Silke Hofmann
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View article: Treatment Preferences Among Systemic Therapy-Naïve Patients with Atopic Dermatitis or Psoriasis in Germany: A Multicentre Study
Treatment Preferences Among Systemic Therapy-Naïve Patients with Atopic Dermatitis or Psoriasis in Germany: A Multicentre Study Open
Most topically treated patients with moderate-to-severe AD or PSO desire systemic therapy, with distinct disease-specific administration preferences.
View article: Bronchiolitis Obliterans in a Young Female Patient with Paraneoplastic Pemphigus Associated with Unicentric Castleman’s Disease
Bronchiolitis Obliterans in a Young Female Patient with Paraneoplastic Pemphigus Associated with Unicentric Castleman’s Disease Open
Background: Castleman’s disease (CD), also known as angiofollicular lymph node hyperplasia, describes a rare group of diseases manifesting with enlarged lymph nodes and various inflammatory symptoms. The association between Castleman’s dis…
View article: Avapritinib reduces symptoms and mast cell burden in systemic mastocytosis
Avapritinib reduces symptoms and mast cell burden in systemic mastocytosis Open
Background Mastocytosis is driven by a clonal expansion of mast cells, commonly triggered by the KIT D816V mutation which is present in over 90% of adult patients. Individuals with indolent systemic mastocytosis (ISM) frequently experience…
View article: Improved survival of advanced melanoma patients receiving immunotherapy with concomitant antithrombotic therapy – A multicenter study on 2419 patients from the prospective skin cancer registry ADOReg
Improved survival of advanced melanoma patients receiving immunotherapy with concomitant antithrombotic therapy – A multicenter study on 2419 patients from the prospective skin cancer registry ADOReg Open
Our study indicates a positive prognostic effect of anticoagulant and antiplatelet concomitant medication in melanoma patients receiving ICI. Further studies are needed to confrim the cancer-related benefit of adding anticoagulation or pla…
View article: S3 guideline: Diagnosis and treatment of epidermal necrolysis (Stevens‐Johnson syndrome and toxic epidermal necrolysis) – Part 2: Supportive therapy of EN in the acute and post‐acute stages
S3 guideline: Diagnosis and treatment of epidermal necrolysis (Stevens‐Johnson syndrome and toxic epidermal necrolysis) – Part 2: Supportive therapy of EN in the acute and post‐acute stages Open
Summary Stevens‐Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) are rare, predominantly drug‐induced, acute life‐threatening diseases of skin and mucosae. SJS and TEN are nowadays considered as variants of one disease entity with…
View article: Novel Onset of Cutaneous Lupus Erythematosus Induced by Pembrolizumab
Novel Onset of Cutaneous Lupus Erythematosus Induced by Pembrolizumab Open
is missing (Short Communication)
View article: S3 guideline: Diagnosis and treatment of epidermal necrolysis (Stevens‐Johnson syndrome and toxic epidermal necrolysis) – Part 1: Diagnosis, initial management, and immunomodulating systemic therapy
S3 guideline: Diagnosis and treatment of epidermal necrolysis (Stevens‐Johnson syndrome and toxic epidermal necrolysis) – Part 1: Diagnosis, initial management, and immunomodulating systemic therapy Open
Summary Stevens‐Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) are rare, predominantly drug‐induced, acute, life‐threatening diseases of skin and mucosae. SJS and TEN are nowadays considered variants of one disease entity with v…
View article: Photodynamic therapy in dermatology: established and new indications
Photodynamic therapy in dermatology: established and new indications Open
Summary Photodynamic therapy (PDT) is internationally established as an approved treatment option for in situ forms of keratinocytic skin cancer (actinic keratoses, Bowen's disease, basal cell carcinoma). For these indications, there are s…
View article: Hydrochlorothiazide and increased risk of atypical fibroxanthoma and pleomorphic dermal sarcoma
Hydrochlorothiazide and increased risk of atypical fibroxanthoma and pleomorphic dermal sarcoma Open
Summary Background and Objectives Previous work has demonstrated that hydrochlorothiazide (HCTZ) is a risk factor for squamous cell carcinomas (SCC) and basal cell carcinomas (BCC) due to pro‐photocarcinogenic effects. Atypical fibroxantho…
View article: Telephone follow‐up after outpatient nail surgery – a retrospective analysis
Telephone follow‐up after outpatient nail surgery – a retrospective analysis Open
Summary Background One of the areas of care in dermatosurgery is the surgical treatment of diseases of the nail organ. Side effects and complications after nail surgery were investigated by telephone follow‐up (TFU), and its suitability fo…
View article: S2k guidelines on diagnosis and treatment of linear <scp>IgA</scp> dermatosis initiated by the European Academy of Dermatology and Venereology
S2k guidelines on diagnosis and treatment of linear <span>IgA</span> dermatosis initiated by the European Academy of Dermatology and Venereology Open
Introduction Linear IgA dermatosis (LAD) is a rare subepidermal autoimmune bullous disease (AIBD) defined by predominant or exclusive immune deposits of immunoglobulin A at the basement membrane zone of skin or mucous membranes. This disor…
View article: Allergic Reaction to a Commercially Available Insect Snack Caused by House Cricket (<i>Acheta domesticus</i>) Tropomyosin
Allergic Reaction to a Commercially Available Insect Snack Caused by House Cricket (<i>Acheta domesticus</i>) Tropomyosin Open
Scope Edible insects contain allergens with potential cross‐reactivity to other invertebrates. Here, this study examines IgE‐reactive proteins in a house cricket snack ( Acheta domesticus ) leading to an allergic reaction in a 27‐year old …
