activities, and in vitro wound healing potential of the polyherbal formulation MM-24
Phytochemical fingerprinting, antioxidant and antibacterial activities, and in vitro wound healing potential of the polyherbal formulation MM-24 Open
Damage and disruption of skin layers initiate a complex and overlapping wound healing process, including hemostasis, inflammation, proliferation, and remodeling phase. Indeed, the core management is to promote wound closure and tissue rege…
View article: In vitro and in silico investigations of Propolis-derived phytochemicals as potential inhibitors of Plasmodium falciparum
In vitro and in silico investigations of Propolis-derived phytochemicals as potential inhibitors of Plasmodium falciparum Open
Background and Aim: Malaria continues to pose a global health challenge, exacerbated by the emergence of drug-resistant strains of Plasmodium falciparum. This study aimed to evaluate the anti-Plasmodium potential of Propolis extracts colle…
View article: Medicinal plants of Sabah (North Borneo): lest we forget
Medicinal plants of Sabah (North Borneo): lest we forget Open
Sabah's medicinal plants offer tremendous potential for discovering natural products of therapeutic value.
View article: Amebicidal and Antiadhesion Activities of <i>Knema retusa</i> Extract Against <i>Acanthamoeba triangularis</i> T4 Genotype on Contact Lenses and Modeling Simulation of Its Main Compound, E2N, Against <i>Acanthamoeba</i> Beta‐Tubulin
Amebicidal and Antiadhesion Activities of <i>Knema retusa</i> Extract Against <i>Acanthamoeba triangularis</i> T4 Genotype on Contact Lenses and Modeling Simulation of Its Main Compound, E2N, Against <i>Acanthamoeba</i> Beta‐Tubulin Open
Medicinal plants have been used as alternative agents for the treatment of infections. This study aimed to investigate bioactivities of medicinal plant extracts including Knema retusa extract (Kre) against Acanthamoeba triangularis T4 in v…
View article: Development of a novel encystment medium: Enhancing diagnostic potential of Acanthamoeba spp.
Development of a novel encystment medium: Enhancing diagnostic potential of Acanthamoeba spp. Open
Background and Aim: Acanthamoeba spp. are pathogenic microorganisms linked to severe infections in humans and animals, requiring a deeper understanding of their encystation process for effective diagnostics and research. This study focused…
View article: Antibacterial potency of mid-polar extracts obtained from Malaysian plant Parkia speciosa against human pathogenic bacteria
Antibacterial potency of mid-polar extracts obtained from Malaysian plant Parkia speciosa against human pathogenic bacteria Open
P. speciosa fraction could be a potential novel source for the development of a natural antibacterial agent.
View article: Comparative efficacy of <i>Knema retusa</i> extract delivery <i>via</i> PEG-<i>b</i>-PCL, niosome, and their combination against <i>Acanthamoeba triangularis</i> genotype T4: characterization, inhibition, anti-adhesion, and cytotoxic activity
Comparative efficacy of <i>Knema retusa</i> extract delivery <i>via</i> PEG-<i>b</i>-PCL, niosome, and their combination against <i>Acanthamoeba triangularis</i> genotype T4: characterization, inhibition, anti-adhesion, and cytotoxic activity Open
Background Acanthamoeba spp. is a waterborne, opportunistic protozoan that can cause amebic keratitis and granulomatous amebic encephalitis. Knema retusa is a native tree in Malaysia, and its extracts possess a broad range of biological ac…
View article: Antibacterial phenolic compounds from the flowering plants of Asia and the Pacific: coming to the light
Antibacterial phenolic compounds from the flowering plants of Asia and the Pacific: coming to the light Open
Angiosperms from Asia and the Pacific provide a rich source of natural products with the potential to be developed as leads for treating bacterial infections.
View article: Review of Malaysian medicinal plants with potential wound healing activity
Review of Malaysian medicinal plants with potential wound healing activity Open
Wound is defined as the damage to biological tissues including skin, mucous membranes and organ tissues. The acute wound heals in less than 4 weeks without complications, while a chronic wound takes longer than 6 weeks to heal. Wound heali…
View article: Review of: "Phytochemical Analysis and Antioxidant Activity of Extracts from Berchemia zeyheri — A Swazi Medicinal Plant"
Review of: "Phytochemical Analysis and Antioxidant Activity of Extracts from Berchemia zeyheri — A Swazi Medicinal Plant" Open
The subject of this article is interesting, but the basic conditions for publication in a peer-reviewed journal have not yet been met. For now, rejection is advised. After a major correction, this article may be resubmitted.
