Explanipedia

ZBTB24 is a conserved multifaceted transcription factor at genes and centromeres that governs the DNA methylation state and expression of satellite repeats Open

Giacomo Grillo, Ekaterina Boyarchuk, S. John Mihic, Ivana Ivković, Mathilde Bertrand , et al. · 2024

Since its discovery as a causative gene of the Immunodeficiency with Centromeric instability and Facial anomalies syndrome, ZBTB24 has emerged as a key player in DNA methylation, immunity and development. By extensively analyzing ZBTB24 ge…

ZBTB24 is a conserved multifaceted transcription factor at genes and centromeres that governs the DNA methylation state and expression of satellite repeats Open

Giacomo Grillo, Ekaterina Boyarchuk, S. John Mihic, Ivana Ivković, Mathilde Bertrand , et al. · 2023

Since its discovery as an Immunodeficiency with Centromeric instability and Facial anomalies syndrome-causative gene, ZBTB24 has emerged as a key player in DNA methylation, immunity and development. By extensively analyzing ZBTB24 genomic …

F654A and K558Q Mutations in NMDA Receptor 1 Affect Ethanol‐Induced Behaviors in Drosophila Open

Benjamin Troutwine, Annie Park, María E. Vélez-Hernández, Linda Lew, S. John Mihic , et al. · 2019

Background N‐methyl‐D‐aspartate (NMDA) receptors regulate synaptic plasticity and modulate a wide variety of behaviors. Mammalian NMDA receptors are inhibited by ethanol (EtOH) even at low concentrations. In mice, the F639A mutation in tra…

A Novel Peptide Restricts Ethanol Modulation of the BK Channel In Vitro and In Vivo Open

Luisa L. Scott, Sangeetha Iyer, Ashley E. Philpo, Melva Avalos, Natalie S. Wu , et al. · 2018

An intersubunit electrostatic interaction in the GABAA receptor facilitates its responses to benzodiazepines Open

Natasha C. Pflanz, Anna W. Daszkowski, Garrett L. Cornelison, James R. Trudell, S. John Mihic · 2018

Benzodiazepines are positive allosteric modulators of the GABA_A receptor (GABA_AR), acting at the α-γ subunit interface to enhance GABA_AR function. GABA or benzodiazepine binding induces distinct conformatio…

Single Channel Analysis of Isoflurane and Ethanol Enhancement of Taurine-Activated Glycine Receptors Open

Dean Kirson, Jelena Todorović, S. John Mihic · 2017

A novel BK channel-targeted peptide suppresses sound evoked activity in the mouse inferior colliculus Open

Luisa L. Scott, Elliott J. Brecht, Ashley E. Philpo, Sangeetha Iyer, Natalie S. Wu , et al. · 2017

Interactions between Zinc and Allosteric Modulators of the Glycine Receptor Open

Garrett L. Cornelison, Anna W. Daszkowski, Natasha C. Pflanz, S. John Mihic · 2017

Disruption of a putative intersubunit electrostatic bond enhances agonist efficacy at the human α1 glycine receptor Open

Brian T. Welsh, Jelena Todorović, Dean Kirson, Hunter M. Allen, Michelle D. Bayly , et al. · 2016

Identification and characterization of heptapeptide modulators of the glycine receptor Open

Garrett L. Cornelison, Natasha C. Pflanz, Megan E. Tipps, S. John Mihic · 2016

Allosteric modulation of the glycine receptor activated by agonists differing in efficacy Open

Nicole-Marie M Farley, S. John Mihic · 2015

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