Steven Lisgo
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View article: A spatial transcriptomic atlas of autism-associated genes identifies convergence in the developing human thalamus
A spatial transcriptomic atlas of autism-associated genes identifies convergence in the developing human thalamus Open
Autism is a highly heritable neurodevelopmental condition that manifests across a wide phenotypic spectrum. Rare and de novo loss-of-function mutations strongly predispose to autism and co-occurring developmental and intellectual disabilit…
View article: Transcriptomic profiling confirms microRNA-140 is more functional in joint development than in disease
Transcriptomic profiling confirms microRNA-140 is more functional in joint development than in disease Open
miR-140-5p is indispensable for skeletal development, orchestrating endochondral ossification through regulation of chondrocyte proliferation and differentiation, with distinct activity in resting zone chondrocytes and the perichondrium id…
View article: Cell Cycle Arrest of a ‘Zippering’ Epithelial Cell Cluster Shapes the Face and is Disrupted in Craniofacial Disorders
Cell Cycle Arrest of a ‘Zippering’ Epithelial Cell Cluster Shapes the Face and is Disrupted in Craniofacial Disorders Open
Facial features identify individuals, but the mechanisms shaping the human face remain elusive. Orofacial clefting (OFC), the most common craniofacial abnormality, results from failed fusion of the facial prominences that is in part caused…
View article: Charting the single cell transcriptional landscape governing visual imprinting
Charting the single cell transcriptional landscape governing visual imprinting Open
Memory-related transcriptional events in brain remain poorly understood. Visual imprinting is a form of learning in which young animals develop preferences through early exposure to specific stimuli. In chicks, visual imprinting memory is …
View article: The evolution of gene regulatory programs controlling gonadal development in primates
The evolution of gene regulatory programs controlling gonadal development in primates Open
Sex-determining pathways produce dimorphic gonads (ovaries and testes), yet the gene regulatory programs governing gonadogenesis and their evolution in primates remain little explored. Here we report evolutionary analyses of transcriptome …
View article: The evolution of gene regulation in mammalian cerebellum development
The evolution of gene regulation in mammalian cerebellum development Open
Gene regulatory changes are considered major drivers of evolutionary innovations, including the cerebellum’s expansion during human evolution, yet they remain largely unexplored. In this study, we combined single-nucleus measurements of ge…
View article: Multi-omics identification of extracellular components of the fetal monkey and human neocortex
Multi-omics identification of extracellular components of the fetal monkey and human neocortex Open
During development, precursor cells are continuously and intimately interacting with their extracellular environment, which guides their ability to generate functional tissues and organs. Much is known about the development of the neocorte…
View article: Cardiac development demystified by use of the <scp>HDBR</scp> atlas
Cardiac development demystified by use of the <span>HDBR</span> atlas Open
Much has been learned over the last half century regarding the molecular and genetic changes that take place during cardiac development. As yet, however, these advances have not been translated into knowledge regarding the marked changes t…
View article: Cellular development and evolution of the mammalian cerebellum
Cellular development and evolution of the mammalian cerebellum Open
The expansion of the neocortex, a hallmark of mammalian evolution 1,2 , was accompanied by an increase in cerebellar neuron numbers 3 . However, little is known about the evolution of the cellular programmes underlying the development of t…
View article: Spatial transcriptomics reveals novel genes during the remodelling of the embryonic human arterial valves
Spatial transcriptomics reveals novel genes during the remodelling of the embryonic human arterial valves Open
Abnormalities of the arterial valves, including bicuspid aortic valve (BAV) are amongst the most common congenital defects and are a significant cause of morbidity as well as predisposition to disease in later life. Despite this, and compo…
View article: A human prenatal skin cell atlas reveals immune cell regulation of skin morphogenesis
A human prenatal skin cell atlas reveals immune cell regulation of skin morphogenesis Open
Summary Human prenatal skin is populated by innate immune cells including macrophages, and whether they act solely in immunity or have additional functions in morphogenesis is unclear. We assembled the first comprehensive multi-omic refere…
View article: Yolk sac cell atlas reveals multiorgan functions during human early development
Yolk sac cell atlas reveals multiorgan functions during human early development Open
The extraembryonic yolk sac (YS) ensures delivery of nutritional support and oxygen to the developing embryo but remains ill-defined in humans. We therefore assembled a comprehensive multiomic reference of the human YS from 3 to 8 postconc…
View article: Cell Type- and Tissue-specific Enhancers in Craniofacial Development
Cell Type- and Tissue-specific Enhancers in Craniofacial Development Open
The genetic basis of craniofacial birth defects and general variation in human facial shape remains poorly understood. Distant-acting transcriptional enhancers are a major category of non-coding genome function and have been shown to contr…
View article: Spatial transcriptomics reveals novel genes during the remodelling of the embryonic human arterial valves
Spatial transcriptomics reveals novel genes during the remodelling of the embryonic human arterial valves Open
Abnormalities of the arterial valves, including bicuspid aortic valve (BAV) are amongst the most common congenital defects and are a significant cause of morbidity as well as predisposition to disease in later life. Despite this, and compo…
View article: Single-cell RNA sequencing reveals transcriptional changes of human choroidal and retinal pigment epithelium cells during fetal development, in healthy adult and intermediate age-related macular degeneration
Single-cell RNA sequencing reveals transcriptional changes of human choroidal and retinal pigment epithelium cells during fetal development, in healthy adult and intermediate age-related macular degeneration Open
Age-related macular degeneration (AMD) is the most prevalent cause of blindness in the developed world. Vision loss in the advanced stages of the disease is caused by atrophy of retinal photoreceptors, overlying retinal pigment epithelium …
View article: Multi-organ functions of yolk sac during human early development
Multi-organ functions of yolk sac during human early development Open
The yolk sac (YS) represents an evolutionarily-conserved extraembryonic structure that ensures timely delivery of nutritional support and oxygen to the developing embryo. However, the YS remains ill-defined in humans. We therefore assemble…
View article: Reconstituting human somitogenesis <i>in vitro</i>
Reconstituting human somitogenesis <i>in vitro</i> Open
The segmented body plan of vertebrates is established during somitogenesis, a well-studied process in model organisms, but remains largely elusive in humans due to ethical and technical limitations. Despite recent advances with pluripotent…
View article: Cellular development and evolution of the mammalian cerebellum
Cellular development and evolution of the mammalian cerebellum Open
The expansion of the neocortex, one of the hallmarks of mammalian evolution 1,2 , was accompanied by an increase in the number of cerebellar neurons 3 . However, little is known about the evolution of the cellular programs underlying cereb…
View article: Development of a physiological model of human middle ear epithelium
Development of a physiological model of human middle ear epithelium Open
Introduction Otitis media is an umbrella term for middle ear inflammation; ranging from acute infection to chronic mucosal disease. It is a leading cause of antimicrobial therapy prescriptions and surgery in children. Despite this, treatme…
View article: Cells of the human intestinal tract mapped across space and time.
Cells of the human intestinal tract mapped across space and time. Open
The cellular landscape of the human intestinal tract is dynamic throughout life, developing in utero and changing in response to functional requirements and environmental exposures. Here, to comprehensively map cell lineages, we use single…
View article: Intrinsic and extrinsic regulation of human fetal bone marrow haematopoiesis and perturbations in Down syndrome
Intrinsic and extrinsic regulation of human fetal bone marrow haematopoiesis and perturbations in Down syndrome Open
Throughout postnatal life, haematopoiesis in the bone marrow (BM) maintains blood and immune cell production. Haematopoiesis first emerges in human BM at 12 post conception weeks while fetal liver (FL) haematopoiesis is still expanding. Ye…