Artur M. S. Silva
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View article: Comparative Molecular Profiling and Bioactivity Analysis of Algerian Propolis: Antioxidant, Antibacterial Activities, and In Silico NRF2-KEAP1 Pathway Modulation
Comparative Molecular Profiling and Bioactivity Analysis of Algerian Propolis: Antioxidant, Antibacterial Activities, and In Silico NRF2-KEAP1 Pathway Modulation Open
Propolis, a natural bee-derived product rich in diverse phytochemicals with potential therapeutic benefits, remains underexplored in Algeria. This study investigated the molecular profile, antioxidant capacity, and antibacterial activity o…
View article: Unveiling the Power of Computational Tools in Chiral Liquid Chromatography
Unveiling the Power of Computational Tools in Chiral Liquid Chromatography Open
Chiral liquid chromatography (cLC) using chiral stationary phases (CSPs) has become a crucial technique for separating enantiomers. Understanding enantiomeric discrimination is essential for improving chromatographic conditions and elucida…
View article: The role of quinoline in the development of near-infrared fluorescent probes for diagnosis of Alzheimer's disease
The role of quinoline in the development of near-infrared fluorescent probes for diagnosis of Alzheimer's disease Open
Alzheimer's disease (AD) is a common neurodegenerative disorder, having some negative impacts, affecting memory and other cognitive abilities, caused by injuries in brain cells. It is widely accepted that early diagnosis is essential for t…
View article: Single‐Benzene Fluorophore with Enhanced Emission: Insights into Photophysical Properties through Proton Transfer Mapping
Single‐Benzene Fluorophore with Enhanced Emission: Insights into Photophysical Properties through Proton Transfer Mapping Open
A comprehensive study of a single‐benzene fluorophore, characterized by a low molecular weight and a significant Stokes’ shift, is reported. The fluorophore exhibits crystallization‐induced emission enhancement and pH‐dependent luminescenc…
View article: Co0.85Bi0.15Fe1.9X0.1O4 (X = Ce4+, Sm3+, Ho3+, and Er3+) Nanoparticles with Selective Anticancer Activity: A Structural and Morphological Approach
Co0.85Bi0.15Fe1.9X0.1O4 (X = Ce4+, Sm3+, Ho3+, and Er3+) Nanoparticles with Selective Anticancer Activity: A Structural and Morphological Approach Open
In this work, we synthesized the Co0.85Bi0.15Fe1.9X0.1O4 (X = Ce3+, Sm3+, Ho3+, and Er3+) nanoparticles via the auto-combustion method. The cell viability against two breast cancer cells (MDA-MB-231 and T-47D cells) and the PC3 prostate ca…
View article: The Role of Flow Chemistry on the Synthesis of Pyrazoles, Pyrazolines and Pyrazole-Fused Scaffolds
The Role of Flow Chemistry on the Synthesis of Pyrazoles, Pyrazolines and Pyrazole-Fused Scaffolds Open
Nitrogen-containing heterocycles are fundamental scaffolds in organic chemistry, particularly due to their prevalence in pharmaceuticals, agrochemicals and materials science. Among them, five-membered rings, containing two nitrogen atoms i…
View article: Dialectical Behavior Therapy for Patients With Bipolar Disorder: A Systematic Review and Meta-Analysis
Dialectical Behavior Therapy for Patients With Bipolar Disorder: A Systematic Review and Meta-Analysis Open
Introduction Dialectical Behavior Therapy (DBT) is a comprehensive evidence-based psychotherapy that focuses on teaching skills regarding the acceptance of circumstances and coping with emotional responses. Objectives The objective of this…
View article: Applying the Principles of Green Chemistry to Cyclopropanation
Applying the Principles of Green Chemistry to Cyclopropanation Open
The cyclopropane motif is widely found in many natural products and drug candidates with relevant biological activities. Moreover, due to their strained ring, cyclopropanes possess higher reactivity compared to other alkanes, giving access…
