Sean Mackey
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View article: Bridging the medical-dental divide: a public health imperative for temporomandibular disorders
Bridging the medical-dental divide: a public health imperative for temporomandibular disorders Open
View article: Differential encoding of noxious heat and self-reported pain along corticospinal networks: a simultaneous spinal cord-brain fMRI study
Differential encoding of noxious heat and self-reported pain along corticospinal networks: a simultaneous spinal cord-brain fMRI study Open
Chronic pain poses a substantial public health burden. Elucidating how the healthy central nervous system (CNS) differentially encodes objective stimulus intensity and subjective experiences of pain perception may offer key insights into t…
View article: Digital twin learning health systems and multimodal biomarkers transform pain care
Digital twin learning health systems and multimodal biomarkers transform pain care Open
Despite scientific advances, pain care remains fragmented, inaccessible, and imprecise. We propose a future in which Digital Twin Learning Health Systems (DT-LHS) transform pain management by integrating multimodal biomarkers, real-time da…
View article: Real-world data and evidence in pain research: an IMMPACT comprehensive review and best practice recommendations
Real-world data and evidence in pain research: an IMMPACT comprehensive review and best practice recommendations Open
Real-world data (RWD) can be defined as routinely collected clinical or administrative data that might be used for research purposes and to generate real-world evidence (RWE). Computerized search and data mining methods, large electronic d…
View article: Defining chronic pain impact levels: a patient-clinician approach using PROMIS® pain interference scores
Defining chronic pain impact levels: a patient-clinician approach using PROMIS® pain interference scores Open
Our study aims to establish PROMIS Pain Interference score (PI) ranges that clinicians and persons living with chronic pain (PLwCP) associate with none, mild, moderate, and high impact chronic pain. We employed the PRO-Bookmarking techniqu…
View article: Baseline characteristics of participants in the Biomarkers for Evaluating Spine Treatments clinical trial: a sequential multiple assignment randomized trial for chronic low back pain
Baseline characteristics of participants in the Biomarkers for Evaluating Spine Treatments clinical trial: a sequential multiple assignment randomized trial for chronic low back pain Open
Objective Chronic low back pain (cLBP) is a significant public health problem in the United States. A method to identify treatments that are most likely effective for an individual patient based on their unique characteristics is needed. M…
View article: Automated Segmentation of Forearm Muscles: Clinical Associations With Hand Function, Muscle Volume and Intramuscular Fat
Automated Segmentation of Forearm Muscles: Clinical Associations With Hand Function, Muscle Volume and Intramuscular Fat Open
Background Hand function is critical for daily activities and declines early in many diseases, conditions or disorders affecting the musculoskeletal and neurologic systems. Muscle health markers derived from clinically available magnetic r…
View article: Revealing sleep and pain reciprocity with wearables and machine learning
Revealing sleep and pain reciprocity with wearables and machine learning Open
View article: Association Between Opioid Use Disorder and Healthcare Spending and Utilization in Emergency Surgical Patients: A Retrospective Analysis Using Commercial Claims
Association Between Opioid Use Disorder and Healthcare Spending and Utilization in Emergency Surgical Patients: A Retrospective Analysis Using Commercial Claims Open
Objective: To estimate the association between opioid use disorder (OUD) and healthcare spending and utilization in emergency surgical patients, and to evaluate whether the use of opioid agonist treatment (OAT) modifies this relationship. …
View article: The design and rationale of the Biomarkers for Evaluating Spine Treatments trial: a sequential multiple assignment randomized trial
The design and rationale of the Biomarkers for Evaluating Spine Treatments trial: a sequential multiple assignment randomized trial Open
Objective Chronic low back pain (cLBP) is a common condition that impacts quality of life and function. There are many evidence-based treatments to address cLBP; however, treatment effects are modest, perhaps in part due to individual vari…
View article: Latent anger profiles in chronic pain and their associations with current and long-term pain outcomes
Latent anger profiles in chronic pain and their associations with current and long-term pain outcomes Open
Anger is prevalent in chronic pain (CP), often co-occurring with heightened distress and disability. The complexity of the anger construct manifests in heterogeneity of how anger is experienced, expressed, and regulated. Nevertheless, most…
View article: Zoom-Delivered Empowered Relief for Chronic Pain: Observational Longitudinal Pilot Study Exploring Feasibility and Pain-Related Outcomes in Patients on Long-Term Opioids
Zoom-Delivered Empowered Relief for Chronic Pain: Observational Longitudinal Pilot Study Exploring Feasibility and Pain-Related Outcomes in Patients on Long-Term Opioids Open
Background Patients with chronic pain on long-term opioid therapy often face barriers to accessing effective nonpharmacological treatments, including the burden of multiple sessions, lack of trained clinicians, and travel time. Empowered R…
View article: Mapping Hand Function with Simultaneous Brain-Spinal Cord Functional MRI
Mapping Hand Function with Simultaneous Brain-Spinal Cord Functional MRI Open
INTRODUCTION Hand motor control depends on intricate brain-spinal cord interactions that regulate muscle activity. Hand function can be disrupted by injury to the brain, spinal cord, and peripheral nerves leading to weakness and impaired c…
View article: Clinician and researcher responses to the term pain catastrophizing and whether new terminology is needed: Content analysis of international, cross-sectional, qualitative survey data
Clinician and researcher responses to the term pain catastrophizing and whether new terminology is needed: Content analysis of international, cross-sectional, qualitative survey data Open
View article: Innovations in acute and chronic pain biomarkers: enhancing diagnosis and personalized therapy
Innovations in acute and chronic pain biomarkers: enhancing diagnosis and personalized therapy Open
