Scott M. Husson
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View article: Techno‐Economic Analysis of Membrane‐Based Purification Platforms for AAV Vector Production
Techno‐Economic Analysis of Membrane‐Based Purification Platforms for AAV Vector Production Open
Technologies for large‐scale manufacturing of viral vectors for gene therapies, such as tangential flow filtration and membrane chromatography, are under development. In these early stages of process development, techno‐economic analyses a…
View article: Techno‐economic analysis of membrane‐based continuous capture chromatography platforms for large‐scale antibody production
Techno‐economic analysis of membrane‐based continuous capture chromatography platforms for large‐scale antibody production Open
Continuous manufacturing platforms and membrane chromatography are process technologies with the potential to reduce production costs and minimize process variability in monoclonal antibody production. This study presents a simulation and …
View article: Revealing the spatiotemporal dynamics of protein fouling on micropatterned ultrafiltration membranes by in-situ visualization
Revealing the spatiotemporal dynamics of protein fouling on micropatterned ultrafiltration membranes by in-situ visualization Open
View article: Purifying circular RNA by ultrafiltration
Purifying circular RNA by ultrafiltration Open
Developing messenger RNA (mRNA) vaccines for COVID-19 renewed and intensified the interest in using mRNA for disease prevention and treatment. Despite their efficacy, linear mRNA molecules are short-lived in the human body, primarily due t…
View article: Revealing the Spatiotemporal Dynamics of Protein Fouling on Micropatterned Ultrafiltration Membranes by In-Situ Visualization
Revealing the Spatiotemporal Dynamics of Protein Fouling on Micropatterned Ultrafiltration Membranes by In-Situ Visualization Open
View article: Purifying circular RNA by ultrafiltration
Purifying circular RNA by ultrafiltration Open
Developing messenger RNA (mRNA) vaccines for COVID-19 renewed and intensified the interest in using mRNA for disease prevention and treatment. Despite their efficacy, linear mRNA molecules are short-lived in the human body, primarily due t…
View article: A Novel Method for Separating Full and Empty Adeno-Associated Viral Capsids Using Ultrafiltration
A Novel Method for Separating Full and Empty Adeno-Associated Viral Capsids Using Ultrafiltration Open
Adeno-associated viral vectors (AAVs) are the predominant viral vectors used for gene therapy applications. A significant challenge in obtaining effective doses is removing non-therapeutic empty viral capsids lacking DNA cargo. Current met…
View article: Preparation of Protein A Membranes Using Propargyl Methacrylate-Based Copolymers and Copper-Catalyzed Alkyne–Azide Click Chemistry
Preparation of Protein A Membranes Using Propargyl Methacrylate-Based Copolymers and Copper-Catalyzed Alkyne–Azide Click Chemistry Open
The development of convective technologies for antibody purification is of interest to the bioprocessing industries. This study developed a Protein A membrane using a combination of graft polymerization and copper(I)-catalyzed alkyne–azide…
View article: Preparation of Protein A Membrane Adsorbers Using Strain-Promoted, Copper-Free Dibenzocyclooctyne (DBCO)-Azide Click Chemistry
Preparation of Protein A Membrane Adsorbers Using Strain-Promoted, Copper-Free Dibenzocyclooctyne (DBCO)-Azide Click Chemistry Open
Protein A chromatography is the preferred unit operation for purifying Fc-based proteins. Convective chromatography technologies, like membrane adsorbers, can perform the purification rapidly and improve throughput dramatically. While the …
View article: Comparative Evaluation of Commercial Protein A Membranes for the Rapid Purification of Antibodies
Comparative Evaluation of Commercial Protein A Membranes for the Rapid Purification of Antibodies Open
Protein A chromatography is ubiquitous to antibody purification. The high specificity of Protein A for binding the Fc-region of antibodies and related products enables unmatched clearance of process impurities like host cell proteins, DNA,…
View article: Surrogate-based optimization of capture chromatography platforms for the improvement of computational efficiency
Surrogate-based optimization of capture chromatography platforms for the improvement of computational efficiency Open
View article: Acid sorption regeneration process using carbon dioxide
Acid sorption regeneration process using carbon dioxide Open
Carboxylic acids are sorbed from aqueous feedstocks onto a solid adsorbent in the presence of carbon dioxide under pressure. The acids are freed from the sorbent phase by a suitable regeneration method, one of which is treating them with a…
View article: Regeneration of carboxylic acid-laden basic sorbents by leaching with a volatile base in an organic solvent
Regeneration of carboxylic acid-laden basic sorbents by leaching with a volatile base in an organic solvent Open
Carboxylic acids are sorbed from aqueous feedstocks onto a solid adsorbent. The acids are freed from the sorbent phase by treating it with an organic solution of alkylamine thus forming an alkylamine/carboxylic acid complex which is decomp…
View article: Computational framework for the techno-economic analysis of monoclonal antibody capture chromatography platforms
Computational framework for the techno-economic analysis of monoclonal antibody capture chromatography platforms Open
View article: Efficient Retention and Alpha Spectroscopy of Actinides from Aqueous Solutions Using a Combination of Water-Soluble Star-like Polymers and Ultrafiltration Membranes
Efficient Retention and Alpha Spectroscopy of Actinides from Aqueous Solutions Using a Combination of Water-Soluble Star-like Polymers and Ultrafiltration Membranes Open
We explored two approaches to recover uranium and plutonium from aqueous solutions at pH 4 and pH 7 using water-soluble star-like polyacrylamide polymers with a dextran core. In the first approach, a solution comprising a neutral or ionome…
View article: Water Recovery from Bioreactor Mixed Liquors Using Forward Osmosis with Polyelectrolyte Draw Solutions
