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View article: Benefits of an Innovative 90-Day Longevity Workplace Program on Health in the United Arab Emirates (UAE)
Benefits of an Innovative 90-Day Longevity Workplace Program on Health in the United Arab Emirates (UAE) Open
Unhealthy lifestyle behaviors, such as physical inactivity and an unhealthy diet, can decrease quality of life and increase the risk of obesity, depression, and chronic diseases like diabetes and cardiovascular disease. In workplace settin…
View article: The formation and function of calciprotein particles
The formation and function of calciprotein particles Open
View article: Simultaneous Measurement of Calciprotein Particles with Different Assays and Clinical Outcomes in CKD
Simultaneous Measurement of Calciprotein Particles with Different Assays and Clinical Outcomes in CKD Open
Key Points Multiple assays are available to measure calciprotein particles (CPP), but a direct comparison of their association with clinical outcomes is lacking. Higher levels of high-density CPP and secondary CPP were independently associ…
View article: Decarbonisation of Kidney Care in the United Arab Emirates: A Roadmap to an Environmentally Sustainable Care
Decarbonisation of Kidney Care in the United Arab Emirates: A Roadmap to an Environmentally Sustainable Care Open
Chronic kidney disease (CKD) remains a major public health burden and a leading cause of mortality worldwide and in the United Arab Emirates (UAE). Alongside its clinical and humanistic burden, CKD care is associated with a significant car…
View article: Projecting the clinical burden of chronic kidney disease at the patient level (Inside CKD): a microsimulation modelling study
Projecting the clinical burden of chronic kidney disease at the patient level (Inside CKD): a microsimulation modelling study Open
AstraZeneca.
View article: #294 Pragmatic literature reviews to populate a patient-level model to project the future clinical burden of CKD in low-and middle-income countries
#294 Pragmatic literature reviews to populate a patient-level model to project the future clinical burden of CKD in low-and middle-income countries Open
Background and Aims Chronic Kidney Disease (CKD) affects approximately one in ten people around the world and is associated with an increased risk of adverse cardiorenal outcomes and mortality. In low- and middle-income countries (LMICs), …
View article: Gender, age and nationality differences in chronic kidney disease prevalence in the emirate of <scp>Abu Dhabi</scp>, <scp>UAE</scp>
Gender, age and nationality differences in chronic kidney disease prevalence in the emirate of <span>Abu Dhabi</span>, <span>UAE</span> Open
Aim We aimed to better understand the prevalence of chronic kidney disease in Abu Dhabi, UAE, where a very diverse ethnic population lives, each with their own risk profile. Methods Data were analysed on all patients who were tested for se…
View article: Role of CaMKII in diabetes induced vascular injury and its interaction with anti-diabetes therapy
Role of CaMKII in diabetes induced vascular injury and its interaction with anti-diabetes therapy Open
View article: The Australian and New Zealand dialysis workforce study 2021
The Australian and New Zealand dialysis workforce study 2021 Open
Background Quality dialysis care is associated with appropriate staffing levels of trained and educated health professionals. Dialysis workforce models are rapidly changing, requiring workforce analysis to be performed. Aim To identify cur…
View article: Solid Organ Transplantation from SARS-CoV-2–infected Donor to UninfectedRecipients: First in the United Arab Emirates and the Neighboring Region
Solid Organ Transplantation from SARS-CoV-2–infected Donor to UninfectedRecipients: First in the United Arab Emirates and the Neighboring Region Open
Introduction: The lifesaving practice of organ donation and transplantation has been deeply impacted by the COVID-19 pandemic. Up until January 2022, donors were screened out of the donor pool in the UAE if they tested positive for SARS-CO…
View article: Effect of the phosphate binder sucroferric oxyhydroxide in dialysis patients on endogenous calciprotein particles, inflammation, and vascular cells
Effect of the phosphate binder sucroferric oxyhydroxide in dialysis patients on endogenous calciprotein particles, inflammation, and vascular cells Open
