Steven Hébert
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View article: Supplementary Table 4 from A Compendium of Syngeneic, Transplantable Pediatric High-Grade Glioma Models Reveals Subtype-Specific Therapeutic Vulnerabilities
Supplementary Table 4 from A Compendium of Syngeneic, Transplantable Pediatric High-Grade Glioma Models Reveals Subtype-Specific Therapeutic Vulnerabilities Open
Quality control and filtering of snRNA-seq data.
View article: Supplementary Table 6 from A Compendium of Syngeneic, Transplantable Pediatric High-Grade Glioma Models Reveals Subtype-Specific Therapeutic Vulnerabilities
Supplementary Table 6 from A Compendium of Syngeneic, Transplantable Pediatric High-Grade Glioma Models Reveals Subtype-Specific Therapeutic Vulnerabilities Open
ssGEA signatures derived from snRNA-seq data.
View article: Supplementary Figures 1-27 from A Compendium of Syngeneic, Transplantable Pediatric High-Grade Glioma Models Reveals Subtype-Specific Therapeutic Vulnerabilities
Supplementary Figures 1-27 from A Compendium of Syngeneic, Transplantable Pediatric High-Grade Glioma Models Reveals Subtype-Specific Therapeutic Vulnerabilities Open
Figures describing hindbrain vs ganglionic eminence targeting strategies, each of the 16 models generated and validation that they expressed the introduced mutations, survival of GE vs CTX-electroporated embryos, and cell viability data sh…
View article: Supplementary Tables 1-3, 7-9 from A Compendium of Syngeneic, Transplantable Pediatric High-Grade Glioma Models Reveals Subtype-Specific Therapeutic Vulnerabilities
Supplementary Tables 1-3, 7-9 from A Compendium of Syngeneic, Transplantable Pediatric High-Grade Glioma Models Reveals Subtype-Specific Therapeutic Vulnerabilities Open
Tables describing statistical analyses, median survivals, IC50 values calculated from cell viability assays, primer sequences and antibodies.
View article: Supplementary Table 5 from A Compendium of Syngeneic, Transplantable Pediatric High-Grade Glioma Models Reveals Subtype-Specific Therapeutic Vulnerabilities
Supplementary Table 5 from A Compendium of Syngeneic, Transplantable Pediatric High-Grade Glioma Models Reveals Subtype-Specific Therapeutic Vulnerabilities Open
Cell type ontologies derived from snRNA-seq data.
View article: Addendum: Protein arginine methyltransferase 1 regulates B cell fate after positive selection in the germinal center in mice
Addendum: Protein arginine methyltransferase 1 regulates B cell fate after positive selection in the germinal center in mice Open
View article: Author Correction: A diverse landscape of FGFR alterations and co-mutations suggests potential therapeutic strategies in pediatric low-grade gliomas
Author Correction: A diverse landscape of FGFR alterations and co-mutations suggests potential therapeutic strategies in pediatric low-grade gliomas Open
View article: Development of the EPO-Score – a multivariable tool to predict adverse outcome in infants with perinatal asphyxia undergoing therapeutic hypothermia – a retrospective study
Development of the EPO-Score – a multivariable tool to predict adverse outcome in infants with perinatal asphyxia undergoing therapeutic hypothermia – a retrospective study Open
Aim Early outcome prediction in neonates with perinatal asphyxia receiving therapeutic hypothermia (TH) remains difficult. Although several studies have explored prognostic markers and proposed scoring systems, none of these tools has been…
View article: A diverse landscape of FGFR alterations and co-mutations suggests potential therapeutic strategies in pediatric low-grade gliomas
A diverse landscape of FGFR alterations and co-mutations suggests potential therapeutic strategies in pediatric low-grade gliomas Open
Oncogenic alterations in fibroblast growth factor receptor (FGFR)-family proteins occur across cancers, including pediatric gliomas. Our genomic analysis of 11,635 gliomas across ages finds that 5.3% of all gliomas harbor FGFR alterations,…
View article: Figure S1-S10 from Targeting the Dependence on PIK3C3-mTORC1 Signaling in Dormancy-Prone Breast Cancer Cells Blunts Metastasis Initiation
Figure S1-S10 from Targeting the Dependence on PIK3C3-mTORC1 Signaling in Dormancy-Prone Breast Cancer Cells Blunts Metastasis Initiation Open
Supplementary Methods and Supplementary Figures
