Jian Wu
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View article: Unveiling the ITGβ1-CLIC1 axis: a new frontier in oral squamous cell carcinoma progression and immune evasion: insights from the tumor-mimetic ECM system
Unveiling the ITGβ1-CLIC1 axis: a new frontier in oral squamous cell carcinoma progression and immune evasion: insights from the tumor-mimetic ECM system Open
This study provides evidence supporting the association between the ITGβ1-CLIC1 axis and OSCC progression, and suggests its potential involvement in modulating the tumor immune microenvironment, indicating its promise as a therapeutic targ…
View article: Innovative Path of Visual Communication Design for Urban Cultural, Sports and Tourism Integration Projects from the Perspective of Immersive Experience
Innovative Path of Visual Communication Design for Urban Cultural, Sports and Tourism Integration Projects from the Perspective of Immersive Experience Open
In order to solve the problems of homogenization in visual communication design and shallow cultural exploration in urban cultural, sports and tourism integration projects, this study explores from the perspective of immersive experience. …
View article: Moist orographic gravity wave drag parameterization reduces the bias of summer rainfall over the Tibetan Plateau
Moist orographic gravity wave drag parameterization reduces the bias of summer rainfall over the Tibetan Plateau Open
Summer precipitation over the Tibetan Plateau (TP) significantly affects the regional and global climate. In this paper, the orographic gravity wave drag (OGWD) parameterization is revised by incorporating the moisture effect of saturated …
View article: Evaluating dynamic global vegetation models in China: challenges in capturing trends in leaf area and gross primary productivity
Evaluating dynamic global vegetation models in China: challenges in capturing trends in leaf area and gross primary productivity Open
Terrestrial ecosystems are crucial in mitigating global climate change, and dynamic global vegetation models (DGVMs) have become essential tools for simulating these ecosystems. However, uncertainties remain in DGVM simulations for China, …
View article: Value of nafamostat mesylate in venoarterial extracorporeal membrane oxygenation anticoagulation—A retrospective cross‐sectional study
Value of nafamostat mesylate in venoarterial extracorporeal membrane oxygenation anticoagulation—A retrospective cross‐sectional study Open
Background Anticoagulation is a key measure during venoarterial extracorporeal membrane oxygenation (VA‐ECMO) maintenance therapy. Nafamostat mesylate (NM) has emerged as a potential alternative to heparin. We assessed the value of anticoa…
View article: Multi-Layer Soil Moisture Profiling Based on BKA-CNN by Integrating Sentinel-1/2 SAR and Multispectral Data
Multi-Layer Soil Moisture Profiling Based on BKA-CNN by Integrating Sentinel-1/2 SAR and Multispectral Data Open
Soil moisture (SM) is crucial for ecosystems and agriculture. Since the root systems of plants absorb water at different depths with different intensities, monitoring multi-layer SM can better respond to the water demand of plants and offe…
View article: Solution-corrected Constant Potential Model for CO2 Electrocatalysis in Ionic Liquids
Solution-corrected Constant Potential Model for CO2 Electrocatalysis in Ionic Liquids Open
View article: Unveiling metabolic pathway dysregulation in the malignant transformation of polyps to colorectal cancer: a single-cell analysis of epithelial cell trajectories
Unveiling metabolic pathway dysregulation in the malignant transformation of polyps to colorectal cancer: a single-cell analysis of epithelial cell trajectories Open
Background: Although metabolic reprogramming in colorectal cancer (CRC) has been studied, the changes in metabolic pathways and cellular communication from a healthy colon to precancerous adenoma and CRC remain poorly understood. Materials…
View article: Influencing factors and predictive model of the early postoperative recurrence of colorectal cancer with obstruction
Influencing factors and predictive model of the early postoperative recurrence of colorectal cancer with obstruction Open
BACKGROUND In cases of colorectal cancer (CRC) with obstruction, patients experience local tissue edema due to intestinal obstruction. This condition stimulates the accumulation of inflammatory factors, activates cancer cells, and increase…
View article: Numerical Simulation of Shallow Coalbed Methane Based on Geology–Engineering Integration
Numerical Simulation of Shallow Coalbed Methane Based on Geology–Engineering Integration Open
Coalbed-methane (CBM) extraction involves complex processes such as desorption, diffusion, and seepage, significantly increasing the difficulty of numerical simulation. To enable efficient CBM development, this study establishes an integra…
