Mohammad Saeid Hejazi
YOU?
Author Swipe
View article: Growth inhibitory effect of cerebrospinal fluid of multiple sclerosis patients on HFF2 cells
Growth inhibitory effect of cerebrospinal fluid of multiple sclerosis patients on HFF2 cells Open
Multiple sclerosis (MS) is an autoimmune disease characterized by demyelination of the central nervous system (CNS). Occurrence of immunogenic cell death (ICD) in this disease and expression of ICD markers in the CSF of MS patients are doc…
View article: Annexin A1, calreticulin and high mobility group box 1 are elevated in secondary progressive multiple sclerosis: Does immunogenic cell death occur in multiple sclerosis?
Annexin A1, calreticulin and high mobility group box 1 are elevated in secondary progressive multiple sclerosis: Does immunogenic cell death occur in multiple sclerosis? Open
Introduction: Multiple sclerosis (MS) is a chronic neuroinflammatory diseases characterized by demyelination of the nerve fibers. Immunogenic cell death (ICD) is a process, during which damaged and stressed cells release danger-associated …
View article: Annexin A1, Calreticulin and High Mobility Group Box 1 are elevated in Secondary Progressive Multiple Sclerosis: Does Immunogenic Cell Death Occur in Multiple Sclerosis?
Annexin A1, Calreticulin and High Mobility Group Box 1 are elevated in Secondary Progressive Multiple Sclerosis: Does Immunogenic Cell Death Occur in Multiple Sclerosis? Open
Multiple sclerosis (MS) is a chronic neuroinflammatory diseases characterized by demyelination of the nerve fibers. Immunogenic cell death (ICD) is a process, during which damaged and stressed cells release danger-associated molecular patt…
View article: Epstein-Barr virus-encoded BART9 and BART15 miRNAs are elevated in exosomes of cerebrospinal fluid from relapsing-remitting multiple sclerosis patients
Epstein-Barr virus-encoded BART9 and BART15 miRNAs are elevated in exosomes of cerebrospinal fluid from relapsing-remitting multiple sclerosis patients Open
Epstein-Barr virus (EBV) infection is approved as the main environmental trigger of multiple sclerosis (MS). In this path, we quantified EBV-encoded BART9-3p and BART15 miRNAs in exosomes of cerebrospinal fluid (CSF) of untreated relapsing…
View article: Clinical Significance of Carnitine in the Treatment of Cancer: From Traffic to the Regulation
Clinical Significance of Carnitine in the Treatment of Cancer: From Traffic to the Regulation Open
Metabolic reprogramming is a common hallmark of cancer cells. Cancer cells exhibit metabolic flexibility to maintain high proliferation and survival rates. In other words, adaptation of cellular demand is essential for tumorigenesis, since…
View article: Nanoscopic biodosimetry using plasmid DNA in radiotherapy with metallic nanoparticles
Nanoscopic biodosimetry using plasmid DNA in radiotherapy with metallic nanoparticles Open
Nanoscopic lesions (complex damages), are the most lethal lesions for the cells. As nanoparticles have become increasingly popular in radiation therapy and the importance of analyzing nanoscopic dose enhancement has increased, a reliable t…
View article: A Comprehensive Analysis of Radiosensitization Properties of Metallic Nanoparticles in Brachytherapy of Gastric Adenocarcinoma by I-125 Seed: A Simulation Study by MCNPX and MCNP6 Codes
A Comprehensive Analysis of Radiosensitization Properties of Metallic Nanoparticles in Brachytherapy of Gastric Adenocarcinoma by I-125 Seed: A Simulation Study by MCNPX and MCNP6 Codes Open
Purpose: In the current study, we aimed to look into the macroscopic and microscopic dose enhancement effect of metallic nanoparticles in interstitial brachytherapy of gastric adenocarcinoma by Iodine-125 source using a nano-lattice model …
View article: Removal of Tetracycline from Aqueous Solutions Using Modified Pyrolytic Coke Adsorbent Systems
Removal of Tetracycline from Aqueous Solutions Using Modified Pyrolytic Coke Adsorbent Systems Open