View article: Data from Targeting the Dependence on PIK3C3-mTORC1 Signaling in Dormancy-Prone Breast Cancer Cells Blunts Metastasis Initiation
Data from Targeting the Dependence on PIK3C3-mTORC1 Signaling in Dormancy-Prone Breast Cancer Cells Blunts Metastasis Initiation Open
Halting breast cancer metastatic relapse following primary tumor removal remains challenging due to a lack of specific vulnerabilities to target during the clinical dormancy phase. To identify such vulnerabilities, we conducted genome-wide…
View article: Supplementary Data from Targeting the Dependence on PIK3C3-mTORC1 Signaling in Dormancy-Prone Breast Cancer Cells Blunts Metastasis Initiation
Supplementary Data from Targeting the Dependence on PIK3C3-mTORC1 Signaling in Dormancy-Prone Breast Cancer Cells Blunts Metastasis Initiation Open
Tables S6-S8
View article: Supplementary Tables from Targeting the Dependence on PIK3C3-mTORC1 Signaling in Dormancy-Prone Breast Cancer Cells Blunts Metastasis Initiation
Supplementary Tables from Targeting the Dependence on PIK3C3-mTORC1 Signaling in Dormancy-Prone Breast Cancer Cells Blunts Metastasis Initiation Open
Tables S1-S5
View article: Targeting the Dependence on PIK3C3-mTORC1 Signaling in Dormancy-Prone Breast Cancer Cells Blunts Metastasis Initiation
Targeting the Dependence on PIK3C3-mTORC1 Signaling in Dormancy-Prone Breast Cancer Cells Blunts Metastasis Initiation Open
Halting breast cancer metastatic relapse following primary tumor removal remains challenging due to a lack of specific vulnerabilities to target during the clinical dormancy phase. To identify such vulnerabilities, we conducted genome-wide…
View article: Supplementary Table 4 from FOXR2 Targets LHX6<sup>+</sup>/DLX<sup>+</sup> Neural Lineages to Drive Central Nervous System Neuroblastoma
Supplementary Table 4 from FOXR2 Targets LHX6<sup>+</sup>/DLX<sup>+</sup> Neural Lineages to Drive Central Nervous System Neuroblastoma Open
Quality control metrics and processing parameters for single-cell data for patient tumors.
View article: Supplementary Table 10 from FOXR2 Targets LHX6<sup>+</sup>/DLX<sup>+</sup> Neural Lineages to Drive Central Nervous System Neuroblastoma
Supplementary Table 10 from FOXR2 Targets LHX6<sup>+</sup>/DLX<sup>+</sup> Neural Lineages to Drive Central Nervous System Neuroblastoma Open
ssGSEA enrichment of cell type specific gene signatures in bulk RNAseq tumors. For each sample, the highest scoring signature is shown.
View article: Supplementary Table 5 from FOXR2 Targets LHX6<sup>+</sup>/DLX<sup>+</sup> Neural Lineages to Drive Central Nervous System Neuroblastoma
Supplementary Table 5 from FOXR2 Targets LHX6<sup>+</sup>/DLX<sup>+</sup> Neural Lineages to Drive Central Nervous System Neuroblastoma Open
Quality control metrics and processing parameters for single-cell data for murine models.
View article: Supplementary Figure 4 from FOXR2 Targets LHX6<sup>+</sup>/DLX<sup>+</sup> Neural Lineages to Drive Central Nervous System Neuroblastoma
Supplementary Figure 4 from FOXR2 Targets LHX6<sup>+</sup>/DLX<sup>+</sup> Neural Lineages to Drive Central Nervous System Neuroblastoma Open
Bulk RNAseq projections by ssGSEA.
View article: Figure 6 from FOXR2 Targets LHX6<sup>+</sup>/DLX<sup>+</sup> Neural Lineages to Drive Central Nervous System Neuroblastoma
Figure 6 from FOXR2 Targets LHX6<sup>+</sup>/DLX<sup>+</sup> Neural Lineages to Drive Central Nervous System Neuroblastoma Open
Mouse models transcriptomically recapitulate human NB-FOXR2. A, Heatmap showing CNVs in Foxr2 p53LOF and Foxr2 alone models, computed with inferCNV. B, Top, Uniform Manifold Approximation and Projecti…
View article: Supplementary Figure 1 from FOXR2 Targets LHX6<sup>+</sup>/DLX<sup>+</sup> Neural Lineages to Drive Central Nervous System Neuroblastoma
Supplementary Figure 1 from FOXR2 Targets LHX6<sup>+</sup>/DLX<sup>+</sup> Neural Lineages to Drive Central Nervous System Neuroblastoma Open
Quality control (QC) metrics and copy-number variation for scRNAseq datasets of NB-FOXR2 patient tumors.
View article: Supplementary Table 1 from FOXR2 Targets LHX6<sup>+</sup>/DLX<sup>+</sup> Neural Lineages to Drive Central Nervous System Neuroblastoma
Supplementary Table 1 from FOXR2 Targets LHX6<sup>+</sup>/DLX<sup>+</sup> Neural Lineages to Drive Central Nervous System Neuroblastoma Open
Analyses and materials related to murine IUE and orthotopic models.