View article: Halogenated 3-Nitro-2H-Chromenes as Potential Agents Against Multidrug-Resistant Bacteria
Halogenated 3-Nitro-2H-Chromenes as Potential Agents Against Multidrug-Resistant Bacteria Open
Introduction/Objectives: Nosocomial infections caused by S. aureus and S. epidermidis resistant strains are an important cause of morbidity and mortality worldwide. Due to the increasing rate of resistance to conventional antibiotics, the …
View article: Emergence of NDM-7-Producing Klebsiella quasipneumoniae subs. simillipneumoniae ST138 in a Hospital from the Northern Region of Brazil
Emergence of NDM-7-Producing Klebsiella quasipneumoniae subs. simillipneumoniae ST138 in a Hospital from the Northern Region of Brazil Open
Clinical emergent bacterial pathogens are a great threat to the global health system, chiefly Gram-negative carbapenem-resistant Enterobacterales and the Klebsiella pneumoniae species complex. Here, we present the molecular and phenotypic …
View article: Flavonoids as Potential Modulators of Pancreatic Lipase Catalytic Activity
Flavonoids as Potential Modulators of Pancreatic Lipase Catalytic Activity Open
Background/Objectives: Obesity has reached pandemic proportions, with predictions suggesting that, by 2030, over 1.5 billion people will be affected. Pancreatic lipase (PL), the enzyme primarily responsible for the absorption of dietary li…
View article: 1,3,5-Triazine: A Promising Molecular Scaffold for Novel Agents for the Treatment of Alzheimer’s Disease
1,3,5-Triazine: A Promising Molecular Scaffold for Novel Agents for the Treatment of Alzheimer’s Disease Open
Currently, Alzheimer’s disease (AD) is one of the most frequent forms of dementia. From a molecular perspective, the molecular characteristics that better define this disease consist of abnormal protein deposits between neuronal cells, nam…
View article: Effects of Summer Water Deficit Stress on Olive Fruits and Oil Quality
Effects of Summer Water Deficit Stress on Olive Fruits and Oil Quality Open
The Mediterranean basin is the leading worldwide region for olive production. Extreme weather is increasingly frequent in this region, and how these climate extremes will affect olive products and quality remains unknown. We aim to study t…
View article: Phytochemical Study and In Vitro Antioxidant Activity of Helianthemum cinereum Along with Antitumor Activity of the Isolated trans-Tiliroside and Luteolin 4′-O-β-Xyloside
Phytochemical Study and In Vitro Antioxidant Activity of Helianthemum cinereum Along with Antitumor Activity of the Isolated trans-Tiliroside and Luteolin 4′-O-β-Xyloside Open
Twelve compounds (1–12), kaempferol (1), luteolin (2), luteolin 4′-O-β-xyloside (3), luteolin 4′-O-β-glucoside (4), quercetin 4′-O-β-xyloside (5), kaempferol-3-O-[6″-O-(E)-p-coumaroyl]-β-D-glucoside (trans-tiliroside) (6), protocatechuic a…
View article: Transvaginal Evisceration in a Patient With Rectovaginal Prolapse: A Twist in the Tale
Transvaginal Evisceration in a Patient With Rectovaginal Prolapse: A Twist in the Tale Open
Transvaginal evisceration is a rare, potentially life-threatening condition involving herniation of intra-abdominal contents, typically the small bowel, through a defect in the vaginal wall. Most commonly observed in postmenopausal women w…
View article: Bioprospecting a Natural Antioxidant Peptide for Tomato Biostimulation Under Water Limitations: Physiological Approach
Bioprospecting a Natural Antioxidant Peptide for Tomato Biostimulation Under Water Limitations: Physiological Approach Open
Drought causes major agricultural losses, threatening food security worldwide. Thus, innovative strategies have been explored to improve crop tolerance to drought. This work focused on one natural peptide (PpT-2) with antioxidant activity,…
View article: Phytochemical Study and In Vitro Antioxidant Activity of Helianthemum cinereum Along with Antitumor Activity of the Isolated Trans-Tiliroside and Luteolin 4′-O-β-Xyloside