View article: Research on the Modification and Application of Biodegradable Polylactic Acid Materials
Research on the Modification and Application of Biodegradable Polylactic Acid Materials Open
Polylactic acid (PLA), a biodegradable polymer derived from renewable plant resources like corn and sugarcane, exhibits significant environmental benefits compared to petroleum-based plastics, as it degrades into carbon dioxide and water i…
View article: Bovine β-Casein Peptide YPFPGPIH Regulates Inflammation and Macrophage Activity via TLR/NF-κB/MAPK Signaling
Bovine β-Casein Peptide YPFPGPIH Regulates Inflammation and Macrophage Activity via TLR/NF-κB/MAPK Signaling Open
Food-derived bioactive peptides are known to possess immunomodulatory properties, although their molecular mechanisms remain incompletely characterized. In this study, we investigated the immunoregulatory effects and underlying mechanisms …
View article: Durability of DNA-LNP and mRNA-LNP Vaccine-Induced Immunity Against SARS-CoV-2 XBB.1.5
Durability of DNA-LNP and mRNA-LNP Vaccine-Induced Immunity Against SARS-CoV-2 XBB.1.5 Open
mRNA-lipid nanoparticle (LNP) vaccines induce robust adaptive immune responses and have proven highly effective against SARS-CoV-2. However, their long-term effectiveness is limited by waning humoral responses, which decline substantially …
View article: Global antibiotic consumption and regional antimicrobial resistance, 2010–21: an analysis of pharmaceutical sales and antimicrobial resistance surveillance data
Global antibiotic consumption and regional antimicrobial resistance, 2010–21: an analysis of pharmaceutical sales and antimicrobial resistance surveillance data Open
National Key R&D Program of China and National Natural Science Foundation of China.
View article: Recursive Inverse Design Enables Hyper-spectral Photonic Integrated Circuits
Recursive Inverse Design Enables Hyper-spectral Photonic Integrated Circuits Open
Spectrum manipulation is central to photonic systems, where advanced computing and sensing applications often demand highly complex spectral responses to achieve high throughput. Conventional methods for enhancing spectral complexity typic…
View article: Healthcare deprivation matters: a novel framework to unveil the influencing mechanisms of aging anxiety and healthcare utilization
Healthcare deprivation matters: a novel framework to unveil the influencing mechanisms of aging anxiety and healthcare utilization Open
Objectives Aging anxiety is not only a health issue but also a stress response to the structural risk of insufficient medical resources. This study aims to reveal the impact of aging anxiety on individual healthcare utilization and the com…
View article: Multi-omics analysis reveals the mechanism of rosemary extract supplementation in increasing milk production in Sanhe dairy cows via the “rumen-serum-milk” metabolic pathway
Multi-omics analysis reveals the mechanism of rosemary extract supplementation in increasing milk production in Sanhe dairy cows via the “rumen-serum-milk” metabolic pathway Open
Rosemary extract (RE) has shown potential as a plant-derived feed additive, but its effects on Sanhe dairy cows are still unknown. In this study, 30 multiparous Sanhe dairy cows (days in milk 171 ± 17 days) with similar body condition were…
View article: Revisiting Cation-π Interaction Paradigms: Confinement-Induced Unusual Trends and Implications for Reactivity Control
Revisiting Cation-π Interaction Paradigms: Confinement-Induced Unusual Trends and Implications for Reactivity Control Open
View article: O059 Opioid-related central sleep apnea doesn’t harm respiratory and sleep parameters
O059 Opioid-related central sleep apnea doesn’t harm respiratory and sleep parameters Open
Introduction Opioid-related central sleep apnea (CSA) is increasingly common, but its clinical implications are poorly understood. We analysed the “OpSafe” cohort, a large prospective multicentre study of chronic opioid users, to investiga…
View article: A Systematic Framework of Flash Floods Disaster-Causing Mechanisms in Ungauged Mountainous Micro-Watersheds: Case Study of Qialegeer Village, Xinjiang, China
A Systematic Framework of Flash Floods Disaster-Causing Mechanisms in Ungauged Mountainous Micro-Watersheds: Case Study of Qialegeer Village, Xinjiang, China Open
Flash floods are characterized by their destructive power, rapid onset, and unpredictability, often causing severe damage to both natural environments and socioeconomic systems. Understanding the detailed disaster-causing mechanisms of fla…
View article: A Cost‐Effective and Scalable Machine Learning Approach for Quality Assessment of Fresh Maize Kernel Using NIR Spectroscopy
