Sherry Krawitz
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View article: Chronic traumatic encephalopathy-neuropathologic change in a routine neuropathology service: 7-year follow-up
Chronic traumatic encephalopathy-neuropathologic change in a routine neuropathology service: 7-year follow-up Open
To follow our 2016 study of chronic traumatic encephalopathy neuropathologic change (CTE-NC) in our forensic autopsy service, we prospectively screened all cases with clinical histories of multiple concussions, persistent post-head injury …
View article: LGG-23. EXCELLENT CLINICAL / RADIOLOGICAL RESPONSE TO BRAF INHIBITION IN A YOUNG CHILD WITH IN-OPERABLE SUPRA-SELLAR PILOCYTIC ASTROCYTOMA
LGG-23. EXCELLENT CLINICAL / RADIOLOGICAL RESPONSE TO BRAF INHIBITION IN A YOUNG CHILD WITH IN-OPERABLE SUPRA-SELLAR PILOCYTIC ASTROCYTOMA Open
In-operable low grade gliomas (LGG) in the pediatric population continue to present a treatment dilemma. Due to the low-grade nature of these tumors, and variable response to chemotherapy / radiation, the choice of adjuvant treatment is di…
View article: Medial Temporal Lobe Dysgenesis and More in a Man with Hypochondroplasia and Epilepsy
Medial Temporal Lobe Dysgenesis and More in a Man with Hypochondroplasia and Epilepsy Open
Hypochondroplasia, achondroplasia, and thanatophoric dysplasia are related at the molecular level, all caused by fibroblast growth factor receptor 3 (FGFR3) gene mutations. They differ in severity. FGFR3 has critical roles in fibroblast gr…
View article: A 51-year-old Man with Primary Spinal Cord Germinoma
A 51-year-old Man with Primary Spinal Cord Germinoma Open
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View article: DIPG-18. SONIC HEDGEHOG (SHH) SIGNALLING PROMOTES BLOOD BRAIN BARRIER (BBB) INTEGRITY IN DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG)
DIPG-18. SONIC HEDGEHOG (SHH) SIGNALLING PROMOTES BLOOD BRAIN BARRIER (BBB) INTEGRITY IN DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG) Open
DIPG is the most common brainstem tumor in children and is uniformly fatal. The BBB is intact in DIPG and plays an active role in restricting the delivery of systemically administered therapies into the tumor. Recent studies have shown tha…
View article: PATH-43. RETROSPECTIVE RECLASSIFICATION OF ADULT GLIOMAS FROM A MANITOBA PATIENT COHORT ACCORDING TO THE WHO 2016 GUIDELINES
PATH-43. RETROSPECTIVE RECLASSIFICATION OF ADULT GLIOMAS FROM A MANITOBA PATIENT COHORT ACCORDING TO THE WHO 2016 GUIDELINES Open
The new WHO 2016 classification of CNS tumours classifies adult gliomas based on the presence or absence of two key molecular markers, IDH mutation and 1p/19q co-deletion. We applied the new criteria to Manitoba glioma patients diagnosed b…
View article: Blastomyces species and orbital apex syndrome: Unsuspected co-infection
Blastomyces species and orbital apex syndrome: Unsuspected co-infection Open
Blastomyces species are thermally dimorphic fungi existing as yeast in tissue. We report an initially immunocompetent patient with orbital apex syndrome (OAS) whose presentation suggested giant cell arteritis. Subsequently, metastatic carc…
View article: Dovitinib enhances temozolomide efficacy in glioblastoma cells
Dovitinib enhances temozolomide efficacy in glioblastoma cells Open
The multikinase inhibitor and FDA ‐approved drug dovitinib (Dov) crosses the blood–brain barrier and was recently used as single drug application in clinical trials for GB patients with recurrent disease. The Dov‐mediated molecular mechani…
View article: Chronic Traumatic Encephalopathy-Like Abnormalities in a Routine Neuropathology Service
Chronic Traumatic Encephalopathy-Like Abnormalities in a Routine Neuropathology Service Open
Chronic traumatic encephalopathy (CTE) has been described mainly in professional athletes and military personnel and is characterized by deposition of hyperphosphorylated tau at the depths of cortical sulci and around blood vessels. To ass…
View article: RARE-22. MEDULLOBLASTOMA IN A CHILD WITH NEUROFIBROMATOSIS-1: CASE REPORT AND REVIEW
RARE-22. MEDULLOBLASTOMA IN A CHILD WITH NEUROFIBROMATOSIS-1: CASE REPORT AND REVIEW Open
Neurofibromatosis-1(NF-1) is a relatively common inherited cancer predisposition syndrome and patients with NF-1 are prone to develop benign and malignant tumors of the CNS and peripheral nervous system, in addition to malignant diseases a…
View article: PDCT-02. MARKED RECOVERY OF VISION IN A CHILD WITH OPTIC PATHWAY GLIOMA TREATED UPFRONT WITH BEVACIZUMAB AND VINBLASTINE
PDCT-02. MARKED RECOVERY OF VISION IN A CHILD WITH OPTIC PATHWAY GLIOMA TREATED UPFRONT WITH BEVACIZUMAB AND VINBLASTINE Open
Optic Pathway Gliomas (OPGs) are relatively rare and account for up to 5% of brain tumors in children. They are low grade neoplasms (WHO grade I-II), can originate from any location along the visual system (nerve, chiasm, tract or radiatio…
View article: AT-22ALISERTIB MONOTHERAPY IN THE TREATMENT OF RELAPSED ATYPICAL TERATOID RHABDOID TUMOR (ATRT)
AT-22ALISERTIB MONOTHERAPY IN THE TREATMENT OF RELAPSED ATYPICAL TERATOID RHABDOID TUMOR (ATRT) Open
AT-22. ALISERTIB MONOTHERAPY IN THE TREATMENT OF RELAPSED ATYPICAL TERATOID RHABDOID TUMOR (ATRT) Magimairajan Issai Vanan1, Patrick McDonald2, Colin Kazina3, Junliang Liu1, Sherry Krawitz4, Martin Bunge5, Annie Ong1, and Brent Orr6; Cance…
View article: Platinum (IV) coiled coil nanotubes selectively kill human glioblastoma cells
Platinum (IV) coiled coil nanotubes selectively kill human glioblastoma cells Open
The prognosis of malignant glioma remains poor despite medical advances. Platinum, one of the chemotherapeutic agents used, has significant systemic side effects. In this article, the authors employed α-helical right handed coiled coil (RH…