Pharmaceuticals are widely used in the treatment of diseases, and among them, antibiotics are the most widely used group of drugs. The presence of these compounds in the environment is a serious threat to global health. Common methods of r…
View article: COVID-19 infection: an overview on cytokine storm and related interventions
COVID-19 infection: an overview on cytokine storm and related interventions Open
Coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has posed a significant threat to global health. This virus affects the respiratory tract and usually leads to pneumonia in most…
View article: FMSClusterFinder: A new tool for detection and identification of clusters of sequential motifs with varying characteristics inside genomic sequences
FMSClusterFinder: A new tool for detection and identification of clusters of sequential motifs with varying characteristics inside genomic sequences Open
This paper describes FMSClusterFinder, a new tool and algorithm for identification and detection of clusters of sequential blocks inside the DNA and RNA subject sequences. Gene expression and genomic groups’ performance is under the contro…
View article: A case of autosomal recessive hypercholesterolemia with a novel mutation in the LDLRAP1 gene
A case of autosomal recessive hypercholesterolemia with a novel mutation in the LDLRAP1 gene Open
Background : Autosomal recessive hypercholesterolemia (ARH) is a rare monogenic disorder resulting from mutations of the LDLRAP1 gene, which leads to elevated LDL-C levels. Here, using whole exome sequencing (WES), we describe a 22-year-ol…
View article: Phenotypic and phylogenetic characterization of Lactobacillus species isolated from traditional Lighvan cheese
Phenotypic and phylogenetic characterization of Lactobacillus species isolated from traditional Lighvan cheese Open
Lighvan cheese (Lighvan panir) is among the most famous traditional cheese in Iran for its desired aroma and flavor. Undoubtedly, the lactic acid bacteria especially the genus Lactobacillus are the critical factors in developing the aroma,…
View article: Mechanistic Insight on Ras Inhibition Strategies in Cancer Therapy
Mechanistic Insight on Ras Inhibition Strategies in Cancer Therapy Open
Ras proteins are considered as one of the most critical cancer initiators. Mutations of this protein family lead to the continuous activation of the proliferation pathways. Therefore, many efforts have been taken to design the anti-mutant …
View article: Patient-Specific Induced Pluripotent Stem Cell-Derived Hepatocyte-Like Cells as a Model to Study Autosomal Recessive Hypercholesterolemia
Patient-Specific Induced Pluripotent Stem Cell-Derived Hepatocyte-Like Cells as a Model to Study Autosomal Recessive Hypercholesterolemia Open
Autosomal recessive hypercholesterolemia (ARH) is a rare monogenic disorder caused by pathogenic variants in the low-density lipoprotein receptor (LDLR) adaptor protein 1 (LDLRAP1) gene, encoding for the LDLRAP1 protein, which impairs inte…
View article: An Iranian patient affected by autosomal recessive hypercholesterolemia due to a novel variant in the LDLRAP1 gene
An Iranian patient affected by autosomal recessive hypercholesterolemia due to a novel variant in the LDLRAP1 gene Open
Background : Autosomal recessive hypercholesterolemia (ARH) is a rare monogenic disorder resulting from mutations of the LDLRAP1 gene, which leads to elevated LDL-C levels. Here, using whole exome sequencing (WES), we describe a 22-year-ol…
View article: Chemolithotroph Bacteria: From Biology to Application in Medical Sciences
Chemolithotroph Bacteria: From Biology to Application in Medical Sciences Open
Chemolithotrophs are specific bacteria that utilize inorganic compounds as their energy source. These bacteria as the main source of organic molecules have more advantages in various sciences. Unlike phototrophic and organotrophic bacteria…
View article: Cyclin-dependent Kinase 9 Induces Regional and Global Genomic DNA Methylation Via Influencing DNMT Gene Expression in Mouse Myoblast C2C12 Cells During Differentiation
Cyclin-dependent Kinase 9 Induces Regional and Global Genomic DNA Methylation Via Influencing DNMT Gene Expression in Mouse Myoblast C2C12 Cells During Differentiation Open