Water Recovery from Bioreactor Mixed Liquors Using Forward Osmosis with Polyelectrolyte Draw Solutions Open
This paper reports on the use of forward osmosis (FO) with polyelectrolyte draw solutions to recover water from bioreactor mixed liquors. The work was motivated by the need for new regenerative water purification technologies to enable lon…
View article: Membranes for the Capture and Screening of Waterborne Plutonium Based on a Novel Pu-Extractive Copolymer Additive
Membranes for the Capture and Screening of Waterborne Plutonium Based on a Novel Pu-Extractive Copolymer Additive Open
This contribution describes the fabrication of plutonium-adsorptive membranes by non-solvent induced phase separation. The dope solution comprised poly(vinylidene fluoride) (PVDF) and a Pu-extractive copolymer additive of PVDF-g-poly(ethyl…
View article: Evaluating Protein Fouling on Membranes Patterned by Woven Mesh Fabrics
Evaluating Protein Fouling on Membranes Patterned by Woven Mesh Fabrics Open
Membrane surface patterning is one approach used to mitigate fouling. This study used a combination of flux decline measurements and visualization experiments to evaluate the effectiveness of a microscale herringbone pattern for reducing p…
View article: Understanding the Role of Pattern Geometry on Nanofiltration Threshold Flux
Understanding the Role of Pattern Geometry on Nanofiltration Threshold Flux Open
Colloidal fouling can be mitigated by membrane surface patterning. This contribution identifies the effect of different pattern geometries on fouling behavior. Nanoscale line-and-groove patterns with different feature sizes were applied by…
View article: A Professional Development Survey For Engineering Undergraduates
A Professional Development Survey For Engineering Undergraduates Open
NOTE: The first page of text has been automatically extracted and included below in lieu of an abstract A Professional Development Survey for Engineering Undergraduates D.M. Switzer‡, D.A. Bruce†, C.H. Gooding†, G.M. Harrison†, D.E. Hirt†,…
View article: Implementing And Assessing A Hierarchical Cognitive Model To Educate Engineering Undergraduates
Implementing And Assessing A Hierarchical Cognitive Model To Educate Engineering Undergraduates Open
NOTE: The first page of text has been automatically extracted and included below in lieu of an abstract Implementing and Assessing a Hierarchical Cognitive Model to Educate Engineering Undergraduates D.M. Switzer‡, S.M. Husson†, D.A. Bruce…
View article: Applying A Hierarchical Model Of Mental Growth To Educate Undergraduate Engineering Students: Preliminary Assessment
Applying A Hierarchical Model Of Mental Growth To Educate Undergraduate Engineering Students: Preliminary Assessment Open
NOTE: The first page of text has been automatically extracted and included below in lieu of an abstract Main Menu Session 1330 Applying a Hierarchical Model of Mental Growth to Educate Undergraduate Engineering Students: Preliminary Assess…
View article: Numerical simulation of chemical separations using multimodal adsorption isotherms
Numerical simulation of chemical separations using multimodal adsorption isotherms Open
High demand for next-generation biotherapeutics requires the development of novel adsorptive chromatography media to ensure high-volume throughput of purified product. These media use multiple modes of interaction with the product to recov…
View article: Direct ellipsometry for non-destructive characterization of interfacially-polymerized thin-film composite membranes
Direct ellipsometry for non-destructive characterization of interfacially-polymerized thin-film composite membranes Open
View article: Functionalized Polymer Thin Films for Plutonium Capture and Isotopic Screening from Aqueous Sources
Functionalized Polymer Thin Films for Plutonium Capture and Isotopic Screening from Aqueous Sources Open
The rapid screening of plutonium from aqueous sources remains a critical challenge for nuclear nonproliferation efforts. The determination of trace-level Pu isotopes in water requires offsite sample preparation and analysis; therefore, new…
View article: Effect of Short-Term Contact with C1–C4 Monohydric Alcohols on the Water Permeance of MPD-TMC Thin-Film Composite Reverse Osmosis Membranes
Effect of Short-Term Contact with C1–C4 Monohydric Alcohols on the Water Permeance of MPD-TMC Thin-Film Composite Reverse Osmosis Membranes Open
In this paper, we discuss the effect of alcohol contact on the transport properties of thin-film composite reverse osmosis membranes. Five commercial membranes were studied to quantify the changes in water permeance and sodium chloride rej…
View article: Role of Nanocomposite Support Stiffness on TFC Membrane Water Permeance
Role of Nanocomposite Support Stiffness on TFC Membrane Water Permeance Open
This paper discusses the role played by the mechanical stiffness of porous nanocomposite supports on thin-film composite (TFC) membrane water permeance. Helically coiled and multiwall carbon nanotubes (CNTs) were studied as additives in th…
View article: Anion-exchange polymer filament coating for ultra-trace isotopic analysis of plutonium by thermal ionization mass spectrometry
Anion-exchange polymer filament coating for ultra-trace isotopic analysis of plutonium by thermal ionization mass spectrometry Open
View article: Low-Energy Membrane Process for Concentration of Stick Water
Low-Energy Membrane Process for Concentration of Stick Water Open
This communication describes the application of forward osmosis (FO) to concentrate stick water, a nutrient-rich water byproduct of meat rendering operations. The objectives of the study were to carry out a set of batch FO runs in concentr…
View article: Hybrid Nanoparticle–Polymer Brush Composites for Detection of Low‐Level Radiostrontium in Water
Hybrid Nanoparticle–Polymer Brush Composites for Detection of Low‐Level Radiostrontium in Water Open
Combining extraction and scintillation properties within the same material is a relatively new approach in development of sensors for detection of radioactive elements. Structural organization of such materials at a nanoscale typically off…