Stefanie Lerche
YOU?
Author Swipe
View article: Quantification of cerebrospinal fluid α-synuclein seeds by endpoint dilution seed amplification assay in Parkinson’s disease
Quantification of cerebrospinal fluid α-synuclein seeds by endpoint dilution seed amplification assay in Parkinson’s disease Open
Quantitative pathology-specific biomarkers are needed for patients with Parkinson's disease (PD). We estimated the α-syn seeding dose giving 50% of positive seed amplification assay (SAA) reactions (SD50) in serially diluted samples from 2…
View article: Diagnostic and prognostic value of α-synuclein seed amplification assay kinetic measures in Parkinson's disease: a longitudinal cohort study
Diagnostic and prognostic value of α-synuclein seed amplification assay kinetic measures in Parkinson's disease: a longitudinal cohort study Open
© 2025 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license.
View article: Elevated cerebrospinal fluid levels of SERPIN E1 in participants with lewy body diseases
Elevated cerebrospinal fluid levels of SERPIN E1 in participants with lewy body diseases Open
Parkinson’s disease (PD) exhibits substantial phenotypic variability, likely influenced, at least in part, by proteins associated with pathways integral to aging processes. Plasminogen activator inhibitor-1 (SERPIN E1) is known for its ass…
View article: Differences in age-related distribution of CSF alpha-synuclein seeding and Alzheimer profiles between PD with and without GBA1 variants
Differences in age-related distribution of CSF alpha-synuclein seeding and Alzheimer profiles between PD with and without GBA1 variants Open
We studied the age- and genetic-related prevalence of CSF alpha-Synuclein seeding and Alzheimer profiles in 188 samples from PD participants without GBA1 variants (PD wildtype ) and in 129 samples from PD participants with GBA1 variants (P…
View article: Machine learning-based personalized composite score dissects risk and protective factors for cognitive and motor function in older participants
Machine learning-based personalized composite score dissects risk and protective factors for cognitive and motor function in older participants Open
Introduction With age, sensory, cognitive, and motor abilities decline, and the risk for neurodegenerative disorders increases. These impairments influence the quality of life and increase the need for care, thus putting a high burden on s…
View article: Tissue Factor and Its Cerebrospinal Fluid Protein Profiles in Parkinson’s Disease
Tissue Factor and Its Cerebrospinal Fluid Protein Profiles in Parkinson’s Disease Open
Background: Prior investigations have elucidated pathophysiological interactions involving blood coagulation and neurodegenerative diseases. These interactions pertain to age-related effects and a mild platelet antiaggregant function of ex…
View article: CSF Sphingolipids in Parkinson Disease and Dementia with Lewy Bodies with and without GBA1 variants
CSF Sphingolipids in Parkinson Disease and Dementia with Lewy Bodies with and without GBA1 variants Open
Variants in GBA1 result in dysregulated sphingolipids. We investigated five CSF sphingolipid species in a multicenter cohort comprising people with Parkinson’s Disease and Dementia with Lewy bodies with and without GBA1 variants and health…
View article: Association of elevated cerebrospinal fluid levels of the longevity protein α‐Klotho with a delayed onset of cognitive impairment in Parkinson's disease patients
Association of elevated cerebrospinal fluid levels of the longevity protein α‐Klotho with a delayed onset of cognitive impairment in Parkinson's disease patients Open
Background and Purpose Parkinson's disease (PD) is an age‐related condition characterized by substantial phenotypic variability. Consequently, pathways and proteins involved in biological aging, such as the central aging pathway comprising…
View article: Association of high alpha-Klotho-levels in CSF with a later onset of cognitive impairment in patients with Parkinson´s disease
Association of high alpha-Klotho-levels in CSF with a later onset of cognitive impairment in patients with Parkinson´s disease Open
Background: Parkinson's disease (PD) is an age-related condition characterized by substantial phenotypic variability. Consequently, pathways and proteins involved in biological aging, such as the central aging pathway comprising IGF1, alph…
View article: CSF α-synuclein seed amplification kinetic profiles are associated with cognitive decline in PD
CSF α-synuclein seed amplification kinetic profiles are associated with cognitive decline in PD Open
Seed amplification assays have been implemented in Parkinson’s disease to reveal disease-specific misfolded alpha-synuclein aggregates in biospecimens. While the assays’ qualitative dichotomous seeding response is valuable to stratify and …
View article: Machine learning-based personalized composite score dissects risk and protective factors for cognitive and motor function in elderly
Machine learning-based personalized composite score dissects risk and protective factors for cognitive and motor function in elderly Open
Background: Most nations worldwide have aging populations. With age, sensory, cognitive and motor abilities decline and the risk for neurodegenerative disorders increases. These multiple impairments influence the quality of life and increa…
View article: Impact of <scp><i>APOE</i></scp> Genotype on Cognition in Idiopathic and Genetic Forms of Parkinson's Disease
Impact of <span><i>APOE</i></span> Genotype on Cognition in Idiopathic and Genetic Forms of Parkinson's Disease Open