Objectives: Cyclin-dependent kinases (CDKs) including Cdk9 have been associated with cardiac differentiation. The increasing evidence has proposed that Cdk9 overexpression can regulate the epigenome. However, the current research is the fi…
View article: A case of autosomal recessive hypercholesterolemia with a novel mutation in the <i>LDLRAP1</i> gene
A case of autosomal recessive hypercholesterolemia with a novel mutation in the <i>LDLRAP1</i> gene Open
Familial hypercholesterolemia (FH, OMIM number #143890), a life-threatening monogenic disorder characterized by high levels of low-density lipoprotein cholesterol (LDL-C), is classified into dominant and recessive types (1). The dominant f…
View article: Silibinin sensitizes chemo-resistant breast cancer cells to chemotherapy
Silibinin sensitizes chemo-resistant breast cancer cells to chemotherapy Open
Context: Multiple drug resistance is the major obstacle to conventional chemotherapy. Silibinin, a nontoxic naturally occurring compound, has anticancer activity and can increase the cytotoxic effects of chemotherapy in various cancer mode…
View article: Potential Roles of MyomiRs in Cardiac Development and Related Diseases
Potential Roles of MyomiRs in Cardiac Development and Related Diseases Open
Muscle-specific miRNAs, which are known as MyomiRs, are crucial regulatory elements for cardiovascular development. MyomiRs are abundantly expressed in the myocardium and regulate certain aspects of physiological and pathological processes…
View article: Classification of seed members of five riboswitch families as short sequences based on the features extracted by Block Location-Based Feature Extraction (BLBFE) method
Classification of seed members of five riboswitch families as short sequences based on the features extracted by Block Location-Based Feature Extraction (BLBFE) method Open
Introduction: Riboswitches are short regulatory elements generally found in the untranslated regions of prokaryotes’ mRNAs and classified into several families. Due to the binding possibility between riboswitches and antibiotics, their usa…
View article: <b>Polycyclic Aromatic Hydrocarbons Degradation by Aquatic Bacteria Isolated from Khazar Sea, the World’s Largest Lake</b>
<b>Polycyclic Aromatic Hydrocarbons Degradation by Aquatic Bacteria Isolated from Khazar Sea, the World’s Largest Lake</b> Open
Background: Aquatic microorganisms have an important role in the bioremediation of environmental pollutants. Polycyclic Aromatic Hydrocarbons (PAHs) are described as dangerous pollutants that can bind covalently to the nucleic acids, causi…
View article: Antibacterial and Antifungal Activity of Novel Freshwater Bacterium <i>Tabrizicola aquatica</i> as a Prominent Natural Antibiotic Available in Qurugol Lake
Antibacterial and Antifungal Activity of Novel Freshwater Bacterium <i>Tabrizicola aquatica</i> as a Prominent Natural Antibiotic Available in Qurugol Lake Open
Background : Recently, resistant pathogenic microorganisms have become increasingly wide spread. The search for new natural antibiotics is a viable solution to this problem. For this aim we investigated the antimicrobial ability of Tabrizi…
View article: Hsp70 in Cancer: Partner or Traitor to Immune System
Hsp70 in Cancer: Partner or Traitor to Immune System Open
Heat shock protein 70.1 (Hsp70.1), also known as Hsp70, is a highly conserved member of the heat shock protein family that exists in all living organisms and determines the protein fate as molecular chaperones. Hsp70 basal expression is un…
View article: Classification of Riboswitch Families Using Block Location-Based Feature Extraction (BLBFE) Method
Classification of Riboswitch Families Using Block Location-Based Feature Extraction (BLBFE) Method Open
Purpose: Riboswitches are special non-coding sequences usually located in mRNAs’ un-translated regions and regulate gene expression and consequently cellular function. Furthermore, their interaction with antibiotics has been recently impli…