Marie‐Christine Jaulent
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View article: OpenPVSignal Knowledge Graph: Pharmacovigilance Signal Reports in a Computationally Exploitable FAIR Representation
OpenPVSignal Knowledge Graph: Pharmacovigilance Signal Reports in a Computationally Exploitable FAIR Representation Open
The presented KG could be useful in various data-processing pipelines, including systems that support drug safety activities.
View article: Applying AI to Structured Real-World Data for Pharmacovigilance Purposes: Scoping Review
Applying AI to Structured Real-World Data for Pharmacovigilance Purposes: Scoping Review Open
Background Artificial intelligence (AI) applied to real-world data (RWD; eg, electronic health care records) has been identified as a potentially promising technical paradigm for the pharmacovigilance field. There are several instances of …
View article: Comparing a Large Language Model with Previous Deep Learning Models on Named Entity Recognition of Adverse Drug Events
Comparing a Large Language Model with Previous Deep Learning Models on Named Entity Recognition of Adverse Drug Events Open
The ability to fine-tune pre-trained deep learning models to learn how to process a downstream task using a large training set allow to significantly improve performances of named entity recognition. Large language models are recent models…
View article: Causal Deep Learning for the Detection of Adverse Drug Reactions: Drug-Induced Acute Kidney Injury as a Case Study
Causal Deep Learning for the Detection of Adverse Drug Reactions: Drug-Induced Acute Kidney Injury as a Case Study Open
Causal Deep/Machine Learning (CDL/CML) is an emerging Artificial Intelligence (AI) paradigm. The combination of causal inference and AI could mine explainable causal relationships between data features, providing useful insights for variou…
View article: Artificial intelligence integration in the drug lifecycle and in regulatory science: policy implications, challenges and opportunities
Artificial intelligence integration in the drug lifecycle and in regulatory science: policy implications, challenges and opportunities Open
Artificial intelligence tools promise transformative impacts in drug development. Regulatory agencies face challenges in integrating AI while ensuring reliability and safety in clinical trial approvals, drug marketing authorizations, and p…
View article: Monitoring Adverse Drug Events in Web Forums: Evaluation of a Pipeline and Use Case Study
Monitoring Adverse Drug Events in Web Forums: Evaluation of a Pipeline and Use Case Study Open
Background To mitigate safety concerns, regulatory agencies must make informed decisions regarding drug usage and adverse drug events (ADEs). The primary pharmacovigilance data stem from spontaneous reports by health care professionals. Ho…
View article: Applying AI to Structured Real-World Data for Pharmacovigilance Purposes: Scoping Review (Preprint)
Applying AI to Structured Real-World Data for Pharmacovigilance Purposes: Scoping Review (Preprint) Open
BACKGROUND Artificial intelligence (AI) applied to real-world data (RWD; eg, electronic health care records) has been identified as a potentially promising technical paradigm for the pharmacovigilance field. There are several instances of…
View article: Rapid Review on Publicly Available Datasets for Health Misinformation Detection
Rapid Review on Publicly Available Datasets for Health Misinformation Detection Open
The proliferation of health misinformation in recent years has prompted the development of various methods for detecting and combatting this issue. This review aims to provide an overview of the implementation strategies and characteristic…
View article: Transfer Learning for Early Prediction of Adverse Drug Reactions: Docetaxel and Alopecia in Breast Cancer as a Case Study
Transfer Learning for Early Prediction of Adverse Drug Reactions: Docetaxel and Alopecia in Breast Cancer as a Case Study Open
Transfer Learning (TL) is an approach which has not yet been widely investigated in healthcare, mostly applied in image data. This study outlines a TL pipeline leveraging Individual Case Safety reports (ICSRs) and Electronic Health Records…
View article: Patient and public involvement in the benefit–risk assessment and decision concerning health products: position of the Scientific Advisory Board of the French National Agency for Medicines and Health Products Safety (ANSM)
Patient and public involvement in the benefit–risk assessment and decision concerning health products: position of the Scientific Advisory Board of the French National Agency for Medicines and Health Products Safety (ANSM) Open
International audience
View article: Monitoring Adverse Drug Events in Web Forums: Evaluation of a Pipeline and Use Case Study (Preprint)
Monitoring Adverse Drug Events in Web Forums: Evaluation of a Pipeline and Use Case Study (Preprint) Open
BACKGROUND To mitigate safety concerns, regulatory agencies must make informed decisions regarding drug usage and adverse drug events (ADEs). The primary pharmacovigilance data stem from spontaneous reports by health care professionals. H…
View article: Encouraging Behavior Changes and Preventing Cardiovascular Diseases Using the Prevent Connect Mobile Health App: Conception and Evaluation of App Quality
Encouraging Behavior Changes and Preventing Cardiovascular Diseases Using the Prevent Connect Mobile Health App: Conception and Evaluation of App Quality Open
Background Cardiovascular diseases are a major cause of death worldwide. Mobile health apps could help in preventing cardiovascular diseases by improving modifiable risk factors such as eating habits, physical activity levels, and alcohol …
View article: An Integrated Care Platform System (C3-Cloud) for Care Planning, Decision Support, and Empowerment of Patients With Multimorbidity: Protocol for a Technology Trial
An Integrated Care Platform System (C3-Cloud) for Care Planning, Decision Support, and Empowerment of Patients With Multimorbidity: Protocol for a Technology Trial Open
Background There is an increasing need to organize the care around the patient and not the disease, while considering the complex realities of multiple physical and psychosocial conditions, and polypharmacy. Integrated patient-centered car…
