Shigeyuki Matsui
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View article: Utility of the continuous spectrum formed by pathological states in characterizing disease properties
Utility of the continuous spectrum formed by pathological states in characterizing disease properties Open
Understanding diseases as the result of continuous transitions from a healthy system is more realistic than understanding them as discrete states. Here, we designed the spectrum formation approach (SFA), a machine learning-based method tha…
View article: Midterm results of aortic arch replacement with frozen elephant trunk for chronic dissecting aortic aneurysm involving the aortic arch.
Midterm results of aortic arch replacement with frozen elephant trunk for chronic dissecting aortic aneurysm involving the aortic arch. Open
We performed total aortic arch replacement (TAR) with a frozen elephant trunk (FET) for chronic dissecting aortic aneurysm (DAA) involving the aortic arch as the initial surgery and carefully observed these aortic findings with periodic co…
View article: Development and Validation of Predictive Risk Scores for Ovarian Clear Cell Carcinoma: A Penalized Regression Model
Development and Validation of Predictive Risk Scores for Ovarian Clear Cell Carcinoma: A Penalized Regression Model Open
Background The precision management of ovarian clear cell carcinoma (OCCC) faces limitations due to the absence of personalized prognostic tools. This study aimed to establish predictive risk scores to enable effective stratification and t…
View article: Neurological outcomes with hypothermia versus normothermia in patients with moderate initial illness severity following resuscitation from out-of-hospital cardiac arrest: protocol for a multicentre randomised controlled trial (R-CAST OHCA)
Neurological outcomes with hypothermia versus normothermia in patients with moderate initial illness severity following resuscitation from out-of-hospital cardiac arrest: protocol for a multicentre randomised controlled trial (R-CAST OHCA) Open
Introduction Temperature control is a fundamental intervention for neuroprotection following resuscitation from cardiac arrest. However, evidence regarding the efficacy of hypothermia in post-cardiac arrest syndrome (PCAS) remains unclear.…
View article: Impact of post-decannulation high fever on mortality in patients with severe ARDS treated with veno-venous ECMO: a multicenter retrospective study
Impact of post-decannulation high fever on mortality in patients with severe ARDS treated with veno-venous ECMO: a multicenter retrospective study Open
Background Few studies have examined the prognostic impact of high fever after decannulation from veno-venous extracorporeal membrane oxygenation (V-V ECMO) in patients with severe acute respiratory distress syndrome (ARDS). We aimed to in…
View article: Vonoprazan or Proton Pump Inhibitor for Gastric Endoscopic Submucosal Dissection in Patients Taking Antithrombotic Agents
Vonoprazan or Proton Pump Inhibitor for Gastric Endoscopic Submucosal Dissection in Patients Taking Antithrombotic Agents Open
Background and Aim Delayed bleeding is a major concern after gastric endoscopic submucosal dissection (ESD), especially in patients taking antithrombotic agents. The aim of this study was to evaluate the superiority of vonoprazan (VPZ) ove…
View article: Comprehensive analysis of prognosis markers with molecular features derived from pan-cancer whole-genome sequences
Comprehensive analysis of prognosis markers with molecular features derived from pan-cancer whole-genome sequences Open
Cancer prognosis markers are useful for treatment decisions; however, the omics-level landscape is not well understood across multiple cancer types. Pan-Cancer Analysis of Whole Genomes (PCAWG) provides unprecedented access to various type…
View article: Dose-finding design based on level set estimation in phase I cancer clinical trials
Dose-finding design based on level set estimation in phase I cancer clinical trials Open
The primary objective of phase I cancer clinical trials is to evaluate the safety of a new experimental treatment and to find the maximum tolerated dose (MTD). We show that the MTD estimation problem can be regarded as a level set estimati…
View article: Long-term prognostic significance of ascites cytology in ovarian cancer cases in which R0 resection was achieved in the initial surgery: a multi-institutional retrospective cohort study
Long-term prognostic significance of ascites cytology in ovarian cancer cases in which R0 resection was achieved in the initial surgery: a multi-institutional retrospective cohort study Open
Background In ovarian cancer (OvCa), achieving complete resection (RO) in initial surgery is crucial for improving prognosis. However, patients with undetected microscopic metastasis post-RO surgery often have poorer outcomes. This study e…
View article: Establishment of a machine learning model for predicting splenic hilar lymph node metastasis
Establishment of a machine learning model for predicting splenic hilar lymph node metastasis Open
Upper gastrointestinal cancer (UGC) sometimes metastasizes to the splenic hilum lymph node (SHLN). However, surgical removal of SHLN is technically difficult, and the risk of postoperative complications is high. Although there are models t…
