Vishal S. Patil
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View article: Phytosomal Nanocarrier of <i>Tagetes erecta</i> for Anti‐Urolithiatic Therapy Through Network Systems Biology, in Vitro, and in Vivo Insights
Phytosomal Nanocarrier of <i>Tagetes erecta</i> for Anti‐Urolithiatic Therapy Through Network Systems Biology, in Vitro, and in Vivo Insights Open
Urolithiasis remains a persistent clinical challenge with limited preventive therapies and poor recurrence control. Despite the known antioxidant and hepatoprotective properties of Tagetes erecta (T. erecta) , its potential against urolith…
View article: Network pharmacology-based toxicity, molecular docking, and molecular dynamics analysis of phytoconstituents from roots of Nerium indicum L
Network pharmacology-based toxicity, molecular docking, and molecular dynamics analysis of phytoconstituents from roots of Nerium indicum L Open
Background: Herbal medicine plays a vital role in healthcare, but safety concerns arise due to potential toxicity risks. Nerium indicum (夹竹桃, jiā zhú táo) is used in Chinese herbal medicine for its therapeutic effects, yet it contains toxi…
View article: Quality by design-based optimization and HP-TLC densitometric standardization of Theobroma cacao L. extract as a nutraceutical supplement
Quality by design-based optimization and HP-TLC densitometric standardization of Theobroma cacao L. extract as a nutraceutical supplement Open
Background Our previous studies identified the hydroalcoholic extract of defatted Theobroma cacao L. bean (CE) as a cancer-preventive and a protective agent against chemotherapeutic-induced toxicities, specifically doxorubicin-induced hear…
View article: Exploring disulfiram mechanisms in renal fibrosis: insights from biological data and computational approaches
Exploring disulfiram mechanisms in renal fibrosis: insights from biological data and computational approaches Open
Background Disulfiram (DSF) is an anti-alcoholic drug that has been reported to inhibit the epithelial-to-mesenchymal transition and crosslinking during fibrosis, pyroptosis, and inflammatory NF-κB and Nrf-2 signaling pathways. However, th…
View article: Exploring Cannabidiol–TRPV3 Mediated Biological Activities—Findings From Molecular Docking, Simulation and Proteins Network Interactions
Exploring Cannabidiol–TRPV3 Mediated Biological Activities—Findings From Molecular Docking, Simulation and Proteins Network Interactions Open
Transient receptor potential vanilloid 3 (TRPV3) is a thermosensitive calcium‐permeable ion channel and has a function in sensory perception, epidermal barrier function, inflammation and keratinocyte proliferation. TRPV3 dysfunction is lin…
View article: Stereotactic Body Radiotherapy for Unresectable Locally Advanced Pancreatic Cancer: A Retrospective Observational Study from a Regional Cancer Center in South Asia—A Case Series
Stereotactic Body Radiotherapy for Unresectable Locally Advanced Pancreatic Cancer: A Retrospective Observational Study from a Regional Cancer Center in South Asia—A Case Series Open
Introduction Concurrent chemoradiation is the treatment of choice for unresectable locally advanced pancreatic cancer (LAPC). Recent progress toward an effective chemotherapeutic regime has seen improvement in systemic control; however, lo…
View article: Antibacterial efficacy and antibiotic sensitivity augmentation potential of selected traditional medicinal plant extracts against Vibrio cholerae O1 E1 Tor Ogawa
Antibacterial efficacy and antibiotic sensitivity augmentation potential of selected traditional medicinal plant extracts against Vibrio cholerae O1 E1 Tor Ogawa Open
Background The leaves of Psidium guajava (PGAE) , fruit peel of Punica granatum (PGRPE), and the bark of Careya arborea (CAE) are widely used traditional medicinal plants for treating diarrheal diseases across India. Our previous studies s…
View article: Functional Outcome of Radial Head Fracture Treated with Open Reduction Internal Fixation using Plating Versus Herbert Screw Fixation: A Case Series
Functional Outcome of Radial Head Fracture Treated with Open Reduction Internal Fixation using Plating Versus Herbert Screw Fixation: A Case Series Open
Background: Radial head fractures can be addressed with open reduction and internal fixation (ORIF) using either plating or Herbert screw fixation. This study aimed to evaluate and compare the functional outcomes of these two techniques. M…
View article: Management of Neglected Floating Knee with Rotational Deformity and Limb Shortening Using the Ortho-SUV Frame: A Case Report
Management of Neglected Floating Knee with Rotational Deformity and Limb Shortening Using the Ortho-SUV Frame: A Case Report Open
Floating Knee Injury (FKI) are associated with significant complications, including deformity and limb shortening. The OrthoSolomin-Utekhin-Vilensky (SUV) (OSF) system, integrated with computer software for precision correction, offers an …
View article: <i>In silico</i> profiling of <i>Cynodon dactylon</i> L. Bioactives: Targeting Alzheimer’s pathways through network pharmacology, molecular docking and ADMET analysis
<i>In silico</i> profiling of <i>Cynodon dactylon</i> L. Bioactives: Targeting Alzheimer’s pathways through network pharmacology, molecular docking and ADMET analysis Open
Objectives: The present study aims to investigate the therapeutic potential of Cynodon dactylon in alleviating memory deficits associated with Alzheimer’s disease (AD). Specifically, we seek to explore its antioxidant properties and evalua…
View article: In silico molecular docking and molecular dynamic simulation of agarwood compounds with molecular targets of Alzheimer’s disease
In silico molecular docking and molecular dynamic simulation of agarwood compounds with molecular targets of Alzheimer’s disease Open
Background Alzheimer’s disease (AD) is a neurological condition that primarily affects older people. Currently available AD drugs are associated with side effects and there is a need to develop natural drugs from plants. Aquilaria is as an…
