Robert S. Hoffman
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View article: Dexmedetomidine for Alcohol Withdrawal: Looks Can Be Deceiving
Dexmedetomidine for Alcohol Withdrawal: Looks Can Be Deceiving Open
View article: 438 Hemp Legalization and Pediatric Cannabis Exposures in Texas: A 10-Year Retrospective Study
438 Hemp Legalization and Pediatric Cannabis Exposures in Texas: A 10-Year Retrospective Study Open
View article: A novel synonymous SGCA variant associated with arrhythmogenic cardiomyopathy in limb-girdle muscular dystrophy type 3
A novel synonymous SGCA variant associated with arrhythmogenic cardiomyopathy in limb-girdle muscular dystrophy type 3 Open
Background Limb-girdle muscular dystrophy type 3 (LGMDR3) is an autosomal recessive disorder caused by pathogenic variants in the SGCA gene encoding α-sarcoglycan. While LGMDR3 predominantly presents with progressive proximal muscle weakne…
View article: Effectiveness and tolerability of methylthioninium chloride (methylene blue) for the treatment of methemoglobinemia: twenty-four years of experience at a single poison center
Effectiveness and tolerability of methylthioninium chloride (methylene blue) for the treatment of methemoglobinemia: twenty-four years of experience at a single poison center Open
In this series, methylthioninium chloride was both efficacious and well tolerated in patients with methemoglobinemia, with a single dose of 1-2 mg/kg being sufficient to treat most patients.
View article: Neurotoxicity from Inordinate Valacyclovir Dosage in an Elderly Woman with Stage 5 Chronic Kidney Disease
Neurotoxicity from Inordinate Valacyclovir Dosage in an Elderly Woman with Stage 5 Chronic Kidney Disease Open
View article: Legislating the Final Frontier
Legislating the Final Frontier Open
The frontier of outer space has always been a compelling subject of interest, capturing the collective imagination of humanity for decades. Initially, the realm of space was not just a venue for scientific exploration and technological inn…
View article: Development and validation of quantitative PCR assays for HIV-associated cryptococcal meningitis in sub-Saharan Africa: a diagnostic accuracy study
Development and validation of quantitative PCR assays for HIV-associated cryptococcal meningitis in sub-Saharan Africa: a diagnostic accuracy study Open
European and Developing Countries Clinical Trials Partnership; Swedish International Development Cooperation Agency; Wellcome Trust/UK Medical Research Council/UKAID Joint Global Health Trials; and UK National Institute for Health Research.
View article: Successful Treatment of Confirmed Severe Bupropion Cardiotoxicity With Veno-Arterial Extracorporeal Membrane Oxygenation Initiation Prior to Cardiac Arrest
Successful Treatment of Confirmed Severe Bupropion Cardiotoxicity With Veno-Arterial Extracorporeal Membrane Oxygenation Initiation Prior to Cardiac Arrest Open
Bupropion is a substituted cathinone (β-keto amphetamine) norepinephrine/dopamine reuptake inhibitor andnoncompetitive nicotinic acetylcholine receptor antagonist that is frequently used to treat major depressive disorder. Bupropion overdo…
View article: Closing the xylazine knowledge gap
Closing the xylazine knowledge gap Open
View article: Confirmed Fatal Colchicine Poisoning in an Adolescent with Blood and Bile Concentrations—Implications for GI Decontamination?
Confirmed Fatal Colchicine Poisoning in an Adolescent with Blood and Bile Concentrations—Implications for GI Decontamination? Open
View article: Defining the roles of computed tomography and esophagogastroduodenoscopy in patients with caustic ingestions
Defining the roles of computed tomography and esophagogastroduodenoscopy in patients with caustic ingestions Open
View article: Ex vivo reprogramming of human hematopoietic stem cells is accompanied by increased transcripts of genes regulating metabolic integrity
Ex vivo reprogramming of human hematopoietic stem cells is accompanied by increased transcripts of genes regulating metabolic integrity Open
View article: Data from Correction of the Abnormal Trafficking of Primary Myelofibrosis CD34<sup>+</sup> Cells by Treatment with Chromatin-Modifying Agents
Data from Correction of the Abnormal Trafficking of Primary Myelofibrosis CD34<sup>+</sup> Cells by Treatment with Chromatin-Modifying Agents Open
The abnormal trafficking of CD34+ cells is a unique characteristic of primary myelofibrosis (PMF). We have further studied the behavior of PMF CD34+ cells by examining their homing to the marrow and the spleens of non…
View article: Extracorporeal treatment for ethylene glycol poisoning: systematic review and recommendations from the EXTRIP workgroup
Extracorporeal treatment for ethylene glycol poisoning: systematic review and recommendations from the EXTRIP workgroup Open
View article: Intralipid administration in case of a severe venlafaxine overdose in a patient with previous gastric bypass surgery
Intralipid administration in case of a severe venlafaxine overdose in a patient with previous gastric bypass surgery Open
View article: Extracorporeal Treatment for Methotrexate Poisoning: Systematic Review and Recommendations from the EXTRIP Workgroup.