View article: Visualising Patterns Associated with Adverse Drug Reactions in French Forums
Visualising Patterns Associated with Adverse Drug Reactions in French Forums Open
As social media are an interesting source of information for pharmacovigilance, we implemented a novel visualisation method for pharmacovigilance specialists applied to French discussion forums. A word embedding model was trained on posts …
View article: Influence of Connected Health Interventions for Adherence to Cardiovascular Disease Prevention: A Scoping Review
Influence of Connected Health Interventions for Adherence to Cardiovascular Disease Prevention: A Scoping Review Open
Background Recent health care developments include connected health interventions to improve chronic disease management and/or promote actions reducing aggravating risk factors for conditions such as cardiovascular diseases. Adherence is o…
View article: An Integrated Care Platform System (C3-Cloud) for Care Planning, Decision Support, and Empowerment of Patients With Multimorbidity: Protocol for a Technology Trial (Preprint)
An Integrated Care Platform System (C3-Cloud) for Care Planning, Decision Support, and Empowerment of Patients With Multimorbidity: Protocol for a Technology Trial (Preprint) Open
BACKGROUND There is an increasing need to organize the care around the patient and not the disease, while considering the complex realities of multiple physical and psychosocial conditions, and polypharmacy. Integrated patient-centered ca…
View article: Vassilis Koutkias (1975 - 2019) - the Painful Loss of a Rare Person
Vassilis Koutkias (1975 - 2019) - the Painful Loss of a Rare Person Open
Vassilis G. Koutkias died on December 14, 2019, at the age of 44. He leaves his wife Andigoni, his two little girls (9 and 7 years-old), and a brilliant career as a young scientist in Biomedical Informatics.
View article: Supporting Active Pharmacovigilance via IT Tools in the Clinical Setting and Beyond: Regulatory and Management Aspects
Supporting Active Pharmacovigilance via IT Tools in the Clinical Setting and Beyond: Regulatory and Management Aspects Open
Information Technology (IT) could have a prominent role towards the "Active Pharmacovigilance" (AP) paradigm by facilitating the analysis of potential Adverse Drug Reactions (ADRs). PVClinical project aims to build an IT platform enabling …
View article: Classification of the Severity of Adverse Drugs Reactions
Classification of the Severity of Adverse Drugs Reactions Open
This poster presents a non-exhaustive study of machine learning classification algorithms on pharmacovigilance data. In this study, we have taken into account the patient's clinical data such as medical history, medications taken and their…
View article: Decision Support System for Selection of e-Health Interventions
Decision Support System for Selection of e-Health Interventions Open
The main goal of this work was to design a decision support system for effective personalized cardiovascular risk prevention: i) to identify behavioral groups associated with clinical risk factors, ii) to provide recommendations associated…
View article: Localisation, Personalisation and Delivery of Best Practice Guidelines on an Integrated Care and Cure Cloud Architecture: The C3-Cloud Approach to Managing Multimorbidity
Localisation, Personalisation and Delivery of Best Practice Guidelines on an Integrated Care and Cure Cloud Architecture: The C3-Cloud Approach to Managing Multimorbidity Open
Background: C3-Cloud is an integrated care ICT infrastructure offering seamless patient-centered approach to managing multimorbidity, deployed in three European pilot sites. Challenge: The digital delivery of best practice guidelines unifi…
View article: Ontological and Non-Ontological Resources for Associating Medical Dictionary for Regulatory Activities Terms to SNOMED Clinical Terms With Semantic Properties
Ontological and Non-Ontological Resources for Associating Medical Dictionary for Regulatory Activities Terms to SNOMED Clinical Terms With Semantic Properties Open
Background: Formal definitions allow selecting terms (e.g., identifying all terms related to "Infectious disease" using the query "has causative agent organism") and terminological reasoning (e.g., "hepatitis B" is a "hepatitis" and is an …
View article: Computational Advances in Drug Safety: Systematic and Mapping Review of Knowledge Engineering Based Approaches
Computational Advances in Drug Safety: Systematic and Mapping Review of Knowledge Engineering Based Approaches Open
Drug Safety (DS) is a domain with significant public health and social impact. Knowledge Engineering (KE) is the Computer Science discipline elaborating on methods and tools for developing "knowledge-intensive" systems, depending on a conc…
View article: Semantic Interpretation of the map with Diabetes-Related Websites (Preprint)
Semantic Interpretation of the map with Diabetes-Related Websites (Preprint) Open
BACKGROUND Diabetes as a chronic condition requires continuous medical care and constant patient self-management. Such care and self-management involve several stakeholders in order to improve health outcome and patient quality of life. I…
View article: Semantic Queries Expedite MedDRA Terms Selection Thanks to a Dedicated User Interface: A Pilot Study on Five Medical Conditions
Semantic Queries Expedite MedDRA Terms Selection Thanks to a Dedicated User Interface: A Pilot Study on Five Medical Conditions Open
Background: Searching into the MedDRA terminology is usually limited to a hierarchical search, and/or a string search. Our objective was to compare user performances when using a new kind of user interface enabling semantic queries versus …
View article: Mapping the Hyperlink Structure of Diabetes Online Communities
Mapping the Hyperlink Structure of Diabetes Online Communities Open
Diabetes is one of the largest global health emergencies of the 21st century. As a chronic disease, diabetes requires continuous medical care and constant patient self-management. Such care involves several stakeholders to improve health o…