Background Calciprotein particles (CPPs), colloidal mineral-protein nanoparticles, have emerged as potential mediators of phosphate toxicity in dialysis patients, with putative links to vascular calcification, endothelial dysfunction and i…
View article: The Omicron <scp>COVID</scp>‐19 threat to dialysis patients is dramatically lower than previous variants
The Omicron <span>COVID</span>‐19 threat to dialysis patients is dramatically lower than previous variants Open
In 2021, we reported the mortality of the first waves of COVID-19 in dialysis patients,1 and on the antibody efficiency of the SinoPharm vaccine in this patient group.2 Whilst spike antibody levels were sufficiently induced in ~50% of pati…
View article: Reduced hip bone mineral density is associated with high levels of calciprotein particles in patients with Fabry disease
Reduced hip bone mineral density is associated with high levels of calciprotein particles in patients with Fabry disease Open
View article: Effect of lanthanum carbonate on serum calciprotein particles in patients with stage 3–4 CKD—results from a placebo-controlled randomized trial
Effect of lanthanum carbonate on serum calciprotein particles in patients with stage 3–4 CKD—results from a placebo-controlled randomized trial Open
Background Calciprotein particles (CPP) are colloidal aggregates of calcium phosphate and the mineral-binding protein fetuin-A, and are potential mediators of cardiovascular disease in chronic kidney disease (CKD). Emerging evidence sugges…
View article: Coronavirus Disease 2019 Infection and ABO Blood Groups in a Hemodialysis Cohort in the United Arab Emirates
Coronavirus Disease 2019 Infection and ABO Blood Groups in a Hemodialysis Cohort in the United Arab Emirates Open
Some epidemiological data have implicated blood groups in susceptibility to coronavirus disease 2019 (COVID-19) infection. We were interested to see if there was any apparent effect of different ABO blood groups on susceptibility to COVID-…
View article: An analysis of antibody responses and clinical sequalae of the Sinopharm <scp>HB02 COVID19</scp> vaccine in dialysis patients in the <scp>United Arab Emirates</scp>
An analysis of antibody responses and clinical sequalae of the Sinopharm <span>HB02 COVID19</span> vaccine in dialysis patients in the <span>United Arab Emirates</span> Open
Aim To establish the responses to the Sinopharm HB02 COVID‐19 vaccination in the dialysis population, which are not well established. We examined the humoral responses to the Sinopharm COVID vaccine in haemodialysis patients. Methods Stand…
View article: Reduction of Calciprotein Particles in Adults Receiving Infliximab for Chronic Inflammatory Disease
Reduction of Calciprotein Particles in Adults Receiving Infliximab for Chronic Inflammatory Disease Open
Patients with chronic inflammatory diseases (CID) experience accelerated loss of bone mineral density, which is often accompanied by increased vascular calcification. These disturbances can be attenuated by therapies for inflammation, such…
View article: Hepatitis B related dilemmas in the renal unit
Hepatitis B related dilemmas in the renal unit Open
Testing for hepatitis B in dialysis patients is routine, but newer and more sensitive detection methods mean that there is sometimes confusion around viral loads and occult infection. There are frequently difficult choices surrounding isol…
View article: Outcomes of patients with End Stage Kidney Disease on dialysis with COVID-19. From PCR to Antibody.
Outcomes of patients with End Stage Kidney Disease on dialysis with COVID-19. From PCR to Antibody. Open
Background: End stage kidney disease patients on maintenance dialysis are vulnerable to contract COVID-19 infection and variable degrees of disease severity have been reported. SEHA Kidney Care (SKC) is the largest provider of dialysis ser…
View article: A Randomized Trial on the Effect of Phosphate Reduction on Vascular End Points in CKD (IMPROVE-CKD)
A Randomized Trial on the Effect of Phosphate Reduction on Vascular End Points in CKD (IMPROVE-CKD) Open
Significance Statement In patients with CKD, higher serum phosphate levels are associated with increased fibroblast growth factor 23 (FGF23) levels, arterial calcification, and cardiovascular mortality. Limited trials assessing phosphate-l…
View article: Noninfectious mixed cryoglobulinaemic glomerulonephritis and monoclonal gammopathy of undetermined significance: a coincidental association?