View article: Arthroscopic Subacromial Decompression in Patients With Subacromial Impingement Syndrome
Arthroscopic Subacromial Decompression in Patients With Subacromial Impingement Syndrome Open
ASAD significantly improves shoulder function and reduces symptoms in patients with SIS. The Constant-Murley and ASES scores demonstrate substantial improvement over a 12-month follow-up period. The procedure is associated with favorable o…
View article: Trigonelline mitigates bleomycin-induced idiopathic pulmonary fibrosis in mice
Trigonelline mitigates bleomycin-induced idiopathic pulmonary fibrosis in mice Open
Objective: To evaluate the effect of trigonelline on bleomycin-induced idiopathic pulmonary fibrosis (IPF) and to explore its underlying mechanisms using network pharmacology. Methods: IPF was induced in C57BL/6 mice by a single intratrach…
View article: Exploring the globoid cell leukodystrophy protein network and therapeutic interventions
Exploring the globoid cell leukodystrophy protein network and therapeutic interventions Open
Globoid cell leukodystrophy is a severe rare disorder characterized by white matter degradation, resulting in a progressive loss of physical and mental abilities and has extremely limited therapeutic interventions. Therefore, this study ai…
View article: First Report of Chenopodiastrum murale (L.) S. Fuentes, Uotila and Borsch from Baramati Tehsil Maharashtra, India
First Report of Chenopodiastrum murale (L.) S. Fuentes, Uotila and Borsch from Baramati Tehsil Maharashtra, India Open
Field survey was carried out in Baramati Tehsil and plant material was collected. and then the collected plant was identified this as Chenopodiastrum murale (L.). This genus was not earlier reported by any researcher and not found in Flora…
View article: Synergistic effects of Momordica charantia, Nigella sativa, and Anethum graveolens on metabolic syndrome targets: In vitro enzyme inhibition and in silico analyses
Synergistic effects of Momordica charantia, Nigella sativa, and Anethum graveolens on metabolic syndrome targets: In vitro enzyme inhibition and in silico analyses Open
Momordica charantia, Nigella sativa, and Anethum graveolens are established medicinal plants possessing noted anti-diabetic and anti-obesity properties. However, the molecular mechanisms underscoring their inhibitory effects on pancreatic …
View article: Osteochondral Fragment Fixation in Transient Patellar Dislocation of an Adolescent: A Case Report
Osteochondral Fragment Fixation in Transient Patellar Dislocation of an Adolescent: A Case Report Open
Osteochondral Fractures (OCFs) of the patella are common in adolescents due to ligament laxity and weak osteochondral junctions. OCFs following patellar dislocation are particularly challenging in this age group. Magnetic Resonance Imaging…
View article: Computational analysis of Salmalia malabarica (Bombax ceiba) for the management of ulcerative colitis
Computational analysis of Salmalia malabarica (Bombax ceiba) for the management of ulcerative colitis Open
Bombax ceiba leaf petiole is used as an enema in the management of ulcerative colitis, but its molecular mechanisms are yet to be established. The current study employed gene set enrichment, network pharmacology, and molecular docking stud…
View article: Bioactive Compounds from Momordica charantia, Nigella sativa, and Anethum graveolens against Metabolic Syndrome: Untangling the Complex Relationship
Bioactive Compounds from Momordica charantia, Nigella sativa, and Anethum graveolens against Metabolic Syndrome: Untangling the Complex Relationship Open
Rajashekar S. Chavan, Nayeem A. Khatib and Vishal S. Patil Author informationArticle notesCopyright and License informationPDFCitations Department of Pharmacology, KLE College of Pharmacy, Belagavi, KLE Academy of Higher Education and Rese…
View article: Elucidating the hepatoprotective mechanisms of Vernonia cinerea phytoactives in drug-induced liver injury by computational approach of network pharmacology, molecular docking and dynamic simulation studies
Elucidating the hepatoprotective mechanisms of Vernonia cinerea phytoactives in drug-induced liver injury by computational approach of network pharmacology, molecular docking and dynamic simulation studies Open
Drug-Induced Liver Injury (DILI), also known as Hepatotoxicity, refers to unexpected liver damage triggered by common medications, which harms hepatocytes and other liver cells. This damage can either be intrinsic, appearing shortly after …
View article: Barosmin against postprandial hyperglycemia: outputs from computational prediction to functional responses in vitro
Barosmin against postprandial hyperglycemia: outputs from computational prediction to functional responses in vitro Open
Previously, barosmin has been demonstrated to possess anti-diabetic action. However, its effect to inhibit α-amylase and α-glucosidase, including glucose utilization efficacy, has yet to be revealed. Hence, the current study attempted to a…
View article: System Biology Investigation Revealed Lipopolysaccharide and Alcohol-Induced Hepatocellular Carcinoma Resembled Hepatitis B Virus Immunobiology and Pathogenesis
System Biology Investigation Revealed Lipopolysaccharide and Alcohol-Induced Hepatocellular Carcinoma Resembled Hepatitis B Virus Immunobiology and Pathogenesis Open
Hepatitis B infection caused by the hepatitis B virus is a life-threatening cause of liver fibrosis, cirrhosis, and hepatocellular carcinoma. Researchers have produced multiple in vivo models for hepatitis B virus (HBV) and, currently, the…
View article: Cananga odorata (Ylang-Ylang) modulate pathways involved in cancer: Gene set enrichment and network pharmacology approach
Cananga odorata (Ylang-Ylang) modulate pathways involved in cancer: Gene set enrichment and network pharmacology approach Open
Traditionally, Cananga odorata Hook. F. & Thomson (Ylang-Ylang) is commonly used to treat various diseases and has been assessed for anti-cancer potency in experimental animal models. However, the affinity of its phytocompounds with multip…