View article: Supplementary Figure 5 from FOXR2 Targets LHX6<sup>+</sup>/DLX<sup>+</sup> Neural Lineages to Drive Central Nervous System Neuroblastoma
Supplementary Figure 5 from FOXR2 Targets LHX6<sup>+</sup>/DLX<sup>+</sup> Neural Lineages to Drive Central Nervous System Neuroblastoma Open
NB-FOXR2 tumors transcriptionally resemble interneurons and oligodendrocyte precursor cells.
View article: Supplementary Table 7 from FOXR2 Targets LHX6<sup>+</sup>/DLX<sup>+</sup> Neural Lineages to Drive Central Nervous System Neuroblastoma
Supplementary Table 7 from FOXR2 Targets LHX6<sup>+</sup>/DLX<sup>+</sup> Neural Lineages to Drive Central Nervous System Neuroblastoma Open
Reference dataset labels used for cell type annotation of mouse model single-cell datasets.
View article: Figure 3 from FOXR2 Targets LHX6<sup>+</sup>/DLX<sup>+</sup> Neural Lineages to Drive Central Nervous System Neuroblastoma
Figure 3 from FOXR2 Targets LHX6<sup>+</sup>/DLX<sup>+</sup> Neural Lineages to Drive Central Nervous System Neuroblastoma Open
FOXR2 does not induce expression of MGE or EC-NB TFs. A, Bulk RNA-seq expression of telencephalon patterning TFs. Top and third rows, tumor samples from this study cohort. Second row, EC-NB samples (Gartlgruber and colleagues…
View article: Supplementary Table 3 from FOXR2 Targets LHX6<sup>+</sup>/DLX<sup>+</sup> Neural Lineages to Drive Central Nervous System Neuroblastoma
Supplementary Table 3 from FOXR2 Targets LHX6<sup>+</sup>/DLX<sup>+</sup> Neural Lineages to Drive Central Nervous System Neuroblastoma Open
Post-alignment quality control for bulk RNAseq data for pediatric brain tumors.
View article: Supplementary Figure 6 from FOXR2 Targets LHX6<sup>+</sup>/DLX<sup>+</sup> Neural Lineages to Drive Central Nervous System Neuroblastoma
Supplementary Figure 6 from FOXR2 Targets LHX6<sup>+</sup>/DLX<sup>+</sup> Neural Lineages to Drive Central Nervous System Neuroblastoma Open
Mouse models transcriptomically recapitulate human NB-FOXR2
View article: Supplementary Figure 3 from FOXR2 Targets LHX6<sup>+</sup>/DLX<sup>+</sup> Neural Lineages to Drive Central Nervous System Neuroblastoma
Supplementary Figure 3 from FOXR2 Targets LHX6<sup>+</sup>/DLX<sup>+</sup> Neural Lineages to Drive Central Nervous System Neuroblastoma Open
NB-FOXR2 express a transcription factor fingerprint of the medial ganglionic eminence.
View article: Data from FOXR2 Targets LHX6<sup>+</sup>/DLX<sup>+</sup> Neural Lineages to Drive Central Nervous System Neuroblastoma
Data from FOXR2 Targets LHX6<sup>+</sup>/DLX<sup>+</sup> Neural Lineages to Drive Central Nervous System Neuroblastoma Open
Central nervous system neuroblastoma with forkhead box R2 (FOXR2) activation (NB-FOXR2) is a high-grade tumor of the brain hemispheres and a newly identified molecular entity. Tumors express dual neuronal and glial markers, l…
View article: Figure 7 from FOXR2 Targets LHX6<sup>+</sup>/DLX<sup>+</sup> Neural Lineages to Drive Central Nervous System Neuroblastoma
Figure 7 from FOXR2 Targets LHX6<sup>+</sup>/DLX<sup>+</sup> Neural Lineages to Drive Central Nervous System Neuroblastoma Open
Foxr2 chromatin binding sites in Foxr2 p53LOF neurosphere show enrichment in ETS and glial pathways. A, Validation of FOXR2 overexpression and p53 downregulation in ex vivoFoxr2 p53LOF neur…
View article: Figure 2 from FOXR2 Targets LHX6<sup>+</sup>/DLX<sup>+</sup> Neural Lineages to Drive Central Nervous System Neuroblastoma
Figure 2 from FOXR2 Targets LHX6<sup>+</sup>/DLX<sup>+</sup> Neural Lineages to Drive Central Nervous System Neuroblastoma Open
NB-FOXR2 expresses a TF fingerprint of the MGE. A, Expression of telencephalon-patterning TFs in the embryonal mouse brain. Top, stereo-seq in situ RNA expression of telencephalon-patterning TFs in E14 mouse (Chen and colleag…