Sharada Karanth
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View article: Ascorbic acid stimulates gonadotropin release by autocrine action by means of NO
Ascorbic acid stimulates gonadotropin release by autocrine action by means of NO Open
Because high concentrations of ascorbic acid (AA) are found in the adenohypophysis, we hypothesized that it might have an acute effect on the secretion of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the gland, part…
View article: Role of the hypothalamic pituitary adrenal axis in the control of the response to stress and infection
Role of the hypothalamic pituitary adrenal axis in the control of the response to stress and infection Open
The release of adrenocorticotropin (ACTH) from the corticotrophs is controlled principally by vasopressin and corticotropin-releasing hormone (CRH). Oxytocin may augment the release of ACTH under certain conditions, whereas atrial natriure…
View article: Ascorbic acid acts as an inhibitory transmitter in the hypothalamus to inhibit stimulated luteinizing hormone-releasing hormone release by scavenging nitric oxide
Ascorbic acid acts as an inhibitory transmitter in the hypothalamus to inhibit stimulated luteinizing hormone-releasing hormone release by scavenging nitric oxide Open
Because ascorbic acid (AA) is concentrated in synaptic vesicles containing glutamic acid, we hypothesized that AA might act as a neurotransmitter. Because AA is an antioxidant, it might therefore inhibit nitric oxidergic (NOergic) activati…
View article: The role of nitric oxide in reproduction
The role of nitric oxide in reproduction Open
Nitric oxide (NO) plays a crucial role in reproduction at every level in the organism. In the brain, it activates the release of luteinizing hormone-releasing hormone (LHRH). The axons of the LHRH neurons project to the mating centers in t…
View article: Estrogen and Leptin Have Differential Effects on FSH and LH Release in Female Rats<sup>2</sup>
Estrogen and Leptin Have Differential Effects on FSH and LH Release in Female Rats<sup>2</sup> Open
Prior experiments have shown that the adipocyte hormone leptin can advance puberty in mice. We hypothesized that it would also stimulate gonadotrophin secretion in adults. Since the secretion of follicle stimulating hormone (FSH) and lutei…
View article: Reduced Activity of Hypothalamic Corticotropin-Releasing Hormone Neurons in Transgenic Mice with Impaired Glucocorticoid Receptor Function
Reduced Activity of Hypothalamic Corticotropin-Releasing Hormone Neurons in Transgenic Mice with Impaired Glucocorticoid Receptor Function Open
Loss of central glucocorticoid receptor (GR) function is thought to be involved in the development of neuroendocrine and psychiatric disorders associated with corticotropin-releasing hormone (CRH) hyperactivity. The possible causal relatio…
View article: Nitric Oxide Mediates Leptin-Induced Luteinizing Hormone-Releasing Hormone (LHRH) and LHRH and Leptin-Induced LH Release from the Pituitary Gland
Nitric Oxide Mediates Leptin-Induced Luteinizing Hormone-Releasing Hormone (LHRH) and LHRH and Leptin-Induced LH Release from the Pituitary Gland Open
Previous experiments have demonstrated that leptin releases luteinizing hormone-releasing hormone (LHRH) from median eminence (ME)-arcuate explants from male rats and also stimulates the release of follicle-stimulating hormone (FSH) and LH…
View article: A hypothalamic follicle-stimulating hormone-releasing decapeptide in the rat
A hypothalamic follicle-stimulating hormone-releasing decapeptide in the rat Open
Previous studies indicated that there is a separate hypothalamic control of follicle-stimulating hormone (FSH) release distinct from that of luteinizing hormone (LH). An FSH-releasing factor (FSHRF) was purified from rat and sheep hypothal…
View article: Hypothalamic-Pituitary-Adrenocortical Axis Changes in a Transgenic Mouse with Impaired Glucocorticoid Receptor Function*
Hypothalamic-Pituitary-Adrenocortical Axis Changes in a Transgenic Mouse with Impaired Glucocorticoid Receptor Function* Open
Recently, a transgenic mouse with impaired glucocorticoid receptor (GR) function was created to serve as an animal model for the study of neuroendocrine changes occurring in stress-related disorders, such as major depression. Here, we inve…
View article: Role of leptin in hypothalamic–pituitary function
Role of leptin in hypothalamic–pituitary function Open
A defect in the structure of the obese gene is responsible for development of obesity in the ob / ob mouse. The product of expression of the gene is the protein hormone leptin. Leptin causes weight loss in ob / ob and normal mice, it is se…
View article: Role of nitric oxide in the hypothalamic action of cytokines to alter releasing hormone secretion
Role of nitric oxide in the hypothalamic action of cytokines to alter releasing hormone secretion Open
An iterative extended Hückel-level method is applied to the photoelectron spectra of naphthalene, quinoline, isoquinoline and the ten diazanaphthalenes. The thirteen highest molecular orbital energies of each compound are discussed and com…
View article: Role of nitric oxide in interleukin 2-induced corticotropin-releasing factor release from incubated hypothalami.
Role of nitric oxide in interleukin 2-induced corticotropin-releasing factor release from incubated hypothalami. Open
Stimulation of corticotropin-releasing factor (CRF) release from the hypothalamus by interleukin 2 (IL-2) was recently demonstrated. Cytokines induce nitric oxide synthase (NOS), an enzyme that converts L-arginine into L-citrulline and nit…
View article: Anterior pituitary hormone control by interleukin 2.
Anterior pituitary hormone control by interleukin 2. Open
Several monokines, proteins secreted by monocytes and macrophages, alter release of hormones from the anterior pituitary. We report here the ability of femtomolar concentrations of interleukin 2 (IL-2), a lymphokine released from T lymphoc…
View article: An assessment of inhibin‐like activity secreted by Sertoli cells in culture using castrated adult male rats
An assessment of inhibin‐like activity secreted by Sertoli cells in culture using castrated adult male rats Open
Sertoli cells isolated from testes of 16–18 days old male rats were maintained in culture. Incubation media from these culture were pooled on day 7 and tested for its inhibin‐like activity either with (SCCM) or after charcoal treatment (CS…