The data supporting the findings of this study are available upon reasonable request from any qualified investigator. Data S1. Supporting Information. Figure S1. The frequency of presence of at least one APOE ε4 allele (either in heterozyg…
View article: Machine learning-based personalized composite score dissects risk and protective factors for cognitive and motor function in elderly
Machine learning-based personalized composite score dissects risk and protective factors for cognitive and motor function in elderly Open
Most nations worldwide have aging populations. With age, sensory, cognitive and motor abilities decline and the risk for neurodegenerative disorders increases. These multiple impairments influence the quality of life and increase the need …
View article: Impact of<i>APOE</i>genotype on cognition in idiopathic and genetic forms of Parkinson’s disease
Impact of<i>APOE</i>genotype on cognition in idiopathic and genetic forms of Parkinson’s disease Open
Background Apolipoprotein E-ε4 ( APOE ε4) genotype may be associated with the development of cognitive decline in idiopathic Parkinson’s disease i(PD), however its effect in genetic PD is understudied. Objectives In the current work we aim…
View article: Inflammatory CSF profiles and longitudinal development of cognitive decline in sporadic and GBA-associated PD
Inflammatory CSF profiles and longitudinal development of cognitive decline in sporadic and GBA-associated PD Open
Inflammation modifies incidence and progression of Parkinson’s disease (PD). By using 30 inflammatory markers in CSF in 498 people with PD and 67 people with Dementia with Lewy Bodies (DLB) we show that: 1) levels of ICAM-1, Interleukin-8,…
View article: CSF and Serum Levels of Inflammatory Markers in PD: Sparse Correlation, Sex Differences and Association With Neurodegenerative Biomarkers
CSF and Serum Levels of Inflammatory Markers in PD: Sparse Correlation, Sex Differences and Association With Neurodegenerative Biomarkers Open
Background An involvement of the central-nervous and peripheral, innate and adaptive immune system in the pathogenesis of Parkinson's disease (PD) is nowadays well established. Objectives We face several open questions in preparation of cl…
View article: <scp>CSF</scp> Protein Level of Neurotransmitter Secretion, Synaptic Plasticity, and Autophagy in <scp>PD</scp> and <scp>DLB</scp>
<span>CSF</span> Protein Level of Neurotransmitter Secretion, Synaptic Plasticity, and Autophagy in <span>PD</span> and <span>DLB</span> Open
Background Molecular pathways associated with α‐synuclein proteostasis have been detected in genetic studies and in cell models and include autophagy, ubiquitin‐proteasome system, mitochondrial homeostasis, and synaptic plasticity. However…
View article: The Mutation Matters: <scp>CSF</scp> Profiles of <scp>GCase</scp>, Sphingolipids, α‐Synuclein in <scp>PD<sub>GBA</sub></scp>
The Mutation Matters: <span>CSF</span> Profiles of <span>GCase</span>, Sphingolipids, α‐Synuclein in <span>PD<sub>GBA</sub></span> Open
Background With pathway‐specific trials in PD associated with variants in the glucocerebrosidase gene (PD GBA ) under way, we need markers that confirm the impact of genetic variants in patient‐derived biofluids in order to allow patient s…
View article: The longevity gene <i>Klotho</i> and its cerebrospinal fluid protein profiles as a modifier for Parkinson´s disease
The longevity gene <i>Klotho</i> and its cerebrospinal fluid protein profiles as a modifier for Parkinson´s disease Open
Background Parkinson´s disease (PD) has a large phenotypic variability, which may, at least partly, be genetically driven including alterations of gene products. Candidates might not only be proteins associated with disease risk but also p…
View article: Orthostatic hypotension as a risk factor for longitudinal deterioration of cognitive function in the elderly
Orthostatic hypotension as a risk factor for longitudinal deterioration of cognitive function in the elderly Open
Background and purpose Orthostatic hypotension is frequent with aging with a prevalence of 20%–30% in people aged 65 or older and is considered to increase the risk for coronary events, strokes and dementia. Our objective was to characteri…
View article: Global, Yet Incomplete Overview of Cohort Studies in Parkinson’s disease
Global, Yet Incomplete Overview of Cohort Studies in Parkinson’s disease Open
Existing data of PD cohorts provide vast collaboration opportunities. We propose to establish a comprehensive, up-to-date, open-access internet platform with easy-to-use search tools of PD cohort descriptions and potentially available data…
View article: Prodromal Markers in Parkinson’s Disease: Limitations in Longitudinal Studies and Lessons Learned
Prodromal Markers in Parkinson’s Disease: Limitations in Longitudinal Studies and Lessons Learned Open
A growing body of evidence supports a prodromal neurodegenerative process preceding the clinical onset of Parkinson's disease (PD). Studies have identified several different prodromal markers that may have the potential to predict the conv…
View article: Aiming for Study Comparability in Parkinson's Disease: Proposal for a Modular Set of Biomarker Assessments to be Used in Longitudinal Studies
Aiming for Study Comparability in Parkinson's Disease: Proposal for a Modular Set of Biomarker Assessments to be Used in Longitudinal Studies Open
Parkinson's disease (PD) is an example for a complex field of research, which is driven by the multifactorial etiology, the heterogeneity in phenotype and the variability in disease progression, as well as the presence of a long pre-diagno…