Noninfectious mixed cryoglobulinaemic glomerulonephritis and monoclonal gammopathy of undetermined significance: a coincidental association? Open
View article: Vascular calcification in skin and subcutaneous tissue in patients with chronic and end-stage kidney disease
Vascular calcification in skin and subcutaneous tissue in patients with chronic and end-stage kidney disease Open
View article: The potential role of antibodies against minor blood group antigens in renal transplantation
The potential role of antibodies against minor blood group antigens in renal transplantation Open
Blood group antigens are red blood cell (RBC) surface markers comprising specific carbohydrate moieties attached to the glycolipids and glycoproteins within the membrane. In addition to the major ABO blood group antigens, at least 35 minor…
View article: Effect of Sevelamer on Calciprotein Particles in Hemodialysis Patients: The Sevelamer Versus Calcium to Reduce Fetuin-A-Containing Calciprotein Particles in Dialysis (SCaRF) Randomized Controlled Trial
Effect of Sevelamer on Calciprotein Particles in Hemodialysis Patients: The Sevelamer Versus Calcium to Reduce Fetuin-A-Containing Calciprotein Particles in Dialysis (SCaRF) Randomized Controlled Trial Open
Compared with treatment with CC, use of sevelamer for 24 weeks was associated with lower serum CPP-1 levels and a reduction in aPWV and systemic inflammation.
View article: Noninfectious mixed cryoglobulinaemic glomerulonephritis associated with monoclonal gammopathy of undetermined significance
Noninfectious mixed cryoglobulinaemic glomerulonephritis associated with monoclonal gammopathy of undetermined significance Open
Background Cryoglobulins are cold-precipitable immunoglobulins that may be found in association with systemic vasculitis including cryoglobulinaemic glomerulonephritis (CGN). Type 1 cryoglobulins consist of isolated monoclonal immunoglobul…
View article: SUN-097 APOA1-MIMETIC PEPTIDES ENHANCE CELLULAR CLEARANCE OF CALCIPROTEIN PARTICLES AND ATTENUATE INFLAMMATORY PRIMING
SUN-097 APOA1-MIMETIC PEPTIDES ENHANCE CELLULAR CLEARANCE OF CALCIPROTEIN PARTICLES AND ATTENUATE INFLAMMATORY PRIMING Open
Calciprotein particles (CPP) - colloidal nanoaggregates of calcium phosphate mineral, proteins and other biomolecules - have emerged as potential mediators of pro-inflammatory mineral stress in CKD. Transformation of CPP to the crystalline…
View article: SAT-477 INDIVIDUAL VERSUS GROUP CHRONIC KIDNEY DISEASE EDUCATION
SAT-477 INDIVIDUAL VERSUS GROUP CHRONIC KIDNEY DISEASE EDUCATION Open
Patients with chronic kidney disease (CKD) who are approaching the need for renal replacement therapy (RRT) benefit from some form of education on their treatment options. This education should include information on transplantation, all d…
View article: SUN-094 A RANDOMISED CROSS-OVER TRIAL OF THE EFFECTS OF CALCIUM CARBONATE AND SEVELAMER PHOSPHATE BINDERS ON CALCIPROTEIN PARTICLES IN PREVALENT HAEMODIALYSIS PATIENTS
SUN-094 A RANDOMISED CROSS-OVER TRIAL OF THE EFFECTS OF CALCIUM CARBONATE AND SEVELAMER PHOSPHATE BINDERS ON CALCIPROTEIN PARTICLES IN PREVALENT HAEMODIALYSIS PATIENTS Open
Conclusions:The mechanisms of damage to the heart and blood vessels in patients with CKD begin to function already in the initial stage of renal failure and increase as it progresses.The need to know the data of clinical, laboratory and in…
View article: Monitoring skin temperature at the wrist in hospitalised patients may assist in the detection of infection
Monitoring skin temperature at the wrist in hospitalised patients may assist in the detection of infection Open
Background Measuring temperature has always been a key observation in the diagnosis of infection. No studies have examined the usefulness of measuring temperature at the wrist to detect infection. Aim We sought to determine whether a watch…
View article: αKlotho–FGF23 interactions and their role in kidney disease: a molecular insight
αKlotho–FGF23 interactions and their role in kidney disease: a molecular insight Open
Following the serendipitous discovery of the ageing suppressor, αKlotho (αKl), several decades ago, a growing body of evidence has defined a pivotal role for its various forms in multiple aspects of vertebrate physiology and pathology. The…