View article: Evaluating treatment effect modifiers using data from randomized two-sequence, two-period crossover clinical trials: application to a diabetes study
Evaluating treatment effect modifiers using data from randomized two-sequence, two-period crossover clinical trials: application to a diabetes study Open
Type 2 diabetes is known as a heterogeneous disease with diverse pathophysiology. The identification of treatment effect modifiers for personalized medicine, however, has been difficult in basic research due to complex biological mechanism…
View article: Effect Size of Targeted Temperature Management in Pediatric Patients with Post-Cardiac Arrest Syndrome According to the Severity
Effect Size of Targeted Temperature Management in Pediatric Patients with Post-Cardiac Arrest Syndrome According to the Severity Open
Aim: Few studies have investigated the differential effects of targeted temperature management (TTM) according to the severity of the condition in pediatric patients with post-cardiac arrest syndrome (PCAS). This study was aimed at evaluat…
View article: Histology-specific long-term oncologic outcomes in patients with epithelial ovarian cancer who underwent complete tumor resection: The implication of occult seeds after initial surgery
Histology-specific long-term oncologic outcomes in patients with epithelial ovarian cancer who underwent complete tumor resection: The implication of occult seeds after initial surgery Open
Objective Assessing the histology-specific prognosis of epithelial ovarian cancer (OvCa) is clinically challenging, especially in a patient population with a favorable prognosis. This study investigated the histology-specific long-term onc…
View article: Increased national critical care demands were associated with a higher mortality of intubated COVID-19 patients in Japan: a retrospective observational study
Increased national critical care demands were associated with a higher mortality of intubated COVID-19 patients in Japan: a retrospective observational study Open
Background There was no study to investigate the association between the national surge of Coronavirus disease 2019 (COVID-19) patients and the mortality of mechanically ventilated COVID-19 patients. The aim of this study was to assess the…
View article: Aging affects regrowth of stealthperitoneal dissemination of advanced ovarian cancer: a multicenter retrospective cohort study
Aging affects regrowth of stealthperitoneal dissemination of advanced ovarian cancer: a multicenter retrospective cohort study Open
Ovarian cancer (OvCa) is one of the most lethal gynecological malignancies, and most patients are diagnosed at advanced stage with peritoneal dissemination. Although age at diagnosis is considered an independent prognostic factor, its impa…
View article: Identifying Subgroups with Differential Responses to Amiodarone among Cardiac Arrest Patients with a Shockable Rhythm at Hospital Arrival using the Machine Learning Approach
Identifying Subgroups with Differential Responses to Amiodarone among Cardiac Arrest Patients with a Shockable Rhythm at Hospital Arrival using the Machine Learning Approach Open
Background: There are few reports of studies on the differential effects of amiodarone among out-of-hospital cardiac arrest (OHCA) patients with a shockable rhythm at hospital arrival. The present study aimed to investigate the clinical he…
View article: CHST4 Gene as a Potential Predictor of Clinical Outcome in Malignant Pleural Mesothelioma
CHST4 Gene as a Potential Predictor of Clinical Outcome in Malignant Pleural Mesothelioma Open
Malignant pleural mesothelioma (MPM) develops primarily from asbestos exposures and has a poor prognosis. In this study, The Cancer Genome Atlas was used to perform a comprehensive survival analysis, which identified the CHST4 gene as a po…
View article: RENEWAL OF HIGHWAY BRIDGE SLABS BY COTTER PRECAST PC DECKS AND THE FATIGUE DURABILITY
RENEWAL OF HIGHWAY BRIDGE SLABS BY COTTER PRECAST PC DECKS AND THE FATIGUE DURABILITY Open
疲労等で損傷した道路橋RC床版を,交通規制をしてPCaPC床版に取替える工事が進められている.しかし,PCaPC床版の接合の際,ループ継手等の従来工法は突出した鉄筋の重ね継手で接続するため接合部幅が30〜40cm程度と大きく,施工性改善,作業時間短縮が模索されている.このため本研究者らはPCaPC床版端部にC型金物を埋め込み,床版設置後に相対するC型金物をH型金物で嵌合した後,目地材を充填し接合が完了する「コッター床版工法」を開発した.この機械式継手により接合部幅を19mm…
View article: Aging affects regrowth of stealth peritoneal dissemination of advanced ovarian cancer: A multicenter retrospective cohort study
Aging affects regrowth of stealth peritoneal dissemination of advanced ovarian cancer: A multicenter retrospective cohort study Open
Aging contributes to a worse prognosis in advanced ovarian cancer patients with peritoneal dissemination that was completely resected in the debulking surgery. Ovarian cancer (OvCa) is one of the most lethal gynecological malignancies, and…
View article: Prognostic impact of highly solid component in early-stage solid lung adenocarcinoma
Prognostic impact of highly solid component in early-stage solid lung adenocarcinoma Open
In patients with early-stage solid lung adenocarcinoma, the measurement of three-dimensional solid tumor volume, which is correlated with PIV, accurately predicted the postoperative outcome.