View article: Efficacy of propolis extract and eye drop solutions to suppress encystation and excystation of <i>Acanthamoeba triangularis</i> WU19001-T4 genotype
Efficacy of propolis extract and eye drop solutions to suppress encystation and excystation of <i>Acanthamoeba triangularis</i> WU19001-T4 genotype Open
Background Propolis is a natural resinous product from a variety of plants and combines it with beeswax and salivary enzymes to create bee glue. Its potentials have been employed in the treatment of many diseases and conditions for centuri…
View article: Inhibitory and anti-adherent effects of Piper betle L. leaf extract against Acanthamoeba triangularis in co-infection with Staphylococcus aureus and Pseudomonas aeruginosa: A sustainable one-health approach
Inhibitory and anti-adherent effects of Piper betle L. leaf extract against Acanthamoeba triangularis in co-infection with Staphylococcus aureus and Pseudomonas aeruginosa: A sustainable one-health approach Open
Background and Aim: Keratitis is a serious ocular infection often caused by pathogenic micro-organisms such as Acanthamoeba spp. Among other harmful microbes, Acanthamoeba keratitis presents a particular challenge due to its resistance to …
View article: Preparation and evaluation of a niosomal delivery system containing <i>G. mangostana</i> extract and study of its anti-<i>Acanthamoeba</i> activity
Preparation and evaluation of a niosomal delivery system containing <i>G. mangostana</i> extract and study of its anti-<i>Acanthamoeba</i> activity Open
Garcinia mangostana extract (GME) has severe pharmacokinetic deficiencies and is made up of a variety of bioactive components.
View article: Referee report. For: Anti-ischemic effect of Tamarindus indica L. seed extract against myocardial hypoxic injury [version 1; peer review: 1 approved]
Referee report. For: Anti-ischemic effect of Tamarindus indica L. seed extract against myocardial hypoxic injury [version 1; peer review: 1 approved] Open
View article: CCDC 2295818: Experimental Crystal Structure Determination
CCDC 2295818: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Acinetobacter baumannii in suspected bacterial infections: Association between multidrug resistance, virulence genes, & biofilm production
Acinetobacter baumannii in suspected bacterial infections: Association between multidrug resistance, virulence genes, & biofilm production Open
Background & objectives: Acinetobacter baumannii has emerged as a nosocomial pathogen with a tendency of high antibiotic resistance and biofilm production. This study aimed to determine the occurrence of A. baumannii from different clinica…
View article: The Garlic Tree of Borneo, Scorodocarpus borneensis (Baill.) Becc. (Olacaceae): Potential Utilization in Pharmaceutical, Nutraceutical, and Functional Cosmetic Industries
The Garlic Tree of Borneo, Scorodocarpus borneensis (Baill.) Becc. (Olacaceae): Potential Utilization in Pharmaceutical, Nutraceutical, and Functional Cosmetic Industries Open
Scorodocarpus borneensis (Baill.) Becc. is attracting increased attention as a potential commercial medicinal plant product in Southeast Asia. This review summarizes the current knowledge on the taxonomy, habitat, distribution, medicinal u…
View article: Green synthesis of silver nanoparticles using <i>Ocimum sanctum</i> Linn. and its antibacterial activity against multidrug resistant <i>Acinetobacter baumannii</i>
Green synthesis of silver nanoparticles using <i>Ocimum sanctum</i> Linn. and its antibacterial activity against multidrug resistant <i>Acinetobacter baumannii</i> Open
The biosynthesis of nanoparticles using the green route is an effective strategy in nanotechnology that provides a cost-effective and environmentally friendly alternative to physical and chemical methods. This study aims to prepare an aque…
View article: Synthesis, Crystal Structure, Antibacterial and In Vitro Anticancer Activity of Novel Macroacyclic Schiff Bases and Their Cu (II) Complexes Derived from S-Methyl and S-Benzyl Dithiocarbazate
Synthesis, Crystal Structure, Antibacterial and In Vitro Anticancer Activity of Novel Macroacyclic Schiff Bases and Their Cu (II) Complexes Derived from S-Methyl and S-Benzyl Dithiocarbazate Open
A series of novel macroacyclic Schiff base ligands and their Cu (II) complexes were synthesised via reacting dicarbonyls of varying chain lengths with S-methyl dithiocarbazate (SMDTC) and S-benzyl dithiocarbazate (SBDTC) followed by coordi…
View article: Antibacterial and Antifungal Terpenes from the Medicinal Angiosperms of Asia and the Pacific: Haystacks and Gold Needles
Antibacterial and Antifungal Terpenes from the Medicinal Angiosperms of Asia and the Pacific: Haystacks and Gold Needles Open
This review identifies terpenes isolated from the medicinal Angiosperms of Asia and the Pacific with antibacterial and/or antifungal activities and analyses their distribution, molecular mass, solubility, and modes of action. All data in t…
View article: Development of SARS-CoV-2 Vaccine: Challenges and Prospects
Development of SARS-CoV-2 Vaccine: Challenges and Prospects Open
The WHO declared coronavirus disease 2019 (COVID-19) a pandemic in March 2020, which was caused by novel coronavirus severe acute respiratory coronavirus 2 (SARS-CoV-2). SARS-CoV-2 made its first entry into the world in November 2019, and …
View article: Evaluation of phytochemicals and antioxidant potential of a new polyherbal formulation TC-16: additive, synergistic or antagonistic?