Pain affects millions worldwide, posing significant challenges in diagnosis and treatment. Despite advances in understanding pain mechanisms, there remains a critical need for validated biomarkers to enhance diagnosis, prognostication, and …
View article: Leg Muscle Volume, Intramuscular Fat and Force Generation: Insights From a Computer‐Vision Model and Fat‐Water MRI
Leg Muscle Volume, Intramuscular Fat and Force Generation: Insights From a Computer‐Vision Model and Fat‐Water MRI Open
Background Maintaining skeletal muscle health (i.e., muscle size and quality) is crucial for preserving mobility. Decreases in lower limb muscle volume and increased intramuscular fat (IMF) are common findings in people with impaired mobil…
View article: EPISeg: Automated segmentation of the spinal cord on echo planar images using open-access multi-center data
EPISeg: Automated segmentation of the spinal cord on echo planar images using open-access multi-center data Open
Functional magnetic resonance imaging (fMRI) of the spinal cord is relevant for studying sensation, movement, and autonomic function. Preprocessing of spinal cord fMRI data involves segmentation of the spinal cord on gradient-echo echo pla…
View article: Problem of pain in the USA: evaluating the generalisability of high-impact chronic pain models over time using National Health Interview Survey (NHIS) data
Problem of pain in the USA: evaluating the generalisability of high-impact chronic pain models over time using National Health Interview Survey (NHIS) data Open
Introduction High-impact chronic pain (HICP) significantly affects the quality of life for millions of US adults, imposing substantial economic/healthcare burdens. Disproportionate effects are observed among racial/ethnic minorities and ol…
View article: EPISeg: Automated segmentation of the spinal cord on echo planar images using open-access multi-center data
EPISeg: Automated segmentation of the spinal cord on echo planar images using open-access multi-center data Open
Functional magnetic resonance imaging (fMRI) of the spinal cord is relevant for studying sensation, movement, and autonomic function. Preprocessing of spinal cord fMRI data involves segmentation of the spinal cord on gradient-echo echo pla…
View article: Mapping hand function with simultaneous brain–spinal cord functional MRI
Mapping hand function with simultaneous brain–spinal cord functional MRI Open
Hand motor control depends on intricate brain–spinal cord interactions that regulate muscle activity. Hand function can be disrupted by injury to the brain, spinal cord, and peripheral nerves leading to weakness and impaired coordination. …
View article: Body size and intracranial volume interact with the structure of the central nervous system: A multi-center in vivo neuroimaging study
Body size and intracranial volume interact with the structure of the central nervous system: A multi-center in vivo neuroimaging study Open
Clinical research emphasizes the implementation of rigorous and reproducible study designs that rely on between-group matching or controlling for sources of biological variation such as subject’s sex and age. However, corrections for body …
View article: The problem of pain in systemic lupus erythematosus: A comprehensive analysis of pain distribution using the CHOIR body map and PROMIS measures
The problem of pain in systemic lupus erythematosus: A comprehensive analysis of pain distribution using the CHOIR body map and PROMIS measures Open
Background Our study investigates the associations between pain distribution, biopsychosocial factors, and Patient-Reported Outcomes Measurement Information System (PROMIS) measures in patients with systemic lupus erythematosus (SLE). Empl…
View article: Three-dimensional spatial distribution of lumbar paraspinal intramuscular fat revealed by spatial parametric mapping
Three-dimensional spatial distribution of lumbar paraspinal intramuscular fat revealed by spatial parametric mapping Open
View article: Breaking barriers: addressing opioid stigma in chronic pain and opioid use disorder
Breaking barriers: addressing opioid stigma in chronic pain and opioid use disorder Open
View article: Methods for pragmatic randomized clinical trials of pain therapies: IMMPACT statement
Methods for pragmatic randomized clinical trials of pain therapies: IMMPACT statement Open
Pragmatic, randomized, controlled trials hold the potential to directly inform clinical decision making and health policy regarding the treatment of people experiencing pain. Pragmatic trials are designed to replicate or are embedded withi…
View article: Body size interacts with the structure of the central nervous system: A multi-center in vivo neuroimaging study
Body size interacts with the structure of the central nervous system: A multi-center in vivo neuroimaging study Open
Clinical research emphasizes the implementation of rigorous and reproducible study designs that rely on between-group matching or controlling for sources of biological variation such as subject’s sex and age. However, corrections for body …
View article: Comprehensive overview of the anesthesiology research landscape: A machine Learning Analysis of 737 NIH-funded anesthesiology primary Investigator's publication trends
Comprehensive overview of the anesthesiology research landscape: A machine Learning Analysis of 737 NIH-funded anesthesiology primary Investigator's publication trends Open
View article: The Problem of Pain in Lupus: Epidemiological Profiles of Patients Attending Multidisciplinary Pain Clinics
The Problem of Pain in Lupus: Epidemiological Profiles of Patients Attending Multidisciplinary Pain Clinics Open
View article: Utilizing a learning health system to capture real‐world patient data: Application of the reliable change index to evaluate and improve the outcome of a pain rehabilitation program
Utilizing a learning health system to capture real‐world patient data: Application of the reliable change index to evaluate and improve the outcome of a pain rehabilitation program Open
Background and Objectives The learning healthcare system (LHS) has been developed to integrate patients' clinical data into clinical decisions and improve treatment outcomes. Having little guidance on this integration process, we aim to ex…
View article: Investigating the associations between lumbar paraspinal muscle health and age, BMI, sex, physical activity, and back pain using an automated computer-vision model: a UK Biobank study
Investigating the associations between lumbar paraspinal muscle health and age, BMI, sex, physical activity, and back pain using an automated computer-vision model: a UK Biobank study Open