Nikhil Narang
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View article: A Contemporary Guide of Venoarterial Extracorporeal Membrane Oxygenation in Cardiogenic Shock
A Contemporary Guide of Venoarterial Extracorporeal Membrane Oxygenation in Cardiogenic Shock Open
Managing refractory cardiogenic shock is individualized, with few aspects considered routine or universally contraindicated. Venoarterial extracorporeal membrane oxygenation (VA-ECMO) is a temporary mechanical circulatory support strategy,…
View article: Complications and Status Upgrades among Adult Heart Transplant Candidates with Durable LVADs: Waiting 6 to 8 Years for Status Escalation Is Too Long
Complications and Status Upgrades among Adult Heart Transplant Candidates with Durable LVADs: Waiting 6 to 8 Years for Status Escalation Is Too Long Open
Introduction: After the 2018 allocation policy change, the rate of listings and transplants with durable LVADs has decreased significantly in favor of bridging patients from temporary mechanical circulatory support to heart transplant. The…
View article: A Knowledge Graph-based Retrieval-Augmented Generation Framework for Algorithm Selection in the Facility Layout Problem
A Knowledge Graph-based Retrieval-Augmented Generation Framework for Algorithm Selection in the Facility Layout Problem Open
Selecting a solution algorithm for the Facility Layout Problem (FLP), an NP-hard optimization problem with multiobjective trade-off, is a complex task that requires deep expert knowledge. The performance of a given algorithm depends on the…
View article: High Rate of Transplantation Prior to Review of Status Exception Requests among Adult Heart Transplant Candidates
High Rate of Transplantation Prior to Review of Status Exception Requests among Adult Heart Transplant Candidates Open
Background In the United States heart allocation system, when transplant centers submit applications for status exceptions to increase waitlist priority, patients obtain the requested status upgrades immediately while their applications ar…
View article: Analysis of outcomes in patients with HeartMate 3 with and without right ventricular assist device support
Analysis of outcomes in patients with HeartMate 3 with and without right ventricular assist device support Open
Aims Following HeartMate 3 (HM3) LVAD implantation, acute right heart failure necessitating temporary right ventricular assist device (tRVAD) support has not been extensively described. We examined clinical outcomes in patients with HM3 LV…
View article: Prediction of Heart Disease Using XGBoost Algorithm
Prediction of Heart Disease Using XGBoost Algorithm Open
Heart disease remains a major global health concern, making early diagnosis crucial for reducingmortality rates. This study focuses on developing a predictive model using the XGBoost algorithm,optimized through Optuna hyperparameter tuning…
View article: Sex Hormones and Heart Failure Risk
Sex Hormones and Heart Failure Risk Open
Heart failure (HF) is a significant cause of morbidity and mortality. Although there are inconsistencies, epidemiological studies have implicated sex hormones (SHs) in pathways that are linked to HF. The age-related decline in SH levels ca…
View article: Impact of Remote Dielectric Sensing on Predicting Worsening Heart Failure During Hospitalization for Heart Failure
Impact of Remote Dielectric Sensing on Predicting Worsening Heart Failure During Hospitalization for Heart Failure Open
Background: A remote dielectric sensing (ReDS) system quickly quantifies pulmonary congestion. Nonetheless, its efficacy in predicting an in-hospital increase in plasma B-type natriuretic peptide levels, the potential surrogate of worsenin…
View article: Delays in Cardiopulmonary Resuscitation, Defibrillation, and Epinephrine Administration in Out-of-Hospital Cardiac Arrest ― Composite Time-Dependent Effects of Prehospital Interventions on 30-Day Favorable Neurological Outcomes and Social Implications From a Prospective Nationwide Population-Based Cohort Study ―
Delays in Cardiopulmonary Resuscitation, Defibrillation, and Epinephrine Administration in Out-of-Hospital Cardiac Arrest ― Composite Time-Dependent Effects of Prehospital Interventions on 30-Day Favorable Neurological Outcomes and Social Implications From a Prospective Nationwide Population-Based Cohort Study ― Open
Among patients with witnessed OHCA, there was a dose-response relationship between delays in the collapse-CPR initiation interval, and subsequent intervals to defibrillation or epinephrine administration, and 30-day favorable neurological …
View article: Haemodynamic effects of intra‐aortic balloon pumps stratified by baseline pulmonary artery pulsatility index
