Steven L. Kunkel
YOU?
Author Swipe
View article: The histone methyltransferase Mixed-lineage-leukemia-1 drives T cell phenotype via Notch signaling in diabetic tissue repair
The histone methyltransferase Mixed-lineage-leukemia-1 drives T cell phenotype via Notch signaling in diabetic tissue repair Open
Immune cell-mediated inflammation is important in normal tissue regeneration but can be pathologic in diabetic wounds. Limited literature exists on the role of CD4+ T cells in normal or diabetic wound repair; however, the imbalance of CD4+…
View article: Histone demethylase JARID1C/KDM5C regulates Th17 cells by increasing IL-6 expression in diabetic plasmacytoid dendritic cells
Histone demethylase JARID1C/KDM5C regulates Th17 cells by increasing IL-6 expression in diabetic plasmacytoid dendritic cells Open
Plasmacytoid dendritic cells (pDCs) are first responders to tissue injury, where they prime naive T cells. The role of pDCs in physiologic wound repair has been examined, but little is known about pDCs in diabetic wound tissue and their in…
View article: Metabolic reprogramming and dysregulated IL-17 production impairs CD4 T cell function post sepsis
Metabolic reprogramming and dysregulated IL-17 production impairs CD4 T cell function post sepsis Open
Sepsis survivors are at high risk for infection-related rehospitalization and mortality for years following the resolution of the acute septic event. These infection-causing microorganisms generally do not cause disease in immunocompetent …
View article: THE CRITICAL ROLE OF THE HISTONE MODIFICATION ENZYME SETDB2 IN THE PATHOGENESIS OF ACUTE RESPIRATORY DISTRESS SYNDROME
THE CRITICAL ROLE OF THE HISTONE MODIFICATION ENZYME SETDB2 IN THE PATHOGENESIS OF ACUTE RESPIRATORY DISTRESS SYNDROME Open
Introduction: Acute respiratory distress syndrome (ARDS) is a severe hypoxemic respiratory failure with a high in-hospital mortality. However, the molecular mechanisms underlying ARDS remain unclear. Recent findings have indicated that the…
View article: The histone methyltransferase Whsc1 regulates TGFβ-driven macrophage to myofibroblast transition
The histone methyltransferase Whsc1 regulates TGFβ-driven macrophage to myofibroblast transition Open
In normal wound healing, macrophages regulate early and late inflammation, allowing for resolution of tissue injury and subsequent healing. During normal tissue repair, macrophages undergo transition to myofibroblasts, which promote wound …
View article: Jagged-1 Reduces Th2 Inflammation and Memory Cell Expansion in Allergic Airway Disease
Jagged-1 Reduces Th2 Inflammation and Memory Cell Expansion in Allergic Airway Disease Open
Notch ligands present during interactions between T cells and dendritic cells (DCs) dictate cell phenotype through a myriad of effects including the induction of T cell regulation, survival, and cytokine response. The presence of Notch lig…
View article: Macrophage-specific inhibition of the histone demethylase JMJD3 decreases STING and pathologic inflammation in diabetic wound repair
Macrophage-specific inhibition of the histone demethylase JMJD3 decreases STING and pathologic inflammation in diabetic wound repair Open
Macrophage plasticity is critical for normal tissue repair following injury. In pathologic states such as diabetes, macrophage plasticity is impaired, and macrophages remain in a persistent proinflammatory state; however, the reasons for t…
View article: Single-cell Transcriptomics Reveals Dynamic Role of Smooth Muscle Cells and Enrichment of Immune Cell Subsets in Human Abdominal Aortic Aneurysms
Single-cell Transcriptomics Reveals Dynamic Role of Smooth Muscle Cells and Enrichment of Immune Cell Subsets in Human Abdominal Aortic Aneurysms Open
Objective: To determine cell-specific gene expression profiles that contribute to development of abdominal aortic aneurysms (AAAs). Background: AAAs represent the most common pathological aortic dilation leading to the fatal consequence of…
View article: Differences in <scp>H3K4me3</scp> and chromatin accessibility contribute to altered T‐cell receptor signaling in neonatal naïve <scp>CD4</scp> T cells
Differences in <span>H3K4me3</span> and chromatin accessibility contribute to altered T‐cell receptor signaling in neonatal naïve <span>CD4</span> T cells Open
Neonatal CD4 + T cells have reduced or delayed T‐cell receptor (TCR) signaling responses compared with adult cells, but the mechanisms underlying this are poorly understood. This study tested the hypothesis that human neonatal naïve CD4 + …
View article: IFN-κ is critical for normal wound repair and is decreased in diabetic wounds
IFN-κ is critical for normal wound repair and is decreased in diabetic wounds Open
Wound repair following acute injury requires a coordinated inflammatory response. Type I IFN signaling is important for regulating the inflammatory response after skin injury. IFN-κ, a type I IFN, has recently been found to drive skin infl…
View article: Coronavirus induces diabetic macrophage-mediated inflammation via SETDB2
Coronavirus induces diabetic macrophage-mediated inflammation via SETDB2 Open
Significance The COVID-19 pandemic has disproportionately affected patients with comorbidities, namely, obesity and type 2 diabetes. Macrophages (Mφs) are a key innate immune cell primarily responsible for the harmful, hyperinflammatory “c…
View article: Inhibition of macrophage histone demethylase JMJD3 protects against abdominal aortic aneurysms
Inhibition of macrophage histone demethylase JMJD3 protects against abdominal aortic aneurysms Open
Abdominal aortic aneurysms (AAAs) are a life-threatening disease for which there is a lack of effective therapy preventing aortic rupture. During AAA formation, pathological vascular remodeling is driven by macrophage infiltration, and the…
View article: Dysregulation of intercellular signaling by MOF deletion leads to liver injury
