Soheila J. Maleki
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View article: Linear and conformational epitopes of vicilin-buried peptides as a model for improved nut allergy diagnostics
Linear and conformational epitopes of vicilin-buried peptides as a model for improved nut allergy diagnostics Open
Introduction Individuals allergic to peanuts (PN) may show IgE cross-reactivity to tree nuts, especially walnuts (WN), which often complicates diagnosis. Vicilin-buried peptides (VBPs), short segments within the N-terminal vicilin leader s…
View article: Convergent monoclonal IgE antibodies from peanut allergic patients are multispecific to immunodominant epitopes of unrelated major peanut and tree nut allergens
Convergent monoclonal IgE antibodies from peanut allergic patients are multispecific to immunodominant epitopes of unrelated major peanut and tree nut allergens Open
The biological activity of affinity-matured cross-reactive antibodies with Ara h 2-associated sequence convergence may explain the high allergenic potency of peanut and clinically irrelevant co-sensitizations to tree nuts commonly observed…
View article: Purification and Epitope Mapping of Jug r 4, a Major Walnut Allergen
Purification and Epitope Mapping of Jug r 4, a Major Walnut Allergen Open
Background: Tree nut allergy affects approximately 1% of the U.S. population and the prevalence is increasing. Walnut allergy is the most commonly reported tree nut allergy in the United States. This study aimed to investigate the IgE cros…
View article: Murine model of cross-IgE sensitization and cross-anaphylactic reactions among multiple group food allergens
Murine model of cross-IgE sensitization and cross-anaphylactic reactions among multiple group food allergens Open
Rationale Approximately 32 million people in the United States suffer from food allergies. Some food groups, such as legumes – peanuts, tree nuts, fish, and shellfish, have a high risk of cross-reactivity. However, the murine model of mult…
View article: Mitigating Food Protein Allergenicity with Biopolymers, Bioactive Compounds, and Enzymes
Mitigating Food Protein Allergenicity with Biopolymers, Bioactive Compounds, and Enzymes Open
This review explores strategies for mitigating food allergies by treating foods with biopolymers, bioactive compounds, and food-grade enzymes. Biopolymers like chitosan, alginate, and pectin show potential in reducing the allergenic proper…
View article: IgE and IgG4 epitopes of the peanut allergens shift following oral immunotherapy
IgE and IgG4 epitopes of the peanut allergens shift following oral immunotherapy Open
Background Oral immunotherapy (OIT) with peanut (Arachis hypogaea) allergen powder-dnfp (PTAH; Aimmune Therapeutics) is an FDA-approved treatment to desensitize peanut allergic participants. Objective Here we assessed shifts in IgE and IgG…
View article: IgE and IgG4 epitopes of the peanut allergens shift following oral immunotherapy
IgE and IgG4 epitopes of the peanut allergens shift following oral immunotherapy Open
Background Oral immunotherapy (OIT) with peanut ( Arachis hypogaea ) allergen powder-dnfp (PTAH; Aimmune Therapeutics) is an FDA-approved treatment to desensitize peanut allergic participants. Objective Here we assessed shifts in IgE and I…
View article: Structure and IgE Cross-Reactivity among Cashew, Pistachio, Walnut, and Peanut Vicilin-Buried Peptides
Structure and IgE Cross-Reactivity among Cashew, Pistachio, Walnut, and Peanut Vicilin-Buried Peptides Open
Peanut and tree-nut allergies are frequently comorbid for reasons not completely understood. Vicilin-buried peptides (VBPs) are an emerging family of food allergens whose conserved structural fold could mediate peanut/tree-nut co-allergy. …
View article: IgE epitopes of Ara h 9, Jug r 3, and Pru p 3 in peanut-allergic individuals from Spain and the US
IgE epitopes of Ara h 9, Jug r 3, and Pru p 3 in peanut-allergic individuals from Spain and the US Open
Non-specific lipid transfer proteins (LTPs) are well studied allergens that can lead to severe reactions, but often cause oral allergy syndrome in the Mediterranean area and other European countries. However, studies focused on LTP reactiv…
View article: Manufacturing processes of peanut (Arachis hypogaea) allergen powder-dnfp
Manufacturing processes of peanut (Arachis hypogaea) allergen powder-dnfp Open
Background Important components of drug safety, efficacy, and acceptability involve manufacturing and testing of the drug substance and drug product. Peanut flour sourcing/processing and manufacturing processes may affect final drug produc…
View article: Manufacturing Processes of Peanut (<i>Arachis hypogaea</i>) Allergen Powder-dnfp
Manufacturing Processes of Peanut (<i>Arachis hypogaea</i>) Allergen Powder-dnfp Open
Important components of drug safety, efficacy, and acceptability involve manufacturing and testing of the drug substance and drug product. Peanut flour sourcing/processing and manufacturing processes may affect final drug product allergen …
View article: Structure, Immunogenicity, and IgE Cross-Reactivity among Walnut and Peanut Vicilin-Buried Peptides
Structure, Immunogenicity, and IgE Cross-Reactivity among Walnut and Peanut Vicilin-Buried Peptides Open
Vicilin-buried peptides (VBPs) from edible plants are derived from the N-terminal leader sequences (LSs) of seed storage proteins. VBPs are defined by a common α-hairpin fold mediated by conserved CxxxCx(10-14)CxxxC motifs. Here, peanut an…
View article: Structure and IgE cross-reactivity among walnut and peanut vicilin leader sequences
Structure and IgE cross-reactivity among walnut and peanut vicilin leader sequences Open
Background: Vicilin seed storage proteins are translated with N-terminal leader sequences (LSs) that are cleaved to yield the mature protein. These LSs were thought to be unstructured and rapidly degraded. However, Ara h 1 and Jug r 2 LS (…
View article: Interaction of Monocyte-Derived Dendritic Cells with Ara h 2 from Raw and Roasted Peanuts
Interaction of Monocyte-Derived Dendritic Cells with Ara h 2 from Raw and Roasted Peanuts Open
Ara h 2 is a relevant peanut allergen linked to severe allergic reactions. The interaction of Ara h 2 with components of the sensitization phase of food allergy (e.g., dendritic cells) has not been investigated, and could be key to underst…
View article: Incorporation of T-cell epitopes from tetanus and diphtheria toxoids into in-silico-designed hypoallergenic vaccine may enhance the protective immune response against allergens.
Incorporation of T-cell epitopes from tetanus and diphtheria toxoids into in-silico-designed hypoallergenic vaccine may enhance the protective immune response against allergens. Open
Collectively, incorporation of T-cell epitopes of tetanus and diphtheria into hypoallergenic vaccines can dramatically enhance anti-allergic immune mechanisms, particularly in poor responders.
View article: T follicular regulatory cells and IL-10 promote food antigen–specific IgE
T follicular regulatory cells and IL-10 promote food antigen–specific IgE Open
Food allergies are a major clinical problem and are driven by IgE antibodies (Abs) specific for food antigens (Ags). T follicular regulatory (Tfr) cells are a specialized subset of FOXP3+ T cells that modulate Ab responses. Here, we analyz…
View article: IgE to epitopes of Ara h 2 enhance the diagnostic accuracy of Ara h 2‐specific IgE
IgE to epitopes of Ara h 2 enhance the diagnostic accuracy of Ara h 2‐specific IgE Open
Background Understanding the discrepancy between IgE sensitization and allergic reactions to peanut could facilitate diagnosis and lead to novel means of treating peanut allergy. Objective To identify differences in IgE and IgG4 binding to…