Haemodynamic effects of intra‐aortic balloon pumps stratified by baseline pulmonary artery pulsatility index Open
Aims Intra‐aortic balloon pump (IABP) devices are commonly used in patients with heart failure related cardiogenic shock (HF‐CS), including those with out‐of‐proportion right ventricular (RV) dysfunction. Pulmonary artery pulsatility index…
View article: Impaired Gastrointestinal Motility and Worsening Heart Failure in Patients Receiving Trans-Catheter Aortic Valve Replacement
Impaired Gastrointestinal Motility and Worsening Heart Failure in Patients Receiving Trans-Catheter Aortic Valve Replacement Open
Background: Impaired gastric motility in the form of constipation may often occur in elderly patients with chronic heart failure. Candidates for trans-catheter aortic replacement (TAVR) are of old age and have multiple comorbidities, proba…
View article: A Lower Remote Dielectric Sensing Value Was Associated with Hypovolemia and Worse Clinical Outcomes
A Lower Remote Dielectric Sensing Value Was Associated with Hypovolemia and Worse Clinical Outcomes Open
Background: Remote dielectric sensing (ReDS) systems can estimate the amount of lung fluid non-invasively and easily without expert techniques. The correlation between the elevated ReDS value and other modalities that estimate pulmonary co…
View article: Clinical Implications of Remote Dielectric Sensing-Guided Management
Clinical Implications of Remote Dielectric Sensing-Guided Management Open
Background: Remote dielectric sensing (ReDS) systems can quantify the degree of pulmonary congestion rapidly and non-invasively. However, the clinical implications of ReDS-guided medication adjustment remain uncertain. Methods: Patients ho…
View article: Development and Validation of a Risk Score Predicting Death Without Transplant in Adult Heart Transplant Candidates
Development and Validation of a Risk Score Predicting Death Without Transplant in Adult Heart Transplant Candidates Open
Importance The US heart allocation system prioritizes medically urgent candidates with a high risk of dying without transplant. The current therapy-based 6-status system is susceptible to manipulation and has limited rank ordering ability.…
View article: Financial Implication of Sodium Zirconium Cyclosilicate Therapy in Patients with Systolic Heart Failure and Hyperkalemia
Financial Implication of Sodium Zirconium Cyclosilicate Therapy in Patients with Systolic Heart Failure and Hyperkalemia Open
Sodium zirconium cyclosilicate (SZC), a newly-introduced potassium binder, can be used to manage hyperkalemia especially in patients with chronic kidney disease and in those on medical therapy which may raise serum potassium levels. The me…
View article: Earlier First Publication Is Associated with More Future Publication
Earlier First Publication Is Associated with More Future Publication Open
Participation in clinical research has served clinicians to develop academic careers, as well as to deepen clinical insights, implement evidence-based medicine practices, and even inspire new clinical questions. Early engagement in academi…
View article: Hemodynamic Optimization of the<scp>LVAD</scp>Patient
Hemodynamic Optimization of the<span>LVAD</span>Patient Open
Continuous flow left ventricular assist devices (LVADs) offer therapy for patients with advanced heart failure to improve quality of life and survival, as either destination therapy or bridge to transplantation. This chapter covers the fol…
View article: Estimation of Small Dense LDL-Cholesterol Levels in Patients with Acute Coronary Syndrome
Estimation of Small Dense LDL-Cholesterol Levels in Patients with Acute Coronary Syndrome Open
Small dense LDL-cholesterol is an established risk factor for atherosclerosis, but it is not routinely measured in clinical practice, and its measurement has not yet been reimbursed. The Sampson equation that uses triglyceride and LDL-chol…
View article: Negative Prognostic Impact of Mineralocorticoid Receptor Antagonist in Elderly Patients Receiving TAVR
Negative Prognostic Impact of Mineralocorticoid Receptor Antagonist in Elderly Patients Receiving TAVR Open
Background: Morbidity and mortality following trans-catheter aortic valve replacement (TAVR) remain high. Renin-angiotensin system inhibitors improve clinical outcomes in the cohort studied in this work. However, post-TAVR prognostic impac…
View article: Device Exchange to HeartMate 3 LVAD: Impact of Previous Pump Model on Clinical Outcomes
Device Exchange to HeartMate 3 LVAD: Impact of Previous Pump Model on Clinical Outcomes Open
Patients being considered for device exchange from HVAD to HM3 may have a more complicated clinical course compared with HM2 to HM3 patients.