Evaluation of phytochemicals and antioxidant potential of a new polyherbal formulation TC-16: additive, synergistic or antagonistic? Open
Background Scientific literature has demonstrated the association of free radicals in the aetiology of various chronic diseases. Hence, the identification of potent antioxidants remains a useful task. The combination of multiple herbs in p…
View article: Targeting Acanthamoeba proteins interaction with flavonoids of Propolis extract by in vitro and in silico studies for promising therapeutic effects
Targeting Acanthamoeba proteins interaction with flavonoids of Propolis extract by in vitro and in silico studies for promising therapeutic effects Open
Background: Propolis is a natural resinous mixture produced by bees. It provides beneficial effects on human health in the treatment/management of many diseases. The present study was performed to demonstrate the anti-Acanthamoeba activity…
View article: Targeting Acanthamoeba proteins interaction with flavonoids of Propolis extract by in vitro and in silico studies for promising therapeutic effects
Targeting Acanthamoeba proteins interaction with flavonoids of Propolis extract by in vitro and in silico studies for promising therapeutic effects Open
Background: Propolis is a natural resinous mixture produced by bees. It provides beneficial effects on human health in the treatment/management of many diseases. The present study was performed to demonstrate the anti-Acanthamoeba activity…
View article: Are Fermented Foods Effective against Inflammatory Diseases?
Are Fermented Foods Effective against Inflammatory Diseases? Open
Fermented foods have been used over the centuries in various parts of the world. These foods are rich in nutrients and are produced naturally using various biological tools like bacteria and fungi. Fermentation of edible foods has been roo…
View article: Antimalarial Property of Compounds from Propolis Extract as New Antimalarial Agent Candidates: In Vitro and In Silico Analysis
Antimalarial Property of Compounds from Propolis Extract as New Antimalarial Agent Candidates: In Vitro and In Silico Analysis Open
View article: Conserved Candidate Antigens and Nanoparticles to Develop Vaccine against Giardia intestinalis
Conserved Candidate Antigens and Nanoparticles to Develop Vaccine against Giardia intestinalis Open
Giardia intestinalis (Giardia lambia, Giardia duodenalis) infections in humans may be asymptomatic or symptomatic and associated with diarrhea (without blood), abdominal cramps, bloating, flatulence, and weight loss. The protozoan Giardia …
View article: Anti- <i>Acanthamoeba</i> activity of a semi-synthetic mangostin derivative and its ability in removal of <i>Acanthamoeba triangularis</i> WU19001 on contact lens
Anti- <i>Acanthamoeba</i> activity of a semi-synthetic mangostin derivative and its ability in removal of <i>Acanthamoeba triangularis</i> WU19001 on contact lens Open
Garcinia mangostana L., also known as the mangosteen tree, is a native medicinal plant in Southeast Asia having a wide variety of pharmacologically active compounds, including xanthonoid mangostin. In this study, we examined the pharmacolo…
View article: Targeting Acanthamoeba proteins interaction with flavonoids of Propolis extract by in vitro and in silico studies for promising therapeutic effects
Targeting Acanthamoeba proteins interaction with flavonoids of Propolis extract by in vitro and in silico studies for promising therapeutic effects Open
Background: Propolis is a natural resinous mixture produced by bees. It provides beneficial effects on human health in the treatment/management of many diseases. The present study was performed to demonstrate the anti-Acanthamoeba activity…
View article: Plant as an Alternative Source of Antifungals against Aspergillus Infections: A Review
Plant as an Alternative Source of Antifungals against Aspergillus Infections: A Review Open
Aspergillus species consists of a group of opportunistic fungi that is virulent when the immunity of the host is compromised. Among the various species, Aspergillus fumigatus is the most prevalent species. However, the prevalence of fungal…