Phytochemical Study and In Vitro Antioxidant Activity of Helianthemum cinereum Along with Antitumor Activity of the Isolated Trans-Tiliroside and Luteolin 4′-O-β-Xyloside Open
Twelve compounds (1-12): kaempferol (1), luteolin (2), luteolin 4'-O-β-xyloside (3), luteolin 4'-O-β-glucoside (4), quercetin 4'-O-β-xyloside (5), kaempferol-3-O-[6"-O-(E)-p-coumaroyl]-β-D-glucoside (trans-tiliroside) (…
View article: Monoterpene Hydroxy Lactones Isolated from Thalassiosira sp. Microalga and Their Antibacterial and Antioxidant Activities
Monoterpene Hydroxy Lactones Isolated from Thalassiosira sp. Microalga and Their Antibacterial and Antioxidant Activities Open
Two monoterpenoid lactones, loliolide (1) and epi-loliolide (2), were isolated from the crude dichloromethane extract of a microalga, Thalassiosira sp.). The structures of loliolide (1) and epi-loliolide (2) were elucidated by 1D and 2D NM…
View article: Ascophyllum nodosum Extract Improves Olive Performance Under Water Deficit Through the Modulation of Molecular and Physiological Processes
Ascophyllum nodosum Extract Improves Olive Performance Under Water Deficit Through the Modulation of Molecular and Physiological Processes Open
The olive tree is well adapted to the Mediterranean climate, but how orchards based on intensive practices will respond to increasing drought is unknown. This study aimed to determine if the application of a commercial biostimulant improve…
View article: Ultrasensitive Raman Gas Spectroscopy for Dinitrogen Sensing at the Parts-per-Billion Level
Ultrasensitive Raman Gas Spectroscopy for Dinitrogen Sensing at the Parts-per-Billion Level Open
Sensing small changes in the concentration of dinitrogen (N2) is a difficult analytical task. As N2-sensing is crucial for nitrogen cycle research in general and studies of denitrification in particular, researchers went to great lengths t…
View article: Comparative metabolomics of leaves and stems of three Italian olive cultivars under drought stress
Comparative metabolomics of leaves and stems of three Italian olive cultivars under drought stress Open
The Mediterranean will be one of the focal points of climate change. The predicted dry and hot summers will lead to water scarcity in agriculture, which may limit crop production and growth. The olive tree serves as a model woody plant for…
View article: High-Precision Optical Fiber-Based Lickometer
High-Precision Optical Fiber-Based Lickometer Open
Quantifying and analyzing licking behavior can offer valuable insights into fundamental neurobiological mechanisms controlling animal consummatory behaviors. Lickometers are typically based on electrical properties, a strategy that comes w…
View article: Exploring the fate of phlorotannins from Laminaria digitata across the gastrointestinal tract: Insights into susceptibility and bioactivity prior and post gastrointestinal digestion
Exploring the fate of phlorotannins from Laminaria digitata across the gastrointestinal tract: Insights into susceptibility and bioactivity prior and post gastrointestinal digestion Open
Phlorotannins are phenolic compounds exclusive from brown macroalgae endowed with promising bioactive properties. However, considering that diet is their main route of entrance to our system, gastrointestinal digestion might affect such bi…
View article: Pyrazoles have a multifaceted anti-inflammatory effect targeting prostaglandin E2, cyclooxygenases and leukocytes’ oxidative burst
Pyrazoles have a multifaceted anti-inflammatory effect targeting prostaglandin E2, cyclooxygenases and leukocytes’ oxidative burst Open
Elevated levels of prostaglandin E2 have been implicated in the pathophysiology of various diseases. Anti-inflammatory drugs that act through the inhibition of cyclooxygenase enzymatic activity, thereby leading to the suppression of prosta…