Extracorporeal Treatment for Methotrexate Poisoning: Systematic Review and Recommendations from the EXTRIP Workgroup. Open
Methotrexate is used in the treatment of many malignancies, rheumatological diseases, and inflammatory bowel disease. Toxicity from use is associated with severe morbidity and mortality. Rescue treatments include intravenous hydration, fol…
View article: Extracorporeal Treatment for Methotrexate Poisoning
Extracorporeal Treatment for Methotrexate Poisoning Open
Methotrexate is used in the treatment of many malignancies, rheumatological diseases, and inflammatory bowel disease. Toxicity from use is associated with severe morbidity and mortality. Rescue treatments include intravenous hydration, fol…
View article: Meeting people where they are: implementing hospital-based substance use harm reduction
Meeting people where they are: implementing hospital-based substance use harm reduction Open
View article: Extracorporeal Treatment for Gabapentin and Pregabalin Poisoning: Systematic Review and Recommendations From the EXTRIP Workgroup
Extracorporeal Treatment for Gabapentin and Pregabalin Poisoning: Systematic Review and Recommendations From the EXTRIP Workgroup Open
View article: Recommendations for the Empirical Assessment of Human-AI Work Systems: A Contribution to AI Measurement Science
Recommendations for the Empirical Assessment of Human-AI Work Systems: A Contribution to AI Measurement Science Open
This Report is a companion to the Report titled "Requirements for the Evaluation of Human-AI Work Systems." Whereas that Report focused on the minimum necessary empirical requirements for the assessment of AI systems, this Report provides …
View article: The Plausibility Gap: A model of sensemaking
The Plausibility Gap: A model of sensemaking Open
When people make plausibility judgments about an assertion, an event, or a piece of evidence, they are gauging whether it makes sense. Therefore, we can treat plausibility judgments as sensemaking activities. In this paper, we review the r…
View article: Young Female With Seizure
Young Female With Seizure Open
View article: Systematic review on the use of activated charcoal for gastrointestinal decontamination following acute oral overdose
Systematic review on the use of activated charcoal for gastrointestinal decontamination following acute oral overdose Open
The use of activated charcoal in poisoning remains both a pillar of modern toxicology and a source of debate. Following the publication of the joint position statements on the use of single-dose and multiple-dose activated charcoal by the …
View article: Extracorporeal treatment for poisoning to beta-adrenergic antagonists: systematic review and recommendations from the EXTRIP workgroup
Extracorporeal treatment for poisoning to beta-adrenergic antagonists: systematic review and recommendations from the EXTRIP workgroup Open
View article: Response to "Ventricular Tachycardia in Association with Propafenone Overdose" by Hyun Kuk Kim.
Response to "Ventricular Tachycardia in Association with Propafenone Overdose" by Hyun Kuk Kim. Open
View article: A Report of Two Cases: Unlearning Lactic Acidosis
A Report of Two Cases: Unlearning Lactic Acidosis Open
Introduction: The term “lactic acidosis” reinforces the misconception that lactate contributes to acidemia. Although it is common to discover an anion gap acidosis with a concomitant elevated lactate concentration, the two are not mutually…
View article: Comparison of the EXtracorporeal TReatments In Poisoning (EXTRIP) and Paris criteria for neurotoxicity in lithium poisoned patients
Comparison of the EXtracorporeal TReatments In Poisoning (EXTRIP) and Paris criteria for neurotoxicity in lithium poisoned patients Open
Aims Two guidelines for haemodialysis in lithium poisoning, one from the Extracorporeal TReatments in Poisoning (EXTRIP) workgroup and a single centre retrospective one (Paris) differ. We compared outcomes in lithium poisoning based on the…
View article: An Outline of the Outset of Thrombopoiesis in Human Embryos At Last
An Outline of the Outset of Thrombopoiesis in Human Embryos At Last Open
View article: Distinguishing between toxic alcohol ingestion vs alcoholic ketoacidosis: how can we tell the difference?
Distinguishing between toxic alcohol ingestion vs alcoholic ketoacidosis: how can we tell the difference? Open
In this retrospective analysis, the odds of diagnosing AKA instead of TA ingestion increased as ethanol concentration increased. The limited ability of common clinical factors to differentiate these diagnoses highlights the need to obtain …
View article: Comparison of the Extracorporeal Treatments in Poisoning (EXTRIP) and Paris Criteria for Lithium Poisoned Patients
Comparison of the Extracorporeal Treatments in Poisoning (EXTRIP) and Paris Criteria for Lithium Poisoned Patients Open
Aim: Two recommendations for hemodialysis in lithium poisoning, one from the Extracorporeal TReatments in Poisoning (EXTRIP) workgroup and a single center retrospective one (Paris), differ. We compared outcomes in lithium poisoning based o…