View article: Systematic Review and Meta-Analysis of the Use of Serum Leucine-Rich Alpha-2 Glycoprotein to Assess Crohn’s Disease Activity
Systematic Review and Meta-Analysis of the Use of Serum Leucine-Rich Alpha-2 Glycoprotein to Assess Crohn’s Disease Activity Open
Background Although fecal calprotectin is the most widely used biomarker for assessing Crohn’s disease activity, serum leucine-rich alpha-2 glycoprotein has recently attracted attention, especially in Japan. Here we performed a systematic …
View article: Evaluating glucose variability through OGTT in early pregnancy and its association with hypertensive disorders of pregnancy in non-diabetic pregnancies: a large-scale multi-center retrospective study
Evaluating glucose variability through OGTT in early pregnancy and its association with hypertensive disorders of pregnancy in non-diabetic pregnancies: a large-scale multi-center retrospective study Open
Background Recent evidence suggests increased glucose variability (GV) causes endothelial dysfunction, a central pathology of hypertensive disorders of pregnancy (HDP). We aimed to investigate the association between GV in early pregnancy …
View article: Factors associated with adverse drug reactions or death in very elderly hospitalized patients with pulmonary tuberculosis
Factors associated with adverse drug reactions or death in very elderly hospitalized patients with pulmonary tuberculosis Open
The aging of patients with tuberculosis and better therapeutic management for them are recent concerns. This study aimed to identify risk factors for adverse drug reactions (ADRs) or death in very elderly patients with pulmonary tuberculos…
View article: Supplementary Figure 3 from Comparison of Statistical Analysis Plans in Randomize-All Phase III Trials with a Predictive Biomarker
Supplementary Figure 3 from Comparison of Statistical Analysis Plans in Randomize-All Phase III Trials with a Predictive Biomarker Open
PDF file - 63KB, P overall, P subset, and P success, for various numbers of events, E, under a quantitative interaction (HR+, HR−) = (0.5, 0.8).
View article: Supplemental Material 2: Impact of the prevalence of marker-positive patients in the general population on the characteristics of the marker-based designs. from Biomarker-Stratified Phase III Clinical Trials: Enhancement with a Subgroup-Focused Sequential Design
Supplemental Material 2: Impact of the prevalence of marker-positive patients in the general population on the characteristics of the marker-based designs. from Biomarker-Stratified Phase III Clinical Trials: Enhancement with a Subgroup-Focused Sequential Design Open
Impact of the prevalence of marker-positive patients in the general population on the characteristics of the marker-based designs
View article: Supplemental Material 1: Proposed marker-stratified design from Biomarker-Stratified Phase III Clinical Trials: Enhancement with a Subgroup-Focused Sequential Design
Supplemental Material 1: Proposed marker-stratified design from Biomarker-Stratified Phase III Clinical Trials: Enhancement with a Subgroup-Focused Sequential Design Open
Proposed marker-stratified design
View article: Supplementary Figure 3 from Comparison of Statistical Analysis Plans in Randomize-All Phase III Trials with a Predictive Biomarker
Supplementary Figure 3 from Comparison of Statistical Analysis Plans in Randomize-All Phase III Trials with a Predictive Biomarker Open
PDF file - 63KB, P overall, P subset, and P success, for various numbers of events, E, under a quantitative interaction (HR+, HR−) = (0.5, 0.8).