S. Kaspar Grimm
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View article: Antagonizing <scp>microRNA</scp> ‐19a/b augments <scp>PTH</scp> anabolic action and restores bone mass in osteoporosis in mice
Antagonizing <span>microRNA</span> ‐19a/b augments <span>PTH</span> anabolic action and restores bone mass in osteoporosis in mice Open
View article: Pausing guides RNA folding to populate transiently stable RNA structures for riboswitch-based transcription regulation
Pausing guides RNA folding to populate transiently stable RNA structures for riboswitch-based transcription regulation Open
In bacteria, the regulation of gene expression by cis-acting transcriptional riboswitches located in the 5'-untranslated regions of messenger RNA requires the temporal synchronization of RNA synthesis and ligand binding-dependent conformat…
View article: Author response: Pausing guides RNA folding to populate transiently stable RNA structures for riboswitch-based transcription regulation
Author response: Pausing guides RNA folding to populate transiently stable RNA structures for riboswitch-based transcription regulation Open
Article Figures and data Abstract Introduction Discussion Materials and methods References Decision letter Author response Article and author information Metrics Abstract In bacteria, the regulation of gene expression by cis-acting transcr…
View article: PAIN-less identification and evaluation of small molecule inhibitors against protein tyrosine phosphatase 1B
PAIN-less identification and evaluation of small molecule inhibitors against protein tyrosine phosphatase 1B Open
A miniaturized assay was set up to test a set of natural products against protein tyrosine phosphatase 1B (PTP1B). By using several read-out and counter assays, berberine and palmatine were identified as PAINS (pan-assay interference compo…