A Cost‐Effective and Scalable Machine Learning Approach for Quality Assessment of Fresh Maize Kernel Using NIR Spectroscopy Open
In fresh maize breeding, developing robust and accurate near‐infrared (NIR) calibration models traditionally requires significant time, cost, and labor. To address these challenges, a novel machine learning approach is proposed using a Pre…
View article: Response of Residence Time to Coastline Change in Xiamen Bay, China
Response of Residence Time to Coastline Change in Xiamen Bay, China Open
Xiamen Bay (XMB), a representative semi-enclosed bay, demonstrates hydrodynamic conditions and water exchange characteristics that are significantly influenced by alterations in the coastline. The three-dimensional hydrodynamic model and r…
View article: RIP3 and MLKL regulate Hepatic ER stress in alcohol-associated liver disease and pharmacological ER stress models: insights beyond necroptosis
RIP3 and MLKL regulate Hepatic ER stress in alcohol-associated liver disease and pharmacological ER stress models: insights beyond necroptosis Open
Background and Aim Endoplasmic reticulum (ER) stress is an important contributor to liver disease progression, including alcohol-associated liver disease (ALD). While receptor-interacting protein kinase-3 (RIP3) and mixed lineage kinase do…
View article: Angle Effects in UAV Quantitative Remote Sensing: Research Progress, Challenges and Trends
Angle Effects in UAV Quantitative Remote Sensing: Research Progress, Challenges and Trends Open
In recent years, unmanned aerial vehicle (UAV) quantitative remote sensing technology has demonstrated significant advantages in fields such as agricultural monitoring and ecological environment assessment. However, achieving the goal of q…
View article: Multiomics Analyses Reveal an Essential Role of Tryptophan in Treatment of csDMARDs in Rheumatoid Arthritis
Multiomics Analyses Reveal an Essential Role of Tryptophan in Treatment of csDMARDs in Rheumatoid Arthritis Open
Rheumatoid arthritis (RA) is a autoimmune disease characterized by heterogeneity in response to conventional synthetic disease‐modifying antirheumatic drugs (csDMARDs). This study aims to elucidate molecular differences in response mechani…
View article: Sleep quality moderated the mediating effect of BMI and waist circumference on the relationship between screen time and mental health in Chinese adolescents
Sleep quality moderated the mediating effect of BMI and waist circumference on the relationship between screen time and mental health in Chinese adolescents Open
Objective This study aimed to investigate whether body mass index and waist circumference can moderate the relationship between screen time and adolescent mental health, and whether sleep quality can moderate these effects. Method Using a …
View article: The Digital Transformation Path of UI Design Course in Private Colleges and Universities Under The Perspective of Blended Teaching
The Digital Transformation Path of UI Design Course in Private Colleges and Universities Under The Perspective of Blended Teaching Open
In the context of educational digital transformation, UI design courses in private universities face dual challenges of innovating teaching models and enhancing talent cultivation quality. Blended learning, as a new teaching model integrat…
View article: Correction: Wu et al. Bi-Directional Pollution Characteristics and Ecological Health Risk Assessment of Heavy Metals in Soil and Crops in Wanjiang Economic Zone, Anhui Province, China. Int. J. Environ. Res. Public Health 2022, 19, 9669
Correction: Wu et al. Bi-Directional Pollution Characteristics and Ecological Health Risk Assessment of Heavy Metals in Soil and Crops in Wanjiang Economic Zone, Anhui Province, China. Int. J. Environ. Res. Public Health 2022, 19, 9669 Open
Xia Gao and Guojun Cai were removed as authors in the original publication [...]
View article: A PointNet++-Based Deep Learning Approach Using Patient-Specific 3D Point Clouds for Personalized DBS Efficacy Prediction in Parkinson’s Disease
A PointNet++-Based Deep Learning Approach Using Patient-Specific 3D Point Clouds for Personalized DBS Efficacy Prediction in Parkinson’s Disease Open
Personalizing deep brain stimulation (DBS) for Parkinson’s disease remains challenged by trial-and-error programming and feature-engineered models that fail to capture critical 3D spatial-field interactions, as traditional volume of tissue…
View article: Innate immune cells in oral squamous cell carcinoma: Characteristics and therapeutic potential
Innate immune cells in oral squamous cell carcinoma: Characteristics and therapeutic potential Open
Innate immune cells play an important role in the immune system and are mainly responsible for the rapid response to foreign pathogens, damaged tissues, or abnormal cells. However, their immunophenotype in oral squamous cell carcinoma (OSC…