View article: Corrigendum: S2k guidelines on the management of paraneoplastic pemphigus/paraneoplastic autoimmune multiorgan syndrome initiated by the European Academy of Dermatology and Venereology (<scp>EADV</scp>)
Corrigendum: S2k guidelines on the management of paraneoplastic pemphigus/paraneoplastic autoimmune multiorgan syndrome initiated by the European Academy of Dermatology and Venereology (<span>EADV</span>) Open
Correction for the following article: S2k guidelines on the management of paraneoplastic pemphigus/paraneoplastic autoimmune multiorgan syndrome initiated by the European Academy of Dermatology and Venereology (EADV)
View article: Paradoxical tralokinumab-induced psoriasis in a patient with atopic dermatitis
Paradoxical tralokinumab-induced psoriasis in a patient with atopic dermatitis Open
Purpose: Although psoriasis and atopic dermatitis (AD) were for decades considered to be opposing diseases, it is now known that these skin conditions can coexist or even overlap in the same individual. Especially when using modern drugs w…
View article: Bronchiolitis obliterans in a young female patient with paraneoplastic pemphigus associated with unicentric Castelman's disease
Bronchiolitis obliterans in a young female patient with paraneoplastic pemphigus associated with unicentric Castelman's disease Open
Background: Castelman’s disease (CD), also known as angiofollicular lymph node hyperplasia, describes a rare group of diseases manifesting with enlarged lymph nodes and various inflammatory symptoms. The association between Castelman’s dis…
View article: Effects of the COVID‐19 pandemic on inpatient skin surgery in Germany: results of the DESSI‐survey
Effects of the COVID‐19 pandemic on inpatient skin surgery in Germany: results of the DESSI‐survey Open
Summary Background The aim of the survey was to investigate a possible impairment of inpatient dermatological and dermatosurgical care in Germany due to the COVID‐19 pandemic. Methods An online survey on the impact of pandemic‐related meas…
View article: S2k guidelines on the management of paraneoplastic pemphigus/paraneoplastic autoimmune multiorgan syndrome initiated by the European Academy of Dermatology and Venereology (<scp>EADV</scp>)
S2k guidelines on the management of paraneoplastic pemphigus/paraneoplastic autoimmune multiorgan syndrome initiated by the European Academy of Dermatology and Venereology (<span>EADV</span>) Open
Background Paraneoplastic pemphigus (PNP), also called paraneoplastic autoimmune multiorgan syndrome (PAMS), is a rare autoimmune disease with mucocutaneous and multi‐organ involvement. PNP/PAMS is typically associated with lymphoprolifera…
View article: Medical error analysis in dermatology according to the reports of the North Rhine Medical Association from 2004 to 2018
Medical error analysis in dermatology according to the reports of the North Rhine Medical Association from 2004 to 2018 Open
Summary Background Assessment of complaints addressed to the Expert Committee for Medical Malpractice Claims of the North Rhine Medical Association helps to identify quality assurance problems in dermatology. Methods 333 dermatological rep…
View article: Increase of atypical fibroxanthoma and pleomorphic dermal sarcoma: a retrospective analysis of four German skin cancer centers
Increase of atypical fibroxanthoma and pleomorphic dermal sarcoma: a retrospective analysis of four German skin cancer centers Open
Summary Background and objectives In recent years, considerable insight has been gained into the pathogenesis, diagnosis and treatment of cutaneous sarcomas, including atypical fibroxanthoma (AFX) and pleomorphic dermal sarcoma (PDS). Both…
View article: S2k Guideline for the diagnosis and treatment of mucous membrane pemphigoid
S2k Guideline for the diagnosis and treatment of mucous membrane pemphigoid Open
Summary Mucous membrane pemphigoid (MMP) is a pemphigoid disease with predominant mucous membrane involvement. It mainly affects the mucous membranes of the mouth, eyes, nose and pharynx, but also the larynx, trachea, esophagus, genital an…
View article: Lipid transfer protein allergy: characterization and comparison to birch‐related food allergy
Lipid transfer protein allergy: characterization and comparison to birch‐related food allergy Open
Summary Background Lipid transfer proteins (LTP) are a frequent elicitor of anaphylaxis to plant‐derived food allergens in southern Europe. Patients and methods 15 German patients with LTP allergy were compared to 17 patients with birch‐re…
View article: Updated<scp>S2</scp>K guidelines for the management of bullous pemphigoid initiated by the European Academy of Dermatology and Venereology (<scp>EADV</scp>)
Updated<span>S2</span>K guidelines for the management of bullous pemphigoid initiated by the European Academy of Dermatology and Venereology (<span>EADV</span>) Open
Background Bullous pemphigoid (BP) is the most common autoimmune subepidermal blistering disease of the skin and mucous membranes. This disease typically affects the elderly and presents with itch and localized or, most frequently, general…
View article: Autoreactivity to BP180 Neoepitopes in Patients With Pemphigoid Gestationis
Autoreactivity to BP180 Neoepitopes in Patients With Pemphigoid Gestationis Open
This case series characterizes immune profiles of pregnant people with pemphigoid gestationis.
View article: Isotretinoin-associated exercise-induced anaphylaxis in a patient with birch pollinosis and soybean sensitization: case presentation and literature review
Isotretinoin-associated exercise-induced anaphylaxis in a patient with birch pollinosis and soybean sensitization: case presentation and literature review Open
Background Peanut and soybean allergies are listed as contraindication in the package leaflet of isotretinoin, a widely used treatment of acne vulgaris. Cross-reactivity between PR10-proteins in peanut, tree nuts, and soybean is particular…