Dysregulation of intercellular signaling by MOF deletion leads to liver injury Open
Epigenetic mechanisms that alter heritable gene expression and chromatin structure play an essential role in many biological processes, including liver function. Human MOF (males absent on the first) is a histone acetyltransferase that is …
View article: Epigenetic regulation of the PGE2 pathway modulates macrophage phenotype in normal and pathologic wound repair
Epigenetic regulation of the PGE2 pathway modulates macrophage phenotype in normal and pathologic wound repair Open
Macrophages are a primary immune cell involved in inflammation, and their cell plasticity allows for transition from an inflammatory to a reparative phenotype and is critical for normal tissue repair following injury. Evidence suggests tha…
View article: Palmitate‐TLR4 signaling regulates the histone demethylase, JMJD3, in macrophages and impairs diabetic wound healing
Palmitate‐TLR4 signaling regulates the histone demethylase, JMJD3, in macrophages and impairs diabetic wound healing Open
Chronic macrophage inflammation is a hallmark of type 2 diabetes (T2D) and linked to the development of secondary diabetic complications. T2D is characterized by excess concentrations of saturated fatty acids (SFA) that activate innate imm…
View article: Epigenetic Regulation of TLR4 in Diabetic Macrophages Modulates Immunometabolism and Wound Repair
Epigenetic Regulation of TLR4 in Diabetic Macrophages Modulates Immunometabolism and Wound Repair Open
Macrophages are critical for the initiation and resolution of the inflammatory phase of wound healing. In diabetes, macrophages display a prolonged inflammatory phenotype preventing tissue repair. TLRs, particularly TLR4, have been shown t…
View article: TNF-α regulates diabetic macrophage function through the histone acetyltransferase MOF
TNF-α regulates diabetic macrophage function through the histone acetyltransferase MOF Open
A critical component of wound healing is the transition from the inflammatory phase to the proliferation phase to initiate healing and remodeling of the wound. Macrophages are critical for the initiation and resolution of the inflammatory …
View article: Ly6CLo Monocyte/Macrophages are Essential for Thrombus Resolution in a Murine Model of Venous Thrombosis
Ly6CLo Monocyte/Macrophages are Essential for Thrombus Resolution in a Murine Model of Venous Thrombosis Open
Venous thrombosis (VT) resolution is a complex process, resembling sterile wound healing. Infiltrating blood-derived monocyte/macrophages (Mo/MΦs) are essential for the regulation of inflammation in tissue repair. These cells differentiate…
View article: Epigenetic stabilization of DC and DC precursor classical activation by TNFα contributes to protective T cell polarization
Epigenetic stabilization of DC and DC precursor classical activation by TNFα contributes to protective T cell polarization Open
TNFα is critical for epigenetic DC maturation, DC phenotype stabilization, and driving protective T H 1 immunity to fungal infection.
View article: Inhibition of the stem cell factor 248 isoform attenuates the development of pulmonary remodeling disease
Inhibition of the stem cell factor 248 isoform attenuates the development of pulmonary remodeling disease Open
Stem cell factor (SCF) and its receptor c-kit have been implicated in inflammation, tissue remodeling, and fibrosis. Ingenuity Integrated Pathway Analysis of gene expression array data sets showed an upregulation of SCF transcripts in idio…
View article: Disruption of Neutrophil Extracellular Traps (NETs) Links Mechanical Strain to Post-traumatic Inflammation
Disruption of Neutrophil Extracellular Traps (NETs) Links Mechanical Strain to Post-traumatic Inflammation Open
Inflammation after trauma is both critical to normal wound healing and may be highly detrimental when prolonged or unchecked with the potential to impair physiologic healing and promote de novo pathology. Mechanical strain after trauma is …
View article: Sepsis Induces Prolonged Epigenetic Modifications in Bone Marrow and Peripheral Macrophages Impairing Inflammation and Wound Healing
Sepsis Induces Prolonged Epigenetic Modifications in Bone Marrow and Peripheral Macrophages Impairing Inflammation and Wound Healing Open
Objective: Sepsis represents an acute life-threatening disorder resulting from a dysregulated host response. For patients who survive sepsis, there remains long-term consequences, including impaired inflammation, as a result of profound im…
View article: Jagged-1 regulates <i>Foxp3</i> expression and cytokine production in CD4<sup>+</sup> T cells
Jagged-1 regulates <i>Foxp3</i> expression and cytokine production in CD4<sup>+</sup> T cells Open
Notch ligands are present during the interactions between T cells and dendritic cells (DC) and induce a myriad of effects that facilitate the activation of T cells, including the induction of T cell regulation, survival, and cytokine produ…
View article: Histone Methylation Directs Myeloid TLR4 Expression and Regulates Wound Healing following Cutaneous Tissue Injury
Histone Methylation Directs Myeloid TLR4 Expression and Regulates Wound Healing following Cutaneous Tissue Injury Open
Myeloid cells are critical for orchestrating regulated inflammation during wound healing. TLRs, particularly TLR4, and its downstream-signaling MyD88 pathway play an important role in regulating myeloid-mediated inflammation. Because an in…
View article: Attracting Attention: Discovery of IL-8/CXCL8 and the Birth of the Chemokine Field
Attracting Attention: Discovery of IL-8/CXCL8 and the Birth of the Chemokine Field Open
In the days when almost every biomedical science building has ubiquitous posters on the walls highlighting the various chemokines, their receptors, their alternative names, and the cell types they recruit, it is hard to imagine what it was…