Scott Reza Jafarian Kerman
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FRI562 Not JUST Severe Hypothyroidism: Recognizing Autoimmune Polyglandular Syndrome Open
Disclosure: S.R. Jafarian-Kerman: None. A. Razzeto: None. G. Saini: None. M. Siddiqui: None. M. Islam: None. D. Behman: None. M. Carson: None. Background: Recognizing Autoimmune Polyglandular Syndrome (AIPS) in a patient who has chronic hy…
View article: American Heart Association EPI|Lifestyle Scientific Sessions: 2022 Meeting Highlights
American Heart Association EPI|Lifestyle Scientific Sessions: 2022 Meeting Highlights Open
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Association of a glucagon‐like peptide‐1 receptor gene variant with glucose response to a mixed meal Open
Dipeptidyl peptidase‐4 (DPP‐4) inhibitors increase endogenous glucagon‐like peptide‐1 (GLP‐1). We hypothesized that genetic variation in the gene encoding the GLP‐1 receptor ( GLP1R ) could affect the metabolic response to DPP‐4 inhibition…
Highly Reactive Isolevuglandins Promote Atrial Fibrillation Caused by Hypertension Open
Oxidative damage is implicated in atrial fibrillation (AF), but antioxidants are ineffective therapeutically. The authors tested the hypothesis that highly reactive lipid dicarbonyl metabolites, or isolevuglandins (IsoLGs), are principal d…
High-Sensitive Troponin I and Re-Hospitalization in Patients With Decompensated Congestive Heart Failure Open
- Patients with heart failure (HF) are frequently admitted for episodes of decompensation. Cardiac troponins are easily accessible biomarkers role of which for risk stratification of re-hospitalization among HF patients is less certain. We…
Dipeptidyl Peptidase 4 Inhibition Increases Postprandial Norepinephrine via Substance P (NK1 Receptor) During RAAS Inhibition Open
Context Dipeptidyl peptidase 4 (DPP4) inhibitors may increase the risk of heart failure. Decreased degradation of vasoactive peptides like substance P [also degraded by angiotensin-converting enzyme (ACE)] and Y1 agonists peptide YY (PYY 1…
OR05-6 The Effect of the GLP1R Variant rs6923761 on Post-Prandial Glucose Levels during Treatment with Sitagliptin Open
BACKGROUND: Glucagon-like peptide-1 (GLP-1) functions to increase insulin production in a glucose-dependent manner. Endogenous GLP-1 is rapidly degraded by the enzyme dipeptidyl peptidase 4 (DPP4), and GLP-1 receptor agonists and DPP4 inhi…
DPP (Dipeptidyl Peptidase)-4 Inhibition Potentiates the Vasoconstrictor Response to NPY (Neuropeptide Y) in Humans During Renin-Angiotensin-Aldosterone System Inhibition Open
DPP (dipeptidyl peptidase)-4 inhibitors are antidiabetic drugs that may increase heart failure in high-risk patients. NPY (neuropeptide Y) is coreleased with norepinephrine, causes vasoconstriction via the Y1 receptor, and is degraded by D…
B-type natriuretic peptide and renovascular hypertension; is there any relation? Open
Renal artery stenosis (RAS) is the most prevalent cause of secondary hypertension (HTN). Percutaneous trans-luminal renal angioplasty (PTRA) is used for both diagnosis and treatment of RAS. As many as one third of RAS cases fail to demonst…